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Article ; Online: GBA1 and The Immune System: A Potential Role in Parkinson's Disease?

Al-Azzawi, Zaid A M / Arfaie, Saman / Gan-Or, Ziv

2022 Volume 12, Issue s1, Page(s) S53–S64

Abstract: It is clear that the immune system and inflammation have a role in Parkinson's disease (PD), including sporadic PD and some genetic forms such as LRRK2-associated PD. One of the most important genes associated with PD is GBA1, as variants in this gene ... ...

Abstract	It is clear that the immune system and inflammation have a role in Parkinson's disease (PD), including sporadic PD and some genetic forms such as LRRK2-associated PD. One of the most important genes associated with PD is GBA1, as variants in this gene are found in 5-20% of PD patients in different populations worldwide. Biallelic variants in GBA1 may cause Gaucher disease, a lysosomal storage disorder with involvement of the immune system, and other lines of evidence link GBA1 to the immune system and inflammation. In this review, we discuss these different pieces of evidence and whether the interplay between GBA1 and the immune system may have a role in PD.
MeSH term(s)	Glucosylceramidase/genetics ; Humans ; Immune System ; Inflammation ; Mutation ; Parkinson Disease/genetics
Chemical Substances	Glucosylceramidase (EC 3.2.1.45)
Language	English
Publishing date	2022-09-01
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2620609-2
ISSN	1877-718X ; 1877-7171
ISSN (online)	1877-718X
ISSN	1877-7171
DOI	10.3233/JPD-223423
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Zs.A 6964: Show issues

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Article ; Online: Lessons Learnt from the Second Generation of Anti-Amyloid Monoclonal Antibodies Clinical Trials.

Tian Hui Kwan, Angela / Arfaie, Saman / Therriault, Joseph / Rosa-Neto, Pedro / Gauthier, Serge

Dementia and geriatric cognitive disorders

2020 Volume 49, Issue 4, Page(s) 334–348

Abstract: Background: Alzheimer disease (AD) is a chronic neurodegenerative disorder with complex pathophysiology that affects over 50 million people worldwide. Most drug therapies, to date, have focused on targeting the amyloid-beta (Aβ) pathway, but clinical ... ...

Abstract	Background: Alzheimer disease (AD) is a chronic neurodegenerative disorder with complex pathophysiology that affects over 50 million people worldwide. Most drug therapies, to date, have focused on targeting the amyloid-beta (Aβ) pathway, but clinical outcomes of anti-Aβ antibodies have been unsuccessful and unable to meet their primary endpoints. Similar trends have also been observed in treatments that target the tau pathway. Summary: This paper reviews recent anti-Aβ passive monotherapies, since Bapineuzumab, that have progressed to phase 3 clinical trials. Specifically, we discuss the 4 clinical trial programs of Solanezumab (targets Aβ monomers), Aducanumab (targets Aβ oligomers and plaques), Crenezumab (targets Aβ oligomers), and Gantenerumab (targets Aβ fibrils) which are all exogenous monoclonal antibodies. We conclude with potential reasons for why they have not met their primary endpoints and discuss lessons learnt from these trials. Key Message: Future disease-modifying trials (DMTs) for AD should be conducted in asymptomatic, Aβ-positive individuals. Moreover, potential additive and/or synergistic benefits focusing on anti-Aβ and anti-tau drug combinations merit further investigation.
MeSH term(s)	Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/immunology ; Antibodies, Monoclonal, Humanized/classification ; Antibodies, Monoclonal, Humanized/pharmacology ; Clinical Trials as Topic ; Humans ; tau Proteins/antagonists & inhibitors ; tau Proteins/immunology
Chemical Substances	Amyloid beta-Peptides ; Antibodies, Monoclonal, Humanized ; tau Proteins
Language	English
Publishing date	2020-12-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1026007-9
ISSN	1421-9824 ; 1013-7424
ISSN (online)	1421-9824
ISSN	1013-7424
DOI	10.1159/000511506
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Zs.A 2866: Show issues

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Article ; Online: Neuroanatomical predictors of problematic alcohol consumption in adolescents: a systematic review of longitudinal studies.

