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  1. Article ; Online: Gray matter volume associations in youth with ADHD features of inattention and hyperactivity/impulsivity.

    Reimann, Gabrielle E / Jeong, Hee Jung / Durham, E Leighton / Archer, Camille / Moore, Tyler M / Berhe, Fanual / Dupont, Randolph M / Kaczkurkin, Antonia N

    Human brain mapping

    2024  Volume 45, Issue 5, Page(s) e26589

    Abstract: Background: Prior research has shown smaller cortical and subcortical gray matter volumes among individuals with attention-deficit/hyperactivity disorder (ADHD). However, neuroimaging studies often do not differentiate between inattention and ... ...

    Abstract Background: Prior research has shown smaller cortical and subcortical gray matter volumes among individuals with attention-deficit/hyperactivity disorder (ADHD). However, neuroimaging studies often do not differentiate between inattention and hyperactivity/impulsivity, which are distinct core features of ADHD. The present study uses an approach to disentangle overlapping variance to examine the neurostructural heterogeneity of inattention and hyperactivity/impulsivity dimensions.
    Methods: We analyzed data from 10,692 9- to 10-year-old children from the Adolescent Brain Cognitive Development (ABCD) Study. Confirmatory factor analysis was used to derive factors representing inattentive and hyperactive/impulsive traits. We employed structural equation modeling to examine these factors' associations with gray matter volume while controlling for the shared variance between factors.
    Results: Greater endorsement of inattentive traits was associated with smaller bilateral caudal anterior cingulate and left parahippocampal volumes. Greater endorsement of hyperactivity/impulsivity traits was associated with smaller bilateral caudate and left parahippocampal volumes. The results were similar when accounting for socioeconomic status, medication, and in-scanner motion. The magnitude of these findings increased when accounting for overall volume and intracranial volume, supporting a focal effect in our results.
    Conclusions: Inattentive and hyperactivity/impulsivity traits show common volume deficits in regions associated with visuospatial processing and memory while at the same time showing dissociable differences, with inattention showing differences in areas associated with attention and emotion regulation and hyperactivity/impulsivity associated with volume differences in motor activity regions. Uncovering such biological underpinnings within the broader disorder of ADHD allows us to refine our understanding of ADHD presentations.
    MeSH term(s) Child ; Adolescent ; Humans ; Attention Deficit Disorder with Hyperactivity/diagnostic imaging ; Gray Matter/diagnostic imaging ; Cerebral Cortex ; Cognition ; Impulsive Behavior
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1197207-5
    ISSN 1097-0193 ; 1065-9471
    ISSN (online) 1097-0193
    ISSN 1065-9471
    DOI 10.1002/hbm.26589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4028: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Irritability, Negative Life Events and the Course of Anxiety and Depressive Symptoms in a Clinical Sample of Youth: A Longitudinal Study.

    Archer, Camille / Meza-Cervera, Tatiana / Scheinberg, Brooke / Kircanski, Katharina / Brotman, Melissa A / Pine, Daniel S / Leibenluft, Ellen / Linke, Julia O

    JAACAP open

    2023  Volume 2, Issue 1, Page(s) 45–54

    Abstract: Objective: Irritability, the tendency to react with anger, and the experience of negative life events (NLE) have independently been associated with the emergence of anxiety and depression. Here, we investigate how irritability and cumulative effects of ... ...

    Abstract Objective: Irritability, the tendency to react with anger, and the experience of negative life events (NLE) have independently been associated with the emergence of anxiety and depression. Here, we investigate how irritability and cumulative effects of NLE interactively predict the course of anxiety and depression in the context of common psychiatric disorders.
    Method: 432 youth with no psychiatric diagnosis, or a diagnosis of an anxiety disorder, Attention-Deficit/ Hyperactivity Disorder (ADHD), or Disruptive Mood Dysregulation Disorder (DMDD), participated in this study. At baseline, we assessed NLE, parent and youth reports of irritability and anxiety, and youth reports of depression. Symptoms were annually reassessed for up to four years.
    Results: In youth without psychiatric diagnoses but with elevated baseline irritability, the presence of NLE predicted decreasing anxiety, while the absence of NLE predicted increasing anxiety. In youth with an anxiety disorder, elevated baseline irritability predicted decreasing anxiety independent of NLE, while a large cumulative effect of NLE predicted increasing depression. NLE predicted persisting mild anxiety in ADHD and persisting mild depressive symptoms in DMDD.
    Conclusion: Our findings suggest that, particularly in non-referred samples, NLE might moderate the relationship between irritability and future anxiety such that irritability/ anger in the context of NLE can positively affect the course of anxiety. Future work replicating this finding while repeatedly measuring NLE and rigorously controlling for potentially confounding effects of treatment, is warranted.
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article
    ISSN 2949-7329
    ISSN (online) 2949-7329
    DOI 10.1016/j.jaacop.2023.09.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Early life stress and functional network topology in children.

    Jeong, Hee Jung / Reimann, Gabrielle E / Durham, E Leighton / Archer, Camille / Stier, Andrew J / Moore, Tyler M / Pines, Julia R / Berman, Marc G / Kaczkurkin, Antonia N

    Developmental cognitive neuroscience

    2024  Volume 66, Page(s) 101367

    Abstract: Brain networks are continuously modified throughout development, yet this plasticity can also make functional networks vulnerable to early life stress. Little is currently known about the effect of early life stress on the functional organization of the ... ...

