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  1. Article ; Online: Intravascular ultrasound-guided STAR 2.0: A new technique for chronic total occlusion recanalization.

    Garbo, Roberto / Iannaccone, Mario / Bruno, Francesco / Arioti, Manfredi

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2023  Volume 103, Issue 1, Page(s) 80–88

    Abstract: The use of the subintimal space has allowed a massive advancement in the field of chronic total occlusion percutaneous coronary intervention (PCI). The STAR technique is the first of subintimal techniques. Despite a high acute success rate, follow-up ... ...

    Abstract The use of the subintimal space has allowed a massive advancement in the field of chronic total occlusion percutaneous coronary intervention (PCI). The STAR technique is the first of subintimal techniques. Despite a high acute success rate, follow-up results showed unfavorable outcomes with half of the treated patients showing restenosis/reocclusion at 6 months. We present three cases in which a modification of the STAR technique guided by intravascular ultrasound (IVUS), namely the STAR 2.0, was used as a bailout for successful PCI of chronic total occlusions.
    MeSH term(s) Humans ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/methods ; Treatment Outcome ; Coronary Occlusion/diagnostic imaging ; Coronary Occlusion/therapy ; Coronary Occlusion/etiology ; Chronic Disease ; Ultrasonography, Interventional ; Coronary Angiography
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.30920
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  2. Article ; Online: La terapia antitrombotica dopo chirurgia riparativa della valvola mitrale: revisione delle evidenze e suggerimenti aggiornati.

    Rubboli, Andrea / Fiorentino, Maria Francesca / Lisi, Matteo / Arioti, Manfredi / Galvani, Marcello / Savini, Carlo

    Giornale italiano di cardiologia (2006)

    2024  Volume 25, Issue 3, Page(s) 157–161

    Abstract: Surgical mitral valve repair (SMVR) is performed with various techniques that involve the implantation of non-biological material, such as the prolene of the suture threads, the polytetrafluoroethylene of the neo-chordae or the prosthetic ring for the ... ...

    Title translation Antithrombotic therapy after surgical mitral valve repair: review of the evidence and updated proposals.
    Abstract Surgical mitral valve repair (SMVR) is performed with various techniques that involve the implantation of non-biological material, such as the prolene of the suture threads, the polytetrafluoroethylene of the neo-chordae or the prosthetic ring for the remodeling of the valve annulus, whose exposure to the bloodstream is capable of triggering the blood coagulation cascade and consequently the development of thrombotic/thromboembolic events. The indications of the literature on the use of antithrombotic drugs after SMVR are weak and not univocal given the absence of randomized data and the availability of only small observational case series, which are generally contaminated by the lack of homogeneity of the populations examined. Indeed in these studies, patients not only undergoing SMVR, but also transcatheter repair of the mitral valve or surgical implantation of a biological valve prosthesis (not only in the mitral position) are included. In addition, the indication for antithrombotic therapy, and in particular anticoagulation, is often conditioned by the concomitant presence of atrial fibrillation that either preexists or develops postoperatively. In this review, the current evidence regarding antithrombotic therapy in patients undergoing SMVR, both in the presence or absence of atrial fibrillation, is summarized and updated treatment algorithms are proposed.
    MeSH term(s) Humans ; Mitral Valve/surgery ; Fibrinolytic Agents ; Heart Valve Prosthesis Implantation/methods ; Atrial Fibrillation/surgery ; Treatment Outcome ; Mitral Valve Insufficiency/etiology
    Chemical Substances Fibrinolytic Agents
    Language Italian
    Publishing date 2024-02-23
    Publishing country Italy
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 2272414-X
    ISSN 1972-6481 ; 1827-6806
    ISSN (online) 1972-6481
    ISSN 1827-6806
    DOI 10.1714/4209.42001
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  3. Article ; Online: Power Flush, a Novel Bailout Technique for Stumpless Aorto-Ostial CTOs: A Case-Based Approach.

