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Article ; Online: Correction to: Adipose‑derived stem cells applied to ankle pathologies: a systematic review.

Arceri, A / Mazzotti, A / Artioli, E / Zielli, S O / Barile, F / Manzetti, M / Viroli, G / Ruffilli, A / Faldini, C

2024

Language	English
Publishing date	2024-04-06
Publishing country	Italy
Document type	Published Erratum
ZDB-ID	2495458-5
ISSN	2035-5114 ; 2035-5106
ISSN (online)	2035-5114
ISSN	2035-5106
DOI	10.1007/s12306-023-00809-7
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Article ; Online: Functional evaluation of a novel fibreglass-reinforced polyamide custom dynamic AFO for foot drop patients: A pilot study.

Caravaggi, P / Rogati, G / Zamagni, L / Boriani, L / Arceri, A / Ortolani, M / Lullini, G / Berti, L / Leardini, A

Gait & posture

2024 Volume 109, Page(s) 41–48

Abstract: Background: Ankle-foot orthoses (AFOs) are orthopaedic devices often prescribed to treat foot drop. For patients who are not satisfied with off-the-shelf solutions, custom AFOs personalized to the patient's lower limb anatomy are required. Dynamic AFOs ... ...

Abstract	Background: Ankle-foot orthoses (AFOs) are orthopaedic devices often prescribed to treat foot drop. For patients who are not satisfied with off-the-shelf solutions, custom AFOs personalized to the patient's lower limb anatomy are required. Dynamic AFOs provide stability while allowing for physiological ankle mobility in the stance phase of walking. Research question: Can a morphology-based dynamic custom AFO made of fiberglass-reinforced polyamide restore a quasi-normal gait pattern and improve comfort in patients with foot drop? Methods: In this pilot study, the legs and feet of ten foot drop patients (age=64.9 ± 11.4 years; BMI=26.2 ± 2.1 kg/m Results: The custom AFO resulted in significant increase of stride length and walking speed compared to the shod condition. Except for the hip joint, which exhibited greater maximum flexion and reduced range of motion, the kinematic parameters of all other joints were similar to those observed in a healthy control population. Furthermore, the custom AFO received significantly higher comfort scores compared to the Codivilla spring. Significance: This study has provided evidence supporting the effectiveness of custom orthotic solutions in restoring lower limb kinematics and improving the perceived comfort in foot drop patients compared to off-the-shelf solutions.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Pilot Projects ; Nylons ; Peroneal Neuropathies ; Foot Orthoses ; Ankle Joint ; Muscle Weakness ; Paresis ; Biomechanical Phenomena ; Gait/physiology ; Glass
Chemical Substances	fiberglass ; Nylons
Language	English
Publishing date	2024-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1162323-8
ISSN	1879-2219 ; 0966-6362
ISSN (online)	1879-2219
ISSN	0966-6362
DOI	10.1016/j.gaitpost.2024.01.017
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Article ; Online: Keller's arthroplasty for hallux rigidus: A systematic review.

Artioli, E / Mazzotti, A / Zielli, S / Bonelli, S / Arceri, A / Geraci, G / Faldini, C

Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons

2022 Volume 28, Issue 4, Page(s) 526–533

Abstract: Background: Several surgical procedures have been described to treat hallux rigidus. Keller arthroplasty is a joint-sacrificing procedure proposed in 1904. Considering the current trends to mini-invasiveness and the debate about the technique's ... ...

