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  1. Article ; Online: Intraoperative electromagnetic navigation bronchoscopy (IENB) to localize peripheral lung lesions: A new technique in the pediatric oncology population.

    Harris, Kassem / Schaefer, Edo / Rosenblum, Jeremy / Stewart, F Dylan / Arkovitz, Marc S

    Journal of pediatric surgery

    2021  Volume 57, Issue 9, Page(s) 179–182

    Abstract: Background: The utility, diagnostic yield and accuracy of lung biopsies in pediatric oncology patients are variable. Here we describe our preliminary results using intraoperative electromagnetic navigation bronchoscopy (IENB) for peripheral lung lesions ...

    Abstract Background: The utility, diagnostic yield and accuracy of lung biopsies in pediatric oncology patients are variable. Here we describe our preliminary results using intraoperative electromagnetic navigation bronchoscopy (IENB) for peripheral lung lesions to increase the surgical yield and accuracy in pediatric oncology patients.
    Methods: From May 2018 until October 2020 all surgical lung biopsies on pediatric oncology patients were performed using IENB technology. IENB and tattooing with methylene blue dye, Indocyanine green dye or both followed by Video-assisted Thoracoscopic Surgery (VATS) was performed in the same setting. Data were collected retrospectively. Data points included diagnosis, technical success, pathologic diagnosis and alteration in treatment management and complications.
    Results: A total of 10 biopsy procedures were performed on 8 patients during the study. The youngest patient was 7 years old. All had successful IENB with tattooing. All biopsies were diagnostic. No procedures were converted to open. There were no technical failures or procedure complications. One patient had a total of 11 biopsies, 6 from the right lung and 5 from the left, performed at 2 separate procedures. Another had 2 biopsies, one from the right lung and one from the left performed at the same operation. In 7 of the 8 patients treatment changes were made based on results of their biopsy.
    Conclusion: Here we present the first described experience of IENB and tattooing of peripheral lung lesions in the pediatric population. We have shown that IENB for peripheral lung lesion localization is a safe and effective technique in pediatric oncology.
    MeSH term(s) Bronchoscopy/methods ; Child ; Electromagnetic Phenomena ; Humans ; Lung/pathology ; Lung Neoplasms/diagnosis ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Retrospective Studies ; Solitary Pulmonary Nodule/surgery
    Language English
    Publishing date 2021-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2021.11.011
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  2. Article: Surgical Treatment of Neuroblastoma.

    Ben Barak, Ayelet / Golan, Hana / Waldman, Dalia / Arkovitz, Marc S

    The Israel Medical Association journal : IMAJ

    2017  Volume 19, Issue 11, Page(s) 691–695

    Abstract: Background: Neuroblastoma is the most common non-central nervous system (CNS) solid malignant tumor in children. The surgical treatment of high-risk neuroblastoma presents a challenge, and the benefits of aggressive surgical resection have been called ... ...

    Abstract Background: Neuroblastoma is the most common non-central nervous system (CNS) solid malignant tumor in children. The surgical treatment of high-risk neuroblastoma presents a challenge, and the benefits of aggressive surgical resection have been called into question.
    Objectives: To examine our experience with surgical resection of neuroblastoma.
    Methods: We report on a retrospective chart review of our preliminary surgical experience in 25 patients with neuroblastoma who underwent surgery performed by a single surgeon at two institutions over a 3 year period. Demographic data, including stage of tumor and risk stratification, were recorded. Primary outcome was total gross resection. Patients were followed for 3 years after surgery.
    Results: We found that 80% of the patients, including those with high-risk neuroblastoma tumors, had total gross resection of their tumor with minimal operative morbidity and no mortality; 88% had greater than 90% resection of their tumor. Overall, 3 year survival was 84% (21/25).
    Conclusions: Resection of neuroblastoma, even large, high-risk, bilateral tumors, was possible when performed by surgical teams with considerable experience.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Combined Modality Therapy/methods ; Combined Modality Therapy/statistics & numerical data ; Female ; Humans ; Infant ; Israel ; Male ; Neoplasm Staging ; Neuroblastoma/diagnosis ; Neuroblastoma/pathology ; Neuroblastoma/surgery ; Outcome and Process Assessment (Health Care) ; Peripheral Nervous System Neoplasms/diagnosis ; Peripheral Nervous System Neoplasms/pathology ; Peripheral Nervous System Neoplasms/surgery ; Postoperative Complications/classification ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Prognosis ; Reoperation/methods ; Reoperation/statistics & numerical data ; Risk Assessment ; Surgical Procedures, Operative/adverse effects ; Surgical Procedures, Operative/methods ; Surgical Wound ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2017-11-28
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
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  3. Article ; Online: Polyorchidism in a child with imperforate anus.

    Haley, Mary Jo / Arkovitz, Marc S

    Journal of pediatric surgery

    2008  Volume 43, Issue 8, Page(s) 1548–1550

    Abstract: Polyorchidism is a rare diagnosis. When recovered, it is frequently found in combination with other urologic pathologies. We report the case of a 14-month-old child with imperforate anus who was found to have polyorchia during repair of his inguinal ... ...