    Garbo, Roberto / Arioti, Manfredi / Leoncini, Massimo

    Cardiovascular revascularization medicine : including molecular interventions

    2022  Volume 40S, Page(s) 282–287

    Abstract: Background: Aorto-ostial coronary artery flush chronic total occlusions are a challenging subset of lesion with peculiar characteristic: the near complete lack of guiding catheter support, the presence of a thicker layer of muscular fibers and a greater ...

    Abstract Background: Aorto-ostial coronary artery flush chronic total occlusions are a challenging subset of lesion with peculiar characteristic: the near complete lack of guiding catheter support, the presence of a thicker layer of muscular fibers and a greater collagen and calcium content, responsible for balloon dilatation's resistance and greater recoil tendency. We introduce a novel bailout technique to overcome retrograde wire failure in accessing aorta, a variation of the Carlino technique which we named Power Flush.
    Materials and methods: Power Flush consists in a forceful injection of contrast dye directly through the guiding catheter positioned against the aortic wall in correspondence to the coronary ostium location, to gain access to the extra-plaque space and proceed with the vessel's recanalization. In one case we used a further iteration named Nick And Flush, in which a preliminary nicking of the aortic wall with a penetrative wire was done before the Power Flush.
    Results: We hereby present three cases of aorto-ostial right coronary artery flush chronic total occlusions. In two of them we utilized the Power Flush technique, in one case we employed its variant Nick And Flush. We were successful in all cases and no complication occurred.
    Conclusions: In this kind of lesions Power Flush and Nick And Flush are effective bailout techniques to overcome retrograde wire failure to reach aorta.
    MeSH term(s) Aorta/diagnostic imaging ; Contrast Media ; Coronary Angiography/methods ; Humans ; Treatment Outcome
    Chemical Substances Contrast Media
    Language English
    Publishing date 2022-02-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2212113-4
    ISSN 1878-0938 ; 1553-8389
    ISSN (online) 1878-0938
    ISSN 1553-8389
    DOI 10.1016/j.carrev.2022.02.004
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  4. Article ; Online: A rare but serious complication of ticagrelor therapy: a case report.

    Arioti, Manfredi / Sirianni, Giovanni / Laudisa, Maria Luisa / De Cesare, Nicoletta Bianca

    European heart journal. Case reports

    2020  Volume 4, Issue 5, Page(s) 1–5

    Abstract: Background: Ticagrelor is a widely used P2Y12 inhibitor and represents a fundamental therapeutic agent in acute coronary syndrome treatment and selected post-percutaneous coronary intervention (PCI) cases. Dyspnoea and bradycardia are the most common ... ...

    Abstract Background: Ticagrelor is a widely used P2Y12 inhibitor and represents a fundamental therapeutic agent in acute coronary syndrome treatment and selected post-percutaneous coronary intervention (PCI) cases. Dyspnoea and bradycardia are the most common side effects but the latter has been reported to be of trivial clinical significance.
    Case summary: A 51-year-old gentleman underwent PCI to left anterior descending and obtuse marginal for unstable angina receiving a loading dose of ticagrelor (180 mg). During hospital stay, whilst on telemetry monitoring, a 16 s long, symptomatic, asystolic ventricular standstill was recorded prompting ticagrelor interruption and a switch to prasugrel.
    Discussion: Despite ventricular pauses have been reported in dedicated analyses of Phase III trials, no apparent clinical consequences were documented. However, several reports have shown that significant brady-arrhythmic events might be linked to ticagrelor administration presenting both as sino-atrial and atrio-ventricular conduction disturbances. We report a case of asystole occurring 36 h after the administration of a loading dose.
    Language English
    Publishing date 2020-08-20
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytaa156
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  5. Article ; Online: Contrast Fractional Flow Reserve (cFFR): A pragmatic response to the call for simplification of invasive functional assessment.

    Leone, Antonio Maria / Lassandro Pepe, Francesca / Arioti, Manfredi / Crea, Filippo

    International journal of cardiology

    2018  Volume 268, Page(s) 45–50

    Abstract: Aim: To review the current approaches to simplify functional assessment of coronary stenosis with particular regard for contrast Fractional Flow Reserve (cFFR).: Methods and results: Maximal hyperaemia to assess FFR is perceived as time-consuming, ... ...

