Article ; Online: Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax
Acta tropica. 2012 Feb., v. 121, no. 2 p.152-155
2012
Abstract: We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of ... ...
| Abstract | We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil. IgG antibodies were detected by enzyme-linked immunosorbent assay against four peptides of circumsporozoite protein (CSP) (amino, carboxyl, and VK210 and VK247 repeats) and peptides of merozoite surface protein 1 (MSP-1), apical membrane antigen 1 (AMA-1), and Duffy-binding protein (DBP). We found an association between HLA-DR3 and HLA-DR5 alleles and lack of antibody response to CSP amino terminal, as well as an association between HLA-DR3 and the highest antibody response to MSP1 (Pv200L). In conclusion, we suggest a potential regulatory role of the HLA-DRB1 alleles in the production of antibodies to a conserved region of P. vivax CSP and MSP1 in Brazilian population exposed to malaria. |
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| Keywords | Plasmodium vivax ; alleles ; antibodies ; antibody formation ; antigens ; at-risk population ; enzyme-linked immunosorbent assay ; gene frequency ; humans ; immunoglobulin G ; malaria ; merozoites ; patients ; peptides ; surface proteins ; Brazil |
| Language | English |
| Dates of publication | 2012-02 |
| Size | p. 152-155. |
| Publishing place | Elsevier B.V. |
| Document type | Article ; Online |
| ZDB-ID | 210415-5 |
| ISSN | 1873-6254 ; 0001-706X |
| ISSN (online) | 1873-6254 |
| ISSN | 0001-706X |
| DOI | 10.1016/j.actatropica.2011.10.009 |
| Database | NAL-Catalogue (AGRICOLA) |
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