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  1. Article ; Online: My journey to ASCI: why ASCI is so important to me.

    Ardehali, Hossein

    The Journal of clinical investigation

    2022  Volume 132, Issue 24

    Language English
    Publishing date 2022-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI163625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Manual of research techniques in cardiovascular medicine

    Ardehali, Hossein / Bolli, Roberto / Losordo, Douglas

    2014  

    Title variant Research techniques in cardiovascular medicine
    Author's details ed. by Hossein Ardehali ; Roberto Bolli ; Douglas W. Losordo
    Keywords Cardiology/Research/Methodology ; Cardiovascular system/Diseases
    Subject code 616.1200721
    Language English
    Size XX, 451 S. : zahlr. Ill., graph. Darst., 27 cm
    Publisher Wiley Blackwell
    Publishing place Chichester u.a.
    Publishing country Great Britain
    Document type Book
    Note Formerly CIP.
    HBZ-ID HT018281726
    ISBN 978-0-470-67269-3 ; 9781118495131 ; 9781118495148 ; 9781118495155 ; 9781118495162 ; 0-470-67269-2 ; 1118495136 ; 1118495144 ; 1118495152 ; 1118495160
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2014 A 2179 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Ferric derisomaltose therapy and heart failure: implications and molecular insights.

    Sawicki, Konrad T / Ardehali, Hossein

    Nature cardiovascular research

    2023  Volume 2, Issue 1, Page(s) 3–5

    Abstract: Iron is essential to the production of myocardial energy and proteins critical for cardiovascular function. Nearly 50% of patients with heart failure with reduced ejection fraction (HFrEF) meet current criteria for iron deficiency, and there has been ... ...

    Abstract Iron is essential to the production of myocardial energy and proteins critical for cardiovascular function. Nearly 50% of patients with heart failure with reduced ejection fraction (HFrEF) meet current criteria for iron deficiency, and there has been considerable interest in intravenous repletion of iron stores as a therapeutic strategy to improve HFrEF outcomes. However, the data on intravenous iron therapy in HFrEF have been mixed.
    Language English
    Publishing date 2023-01-05
    Publishing country England
    Document type Journal Article
    ISSN 2731-0590
    ISSN (online) 2731-0590
    DOI 10.1038/s44161-022-00202-w
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  4. Article ; Online: Web Exclusive. Annals for Hospitalists Inpatient Notes - Intravenous Iron Supplementation for Patients With Heart Failure-What Hospitalists Should Know.

    Sawicki, Konrad Teodor / Ardehali, Hossein

    Annals of internal medicine

    2023  Volume 175, Issue 4, Page(s) HO2–HO3

    Language English
    Publishing date 2023-02-03
    Publishing country United States
    Document type Journal Article ; Webcast
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M22-0637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Potential consequences of the immigration ban on the scientific community.

    Ardehali, Hossein

    The Journal of clinical investigation

    2017  Volume 127, Issue 3, Page(s) 735–736

    Abstract: On January 27, 2017, President Trump signed an executive order banning the citizens of 7 countries from obtaining US entry visas for the next 90 days. Since the announcement, the news media have devoted a large portion of their coverage to the ban and ... ...

    Abstract On January 27, 2017, President Trump signed an executive order banning the citizens of 7 countries from obtaining US entry visas for the next 90 days. Since the announcement, the news media have devoted a large portion of their coverage to the ban and its political ramifications. There have been arguments made by both sides that the ban will make our country safer, while others have argued that this executive order will result in the weakening of our country and bolstering of our enemies. As a physician-scientist who was born in Iran and immigrated to the US, I will stay away from the politics of this executive order; rather, I want to discuss the impact of the immigration ban on scientific discourse, education, and research programs, and how it may influence the dissemination of knowledge to physicians and scientists in low- and middle-income countries. I will use my own experience as an example of how the educational and scientific systems in this country benefit those who strive to learn in a free and intellectually stimulating environment.
    MeSH term(s) Biomedical Research/legislation & jurisprudence ; Biomedical Research/trends ; Emigration and Immigration/legislation & jurisprudence ; Humans ; United States
    Language English
    Publishing date 2017-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI93276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Iron Metabolism in Cardiovascular Disease: Physiology, Mechanisms, and Therapeutic Targets.

    Sawicki, Konrad Teodor / De Jesus, Adam / Ardehali, Hossein

    Circulation research

    2023  Volume 132, Issue 3, Page(s) 379–396

    Abstract: The cardiovascular system requires iron to maintain its high energy demands and metabolic activity. Iron plays a critical role in oxygen transport and storage, mitochondrial function, and enzyme activity. However, excess iron is also cardiotoxic due to ... ...