Honarvar, Faraz / Arfaie, Saman / Edalati, Hanie / Ghasroddashti, Arashk / Solgi, Arad / Mashayekhi, Mohammad Sadegh / Mofatteh, Mohammad / Ren, Lily Yuxi / Kwan, Angela T H / Keramatian, Kamyar

Alcohol and alcoholism (Oxford, Oxfordshire)

2023 Volume 58, Issue 5, Page(s) 455–471

Abstract: Aims: This study aimed to systematically review the literature on neuroanatomical predictors of future problematic drinking in adolescents.: Methods: Using PRISMA guidelines, a systematic review was conducted to evaluate neuroanatomical predictors of ...

Abstract	Aims: This study aimed to systematically review the literature on neuroanatomical predictors of future problematic drinking in adolescents. Methods: Using PRISMA guidelines, a systematic review was conducted to evaluate neuroanatomical predictors of problematic alcohol consumption in adolescents. EMBASE, MEDLINE, and PsycINFO databases were searched from inception to 6 January 2023. Studies were included if they were original, had a prospective design, had a sample size of at least 12, had a follow-up period of at least 1 year, had at least one structural neuroimaging scan before 18 with no prior alcohol use, and had alcohol use as the primary outcome. Studies were excluded if they had animals only and were not in English. Risk of bias was conducted using the CASP tool. Results: Out of 1412 studies identified, 19 studies met the criteria, consisting of 11 gray matter (n = 4040), 5 white matter (n = 319), and 3 assessing both (n = 3608). Neuroanatomical predictors of future problematic drinking in adolescents were reported to be distributed across various brain regions such as the orbitofrontal cortex and paralimbic regions. However, the findings were largely heterogeneous. Conclusions: This is the first systematic review to map out the existing literature on neuroanatomical predictors of problematic drinking in adolescents. Future research should focus on the aforementioned regions to determine their role in predicting future problematic drinking with more certainty.
MeSH term(s)	Brain/diagnostic imaging ; Gray Matter ; Cerebral Cortex ; Alcohol Drinking/epidemiology ; Longitudinal Studies
Language	English
Publishing date	2023-08-08
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	604956-4
ISSN	1464-3502 ; 0309-1635 ; 0735-0414
ISSN (online)	1464-3502
ISSN	0309-1635 ; 0735-0414
DOI	10.1093/alcalc/agad049
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Zs.B 798: Show issues

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Article ; Online: Anxiety and Depression in Pediatric-Onset Traumatic Spinal Cord Injury: A Systematic Review.

Mofatteh, Mohammad / Mashayekhi, Mohammad Sadegh / Arfaie, Saman / Chen, Yimin / Malhotra, Armaan K / Skandalakis, Georgios P / Alvi, Mohammed Ali / Afshari, Fardad T / Meshkat, Shakila / Lin, Famu / Abdulla, Ebtesam / Anand, Ayush / Liao, Xuxing / McIntyre, Roger S / Santaguida, Carlo / Weber, Michael H / Fehlings, Michael G

World neurosurgery

2023 Volume 184, Page(s) 267–282.e5

Abstract: Background: Traumatic spinal cord injury (TSCI) is a debilitating neurological condition with significant long-term consequences on the mental health and well-being of affected individuals. We aimed to investigate anxiety and depression in individuals ... ...

Abstract	Background: Traumatic spinal cord injury (TSCI) is a debilitating neurological condition with significant long-term consequences on the mental health and well-being of affected individuals. We aimed to investigate anxiety and depression in individuals with pediatric-onset TSCI. Methods: PubMed, Scopus, and Web of Science databases were searched from inception to December 20th, 2022 following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, and studies were included according to the eligibility criteria. Results: A total of 1013 articles were screened, and 18 studies with 4234 individuals were included in the final review. Of these, 1613 individuals (38.1%) had paraplegia, whereas 1658 (39.2%) had tetraplegia. A total of 1831 participants (43.2%) had complete TSCI, whereas 1024 (24.2%) had incomplete TSCI. The most common etiology of TSCI with 1545 people (36.5%) was motor vehicle accidents. The youngest mean age at the time of injury was 5.92 ± 4.92 years, whereas the oldest was 14.6 ± 2.8 years. Patient Health Questionnaire-9 was the most common psychological assessment used in 9 studies (50.0%). Various risk factors, including pain in 4 studies (22.2%), reduced sleep quality, reduced functional independence, illicit drug use, incomplete injury, hospitalization, reduced quality of life, and duration of injury in 2 (11.1%) studies, each, were associated with elevated anxiety and depression. Conclusions: Different biopsychosocial risk factors contribute to elevated rates of anxiety and depression among individuals with pediatric-onset TSCI. Individuals at risk of developing anxiety and depression should be identified, and targeted support should be provided. Future large-scale studies with long-term follow-up are required to validate and extend these findings.
MeSH term(s)	Child ; Humans ; Infant ; Child, Preschool ; Depression/epidemiology ; Depression/etiology ; Quality of Life ; Spinal Cord Injuries/complications ; Spinal Cord Injuries/epidemiology ; Paraplegia/etiology ; Anxiety/epidemiology ; Anxiety/etiology
Language	English
Publishing date	2023-12-23
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2023.12.092
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Zs.A 1159: Show issues

