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  1. Article ; Online: Early Experience With an Occupational JYNNEOS ( Orthopoxvirus ) Vaccination Program.

    Swift, Melanie D / McDermott, Mary C / Hainy, Caitlin M / Arendt, Christopher J / Anderson, Jennifer A / Mahoo, Jacqueline J / Breeher, Laura E

    Journal of occupational and environmental medicine

    2023  Volume 65, Issue 6, Page(s) 477–480

    Abstract: Objective: The aim of the study is to identify lessons learned implementing JYNNEOS vaccination for laboratory workers exposed to orthopoxviruses such as mpox.: Methods: Workers at risk of laboratory exposure were offered vaccine in a carefully ... ...

    Abstract Objective: The aim of the study is to identify lessons learned implementing JYNNEOS vaccination for laboratory workers exposed to orthopoxviruses such as mpox.
    Methods: Workers at risk of laboratory exposure were offered vaccine in a carefully planned occupational health program. Vaccine was procured from the Centers for Disease Control and Prevention (CDC) Drug Service, which has special requirements. Reasons for accepting or declining vaccine and adverse effects were obtained by survey.
    Results: Most workers accepted JYNNEOS, and occupational risk was the most commonly cited reason for acceptance. Most experienced mild local adverse effects. The administrative requirements of the Centers for Disease Control and Prevention Drug Service are documented.
    Conclusions: Occupational health programs caring for laboratory workers handling unusual biological agents require careful planning and coordination to facilitate access to vaccines that are not commercially available, anticipate and mitigate barriers to vaccination, and comply with special Centers for Disease Control and Prevention requirements.
    MeSH term(s) Humans ; Orthopoxvirus ; Smallpox Vaccine ; Vaccination ; Vaccines
    Chemical Substances smallpox and monkeypox vaccine modified vaccinia ankara-bavarian nordic (TU8J357395) ; Smallpox Vaccine ; Vaccines
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1223932-x
    ISSN 1536-5948 ; 1076-2752
    ISSN (online) 1536-5948
    ISSN 1076-2752
    DOI 10.1097/JOM.0000000000002846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Role of tacrolimus in return of hand function after brachial plexus injury in a lung transplantation patient.

    Saffari, Tiam M / Arendt, Christopher J / Spinner, Robert J / Shin, Alexander Y

    BMJ case reports

    2020  Volume 13, Issue 5

    Abstract: We report a patient who has been on tacrolimus for bilateral lung transplantation and presented with a brachial plexus injury (BPI), with unusual improvement of lower trunk innervated hand function. The lower trunk injury with resultant left hand ... ...

    Abstract We report a patient who has been on tacrolimus for bilateral lung transplantation and presented with a brachial plexus injury (BPI), with unusual improvement of lower trunk innervated hand function. The lower trunk injury with resultant left hand paralysis had developed after his sternotomy 18 months ago. He has been treated with tacrolimus as part of his immunosuppression protocol since the surgery, without severe side effects. Physical examination at 18 months demonstrated unusual excellent grip pattern and full opposition of his thumb with slight claw deformity of his ulnar two digits. While the neurotoxic effects of tacrolimus are more emphasised, the neuroregenerative properties have been recently explored. The recovery in this patient is unique and unusual after BPI and is most likely as a result of the low dose tacrolimus treatment.
    MeSH term(s) Brachial Plexus Neuropathies/etiology ; Brachial Plexus Neuropathies/therapy ; Hand/innervation ; Humans ; Immunosuppressive Agents/therapeutic use ; Lung Transplantation ; Male ; Middle Aged ; Postoperative Complications/etiology ; Postoperative Complications/therapy ; Tacrolimus/therapeutic use
    Chemical Substances Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2020-05-06
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2019-233788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Neurologically intact survival following prolonged cardiac arrest monitored with continuous capnography and subsequent treatment with therapeutic hypothermia.

    White, Roger D / Goodman, Bruce W / Arendt, Christopher J

    Mayo Clinic proceedings

    2011  Volume 86, Issue 11, Page(s) 1124–1125

    MeSH term(s) Angioplasty, Balloon, Coronary ; Capnography ; Cardiopulmonary Resuscitation ; Heart Arrest/therapy ; Humans ; Hypothermia, Induced ; Male ; Middle Aged ; Survivors ; Time Factors ; Ventricular Fibrillation/therapy
    Language English
    Publishing date 2011-10-18
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.4065/mcp.2011.0626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Description of Pharmacogenomic Testing Among Patients Admitted to the Intensive Care Unit After Cardiovascular Surgery.

