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  1. Article ; Online: Ethical considerations when preadolescents request elective or cosmetic dermatologic interventions.

    Beiter, Kaylin / Sable, Kimberly / Arkin, Lisa

    Journal of the American Academy of Dermatology

    2023  

    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Letter
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2023.05.083
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    Zs.A 1540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The Impact of Prenatal Nutrition on the Development of Atopic Dermatitis in Infancy and Childhood.

    Pawlitschek, Traci D / Arkin, Lisa M / Shields, Bridget E

    Cutis

    2022  Volume 109, Issue 3, Page(s) 152–156

    Abstract: Atopic dermatitis (AD) is an inflammatory skin condition characterized by skin barrier disruption and inflammation that has been associated with the development of food allergies, asthma, and allergic rhinitis, known as the atopic march. The prevalence ... ...

    Abstract Atopic dermatitis (AD) is an inflammatory skin condition characterized by skin barrier disruption and inflammation that has been associated with the development of food allergies, asthma, and allergic rhinitis, known as the atopic march. The prevalence of AD has been increasing globally, with a marked increase in developed countries. Although many studies have examined environmental factors contributing to the development of AD in infancy and childhood, less is understood about the influence of prenatal factors. Several studies have examined the role of maternal diet and nutrition on the development of AD in offspring; however, formal recommendations and robust trial data are lacking. Herein, we examine the existing literature surrounding maternal diet on the development of AD in infancy and childhood.
    MeSH term(s) Asthma ; Child ; Dermatitis, Atopic/complications ; Dermatitis, Atopic/etiology ; Diet/adverse effects ; Female ; Food Hypersensitivity/complications ; Humans ; Pregnancy ; Rhinitis, Allergic/complications ; Rhinitis, Allergic/epidemiology
    Language English
    Publishing date 2022-06-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391840-3
    ISSN 2326-6929 ; 0011-4162 ; 0151-9522
    ISSN (online) 2326-6929
    ISSN 0011-4162 ; 0151-9522
    DOI 10.12788/cutis.0479
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    Zs.B 1315: Show issues Location:
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    Zs.MG 44: Show issues

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  3. Article ; Online: Prevalence of food allergy diagnosis in pediatric patients with atopic dermatitis referred to allergy and/or dermatology subspecialty clinics.

    Li, Jennifer Chen / Arkin, Lisa M / Makhija, Melanie M / Singh, Anne Marie

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 9, Page(s) 2469–2471

    MeSH term(s) Child ; Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/epidemiology ; Dermatology ; Food Hypersensitivity/diagnosis ; Food Hypersensitivity/epidemiology ; Humans ; Prevalence
    Language English
    Publishing date 2022-06-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.05.028
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    Zs.A 7086: Show issues Location:
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  4. Article ; Online: SpatialView: an interactive web application for visualization of multiple samples in spatial transcriptomics experiments.

    Mohanty, Chitrasen / Prasad, Aman / Cheng, Lingxin / Arkin, Lisa M / Shields, Bridget E / Drolet, Beth / Kendziorski, Christina

    Bioinformatics (Oxford, England)

    2024  Volume 40, Issue 3

    Abstract: Motivation: Spatial transcriptomics (ST) experiments provide spatially localized measurements of genome-wide gene expression allowing for an unprecedented opportunity to investigate cellular heterogeneity and organization within a tissue. Statistical ... ...

    Abstract Motivation: Spatial transcriptomics (ST) experiments provide spatially localized measurements of genome-wide gene expression allowing for an unprecedented opportunity to investigate cellular heterogeneity and organization within a tissue. Statistical and computational frameworks exist that implement robust methods for pre-processing and analyzing data in ST experiments. However, the lack of an interactive suite of tools for visualizing ST data and results currently limits the full potential of ST experiments.
    Results: To fill the gap, we developed SpatialView, an open-source web browser-based interactive application for visualizing data and results from multiple 10× Genomics Visium ST experiments. We anticipate SpatialView will be useful to a broad array of clinical and basic science investigators utilizing ST to study disease.
    Availability and implementation: SpatialView is available at https://github.com/kendziorski-lab/SpatialView (and https://doi.org/10.5281/zenodo.10223907); a demo application is available at https://www.biostat.wisc.edu/˜kendzior/spatialviewdemo/.
    MeSH term(s) Software ; Genomics/methods ; Genome ; Web Browser ; Gene Expression Profiling/methods
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1422668-6
    ISSN 1367-4811 ; 1367-4803
    ISSN (online) 1367-4811
    ISSN 1367-4803
    DOI 10.1093/bioinformatics/btae117
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    Zs.A 2374: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Purple toes following critical COVID-19 infection.