    Abstract Aim: To review the current approaches to simplify functional assessment of coronary stenosis with particular regard for contrast Fractional Flow Reserve (cFFR).
    Methods and results: Maximal hyperaemia to assess FFR is perceived as time-consuming, costly, unpleasant for the patient and associated with side effects. Resting indexes, like Pd/Pa and iFR, have been proposed to circumvent the use of vasodilators as well as an approach based on the administration of contrast medium to induce coronary vasodilation, the cFFR. Contrast FFR can be obtained quickly, at very low cost in the absence of substantial side effects. Among these alternative indexes, cFFR shows the best correlation with FFR, reduces the use of adenosine even more than a hybrid resting approach but has not yet been tested in a randomized, controlled trial with clinical end-points.
    Conclusion: cFFR represents a cheap, safe and effective alternative to FFR, able to facilitate the dissemination of a functional approach to myocardial revascularization.
    MeSH term(s) Contrast Media/administration & dosage ; Coronary Stenosis/diagnosis ; Coronary Stenosis/physiopathology ; Fractional Flow Reserve, Myocardial/drug effects ; Fractional Flow Reserve, Myocardial/physiology ; Humans ; Hyperemia/diagnosis ; Hyperemia/physiopathology ; Myocardial Revascularization/adverse effects ; Myocardial Revascularization/methods ; Vasodilator Agents/administration & dosage
    Chemical Substances Contrast Media ; Vasodilator Agents
    Language English
    Publishing date 2018-07-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2018.04.048
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  6. Article ; Online: QFR for the Revascularization of Nonculprit Vessels in MI Patients: Insights From the FIRE Trial.

    Erriquez, Andrea / Campo, Gianluca / Guiducci, Vincenzo / Casella, Gianni / Menozzi, Mila / Cerrato, Enrico / Sacchetta, Giorgio / Moreno, Raul / Arena, Marco / Amat Santos, Ignacio / Diez Gil, Jose Luis / Scarsini, Roberto / Ruozzi, Marco / Arioti, Manfredi / Picchi, Andrea / Barbierato, Marco / Moscarella, Elisabetta / Musto D'Amore, Sergio / Lanzilotti, Valerio /
    Cavazza, Caterina / Rezzaghi, Marco / Cocco, Marta / Marrone, Andrea / Verardi, Filippo Maria / Escaned, Javier / Barbato, Emanuele / Colaiori, Iginio / Pesenti, Nicola / Carrara, Greta / Biscaglia, Simone

    JACC. Cardiovascular interventions

    2024  

    Abstract: Background: The role of quantitative flow ratio (QFR) in the treatment of nonculprit vessels of patients with myocardial infarction (MI) is a topic of ongoing discussion.: Objectives: This study aimed to investigate the predictive capability of QFR ... ...

