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  1. Article: [Association between functional and Helicobacter pylori-related dyspepsia].

    Arisawa, Tomiyasu

    Nihon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology

    2014  Volume 111, Issue 6, Page(s) 1088–1095

    MeSH term(s) Dyspepsia/etiology ; Dyspepsia/genetics ; Dyspepsia/physiopathology ; Helicobacter Infections/complications ; Helicobacter pylori ; Humans ; Polymorphism, Genetic
    Language Japanese
    Publishing date 2014-06-05
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
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  2. Article ; Online: Pembrolizumab-induced Eosinophilic Gastrointestinal Disorders.

    Nakamura, Masakatsu / Otsuka, Toshimi / Kumagai, Motona / Arisawa, Tomiyasu

    Internal medicine (Tokyo, Japan)

    2021  Volume 61, Issue 2, Page(s) 267–269

    MeSH term(s) Antibodies, Monoclonal, Humanized/adverse effects ; Carcinoma, Non-Small-Cell Lung ; Gastrointestinal Diseases ; Humans ; Lung Neoplasms
    Chemical Substances Antibodies, Monoclonal, Humanized ; pembrolizumab (DPT0O3T46P)
    Language English
    Publishing date 2021-07-10
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.7725-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: [Association between genetic variations and functional dyspepsia].

    Arisawa, Tomiyasu

    Nihon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology

    2012  Volume 109, Issue 10, Page(s) 1697–1702

    MeSH term(s) Dyspepsia/genetics ; Genetic Variation ; Humans ; MicroRNAs/genetics ; NAV1.8 Voltage-Gated Sodium Channel/genetics ; Polymorphism, Single Nucleotide ; TRPV Cation Channels/genetics
    Chemical Substances MIRN325 microRNA, human ; MicroRNAs ; NAV1.8 Voltage-Gated Sodium Channel ; SCN10A protein, human ; TRPV Cation Channels ; TRPV1 protein, human
    Language Japanese
    Publishing date 2012-10-09
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
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  4. Article ; Online: Preparation of Luciferase-fused Peptides for Immunoassay of Amyloid Beta.

    Sakono, Masafumi / Arisawa, Taiki / Ohya, Takuma / Sakono, Naomi / Manaka, Atsushi

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

    2021  Volume 37, Issue 5, Page(s) 759–763

    Abstract: An immunoassay, such as the enzyme-linked immunosorbent assay (ELISA), is an analytical method that utilizes the interaction of antigens and antibodies. Enzyme-labeled antigens require both molecular recognition by the antibody and enzymatic activity as ... ...

    Abstract An immunoassay, such as the enzyme-linked immunosorbent assay (ELISA), is an analytical method that utilizes the interaction of antigens and antibodies. Enzyme-labeled antigens require both molecular recognition by the antibody and enzymatic activity as a reporter. We designed and constructed an immunodetection system for amyloid beta peptides (Aβ) using an enzyme-labeled antigen expressed from Escherichia coli. Aβ(1-16) fused with renilla luciferase was prepared as the enzyme-labeled antigen. In the presence of this luciferase-fused peptide, the luminescence of coelenterazine-h was observed. The influence of the fusion with Aβ on the luminescence reaction was insignificant. Surface plasmon resonance analysis indicated that the interaction between the luciferase-fused Aβ and anti-Aβ antibody was sufficiently strong. In the competitive ELISA assay for Aβ detection using the luciferase-fused Aβ, the luminescence intensity decreased as the Aβ concentration increased.
    MeSH term(s) Amyloid ; Amyloid beta-Peptides ; Antibodies ; Enzyme-Linked Immunosorbent Assay ; Immunoassay ; Luciferases/genetics
    Chemical Substances Amyloid ; Amyloid beta-Peptides ; Antibodies ; Luciferases (EC 1.13.12.-)
    Language English
    Publishing date 2021-02-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1483376-1
    ISSN 1348-2246 ; 1348-2246
    ISSN (online) 1348-2246
    ISSN 1348-2246
    DOI 10.2116/analsci.20SCP19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Stent-assisted Coil Embolization to Treat Extracranial Carotid Artery Aneurysm 13 Years after Endarterectomy: A Case Report.

    Haruma, Jun / Hirotsune, Nobuyuki / Oka, Tetsuo / Arisawa, Tadashi

    NMC case report journal

    2019  Volume 7, Issue 1, Page(s) 23–27

    Abstract: Development of extracranial carotid artery aneurysm (ECCA) after carotid endarterectomy (CEA) is a rare complication, occurring in connection with <1% of all CEAs. The main causes are infection, suture failure, and degeneration of arterial wall or patch. ...