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Article ; Online: Awake craniotomy during pregnancy: A systematic review of the published literature.

Mofatteh, Mohammad / Mashayekhi, Mohammad Sadegh / Arfaie, Saman / Wei, Hongquan / Kazerouni, Arshia / Skandalakis, Georgios P / Pour-Rashidi, Ahmad / Baiad, Abed / Elkaim, Lior / Lam, Jack / Palmisciano, Paolo / Su, Xiumei / Liao, Xuxing / Das, Sunit / Ashkan, Keyoumars / Cohen-Gadol, Aaron A

Neurosurgical review

2023 Volume 46, Issue 1, Page(s) 290

Abstract: Neurosurgical pathologies in pregnancy pose significant complications for the patient and fetus, and physiological stressors during anesthesia and surgery may lead to maternal and fetal complications. Awake craniotomy (AC) can preserve neurological ... ...

Abstract	Neurosurgical pathologies in pregnancy pose significant complications for the patient and fetus, and physiological stressors during anesthesia and surgery may lead to maternal and fetal complications. Awake craniotomy (AC) can preserve neurological functions while reducing exposure to anesthetic medications. We reviewed the literature investigating AC during pregnancy. PubMed, Scopus, and Web of Science databases were searched from the inception to February 7th, 2023, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. Studies in English investigating AC in pregnant patients were included in the final analysis. Nine studies composed of nine pregnant patients and ten fetuses (one twin-gestating patient) were included. Glioma was the most common pathology reported in six (66.7%) patients. The frontal lobe was the most involved region (4 cases, 44.4%), followed by the frontoparietal region (2 cases, 22.2%). The awake-awake-awake approach was the most common protocol in seven (77.8%) studies. The shortest operation time was two hours, whereas the longest one was eight hours and 29 min. The mean gestational age at diagnosis was 13.6 ± 6.5 (2-22) and 19.6 ± 6.9 (9-30) weeks at craniotomy. Seven (77.8%) studies employed intraoperative fetal heart rate monitoring. None of the AC procedures was converted to general anesthesia. Ten healthy babies were delivered from patients who underwent AC. In experienced hands, AC for resection of cranial lesions of eloquent areas in pregnant patients is safe and feasible and does not alter the pregnancy outcome.
MeSH term(s)	Female ; Humans ; Pregnancy ; Brain Neoplasms/surgery ; Wakefulness/physiology ; Craniotomy/methods ; Glioma/surgery ; Anesthesia, General
Language	English
Publishing date	2023-11-01
Publishing country	Germany
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	6907-3
ISSN	1437-2320 ; 0344-5607
ISSN (online)	1437-2320
ISSN	0344-5607
DOI	10.1007/s10143-023-02187-x
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Article ; Online: Medial temporal tau predicts memory decline in cognitively unimpaired elderly.

Kwan, Angela T H / Arfaie, Saman / Therriault, Joseph / Azizi, Zahra / Lussier, Firoza Z / Tissot, Cecile / Chamoun, Mira / Bezgin, Gleb / Servaes, Stijn / Stevenon, Jenna / Rahmouni, Nesrine / Pallen, Vanessa / Gauthier, Serge / Rosa-Neto, Pedro

Brain communications

2022 Volume 5, Issue 1, Page(s) fcac325

Abstract: Alzheimer's disease can be detected in living people ... ...

Abstract	Alzheimer's disease can be detected in living people using
Language	English
Publishing date	2022-12-09
Publishing country	England
Document type	Journal Article
ISSN	2632-1297
ISSN (online)	2632-1297
DOI	10.1093/braincomms/fcac325
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Article ; Online: Stress, Anxiety, and Depression Associated With Awake Craniotomy: A Systematic Review.