    Abstract Background: The role of quantitative flow ratio (QFR) in the treatment of nonculprit vessels of patients with myocardial infarction (MI) is a topic of ongoing discussion.
    Objectives: This study aimed to investigate the predictive capability of QFR for adverse events and its noninferiority compared to wire-based functional assessment in nonculprit vessels of MI patients.
    Methods: The FIRE (Functional Assessment in Elderly MI Patients With Multivessel Disease) trial randomized 1,445 older MI patients to culprit-only (n = 725) or physiology-guided complete revascularization (n = 720). In the culprit-only arm, angiographic projections of nonculprit vessels were prospectively collected, centrally reviewed for QFR computation, and associated with endpoints. In the complete revascularization arm, endpoints were compared between nonculprit vessels investigated with QFR or wire-based functional assessment. The primary endpoint was the vessel-oriented composite endpoint (VOCE) at 1 year.
    Results: QFR was measured on 903 nonculprit vessels from 685 patients in the culprit-only arm. Overall, 366 (40.5%) nonculprit vessels showed a QFR value ≤0.80, with a significantly higher incidence of VOCEs (22.1% vs 7.1%; P < 0.001). QFR ≤0.80 emerged as an independent predictor of VOCEs (HR: 2.79; 95% CI: 1.64-4.75). In the complete arm, QFR was used in 320 (35.2%) nonculprit vessels to guide revascularization. When compared with propensity-matched nonculprit vessels in which treatment was guided by wire-based functional assessment, no significant difference was observed (HR: 0.57; 95% CI: 0.28-1.15) in VOCEs.
    Conclusions: This prespecified subanalysis of the FIRE trial provides evidence supporting the safety and efficacy of QFR-guided interventions for the treatment of nonculprit vessels in MI patients. (Functional Assessment in Elderly MI Patients With Multivessel Disease [FIRE]; NCT03772743).
    Language English
    Publishing date 2024-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2024.04.022
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  7. Article ; Online: Fractional Flow Reserve or Optical Coherence Tomography to Guide Management of Angiographically Intermediate Coronary Stenosis: A Single-Center Trial.

    Burzotta, Francesco / Leone, Antonio Maria / Aurigemma, Cristina / Zambrano, Aniello / Zimbardo, Giuseppe / Arioti, Manfredi / Vergallo, Rocco / De Maria, Giovanni Luigi / Cerracchio, Emma / Romagnoli, Enrico / Trani, Carlo / Crea, Filippo

    JACC. Cardiovascular interventions

    2020  Volume 13, Issue 1, Page(s) 49–58

    Abstract: Objectives: The aim of this study was to compare optical coherence tomographic (OCT) guidance and fractional flow reserve (FFR) guidance in patients with angiographically intermediate coronary lesions (AICLs) in a single-center, prospective, 1:1 ... ...

    Abstract Objectives: The aim of this study was to compare optical coherence tomographic (OCT) guidance and fractional flow reserve (FFR) guidance in patients with angiographically intermediate coronary lesions (AICLs) in a single-center, prospective, 1:1 randomized trial.
    Background: FFR and OCT imaging may help both in the assessment of AICLs and in percutaneous coronary intervention optimization.
    Methods: Patients with AICLs were randomized to FFR or OCT imaging. In the FFR arm, PCI was performed if FFR was ≤0.80. In the OCT imaging arm, PCI was performed if area stenosis was ≥75% or 50% to 75% with minimal luminal area <2.5 mm
    Results: A total of 350 patients (with 446 AICLs) were enrolled (176 randomized to FFR and 174 to OCT imaging). The primary endpoint of major adverse cardiac events or significant angina at 13 months occurred in 14.8% of patients in the FFR arm and in 8.0% in the OCT imaging arm (p = 0.048). This result was driven by a statistically nonsignificant lower occurrence of all primary endpoint components. Up to 13 months, the rate of medically managed patients was significantly higher (p < 0.001) and total cost significantly lower (p < 0.001) with FFR in comparison with OCT imaging.
    Conclusions: In patients with AICLs, OCT guidance is associated with lower occurrence of the composite of major adverse cardiac events or significant angina. FFR guidance is associated with a higher rate of medical management and lower costs. FFR or OCT Guidance to Revascularize Intermediate Coronary Stenosis Using Angioplasty [FORZA]; NCT01824030).
    MeSH term(s) Aged ; Cardiac Catheterization/economics ; Cardiovascular Agents/adverse effects ; Cardiovascular Agents/economics ; Cardiovascular Agents/therapeutic use ; Clinical Decision-Making ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/economics ; Coronary Stenosis/physiopathology ; Coronary Stenosis/therapy ; Cost Savings ; Cost-Benefit Analysis ; Female ; Fractional Flow Reserve, Myocardial/drug effects ; Health Care Costs ; Humans ; Male ; Middle Aged ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/economics ; Predictive Value of Tests ; Prospective Studies ; Reproducibility of Results ; Rome ; Severity of Illness Index ; Time Factors ; Tomography, Optical Coherence/economics ; Treatment Outcome
    Chemical Substances Cardiovascular Agents
    Language English
    Publishing date 2020-01-10
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2019.09.034
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  8. Article ; Online: Prospective Randomized Comparison of Fractional Flow Reserve Versus Optical Coherence Tomography to Guide Revascularization of Intermediate Coronary Stenoses: One-Month Results.

