Article ; Online: Nicotinamide N-methyl transferase and cancer-associated thrombosis: insights to prevention and management.
2023 Volume 15, Issue 6, Page(s) 385–395
Abstract: Nicotinamide metabolism is important in carcinogenesis. Nicotinamide affects the cellular methyl pool, thus affecting DNA and histone methylation and gene expression. Cancer cells have increased expression of nicotinamide N-methyl transferase (NNMT), the ...
| Abstract | Nicotinamide metabolism is important in carcinogenesis. Nicotinamide affects the cellular methyl pool, thus affecting DNA and histone methylation and gene expression. Cancer cells have increased expression of nicotinamide N-methyl transferase (NNMT), the key enzyme in nicotinamide metabolism. NNMT contributes to tumor angiogenesis. Overexpression of NNMT is associated with poorer prognosis in cancers. Additionally, NNMT can contribute to cancer-associated morbidities, such as cancer-associated thrombosis. 1-methylnicotinamide (1-MNA), a metabolite of nicotinamide, has anti-inflammatory and antithrombotic effects. Therefore, targeting NNMT can affect both carcinogenesis and cancer-associated morbidities. Several antitumor drugs have been shown to inhibit NNMT expression in cancer cells. Implementing these drugs to reverse NNMT effects in addition to 1-MNA supplementation has the potential to prevent cancer-associated thrombosis through various mechanisms. |
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| MeSH term(s) | Humans ; Neoplasms/complications ; Neoplasms/drug therapy ; Neoplasms/genetics ; Antineoplastic Agents/pharmacology ; Carcinogenesis ; Niacinamide/pharmacology ; Niacinamide/therapeutic use ; Transferases ; Nicotinamide N-Methyltransferase/genetics ; Nicotinamide N-Methyltransferase/metabolism |
| Chemical Substances | Antineoplastic Agents ; Niacinamide (25X51I8RD4) ; Transferases (EC 2.-) ; Nicotinamide N-Methyltransferase (EC 2.1.1.1) |
| Language | English |
| Publishing date | 2023-05-22 |
| Publishing country | England |
| Document type | Journal Article ; Review |
| ZDB-ID | 2537199-X |
| ISSN | 1750-192X ; 1750-1911 |
| ISSN (online) | 1750-192X |
| ISSN | 1750-1911 |
| DOI | 10.2217/epi-2023-0078 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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