Article ; Online: Identifying the location of locoregional recurrences after definitive radiotherapy for head and neck cancer using metabolic parameters of baseline and mid-treatment 18F-FDG-PET scans.
Journal of medical imaging and radiation oncology
2022 Volume 67, Issue 1, Page(s) 89–97
Abstract: Introduction: Tumour recurrences after treatment of head and neck squamous cell carcinoma (HNSCC) are more likely to originate from regions of high-baseline FDG-PET uptake. Mid-treatment functional imaging can potentially predict for higher risk of ... ...
| Abstract | Introduction: Tumour recurrences after treatment of head and neck squamous cell carcinoma (HNSCC) are more likely to originate from regions of high-baseline FDG-PET uptake. Mid-treatment functional imaging can potentially predict for higher risk of tumour recurrence. The aim of this study is to correlate the location of locoregional tumour recurrence with baseline FDG-PET metabolic volumes and mid-treatment FDG-PET metabolic volumes in patients with HNSCC following definitive radiotherapy. Methods: A total of 23 patients with 26 local and/or regional recurrences underwent baseline (W0-PET) and mid-treatment (W3-PET) 18F-FDG PET scans as part of their radiotherapy. FDG-PET-based metabolic volumes (MTV20%, MTV40%, MTV60%, MTV80%, SUV2.5, SUVpeak and PET_EDGE) were delineated onto the FDG-PET scans. The recurrence nidus was identified on FDG-PET at the time of recurrence (REC-PET). DIR-based fusion was performed for REC-PET to W0-PET, and REC-PET to W3-PET. The location of the recurrence nidus was correlated with the FDG-PET volumes. Further analysis included a comparison of the recurrence density to FDG-PET metabolic volumes. Results: Most recurrences occurred within the MTV20%, MTV40% and SUV 2.5 volumes. Sixty-nine per cent of recurrences (18 of 26) occurred within both the W0 MTV40% and W3 MTV40% volumes. A higher recurrence density was seen for iso-SUV contours closer to the maximum SUV for both W0 and W3. For a number of the FDG-PET volumes, including MTV20%, MTV40% and SUV2.5, the recurrence density was improved for W3 compared to W0, however, this improvement was small in magnitude. The average volume of MTV40% contours was considerably smaller than MTV20% and SUV2.5 contours. Conclusion: The metabolic parameters of SUV2.5, MTV20% and MTV40% delineated on the baseline and mid-treatment FDG-PET scans encompassed the majority of recurrences. The MTV40% is significantly smaller, hence, we prefer this volume for future dose escalation studies. |
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| MeSH term(s) | Humans ; Fluorodeoxyglucose F18 ; Head and Neck Neoplasms ; Neoplasm Recurrence, Local ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography/methods ; Radiopharmaceuticals ; Recurrence ; Squamous Cell Carcinoma of Head and Neck | |||||
| Chemical Substances | Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals | |||||
| Language | English | |||||
| Publishing date | 2022-10-27 | |||||
| Publishing country | Australia | |||||
| Document type | Clinical Trial, Phase I ; Journal Article | |||||
| ZDB-ID | 2389687-5 | |||||
| ISSN | 1754-9485 ; 1440-1673 ; 1754-9477 ; 0004-8461 | |||||
| ISSN (online) | 1754-9485 ; 1440-1673 | |||||
| ISSN | 1754-9477 ; 0004-8461 | |||||
| DOI | 10.1111/1754-9485.13486 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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