    Peterson, Pamela E / Nicholson, Wayne T / Moyer, Ann M / Arendt, Christopher J / Smischney, Nathan J / Seelhammer, Troy G / Krecke, Catherine A / Haney, Rory M / Yaw, Elissa J / Chlan, Linda L

    Journal of intensive care medicine

    2020  Volume 36, Issue 11, Page(s) 1281–1285

    Abstract: Background: Pharmacogenomic (PGx) testing has the potential to provide information on specific drug-metabolizing enzymes that may lead to an absence, reduction, or increase in medication effect in patients. There is a paucity of prospective studies ... ...

    Abstract Background: Pharmacogenomic (PGx) testing has the potential to provide information on specific drug-metabolizing enzymes that may lead to an absence, reduction, or increase in medication effect in patients. There is a paucity of prospective studies examining PGx testing in the intensive care unit (ICU) setting.
    Research aims: To (1) obtain a PGx panel in a sample of cardiovascular (CV) surgical patients with a planned ICU stay and identify phenotypes, and (2) identify PGx variants that may inform treatment regimens and may warrant prescribing adjustments.
    Design and methods: Descriptive, single cohort cross-sectional design. Adult (≥18 years) CV patients with an anticipated postoperative ICU stay were enrolled from a large Midwestern tertiary academic medical center. Eligible patients provided informed consent at the time of their CV clinic appointment; PGx testing was then ordered. Pharmacogenomic testing consisted of the Focused Pharmacogenomics panel which included 10 genes and 55 medications.
    Results: Of the 272 patients screened, 100 (68% male) patients completed PGx testing (mean age 66.2 ± 9.6 years, mean Acute Physiology, Age and Chronic Health Evaluation III score 76.1 ± standard deviation). Pharmacogenomic results were available in the medical record within a median of 52.4 hours (interquartile range: 33.4-80.3). Pharmacogenomic testing results identified 5
    Conclusions: A significant portion of patients had identified genetic variants that may warrant changes in medication management during and after CV-ICU stay. It remains to be seen if PGx testing leads to improvements in ICU patient outcomes.
    MeSH term(s) Aged ; Cross-Sectional Studies ; Female ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Pharmacogenetics ; Pharmacogenomic Testing ; Prospective Studies
    Language English
    Publishing date 2020-07-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632828-3
    ISSN 1525-1489 ; 0885-0666
    ISSN (online) 1525-1489
    ISSN 0885-0666
    DOI 10.1177/0885066620946303
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  5. Article ; Online: Time to achieving therapeutic international normalized ratio increases hospital length of stay after heart valve replacement surgery.

    Arendt, Christopher J / Hong, Joon Hwa / Daly, Richard C / Scott, Christopher / Mehta, Ramila A / Bailey, Kent / Pathak, Jyotishman / Pereira, Naveen L

    American heart journal

    2017  Volume 187, Page(s) 70–77

    Abstract: Background: Achieving a therapeutic international normalized ratio (INR) before hospital discharge is an important inpatient goal for patients undergoing mechanical cardiac valve replacement (MCVR). The use of clinical algorithms has reduced the time to ...