    Leone, Antonio Maria / Burzotta, Francesco / Aurigemma, Cristina / De Maria, Giovanni Luigi / Zambrano, Aniello / Zimbardo, Giuseppe / Arioti, Manfredi / Cerracchio, Emma / Vergallo, Rocco / Trani, Carlo / Crea, Filippo

    Journal of the American Heart Association

    2019  Volume 8, Issue 15, Page(s) e012772

    Abstract: Background Fractional flow reserve (FFR) and optical coherence tomography (OCT) may help both in assessment and in percutaneous coronary intervention optimization of angiographically intermediate coronary lesions. We designed a prospective trial ... ...

    Abstract Background Fractional flow reserve (FFR) and optical coherence tomography (OCT) may help both in assessment and in percutaneous coronary intervention optimization of angiographically intermediate coronary lesions. We designed a prospective trial comparing the clinical and economic outcomes associated with FFR or OCT in angiographically intermediate coronary lesions. Methods and Results Three hundred fifty patients with angiographically intermediate coronary lesions (n=446) were randomized to FFR or OCT guidance. In the FFR arm, percutaneous coronary intervention was performed if FFR was ≤0.80 aiming for a postprocedure FFR >0.90. In the OCT arm, percutaneous coronary intervention was performed if percentage of area stenosis was ≥75% or 50% to 75% with minimal lumen area <2.5 mm
    MeSH term(s) Aged ; Coronary Angiography ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/physiopathology ; Coronary Stenosis/surgery ; Female ; Fractional Flow Reserve, Myocardial ; Humans ; Male ; Middle Aged ; Percutaneous Coronary Intervention/methods ; Prospective Studies ; Severity of Illness Index ; Surgery, Computer-Assisted ; Time Factors ; Tomography, Optical Coherence ; Treatment Outcome
    Language English
    Publishing date 2019-07-23
    Publishing country England
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.119.012772
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  9. Article ; Online: Prognostic impact of FFR/contrast FFR discordance.

    Leone, Antonio Maria / Arioti, Manfredi / Cialdella, Pio / Vergallo, Rocco / Zimbardo, Giuseppe / Migliaro, Stefano / Anastasia, Gianluca / Di Giusto, Federico / Galante, Domenico / Basile, Eloisa / Pepe, Francesca Lassandro / Ierardi, Carolina / D'Amario, Domenico / Burzotta, Francesco / Aurigemma, Cristina / Niccoli, Giampaolo / Trani, Carlo / Crea, Filippo

    International journal of cardiology

    2020  Volume 327, Page(s) 40–44

    Abstract: Background: Contrast fractional flow reserve (cFFR) is a relatively new tool for the assessment of intermediate coronary artery stenosis and represents a reliable surrogate of FFR with the advantage of potentially simplifying functional evaluation. We ... ...