    Abstract Brain networks are continuously modified throughout development, yet this plasticity can also make functional networks vulnerable to early life stress. Little is currently known about the effect of early life stress on the functional organization of the brain. The current study investigated the association between environmental stressors and network topology using data from the Adolescent Brain Cognitive Development
    Language English
    Publishing date 2024-03-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2572271-2
    ISSN 1878-9307 ; 1878-9307
    ISSN (online) 1878-9307
    ISSN 1878-9307
    DOI 10.1016/j.dcn.2024.101367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Changes in Internalizing Symptoms During the COVID-19 Pandemic in a Transdiagnostic Sample of Youth: Exploring Mediators and Predictors.

    Haller, Simone P / Archer, Camille / Jeong, Annie / Jaffe, Allison / Jones, Emily L / Harrewijn, Anita / Naim, Reut / Linke, Julia O / Stoddard, Joel / Brotman, Melissa A

    Child psychiatry and human development

    2022  Volume 55, Issue 1, Page(s) 206–218

    Abstract: The COVID-19 pandemic is a chronically stressful event, particularly for youth. Here, we examine (i) changes in mood and anxiety symtpoms, (ii) pandemic-related stress as a mediator of change in symptoms, and (ii) threat processing biases as a predictor ... ...

    Abstract The COVID-19 pandemic is a chronically stressful event, particularly for youth. Here, we examine (i) changes in mood and anxiety symtpoms, (ii) pandemic-related stress as a mediator of change in symptoms, and (ii) threat processing biases as a predictor of increased anxiety during the pandemic. A clinically well-characterized sample of 81 youth ages 8-18 years (M = 13.8 years, SD = 2.65; 40.7% female) including youth with affective and/or behavioral psychiatric diagnoses and youth without psychopathology completed pre- and during pandemic assessments of anxiety and depression and COVID-related stress. Forty-six youth also completed a threat processing fMRI task pre-pandemic. Anxiety and depression significantly increased during the pandemic (all ps < 0.05). Significant symptom change was partially mediated by pandemic stress and worries. Increased prefrontal activity in response to neutral faces pre-pandemic was associated with more intense parent-reported anxiety during the pandemic (all Fs(1.95,81.86) > 14.44, ps < 0.001). The present work extends existing knowledge on the mediating role of psychological stress on symptoms of anxiety and depression in youth.
    MeSH term(s) Humans ; Female ; Adolescent ; Male ; Pandemics ; COVID-19 ; Anxiety/diagnosis ; Anxiety/epidemiology ; Anxiety/psychology ; Anxiety Disorders/diagnosis ; Anxiety Disorders/epidemiology ; Anxiety Disorders/psychology ; Psychopathology ; Depression/diagnosis ; Depression/epidemiology ; Depression/psychology
    Language English
    Publishing date 2022-07-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 223895-0
    ISSN 1573-3327 ; 0009-398X
    ISSN (online) 1573-3327
    ISSN 0009-398X
    DOI 10.1007/s10578-022-01382-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 772: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Adverse Childhood Experiences and Chronic Medical Conditions: Emotion Dysregulation as a Mediator of Adjustment.

    Espeleta, Hannah C / Sharkey, Christina M / Bakula, Dana M / Gamwell, Kaitlyn L / Archer, Camille / Perez, Megan N / Roberts, Caroline M / Chaney, John M / Mullins, Larry L

    Journal of clinical psychology in medical settings

    2019  Volume 27, Issue 3, Page(s) 572–581

    Abstract: Adverse childhood experiences (ACEs) are known to contribute to long-term harmful effects on mental health in young adults. Research has demonstrated that having a chronic medical condition (CMC) can also be conceptualized as being a potentially ... ...

    Abstract Adverse childhood experiences (ACEs) are known to contribute to long-term harmful effects on mental health in young adults. Research has demonstrated that having a chronic medical condition (CMC) can also be conceptualized as being a potentially traumatic experience, and that young adults with a CMC are also at risk for negative adjustment. Emotion dysregulation, or difficulty identifying and regulating one's emotions, is common among individuals with ACEs, and is a predictor of young adult adjustment. Given the mediational link between ACEs, emotion dysregulation, and young adult adjustment, it is likely that emotion dysregulation may demonstrate a similar linkage to adjustment in individuals with a CMC. The current study compared the effects of ACEs and having a CMC on depressive and anxious symptoms, while also examining emotion dysregulation as a possible mediator for both ACEs and CMC on adjustment outcomes, specifically depressive and anxious symptoms. College students (N = 1911) completed online questionnaires that assessed history of ACEs, emotion regulation difficulties, adjustment, and chronic illness status. Path analyses demonstrated a significant correlation between ACEs and depressive and anxious symptoms, as well as having a CMC and depressive and anxious symptoms. Furthermore, emotion dysregulation demonstrated a significant mediation between ACEs and negative adjustment, as well as between having a CMC and negative adjustment. This study highlights the importance of emotion dysregulation in understanding outcomes for individuals with a CMC and/or ACEs.
    MeSH term(s) Adolescent ; Adverse Childhood Experiences/statistics & numerical data ; Anxiety/psychology ; Child ; Emotions ; Female ; Humans ; Male ; Mental Health ; Students/psychology ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2019-07-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1235893-9
    ISSN 1573-3572 ; 1068-9583
    ISSN (online) 1573-3572
    ISSN 1068-9583
    DOI 10.1007/s10880-019-09639-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4286: Show issues Location:
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