    Ng, Ashley T / Miller, Allison / Bodemer, Apple A / Drolet, Beth A / Arkin, Lisa

    Pediatric dermatology

    2022  Volume 39, Issue 5, Page(s) 815–817

    MeSH term(s) COVID-19/complications ; Chilblains ; Humans ; Lower Extremity ; SARS-CoV-2 ; Toes
    Language English
    Publishing date 2022-10-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1111/pde.15075
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    Zs.A 1882: Show issues Location:
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  6. Article ; Online: Anifrolumab for Adolescent Discoid Lupus Erythematosus.

    Shaw, Katharina S / Rajeh, Ahmad / Le, Todd / Kahn, Philip J / Oza, Vikash S / Arkin, Lisa M / Vleugels, Ruth Ann

    JAMA network open

    2023  Volume 6, Issue 10, Page(s) e2338200

    MeSH term(s) Humans ; Adolescent ; Antibodies, Monoclonal, Humanized/therapeutic use ; Lupus Erythematosus, Discoid/drug therapy
    Chemical Substances anifrolumab (38RL9AE51Q) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Letter
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.38200
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  7. Article ; Online: Cutaneous manifestations of pediatric lupus.

    Arkin, Lisa M / Nguyen, Cordellia / Klein-Gitelman, Marisa

    Current opinion in rheumatology

    2019  Volume 31, Issue 5, Page(s) 411–420

    Abstract: Purpose of review: To review recent evidence on cutaneous manifestations of lupus, with a focus on evidence for pediatric patients.: Recent findings: Cutaneous manifestations of SLE are common and may precede signs or symptoms of systemic disease. ... ...

    Abstract Purpose of review: To review recent evidence on cutaneous manifestations of lupus, with a focus on evidence for pediatric patients.
    Recent findings: Cutaneous manifestations of SLE are common and may precede signs or symptoms of systemic disease. Early recognition and initiation of therapy improves quality of life by reducing cutaneous disease activity. Antimalarials are first line for moderate-to-severe disease. Photo protection is a critical component of therapy and perhaps the only modifiable risk factor for SLE. Recognition of cutaneous vasculopathy may reduce mortality from vascular occlusion.
    Summary: There is a critical need for better understanding of pathogenesis, risk factors and outcomes in cutaneous lupus to determine optimal treatment and surveillance strategies. Correlation of clinical phenotypes with biomarkers may help to stratify patients, optimize targeted interventions, and influence prognosis.
    MeSH term(s) Child ; Humans ; Lupus Erythematosus, Cutaneous/diagnosis ; Phenotype ; Prognosis ; Quality of Life ; Skin/pathology
    Language English
    Publishing date 2019-06-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000610
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    Zs.A 3028: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Efficacy and safety of apremilast in pediatric patients with moderate-to-severe plaque psoriasis: 16-week results from SPROUT, a randomized controlled trial.

    Fiorillo, Loretta / Becker, Emily / de Lucas, Raul / Belloni-Fortina, Anna / Armesto, Susana / Elewski, Boni / Maes, Peter / Oberoi, Rajneet K / Paris, Maria / Zhang, Wendy / Zhang, Zuoshun / Arkin, Lisa

    Journal of the American Academy of Dermatology

    2024  

    Abstract: Background: Approved systemic treatment options are limited for pediatric patients with moderate to severe plaque psoriasis.: Objective: To assess the efficacy and safety of apremilast over 16 weeks in pediatric patients with plaque psoriasis.: ... ...

    Abstract Background: Approved systemic treatment options are limited for pediatric patients with moderate to severe plaque psoriasis.
    Objective: To assess the efficacy and safety of apremilast over 16 weeks in pediatric patients with plaque psoriasis.
    Methods: SPROUT (NCT03701763) was a phase 3, multicenter, randomized, double-blind, placebo-controlled study of apremilast in patients aged 6-17 years with moderate-to-severe psoriasis (Psoriasis Area and Severity Index [PASI] ≥12, body surface area ≥10%, static Physician Global Assessment [sPGA] ≥3) inadequately controlled by/inappropriate for topical therapy. Patients were stratified by age group and randomized (2:1) to apremilast (20 or 30 mg BID based on weight) or placebo for 16 weeks, followed by apremilast extension to 52 weeks.
    Results: Of 245 patients randomized (apremilast: 163; placebo: 82), 221 (90%) completed the double-blind phase (apremilast: 149; placebo: 72). Significantly more patients achieved sPGA response and ≥75% reduction in PASI with apremilast than placebo, regardless of baseline age, weight, or disease severity. No new safety signals were observed.
    Limitations: Sample size of subgroup analyses.
    Conclusions: Improvements in global disease activity and skin involvement were significantly greater in pediatric patients treated with apremilast versus placebo. Adverse events were consistent with the known apremilast safety profile.
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2023.11.068
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    Zs.A 1540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Vulvar Crohn disease: Diagnostic challenges and approach to therapy.