    Abstract Development of extracranial carotid artery aneurysm (ECCA) after carotid endarterectomy (CEA) is a rare complication, occurring in connection with <1% of all CEAs. The main causes are infection, suture failure, and degeneration of arterial wall or patch. The traditional treatment has been operative repair, which can present a significant technical challenge owing to reoperative neck inflammation and potential cranial nerve injuries. Here, we report a case of successful stent-assisted coil embolization for right noninfectious ECCA. A 63-year-old female was admitted to our hospital for a 3-cm pulsating mass in her right midneck. Doppler examination and digital subtraction angiography revealed a large (15 mm) ECCA at the right common carotid artery (CCA). Thirteen years earlier, eversion CEA with patch angioplasty and abbreviation of the internal carotid artery (ICA) had been performed for a symptomatic 80% diameter stenosis with transient ischemic attack at another hospital. As the patient refused blood transfusion for religious reasons, we treated her with stent-assisted coil embolization, which achieved nearly complete obliteration of the aneurysm while preserving the parent artery patency. Three months after initial treatment, ultrasound revealed complete occlusion of the ECCA, but also showed stent shortening. Hence, we performed an additional stent placement so as to overlap the previous stent by 2.5 cm. Six months after initial treatment, carotid duplex ultrasound confirmed a good outcome. This procedure is an excellent choice for high-risk patients, and a larger case series is needed to establish this technique as the treatment of choice for ECCAs.
    Language English
    Publishing date 2019-12-18
    Publishing country Japan
    Document type Case Reports
    ISSN 2188-4226
    ISSN 2188-4226
    DOI 10.2176/nmccrj.cr.2019-0030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Impact of hydrogen-rich gas mixture inhalation through nasal cannula during post-exercise recovery period on subsequent oxidative stress, muscle damage, and exercise performances in men.

    Shibayama, Yudai / Dobashi, Shohei / Arisawa, Takaaki / Fukuoka, Tamotsu / Koyama, Katsuhiro

    Medical gas research

    2020  Volume 10, Issue 4, Page(s) 155–162

    Abstract: Molecular hydrogen has been suggested to have a cytoprotective effect on the whole body and to enhance exercise performances. However, the effect of hydrogen-rich gas mixture (HG) inhalation on physiological responses has been poorly investigated. We ... ...

    Abstract Molecular hydrogen has been suggested to have a cytoprotective effect on the whole body and to enhance exercise performances. However, the effect of hydrogen-rich gas mixture (HG) inhalation on physiological responses has been poorly investigated. We examined the impact of acute HG inhalation on subsequent oxidative stress, muscle damage, and exercise performances during the recovery period after a strenuous exercise. This is a two-trial, double-blind, crossover, repeated measures study. Eight physically active male volunteers inhaled HG (estimated fraction of inspired oxygen and hydrogen were 21.57 and 4.08% at most, respectively) or normal gas (placebo, ambient air 400 m above sea level) during a 60-minute recovery phase after oxidative stress-inducing exercise) completion comprising 30-minute treadmill running at an intensity corresponding to 75% of maximal oxygen uptake and squat jumps (5 sets × 10 repetitions). Before oxidative stress-inducing exercise and 10 minutes after the post-exercise gas inhalation, blood and urine samples were obtained and exercise performances (jumping ability; pedaling power output; muscle strength) were evaluated. Post-exercise HG inhalation attenuated the increase in urinary 8-hydroxydeoxyguanosine excretion rate (P < 0.05), a DNA oxidation marker, and the reduction in the countermovement jump height (P < 0.05), compared with Placebo inhalation. Other exercise performances and blood oxidative stress and muscle damage markers did not differ between HG and Placebo inhalation. Moreover, the increase in urinary 8-hydroxydeoxyguanosine excretion rate was significantly associated with countermovement jump performance reduction (r = -0.78, P < 0.01). These findings suggested that HG inhalation during post-exercise recovery period might improve exercise performance via reducing systemic oxidative damage. The study was approved by the Human Research Ethics Committee of the University of Yamanashi (approval No. H29-006) on June 28, 2017.
    MeSH term(s) Adult ; Double-Blind Method ; Exercise/physiology ; Humans ; Hydrogen/administration & dosage ; Hydrogen/pharmacology ; Male ; Muscle Strength ; Muscles/drug effects ; Muscles/physiology ; Nose ; Oxidative Stress/drug effects
    Chemical Substances Hydrogen (7YNJ3PO35Z)
    Language English
    Publishing date 2020-12-30
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2616230-1
    ISSN 2045-9912 ; 2045-9912
    ISSN (online) 2045-9912
    ISSN 2045-9912
    DOI 10.4103/2045-9912.304222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Synthesis of New Thermoresponsive Polymers Possessing the Dense 1,2,3-Triazole Backbone.

    Okuno, Koji / Arisawa, Takuya / Kamon, Yuri / Hashidzume, Akihito / Winnik, Françoise M

    Langmuir : the ACS journal of surfaces and colloids

    2021  Volume 38, Issue 17, Page(s) 5156–5165

    Abstract: Thermoresponsive water-soluble polymers, aqueous solutions of which undergo lower critical solution temperature (LCST)-type phase separation, have been investigated in detail for several decades. To develop LCST-type thermoresponsive polymers with new ... ...

