Artikel ; Online: Sustained activation of autophagy suppresses adipocyte maturation via a lipolysis-dependent mechanism.
2019 Band 16, Heft 9, Seite(n) 1668–1682
Abstract: Dysregulation of macroautophagy/autophagy is implicated in obesity and insulin resistance. However, it remains poorly defined how autophagy regulates adipocyte development. Using adipose-specific : Abbreviations: ATG7: autophagy related 7; BAT: brown ... ...
| Abstract | Dysregulation of macroautophagy/autophagy is implicated in obesity and insulin resistance. However, it remains poorly defined how autophagy regulates adipocyte development. Using adipose-specific Abbreviations: ATG7: autophagy related 7; BAT: brown adipose tissue; CEBPB/C/EBPβ: CCAAT enhancer binding protein beta; DGAT1: diacylglycerol O-acyltransferase 1; eWAT: epididymal white adipose tissue; iWAT: inguinal white adipose tissue; KO: knockout; LD: lipid droplet; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin kinase complex 1; PLIN1: perepilin 1; PNPLA2/ATGL: patatin-like phospholipase domain containing 2; PPARG/PPARγ: peroxisome proliferator activated receptor gamma; RPTOR: regulatory associated protein of MTOR complex1; TG: triglyceride; ULK1: unc-51 like kinase 1; UCP1: uncoupling protein 1; WAT: white adipose tissue. |
|---|---|
| Mesh-Begriff(e) | Adipocytes/cytology ; Adipocytes/drug effects ; Adipocytes/metabolism ; Adipocytes/ultrastructure ; Adipose Tissue, Brown/drug effects ; Adipose Tissue, Brown/metabolism ; Animals ; Autophagy/drug effects ; Autophagy-Related Protein 7/metabolism ; Cell Differentiation/drug effects ; Cells, Cultured ; Gene Expression Regulation/drug effects ; Isoproterenol/pharmacology ; Lipid Droplets/metabolism ; Lipolysis/drug effects ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mice, Knockout ; Regulatory-Associated Protein of mTOR/deficiency ; Regulatory-Associated Protein of mTOR/metabolism ; Thermogenesis/drug effects ; Thermogenesis/genetics |
| Chemische Substanzen | Regulatory-Associated Protein of mTOR ; Rptor protein, mouse ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Autophagy-Related Protein 7 (EC 6.2.1.45) ; Isoproterenol (L628TT009W) |
| Sprache | Englisch |
| Erscheinungsdatum | 2019-12-18 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2454135-7 |
| ISSN | 1554-8635 ; 1554-8627 |
| ISSN (online) | 1554-8635 |
| ISSN | 1554-8627 |
| DOI | 10.1080/15548627.2019.1703355 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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