    Shields, Bridget E / Richardson, Catherine / Arkin, Lisa / Kornik, Rachel

    International journal of women's dermatology

    2020  Volume 6, Issue 5, Page(s) 390–394

    Abstract: Crohn disease (CD) may be complicated by contiguous, metastatic, or associated inflammatory cutaneous lesions. Vulvar CD is a rare phenomenon characterized by granulomatous genital inflammation that occurs independently from fistulizing CD. Left ... ...

    Abstract Crohn disease (CD) may be complicated by contiguous, metastatic, or associated inflammatory cutaneous lesions. Vulvar CD is a rare phenomenon characterized by granulomatous genital inflammation that occurs independently from fistulizing CD. Left untreated, vulvar CD can result in debilitating lymphedema, disfiguring anatomic changes, secondary abscesses, cellulitis, and squamous cell carcinoma. We present a series of cases to highlight the clinical presentation of vulvar CD, the diagnostic testing required to distinguish complicating conditions, the asynchronous courses of skin and intestinal disease, and the complexities in the management of this disease and associated conditions. We review our multidisciplinary approach to care, aimed at reducing morbidity and improving patient quality of life.
    Language English
    Publishing date 2020-09-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2832233-2
    ISSN 2352-6475
    ISSN 2352-6475
    DOI 10.1016/j.ijwd.2020.09.007
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  10. Article ; Online: Outcomes and cost of medical and surgical treatments of pilonidal disease: A single institution's 10-year review.

    Janek, Kevin C / Kenfield, Meaghan / Arkin, Lisa M / Stalter, Lily / Tabaro, Giancarlo / Leys, Charles M / Le, Hau D

    Surgery open science

    2022  Volume 9, Page(s) 41–45

    Abstract: Background: Pilonidal disease is a chronic inflammatory skin disorder typically located in the gluteal cleft. Treatment varies from antibiotic therapy to extensive surgical resection and reconstruction; however, complications and recurrence are common. ... ...

    Abstract Background: Pilonidal disease is a chronic inflammatory skin disorder typically located in the gluteal cleft. Treatment varies from antibiotic therapy to extensive surgical resection and reconstruction; however, complications and recurrence are common. To understand risk factors, outcomes, and costs associated with various treatments, we performed a retrospective chart review of all patients treated for pilonidal disease at a single health care system from 2008 to 2018.
    Methods: Patients with an ICD diagnosis code associated with pilonidal disease were identified. Charts were reviewed for demographic, clinical, and cost information related to pilonidal disease encounters. Data were analyzed for risk of recurrence by Cox proportional hazards regression and economic burden by Wilcoxon signed-rank test.
    Results: During the study time frame, 513 patients were diagnosed with pilonidal disease. Primary treatment included 108 patients (21%) with wide excision, 167 (32%) with antibiotics alone, 79 (15%) with incision and drainage, and 109 (21%) with incision and drainage plus antibiotics. The rate of recurrence following antibiotic therapy, incision and drainage, or wide excision was 36.7%, 35.9%, and 21.3%, respectively. Sex, body mass index, obesity, or hidradenitis suppurativa was not associated with recurrence; however, smokers who underwent incision and drainage had a higher risk of recurrence (P < .0001). The median cost of each primary treatment was $3,093 for excision, $607 for incision and drainage, $281 antibiotics alone, and $686 for incision and drainage plus antibiotics.
    Conclusion: Pilonidal disease presents with a high degree of heterogeneity and is often managed primarily with antibiotics, incision and drainage, or surgical excision. Risk of recurrence was less in patients who underwent wide excision; however, these patients had higher overall cost compared to patients that had nonoperative management.
    Level of evidence: Level III.
    Language English
    Publishing date 2022-04-20
    Publishing country United States
    Document type Journal Article
    ISSN 2589-8450
    ISSN (online) 2589-8450
    DOI 10.1016/j.sopen.2022.03.009
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