    Abstract Background: Contrast fractional flow reserve (cFFR) is a relatively new tool for the assessment of intermediate coronary artery stenosis and represents a reliable surrogate of FFR with the advantage of potentially simplifying functional evaluation. We aimed to compare the incidence of major adverse cardiac events (MACE) in patients undergoing functional evaluation with both FFR and cFFR based on the results of the two indexes.
    Method and result: We retrospectively analyzed outcomes in 488 patients who underwent functional evaluation with FFR and cFFR. Patients were divided into four groups using the cutoff values of 0.80 for FFR and 0.85 for cFFR: -/- (n = 298), +/+ (n = 134), -/+(n = 31) and +/- (n = 25). All patients were treated according to FFR value. MACE rate was assessed in each group, including death, myocardial infarction and urgent target vessel revascularization (TVR). Mean follow-up time was 22 ± 15 months. Incidence of MACE at follow-up was 8.3% in FFR-/cFFR-, 14.0% in FFR+/cFFR+, 16.0% in FFR-/cFFR+ and 8.0% in FFR+/cFFR- without a significant difference amongst the 4 groups (p = 0.2). Nevertheless, a significant difference in the rate of TVR comparing FFR-/cFFR- (n = 17) and FFR-/cFFR+ (n = 5) was found at 24 months (5.7% vs 16.0%; p = 0.027).
    Conclusion: cFFR is accurate in predicting FFR and consequently reliable in guiding coronary revascularization. In the rare case of discordance, while FFR+/cFFR- patients show a prognosis similar to FFR-/cFFR- patients, FFR-/cFFR+ patients show a prognosis similar to FFR+/cFFR+ patients.
    MeSH term(s) Coronary Angiography ; Coronary Artery Disease/diagnosis ; Coronary Stenosis/diagnosis ; Fractional Flow Reserve, Myocardial ; Humans ; Myocardial Infarction ; Prognosis ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2020-11-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2020.11.011
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  10. Article ; Online: Fractional flow reserve in acute coronary syndromes and in stable ischemic heart disease: clinical implications.

    Leone, Antonio Maria / Cialdella, Pio / Lassandro Pepe, Francesca / Basile, Eloisa / Zimbardo, Giuseppe / Arioti, Manfredi / Ciriello, Giovanna / D'Amario, Domenico / Buffon, Antonino / Burzotta, Francesco / Porto, Italo / Aurigemma, Cristina / Niccoli, Giampaolo / Rebuzzi, Antonio G / Trani, Carlo / Crea, Filippo

    International journal of cardiology

    2018  Volume 277, Page(s) 42–46

    Abstract: Background: Fractional Flow Reserve (FFR) in Stable Ischemic Heart Disease (SIHD) is universally accepted, while in Acute Coronary Syndromes (ACS) is less established. Aims of this retrospective study were: to compare in patients undergoing FFR ... ...

    Abstract Background: Fractional Flow Reserve (FFR) in Stable Ischemic Heart Disease (SIHD) is universally accepted, while in Acute Coronary Syndromes (ACS) is less established. Aims of this retrospective study were: to compare in patients undergoing FFR assessment the prognostic impact of ACS vs SIHD, to evaluate the clinical relevance of the modality of utilization and timing of FFR assessment and to assess the different outcomes associated with an FFR> or ≤0.80.
    Methods: Major cardiac adverse events were assessed at a follow up of 16.4 ± 10.5 months in 543 patients with SIHD and 231 with ACS needing functional evaluation. FFR was used for lesions of ambiguous significance in the absence of a clear culprit vessel (first intention, FI) and for incidental lesions in the presence of a clear culprit vessel (second intention, SI). The decision to perform FFR and the identification of the stenosis needing functional assessment were left to the operator's discretion. Revascularization was performed when FFR was ≤0.80.
    Results: SIHD and ACS patients were not significantly different for principal clinical characteristics. ACS patients had significantly more events than SIHD, due to an excess of death and myocardial infarction. This was confirmed when FFR was used as FI, in particular if FFR was >0.80. On the contrary, when FFR was used as SI, event rates were similar between ACS and SIHD patients, regardless of FFR value.
    Conclusions: Our study shows that using FFR the risk of recurrent events in ACS is significantly higher than in SIHD. This different outcome is confined to those patients in whom FFR is utilized for lesions of ambiguous significance in the absence of a clear culprit vessel.
    MeSH term(s) Acute Coronary Syndrome/diagnostic imaging ; Acute Coronary Syndrome/physiopathology ; Acute Coronary Syndrome/surgery ; Aged ; Female ; Follow-Up Studies ; Fractional Flow Reserve, Myocardial/physiology ; Humans ; Male ; Middle Aged ; Myocardial Revascularization/methods ; Myocardial Revascularization/trends ; Retrospective Studies
    Language English
    Publishing date 2018-08-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2018.08.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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