    Abstract The cardiovascular system requires iron to maintain its high energy demands and metabolic activity. Iron plays a critical role in oxygen transport and storage, mitochondrial function, and enzyme activity. However, excess iron is also cardiotoxic due to its ability to catalyze the formation of reactive oxygen species and promote oxidative damage. While mammalian cells have several redundant iron import mechanisms, they are equipped with a single iron-exporting protein, which makes the cardiovascular system particularly sensitive to iron overload. As a result, iron levels are tightly regulated at many levels to maintain homeostasis. Iron dysregulation ranges from iron deficiency to iron overload and is seen in many types of cardiovascular disease, including heart failure, myocardial infarction, anthracycline-induced cardiotoxicity, and Friedreich's ataxia. Recently, the use of intravenous iron therapy has been advocated in patients with heart failure and certain criteria for iron deficiency. Here, we provide an overview of systemic and cellular iron homeostasis in the context of cardiovascular physiology, iron deficiency, and iron overload in cardiovascular disease, current therapeutic strategies, and future perspectives.
    MeSH term(s) Animals ; Humans ; Cardiovascular Diseases/drug therapy ; Iron/metabolism ; Iron Overload/drug therapy ; Heart Failure/drug therapy ; Iron Deficiencies ; Mammals
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.122.321667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Intravenous Iron Therapy in Heart Failure With Reduced Ejection Fraction: Tackling the Deficiency.

    Sawicki, Konrad Teodor / Ardehali, Hossein

    Circulation

    2021  Volume 144, Issue 4, Page(s) 253–255

    MeSH term(s) Administration, Intravenous ; Anemia, Iron-Deficiency/complications ; Anemia, Iron-Deficiency/diagnosis ; Anemia, Iron-Deficiency/drug therapy ; Clinical Trials as Topic ; Dietary Supplements ; Disease Management ; Disease Susceptibility ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Heart Failure/etiology ; Humans ; Iron/administration & dosage ; Iron/adverse effects ; Prognosis ; Stroke Volume ; Treatment Outcome
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2021-07-26
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.121.054271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Iron therapy on quality of life in acute heart failure: alternative approaches.

    Sawicki, Konrad Teodor / Ardehali, Hossein

    European heart journal

    2021  Volume 43, Issue 4, Page(s) 345–346

    MeSH term(s) Anemia, Iron-Deficiency/drug therapy ; Health Services ; Heart Failure/drug therapy ; Humans ; Iron/therapeutic use ; Quality of Life
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2021-12-08
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab823
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  9. Article ; Online: Optimized protocol for quantification of mitochondrial non-heme and heme iron content in mouse tissues and cultured cells.

    Sato, Tatsuya / Chang, Hsiang-Chun / Sawicki, Konrad T / Ardehali, Hossein

    STAR protocols

    2023  Volume 4, Issue 1, Page(s) 102064

    Abstract: Impaired mitochondrial iron metabolism is associated with aging and a variety of diseases, and there is a growing need to accurately quantify mitochondrial iron levels. This protocol provides an optimized method for evaluating non-heme and heme iron in ... ...

    Abstract Impaired mitochondrial iron metabolism is associated with aging and a variety of diseases, and there is a growing need to accurately quantify mitochondrial iron levels. This protocol provides an optimized method for evaluating non-heme and heme iron in mitochondrial and cytosolic fractions of tissues and cultured cells. Our protocol consists of three steps: sample fractionation, non-heme iron measurement, and heme iron measurement. For complete details on the use and execution of this protocol, please refer to Sato et al. (2022).
    MeSH term(s) Mice ; Animals ; Iron/metabolism ; Heme ; Mitochondria/metabolism ; Cells, Cultured
    Chemical Substances Iron (E1UOL152H7) ; Heme (42VZT0U6YR)
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2023.102064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease.

    Fang, Xuexian / Ardehali, Hossein / Min, Junxia / Wang, Fudi

    Nature reviews. Cardiology

    2022  Volume 20, Issue 1, Page(s) 7–23

    Abstract: The maintenance of iron homeostasis is essential for proper cardiac function. A growing body of evidence suggests that iron imbalance is the common denominator in many subtypes of cardiovascular disease. In the past 10 years, ferroptosis, an iron- ... ...

    Abstract The maintenance of iron homeostasis is essential for proper cardiac function. A growing body of evidence suggests that iron imbalance is the common denominator in many subtypes of cardiovascular disease. In the past 10 years, ferroptosis, an iron-dependent form of regulated cell death, has become increasingly recognized as an important process that mediates the pathogenesis and progression of numerous cardiovascular diseases, including atherosclerosis, drug-induced heart failure, myocardial ischaemia-reperfusion injury, sepsis-induced cardiomyopathy, arrhythmia and diabetic cardiomyopathy. Therefore, a thorough understanding of the mechanisms involved in the regulation of iron metabolism and ferroptosis in cardiomyocytes might lead to improvements in disease management. In this Review, we summarize the relationship between the metabolic and molecular pathways of iron signalling and ferroptosis in the context of cardiovascular disease. We also discuss the potential targets of ferroptosis in the treatment of cardiovascular disease and describe the current limitations and future directions of these novel treatment targets.
    MeSH term(s) Humans ; Ferroptosis ; Iron/metabolism ; Cardiovascular Diseases/metabolism ; Myocytes, Cardiac/metabolism ; Signal Transduction
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2022-07-04
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-022-00735-4
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