    Abstract Background: Achieving a therapeutic international normalized ratio (INR) before hospital discharge is an important inpatient goal for patients undergoing mechanical cardiac valve replacement (MCVR). The use of clinical algorithms has reduced the time to achieve therapeutic INR (TTI) with warfarin therapy. Whether TTI prolongs length of stay (LOS) is unknown.
    Methods: Patients who underwent MCVR over a consecutive 42-month period were included. Clinical data were obtained from the Society of Thoracic Surgeons Adult Cardiac Surgery database and electronic medical records. Therapeutic INR was defined as per standard guidelines. Warfarin dose was prescribed using an inpatient pharmacy-managed algorithm and computer-based dosing tool. International normalized ratio trajectory, procedural needs, and drug interactions were included in warfarin dose determination.
    Results: There were 708 patients who underwent MCVR, of which 159 were excluded for reasons that would preclude or interrupt warfarin use. Among the remainder of 549 patients, the average LOS was 6.4days and mean TTI was 3.5days. Landmark analysis showed that subjects in hospital on day 4 (n=542) who achieved therapeutic INR were more likely to be discharged by day 6 compared with those who did not achieve therapeutic INR (75% vs 59%, P<.001). Multivariable proportional hazards regression with TTI as a time-dependent effect showed a strong association with discharge (P=.0096, hazard ratio1.3) after adjustment for other significant clinical covariates.
    Conclusions: Time to achieve therapeutic INR is an independent predictor of LOS in patients requiring anticoagulation with warfarin after MCVR surgery. Alternative dosing and anticoagulation strategies will need to be adopted to reduce LOS in these patients.
    MeSH term(s) Algorithms ; Anticoagulants/therapeutic use ; Drug Monitoring/methods ; Female ; Heart Valve Prosthesis Implantation ; Humans ; International Normalized Ratio ; Length of Stay ; Male ; Middle Aged ; Warfarin/therapeutic use
    Chemical Substances Anticoagulants ; Warfarin (5Q7ZVV76EI)
    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80026-0
    ISSN 1097-6744 ; 0002-8703
    ISSN (online) 1097-6744
    ISSN 0002-8703
    DOI 10.1016/j.ahj.2017.02.011
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  6. Article ; Online: A retrospective analysis on the impact of caloric intake on glycemic control in critically ill patients.

    Lau, Yuen Ting / Oyen, Lance J / Malinchoc, Michael / Arendt, Christopher J / Barth, Melissa M

    Intensive care medicine

    2009  Volume 36, Issue 4, Page(s) 725–726

    MeSH term(s) Blood Glucose/analysis ; Chi-Square Distribution ; Critical Illness ; Energy Intake ; Glycemic Index ; Humans ; Hyperglycemia/prevention & control ; Hypoglycemia/prevention & control ; Intensive Care Units ; Retrospective Studies ; Statistics, Nonparametric ; Time Factors
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2009-11-06
    Publishing country United States
    Document type Letter
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-009-1679-x
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  7. Article ; Online: Combined heart and liver transplantation: protection of the cardiac graft from antibody rejection by initial liver implantation.

    Daly, Richard C / Topilsky, Yan / Joyce, Lyle / Hasin, Tal / Gandhi, Manish / Rosen, Charles / Heimbach, Julie / Edwards, Brooks S / Pereira, Naveen / Stulak, John M / Arendt, Christopher J / Park, Soon J / Kushwaha, Sudhir S

    Transplantation

    2013  Volume 95, Issue 2, Page(s) e2–4

    MeSH term(s) Adolescent ; Female ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Graft Survival ; HLA Antigens/immunology ; Heart Transplantation/adverse effects ; Heart Transplantation/immunology ; Histocompatibility ; Histocompatibility Testing ; Humans ; Immunosuppressive Agents/therapeutic use ; Immunotherapy/methods ; Isoantibodies/blood ; Liver Transplantation/adverse effects ; Liver Transplantation/immunology ; Male ; Middle Aged ; Plasmapheresis ; Time Factors ; Treatment Outcome
    Chemical Substances HLA Antigens ; Immunosuppressive Agents ; Isoantibodies
    Language English
    Publishing date 2013-01-27
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0b013e318277226d
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  8. Article ; Online: Rhabdomyolysis with cardiac involvement and acute renal failure in a patient taking rosuvastatin and fenofibrate.

    Ireland, James H E / Eggert, Christoph H / Arendt, Christopher J / Williams, Amy W

    Annals of internal medicine

    2005  Volume 142, Issue 11, Page(s) 949–950

    MeSH term(s) Acute Kidney Injury/chemically induced ; Female ; Fenofibrate/adverse effects ; Fluorobenzenes/adverse effects ; Heart Diseases/chemically induced ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Hypolipidemic Agents/adverse effects ; Middle Aged ; Pyrimidines/adverse effects ; Rhabdomyolysis/chemically induced ; Rosuvastatin Calcium ; Sulfonamides/adverse effects
    Chemical Substances Fluorobenzenes ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Hypolipidemic Agents ; Pyrimidines ; Sulfonamides ; Rosuvastatin Calcium (83MVU38M7Q) ; Fenofibrate (U202363UOS)
    Language English
    Publishing date 2005-04-21
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/0003-4819-142-11-200506070-00020
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