    Abstract Thermoresponsive water-soluble polymers, aqueous solutions of which undergo lower critical solution temperature (LCST)-type phase separation, have been investigated in detail for several decades. To develop LCST-type thermoresponsive polymers with new polymer backbone, 4-azido-5-hexynamide (AHA) derivatives were designed as monomers for copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) polymerization. AHA derivatives carrying secondary amide side chains, that is, 4-azido-
    Language English
    Publishing date 2021-11-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.1c02266
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  8. Article ; Online: [

    Arisawa, Tetsu / Miyazaki, Tomoyuki / Ota, Wataru / Sano, Akane / Suyama, Kumiko / Takada, Yuuki / Takahashi, Takuya

    Neuroscience research

    2021  Volume 173, Page(s) 106–113

    Abstract: The glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) is an important molecule in neurotransmission. We have recently developed the first positron emission tomography (PET) tracer [ ...

    Abstract The glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) is an important molecule in neurotransmission. We have recently developed the first positron emission tomography (PET) tracer [
    MeSH term(s) Blood-Brain Barrier/diagnostic imaging ; Brain/diagnostic imaging ; Brain/metabolism ; Positron-Emission Tomography ; Receptors, AMPA/metabolism ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
    Chemical Substances Receptors, AMPA ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (77521-29-0)
    Language English
    Publishing date 2021-05-24
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 605842-5
    ISSN 1872-8111 ; 0168-0102 ; 0921-8696
    ISSN (online) 1872-8111
    ISSN 0168-0102 ; 0921-8696
    DOI 10.1016/j.neures.2021.05.009
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  9. Article ; Online: Exosome Research and Co-culture Study.

    Shimasaki, Takeo / Yamamoto, Satoko / Arisawa, Tomiyasu

    Biological & pharmaceutical bulletin

    2018  Volume 41, Issue 9, Page(s) 1311–1321

    Abstract: In biological systems, extracellular vesicles including exosomes have recently been revealed to play a significant role in the communication between various cells, and the number of papers on this subject has dramatically increased. In current ... ...

    Abstract In biological systems, extracellular vesicles including exosomes have recently been revealed to play a significant role in the communication between various cells, and the number of papers on this subject has dramatically increased. In current conventional exosome studies, the standard research method is to use liquid biopsies to analyze extracts of various disease exosomes. However, exosomes are only one of many key players in natural cellular interactions. Reproducing the phenomena occurring in vivo and investigating the interactions are required in order to examine their role fully. For exosome research, an alternative to the liquid biopsy method for observing natural interactions is the co-culturing technique. It does not require an exosome extraction procedure, and while the technique has been used in many studies thus far, its application to exosome research has been limited. However, the use of co-culturing technologies is necessary to examine the essential interactions of exosomes. An overview of exosome research methodologies and co-culturing systems is thus provided here.
    MeSH term(s) Animals ; Biomedical Research ; Coculture Techniques ; Exosomes ; Humans
    Language English
    Publishing date 2018-08-31
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1150271-x
    ISSN 1347-5215 ; 0918-6158
    ISSN (online) 1347-5215
    ISSN 0918-6158
    DOI 10.1248/bpb.b18-00223
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  10. Article ; Online: Ultrastrong underwater adhesion on diverse substrates using non-canonical phenolic groups.

    Cheng, Bohan / Yu, Jinhong / Arisawa, Toma / Hayashi, Koki / Richardson, Joseph J / Shibuta, Yasushi / Ejima, Hirotaka

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 1892

    Abstract: Robust underwater adhesion is challenging because a hydration layer impedes the interaction between substrates and adhesives. Phenolic adhesives inspired by marine creatures such as mussels were extensively studied, but these adhesives have not reached ... ...

    Abstract Robust underwater adhesion is challenging because a hydration layer impedes the interaction between substrates and adhesives. Phenolic adhesives inspired by marine creatures such as mussels were extensively studied, but these adhesives have not reached the adhesion strength and substrate diversity of Man-made dry adhesives. Here, we report a class of ultrastrong underwater adhesives with molecular phenolic designs extending beyond what nature has produced. These non-canonical phenolic polymers show versatile adhesion on various materials, with adhesion strengths exceeding 10 MPa on metal. Incorporating even just a small amount (<10%) of non-canonical phenolic groups into a polymer is sufficient for dramatically enhancing underwater adhesion, suggesting that this new class of phenolic materials will be incorporated into various industrial polymer systems in the future.
    MeSH term(s) Adhesives/chemistry ; Animals ; Bivalvia ; Humans ; Physical Phenomena ; Polymers/chemistry
    Chemical Substances Adhesives ; Polymers
    Language English
    Publishing date 2022-04-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-29427-w
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