Abstract	Background: Several surgical procedures have been described to treat hallux rigidus. Keller arthroplasty is a joint-sacrificing procedure proposed in 1904. Considering the current trends to mini-invasiveness and the debate about the technique's suitability, this review intends to state Keller arthroplasty results and the conditions where it could be still adopted in the treatment of hallux rigidus. Methods: Selected articles were reviewed to extract: population data, surgical indications, different surgical techniques, clinical and radiological outcomes, and complications. Results: Seventeen retrospective studies were selected, counting 508 patients. Mean age at surgery was 55 years. Patients were affected by moderate-severe hallux rigidus. Three modified Keller arthroplasty were identified. Good clinical and radiological outcomes were reported. Metatarsalgia was the most frequent complication (12%). Conclusion: Despite for many authors KA seems a viable surgical treatment for middle aged and elderly patients affected by moderate-severe hallux rigidus, the available literature provides little evidence on the real efficacy and safety of the technique. A non-negligible percentage of complications may occur, and therefore is essential to set correct indications through an accurate patients' selection.
MeSH term(s)	Aged ; Arthroplasty/methods ; Follow-Up Studies ; Hallux Rigidus/complications ; Hallux Rigidus/diagnostic imaging ; Hallux Rigidus/surgery ; Humans ; Metatarsalgia/surgery ; Metatarsophalangeal Joint/surgery ; Middle Aged ; Radiography ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2022-03-02
Publishing country	France
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	1424533-4
ISSN	1460-9584 ; 1268-7731
ISSN (online)	1460-9584
ISSN	1268-7731
DOI	10.1016/j.fas.2022.02.019
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Article ; Online: Adipose-derived stem cells applied to ankle pathologies: a systematic review.

Arceri, A / Mazzotti, A / Artioli, E / Zielli, S O / Barile, F / Manzetti, M / Viroli, G / Ruffilli, A / Faldini, C

Musculoskeletal surgery

2023 Volume 108, Issue 1, Page(s) 1–9

Abstract: The purpose of this systematic review was to analyze the current use of adipose-derived mesenchymal stem cells (ADMSCs) and present the available evidence on their therapeutic potential in the treatment of ankle orthopedic issues, evaluating the ... ...

Abstract	The purpose of this systematic review was to analyze the current use of adipose-derived mesenchymal stem cells (ADMSCs) and present the available evidence on their therapeutic potential in the treatment of ankle orthopedic issues, evaluating the applications and results. A literature search of PubMed, Google Scholar, EMBASE and Cochrane Library database was performed. The review was conducted following PRISMA guidelines. Risk of bias assessment was conducted through the Methodological Index for Non-Randomized Studies (MINORS) criteria. Initial search results yielded 4348 articles. A total of 8 articles were included in the review process. No clinical evidence has demonstrated the effectiveness of one isolation method over the other, but nonenzymatic mechanical method has more advantages. In all studies included significant clinical outcomes improvement were recorded in patients affected by osteochondral lesion and osteoarthritis of ankle. All studies performed a concomitant procedure. No serious complications were reported. ADMSC injection, especially through the nonenzymatic mechanical methods, looks to be simple and promising treatment for osteochondral lesions and osteoarthritis of the ankle, with no severe complications. The current scarcity of studies and their low-quality level preclude definitive conclusions presently. LEVEL OF EVIDENCE: III.
MeSH term(s)	Humans ; Ankle ; Ankle Joint ; Osteoarthritis/therapy ; Stem Cells ; Treatment Outcome ; Talus
Language	English
Publishing date	2023-11-09
Publishing country	Italy
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2495458-5
ISSN	2035-5114 ; 2035-5106
ISSN (online)	2035-5114
ISSN	2035-5106
DOI	10.1007/s12306-023-00798-7
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Article ; Online: Covid-19 orthopedic trauma patients characteristics and management during the first pandemic period: report from a single institution in Italy.

Faldini, C / Mazzotti, A / Arceri, A / Broccoli, E / Barbagli, E / Di Martino, A

Musculoskeletal surgery

2021 Volume 106, Issue 4, Page(s) 407–426

Abstract: Purpose: COVID-19 disease is a declared pandemic, affecting all aspects of healthcare, including orthopedics. The aim of this study is to describe the COVID-19 orthopedic trauma patients characteristics and management in a dedicated Orthopedic and ... ...