Mofatteh, Mohammad / Mashayekhi, Mohammad Sadegh / Arfaie, Saman / Chen, Yimin / Hendi, Kasra / Kwan, Angela Tian Hui / Honarvar, Faraz / Solgi, Arad / Liao, Xuxing / Ashkan, Keyoumars

Neurosurgery

2022 Volume 92, Issue 2, Page(s) 225–240

Abstract: Background: Awake craniotomy (AC) enables real-time monitoring of cortical and subcortical functions when lesions are in eloquent brain areas. AC patients are exposed to various preoperative, intraoperative, and postoperative stressors, which might ... ...

Abstract	Background: Awake craniotomy (AC) enables real-time monitoring of cortical and subcortical functions when lesions are in eloquent brain areas. AC patients are exposed to various preoperative, intraoperative, and postoperative stressors, which might affect their mental health. Objective: To conduct a systematic review to better understand stress, anxiety, and depression in AC patients. Methods: PubMed, Scopus, and Web of Science databases were searched from January 1, 2000, to April 20, 2022, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline. Results: Four hundred forty-seven records were identified that fit our inclusion and exclusion criteria for screening. Overall, 24 articles consisting of 1450 patients from 13 countries were included. Sixteen studies (66.7%) were prospective, whereas 8 articles (33.3%) were retrospective. Studies evaluated stress, anxiety, and depression during different phases of AC. Twenty-two studies (91.7%) were conducted on adults, and 2 studies were on pediatrics (8.3 %). Glioma was the most common AC treatment with 615 patients (42.4%). Awake-awake-awake and asleep-awake-asleep were the most common protocols, each used in 4 studies, respectively (16.7%). Anxiety was the most common psychological outcome evaluated in 19 studies (79.2%). The visual analog scale and self-developed questionnaire by the authors (each n = 5, 20.8%) were the most frequently tools used. Twenty-three studies (95.8%) concluded that AC does not increase stress, anxiety, and/or depression in AC patients. One study (4.2%) identified younger age associated with panic attack. Conclusion: In experienced hands, AC does not cause an increase in stress, anxiety, and depression; however, the psychiatric impact of AC should not be underestimated.
MeSH term(s)	Adult ; Humans ; Child ; Brain Neoplasms/surgery ; Depression ; Wakefulness ; Retrospective Studies ; Prospective Studies ; Craniotomy/methods ; Anxiety/etiology
Language	English
Publishing date	2022-11-18
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	135446-2
ISSN	1524-4040 ; 0148-396X
ISSN (online)	1524-4040
ISSN	0148-396X
DOI	10.1227/neu.0000000000002224
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Zs.A 1424: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 539: Show issues

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Article ; Online: Augmented and virtual reality usage in awake craniotomy: a systematic review.

Mofatteh, Mohammad / Mashayekhi, Mohammad Sadegh / Arfaie, Saman / Chen, Yimin / Mirza, Asfand Baig / Fares, Jawad / Bandyopadhyay, Soham / Henich, Edy / Liao, Xuxing / Bernstein, Mark

Neurosurgical review

2022 Volume 46, Issue 1, Page(s) 19

Abstract: Augmented and virtual reality (AR, VR) are becoming promising tools in neurosurgery. AR and VR can reduce challenges associated with conventional approaches via the simulation and mimicry of specific environments of choice for surgeons. Awake craniotomy ( ...

