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  1. Article ; Online: Dengue Virus Infection of

    Gold, Alexander S / Feitosa-Suntheimer, Fabiana / Araujo, Ricardo V / Hekman, Ryan M / Asad, Sultan / Londono-Renteria, Berlin / Emili, Andrew / Colpitts, Tonya M

    International journal of molecular sciences

    2020  Volume 21, Issue 18

    Abstract: Dengue is the most burdensome vector-borne viral disease in the world. Dengue virus (DENV), the etiological cause of dengue, is transmitted primarily by ... ...

    Abstract Dengue is the most burdensome vector-borne viral disease in the world. Dengue virus (DENV), the etiological cause of dengue, is transmitted primarily by the
    MeSH term(s) Aedes/metabolism ; Aedes/virology ; Animals ; Cells, Cultured ; Dengue/transmission ; Dengue/virology ; Dengue Virus ; Extracellular Vesicles/metabolism ; Female ; Humans ; Insect Proteins/metabolism ; Mosquito Vectors/metabolism ; Mosquito Vectors/virology
    Chemical Substances Insect Proteins
    Language English
    Publishing date 2020-09-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21186609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: PROP1 overexpression in corticotrophinomas: evidence for the role of PROP1 in the maintenance of cells committed to corticotrophic differentiation.

    Araujo, Ricardo V / Chang, Claudia V / Cescato, Valter A S / Fragoso, Maria Candida B V / Bronstein, Marcello D / Mendonca, Berenice B / Arnhold, Ivo J P / Carvalho, Luciani R S

    Clinics (Sao Paulo, Brazil)

    2012  Volume 68, Issue 6, Page(s) 887–891

    Abstract: Objective: The expression of transcription factors involved in early pituitary development, such as PROP1 and POU1F1, has been detected in pituitary adenoma tissues. In this study, we sought to characterize the transcriptional profiles of PROP1, POU1F1, ...

    Abstract Objective: The expression of transcription factors involved in early pituitary development, such as PROP1 and POU1F1, has been detected in pituitary adenoma tissues. In this study, we sought to characterize the transcriptional profiles of PROP1, POU1F1, and TBX19 in functioning and nonfunctioning pituitary adenomas in an attempt to identify their roles in tumorigenesis and hormone hypersecretion.
    Methods: RT-qPCR analyses were performed to assess the transcriptional pattern of PROP1, POU1F1, TBX19, and hormone-producing genes in tissue samples of corticotrophinomas (n=10), somatotrophinomas (n=8), and nonfunctioning adenomas (n=6).
    Results: Compared with normal pituitary tissue, POU1F1 was overexpressed in somatotrophinomas by 3-fold. PROP1 expression was 18-fold higher in corticotrophinomas, 10-fold higher in somatotrophinomas, and 3-fold higher in nonfunctioning adenomas. TBX19 expression was 27-fold higher in corticotrophinomas. Additionally, the level of TBX19 mRNA positively correlated with that of pro-opiomelanocortin (r=0.49, p=0.014).
    Conclusions: Our data demonstrate that PROP1 is overexpressed in pituitary adenomas, mainly in corticotrophinomas. Together with previously published data showing that patients who harbor PROP1 loss-of-function mutations present a progressive decline in corticotrope function, our results support a role for PROP1 in pituitary tumor development and in the maintenance of cell lineages committed to corticotrophic differentiation.
    MeSH term(s) ACTH-Secreting Pituitary Adenoma/genetics ; ACTH-Secreting Pituitary Adenoma/metabolism ; ACTH-Secreting Pituitary Adenoma/pathology ; Adenoma/genetics ; Adenoma/metabolism ; Adenoma/pathology ; Adolescent ; Adult ; Aged ; Cell Differentiation ; Female ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Pituitary Gland/metabolism ; RNA, Messenger/metabolism ; Real-Time Polymerase Chain Reaction ; T-Box Domain Proteins/genetics ; T-Box Domain Proteins/metabolism ; Transcription Factor Pit-1/genetics ; Transcription Factor Pit-1/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Young Adult
    Chemical Substances Homeodomain Proteins ; Neoplasm Proteins ; POU1F1 protein, human ; Prophet of Pit-1 protein ; RNA, Messenger ; T-Box Domain Proteins ; TBX19 protein, human ; Transcription Factor Pit-1 ; Transcription Factors
    Language English
    Publishing date 2012-07-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2182801-5
    ISSN 1980-5322 ; 1807-5932
    ISSN (online) 1980-5322
    ISSN 1807-5932
    DOI 10.6061/clinics/2013(06)26
    Database MEDical Literature Analysis and Retrieval System OnLINE

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