Abstract	Purpose: COVID-19 disease is a declared pandemic, affecting all aspects of healthcare, including orthopedics. The aim of this study is to describe the COVID-19 orthopedic trauma patients characteristics and management in a dedicated Orthopedic and Traumatology Hospital in Italy during the first pandemic period. Material and methods: A cohort of 25 consecutive patients with suspected or confirmed COVID-19 infection were retrospectively analyzed. Health system rearrangement, patients' clinical presentation, diagnostic tools role, laboratory finding, treatment and outcomes were evaluated. Results: Health system rearrangement was fast. There was no clear prevalence of comorbidity or surgery type between confirmed and suspected COVID-19 cases. Nine positive swabs tests and 14 cases with only suspected CT scan findings were recorded. Several laboratory changes have been reported since the onset of symptoms: anemia, leukocytosis, lymphopenia, coagulation abnormalities, alkaline phosphatase, liver enzymes and C-reactive protein alterations. Nineteen patients were treated by oxygen supplement, three patients were administered antivirals, eight antibiotic therapy, and nine hydroxychloroquine. The number of discharges reported in this study was greater than 52% and the number of deaths reached 20%. Conclusion: To our experience, the development of patient management algorithms allows the differentiation of the clinical pathways of negative and suspected/positive patients, reducing exposure, and virus spreading. The execution of swabs on all patients allows an early diagnosis and a more adequate management. Considering the different therapy patterns used, there were no significant differences, but anti-thromboembolic prophylaxis administered to all the orthopedic patients may have contributed to complications and mortality rates reduction.
MeSH term(s)	Humans ; Pandemics/prevention & control ; COVID-19/epidemiology ; Retrospective Studies ; SARS-CoV-2 ; Orthopedics ; Italy/epidemiology
Language	English
Publishing date	2021-06-02
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2495458-5
ISSN	2035-5114 ; 2035-5106
ISSN (online)	2035-5114
ISSN	2035-5106
DOI	10.1007/s12306-021-00715-w
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Article: Hallux Valgus Plantar Pressure Distribution before and after a Distal Metatarsal Osteotomy.

Mazzotti, Antonio / Arceri, Alberto / Artioli, Elena / Langone, Laura / Zielli, Simone Ottavio / Martini, Beatrice / Traina, Francesco / Faldini, Cesare / Brognara, Lorenzo

Journal of clinical medicine

2024 Volume 13, Issue 6

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13061731
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Article ; Online: Indications, Associated Procedures, and Results of Ankle Plafond-Plasty for Varus Ankle Osteoarthritis: A Systematic Review and Meta-Analysis.

Zielli, Simone Ottavio / Mazzotti, Antonio / Artioli, Elena / Marcolli, Daniele / Arceri, Alberto / Bonelli, Simone / Faldini, Cesare

Foot & ankle specialist

2024 , Page(s) 19386400241236321

Abstract: Backgrounds: Plafond-plasty is a joint-preserving procedure to treat varus ankle osteoarthritis (OA) with asymmetrical joint involvement. The aim of this systematic review and meta-analysis was to evaluate indications, different surgical techniques, ... ...

Abstract	Backgrounds: Plafond-plasty is a joint-preserving procedure to treat varus ankle osteoarthritis (OA) with asymmetrical joint involvement. The aim of this systematic review and meta-analysis was to evaluate indications, different surgical techniques, associated procedures, and results of plafond-plasty in varus ankle OA and to analyze the level of evidence (LOE) and quality of evidence (QOE) of the included studies. Methods: A systematic review of the literature was performed using MEDLINE, Embase, and Cochrane. Results: Five studies evaluating 99 ankles were included. A non-rigid varus ankle deformity and an ankle OA Takakura stage 3b or less were the most recommended pre-operative indications. Meta-analysis showed a significant post-operative improvement in clinical and radiological parameters. Many associated surgical procedures have been reported, the most frequent being medial additional supramalleolar osteotomy and lateral ankle ligament reconstruction. The level of evidence and methodological quality assessment of the included studies showed an overall low quality. Conclusion: Plafond-plasty seems to be a promising surgical option when managing varus ankle OA with asymmetrical joint involvement, extending the indications for joint sparing surgery. Additional associated procedures should be carefully evaluated case-by-case. Levels of evidence: IV
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2488579-4
ISSN	1938-7636 ; 1938-6400
ISSN (online)	1938-7636
ISSN	1938-6400
DOI	10.1177/19386400241236321
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Article ; Online: How to Prevent Wound Complications After Total Ankle Arthroplasty Through Anterior Approach: A Systematic Review on Current Treatment Options.