Abstract	Augmented and virtual reality (AR, VR) are becoming promising tools in neurosurgery. AR and VR can reduce challenges associated with conventional approaches via the simulation and mimicry of specific environments of choice for surgeons. Awake craniotomy (AC) enables the resection of lesions from eloquent brain areas while monitoring higher cortical and subcortical functions. Evidence suggests that both surgeons and patients benefit from the various applications of AR and VR in AC. This paper investigates the application of AR and VR in AC and assesses its prospective utility in neurosurgery. A systematic review of the literature was performed using PubMed, Scopus, and Web of Science databases in accordance with the PRISMA guidelines. Our search results yielded 220 articles. A total of six articles consisting of 118 patients have been included in this review. VR was used in four papers, and the other two used AR. Tumour was the most common pathology in 108 patients, followed by vascular lesions in eight patients. VR was used for intraoperative mapping of language, vision, and social cognition, while AR was incorporated in preoperative training of white matter dissection and intraoperative visualisation and navigation. Overall, patients and surgeons were satisfied with the applications of AR and VR in their cases. AR and VR can be safely incorporated during AC to supplement, augment, or even replace conventional approaches in neurosurgery. Future investigations are required to assess the feasibility of AR and VR in various phases of AC.
MeSH term(s)	Humans ; Wakefulness ; Augmented Reality ; Virtual Reality ; Craniotomy ; Neurosurgical Procedures/methods
Language	English
Publishing date	2022-12-19
Publishing country	Germany
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	6907-3
ISSN	1437-2320 ; 0344-5607
ISSN (online)	1437-2320
ISSN	0344-5607
DOI	10.1007/s10143-022-01929-7
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Article: The Inception of the Canadian Medical Student Interest Group in Neurosurgery (CaMSIGN): A Student-Led Platform Dedicated to Neurosurgical Education, Research, Mentorship, and Advocacy.

Arfaie, Saman / Laghaei Farimani, Pedram / Mashayekhi, Mohammad Sadegh / Hakak-Zargar, Benyamin / Fatehi Hassanabad, Mostafa / Smith-Forrester, Jenna / Sader, Nicholas / Hodaie, Mojgan / Del Maestro, Rolando / Das, Sunit

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

2022 Volume 50, Issue 2, Page(s) 301–302

MeSH term(s)	Humans ; Neurosurgery/education ; Students, Medical ; Public Opinion ; Mentors ; Canada ; Internship and Residency
Language	English
Publishing date	2022-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	197622-9
ISSN	0317-1671
ISSN	0317-1671
DOI	10.1017/cjn.2022.11
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Zs.A 1203: Show issues

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Article ; Online: Suicidal ideation and attempts in brain tumor patients and survivors: A systematic review.

Mofatteh, Mohammad / Mashayekhi, Mohammad Sadegh / Arfaie, Saman / Chen, Yimin / Malhotra, Armaan K / Alvi, Mohammed Ali / Sader, Nicholas / Antonick, Violet / Fatehi Hassanabad, Mostafa / Mansouri, Alireza / Das, Sunit / Liao, Xuxing / McIntyre, Roger S / Del Maestro, Rolando / Turecki, Gustavo / Cohen-Gadol, Aaron A / Zadeh, Gelareh / Ashkan, Keyoumars

Neuro-oncology advances

2023 Volume 5, Issue 1, Page(s) vdad058

Abstract: Background: Subsequent to a diagnosis of a brain tumor, psychological distress has been associated with negative effects on mental health as well as suicidality. The magnitude of such impact has been understudied in the literature. We conducted a ... ...

Abstract	Background: Subsequent to a diagnosis of a brain tumor, psychological distress has been associated with negative effects on mental health as well as suicidality. The magnitude of such impact has been understudied in the literature. We conducted a systematic review to examine the impact of a brain tumor on suicidality (both ideation and attempts). Methods: In accordance with the PRISMA guidelines, we searched for relevant peer-reviewed journal articles on PubMed, Scopus, and Web of Science databases from inception to October 20, 2022. Studies investigating suicide ideation and/or attempt among patients with brain tumors were included. Results: Our search yielded 1,998 articles which were screened for eligibility. Seven studies consisting of 204,260 patients were included in the final review. Four studies comprising 203,906 patients (99.8%) reported elevated suicidal ideation and suicide attempt incidence compared with the general population. Prevalence of ideation and attempts ranged from 6.0% to 21.5% and 0.03% to 3.33%, respectively. Anxiety, depression, pain severity, physical impairment, glioblastoma diagnosis, male sex, and older age emerged as the primary risk factors associated with increased risk of suicidal ideation and attempts. Conclusion: Suicidal ideation and attempts are increased in patients and survivors of brain tumors compared to the general population. Early identification of patients exhibiting these behaviors is crucial for providing timely psychiatric support in neuro-oncological settings to mitigate potential harm. Future research is required to understand pharmacological, neurobiological, and psychiatric mechanisms that predispose brain tumor patients to suicidality.
Language	English
Publishing date	2023-05-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	3009682-0
ISSN	2632-2498 ; 2632-2498
ISSN (online)	2632-2498
ISSN	2632-2498
DOI	10.1093/noajnl/vdad058
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