Artioli, Elena / Mazzotti, Antonio / Arceri, Alberto / Casadei, Giacomo / Abdi, Pejman / Geraci, Giuseppe / Faldini, Cesare

Foot & ankle specialist

2023 , Page(s) 19386400231191694

Abstract: Introduction: Total ankle arthroplasty (TAA) through anterior approaches is a common treatment for end-stage tibiotalar arthritis. The occurrence of wound healing problems can lead to severe consequences. The aim of this systematic review is to ... ...

Abstract	Introduction: Total ankle arthroplasty (TAA) through anterior approaches is a common treatment for end-stage tibiotalar arthritis. The occurrence of wound healing problems can lead to severe consequences. The aim of this systematic review is to summarize the available methods to minimize postoperative wound complications after TAA through standard anterior approaches. Methods: Three databases were searched for original articles concerning methods to reduce anterior wound complications after TAA. Eligible articles were examined to extract studies' characteristics, population data, type of intervention, and related wound complications. Study risk of bias assessment was conducted through the Newcastle-Ottawa Scale. Results: Thirteen articles were included for analysis, investigating 8 types of intervention, which were grouped into 3 classes: biological, mechanical, and pharmacological methods. A significant decrease in wound complications was reported for negative pressure wound therapy (3% vs 24%, P = .014), soft tissue expansion strips (2% vs 12%, P = .04), and tranexamic acid (TXA) administration (9% vs 22%, P = .002). Conclusion: Despite the limitations of the included studies, this review showed encouraging results for TXA administration. Good results were found for mechanical methods, despite each intervention being supported by only 1 comparative study. Careful selection of patients is recommended to identify potential benefits or contraindications to such interventions. Further prospective randomized studies would be helpful to confirm these results.
Language	English
Publishing date	2023-08-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2488579-4
ISSN	1938-7636 ; 1938-6400
ISSN (online)	1938-7636
ISSN	1938-6400
DOI	10.1177/19386400231191694
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Article: Unveiling dysplasia epiphysealis hemimelica (Trevor's disease) in the foot and ankle: A systematic review.

Artioli, Elena / Mazzotti, Antonio / De Pellegrin, Maurizio / Arceri, Alberto / Zielli, Simone Ottavio / Langone, Laura / Faldini, Cesare

Journal of orthopaedics

2024 Volume 52, Page(s) 49–54

Abstract: Background: Dysplasia epiphysealis hemimelica is a rare non-inherited condition characterized by the unilateral predominance of osteochondromas in one or more epiphyses, with ankles and knees being the most affected joints. Treatment approaches vary ... ...

Abstract	Background: Dysplasia epiphysealis hemimelica is a rare non-inherited condition characterized by the unilateral predominance of osteochondromas in one or more epiphyses, with ankles and knees being the most affected joints. Treatment approaches vary based on the localization of the disease, encompassing both conservative and surgical options. Due to its rarity, there is a lack of definitive surgical guidelines or specific treatment modalities. Therefore, the objective of this systematic review was to thoroughly investigate dysplasia epiphysealis hemimelica to provide evidence-based guidance for managing this condition, specifically focusing on the foot and ankle. Methods: A systematic search was performed on PubMed and the Cochrane Library to identify all published articles related to dysplasia epiphysealis hemimelica of the foot and ankle. Individual patient information, such as gender, age, disease type, follow-up, localization, clinical presentation, intervention, and complications, were systematically extracted from each article and analyzed. Results: Twenty-five eligible publications were included in the review, involving a total of 70 patients (16 females, 53 males). The mean age was 9.6 years (SD 7.3). The talus was the most prevalent location and clinical presentations included mass and pain in 54% of cases. Surgical procedures were chosen in 92% of patients, with 95% undergoing mass excision. Recurrence was the most frequent complication, observed in 9% of cases. Conclusions: Raising awareness about dysplasia epiphysealis hemimelica is crucial for early diagnosis and treatment, positively impacting clinical outcomes. Vigilant monitoring is essential during observational management, as unchecked mass growth can complicate surgical intervention. Surgical treatment focuses on mass excision, feasible even at a young age but requiring precision to prevent recurrence or secondary arthritis. Level of evidence: IV.
Language	English
Publishing date	2024-02-20
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2240839-3
ISSN	0972-978X
ISSN	0972-978X
DOI	10.1016/j.jor.2024.02.036
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Article ; Online: Surgical management of clubfoot overcorrection: a case series

Faldini, Cesare / Artioli, Elena / Panciera, Alessandro / Bonelli, Simone / Arceri, Alberto / Mazzotti, Antonio

Archives of orthopaedic and trauma surgery

2023 Volume 143, Issue 11, Page(s) 6503–6511

Abstract: Introduction: Overcorrection is a possible complication of clubfoot treatment, whose prevalence varies from 5 to 67%. Overcorrected clubfoot usually presented as a complex flatfoot with different degrees of hindfoot valgus, flat top talus, dorsal bunion, ...

Abstract	Introduction: Overcorrection is a possible complication of clubfoot treatment, whose prevalence varies from 5 to 67%. Overcorrected clubfoot usually presented as a complex flatfoot with different degrees of hindfoot valgus, flat top talus, dorsal bunion, and dorsal navicular subluxation. The management of clubfoot overcorrection is challenging, and both conservative and surgical treatments are available. This study aims to present our experience in the surgical management of overcorrected clubfoot and to provide an overview of actual treatment options for each specific sub-deformity. Materials and methods: A retrospective cohort study of patients surgically treated for an overcorrected clubfoot from 2000 to 2015 at our Institution was conducted. Surgical procedures were tailored to the type and symptomatology of the deformity. A medializing calcaneal osteotomy or subtalar arthrodesis was performed for hindfoot valgus. Subtalar and/or midtarsal arthrodesis were considered in cases of dorsal navicular subluxation. The first metatarsus elevatus was addressed through a proximal plantarflexing osteotomy, sometimes associated with a tibialis anterior tendon transfer. Clinical scores and radiographic parameters were obtained pre-operatively and at the last follow-up. Results: Fifteen consecutive patients were enrolled. The series included 4 females and 11 males, with a mean age at surgery of 33,1 (18-56) years, and a mean follow-up of 4,46 (2-10) years. Seven medializing calcaneal osteotomies, 5 subtalar arthrodesis, 11 first metatarsal plantarflexing osteotomies, and 7 anterior tibialis tendon transfers were performed. A statistically significant improvement in both clinical and radiographic scores was observed. Conclusions: Management of overcorrected clubfoot involves many surgical techniques because of the high interpersonal variability of the deformities. The surgical approach showed positive results, as long as the indication is based on clinical symptoms and functional impairment rather than morphological alterations and radiographic findings.
MeSH term(s)	Male ; Female ; Humans ; Clubfoot/surgery ; Retrospective Studies ; Foot ; Osteotomy/methods ; Talus ; Flatfoot/diagnostic imaging ; Flatfoot/surgery ; Flatfoot/etiology
Language	English
Publishing date	2023-06-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80407-1
ISSN	1434-3916 ; 0003-9330 ; 0344-8444
ISSN (online)	1434-3916
ISSN	0003-9330 ; 0344-8444
DOI	10.1007/s00402-023-04946-3
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