    Abstract Polyorchidism is a rare diagnosis. When recovered, it is frequently found in combination with other urologic pathologies. We report the case of a 14-month-old child with imperforate anus who was found to have polyorchia during repair of his inguinal hernia. Although cryptorchidism is not an uncommon finding in patients with imperforate anus, polyorchidism has never been reported. This is an unusual presentation of a rare entity.
    MeSH term(s) Abnormalities, Multiple/diagnosis ; Abnormalities, Multiple/surgery ; Anus, Imperforate/diagnosis ; Anus, Imperforate/surgery ; Cryptorchidism/diagnosis ; Cryptorchidism/surgery ; Follow-Up Studies ; Hernia, Inguinal/diagnosis ; Hernia, Inguinal/surgery ; Humans ; Incidental Findings ; Infant ; Male ; Rare Diseases ; Risk Assessment ; Testis/abnormalities ; Treatment Outcome ; Urogenital Surgical Procedures
    Language English
    Publishing date 2008-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2008.03.032
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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article: Perforated appendicitis presenting as appendicoumbilical fistula.

    Killelea, Brigid K / Arkovitz, Marc S

    Pediatric surgery international

    2006  Volume 22, Issue 3, Page(s) 286–288

    Abstract: Perforated appendicitis is one of the most common diagnoses treated by pediatric surgeons. Although rare, a perforated appendix can present with a cutaneous fistula. Here we present the second reported case of perforated appendicitis presenting as an ... ...

    Abstract Perforated appendicitis is one of the most common diagnoses treated by pediatric surgeons. Although rare, a perforated appendix can present with a cutaneous fistula. Here we present the second reported case of perforated appendicitis presenting as an appendicoumbilical fistula.
    MeSH term(s) Adult ; Appendectomy ; Appendicitis/complications ; Appendicitis/diagnosis ; Appendicitis/surgery ; Appendix ; Colectomy ; Diagnosis, Differential ; Follow-Up Studies ; Humans ; Intestinal Fistula/diagnosis ; Intestinal Fistula/etiology ; Intestinal Fistula/surgery ; Male ; Tomography, X-Ray Computed ; Umbilicus
    Language English
    Publishing date 2006-03
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 632773-4
    ISSN 0179-0358
    ISSN 0179-0358
    DOI 10.1007/s00383-005-1561-z
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    Zs.A 2138: Show issues Location:
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  5. Article ; Online: Timing and expression of the angiopoietin-1-Tie-2 pathway in murine lung development and congenital diaphragmatic hernia.

    Grzenda, Adrienne / Shannon, John / Fisher, Jason / Arkovitz, Marc S

    Disease models & mechanisms

    2012  Volume 6, Issue 1, Page(s) 106–114

    Abstract: Congenital diaphragmatic hernia (CDH) is one of the most common congenital abnormalities. Children born with CDH suffer a number of co-morbidities, the most serious of which is respiratory insufficiency from a combination of alveolar hypoplasia and ... ...

    Abstract Congenital diaphragmatic hernia (CDH) is one of the most common congenital abnormalities. Children born with CDH suffer a number of co-morbidities, the most serious of which is respiratory insufficiency from a combination of alveolar hypoplasia and pulmonary vascular hypertension. All children born with CDH display some degree of pulmonary hypertension, the severity of which has been correlated with mortality. The molecular mechanisms responsible for the development of pulmonary hypertension in CDH remain poorly understood. Angiopoitein-1 (Ang-1), a central mediator in angiogenesis, participates in the vascular development of many tissues, including the lung. Although previous studies have demonstrated that Ang-1 might play an important role in the development of familial pulmonary hypertension, the role of Ang-1 in the development of the pulmonary hypertension associated with CDH is poorly understood. The aim of this study was to examine the role of the Ang-1 pathway in a murine model of CDH. Here, we report that Ang-1 appears important in normal murine lung development, and have established its tissue-level expression and localization patterns at key time-points. Additionally, our data from a nitrofen and bisdiamine-induced murine model of CDH suggests that altered expression patterns of Ang-1, its receptor Tie-2 and one of its transcription factors (epithelium-specific Ets transcription factor 1) might be responsible for development of the pulmonary vasculopathy seen in the setting of CDH.
    MeSH term(s) Angiopoietin-1/genetics ; Angiopoietin-1/metabolism ; Animals ; Disease Models, Animal ; Gene Expression Regulation, Developmental ; Hernia, Diaphragmatic/embryology ; Hernia, Diaphragmatic/genetics ; Hernia, Diaphragmatic/metabolism ; Hernias, Diaphragmatic, Congenital ; Humans ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/genetics ; Hypertension, Pulmonary/metabolism ; Immunohistochemistry ; Lung/blood supply ; Lung/embryology ; Lung/metabolism ; Mice ; Neovascularization, Physiologic/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptor Protein-Tyrosine Kinases/genetics ; Receptor Protein-Tyrosine Kinases/metabolism ; Receptor, TIE-2 ; Teratogens/toxicity
    Chemical Substances Angiopoietin-1 ; Angpt1 protein, mouse ; RNA, Messenger ; Teratogens ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Receptor, TIE-2 (EC 2.7.10.1) ; Tek protein, mouse (EC 2.7.10.1)
    Language English
    Publishing date 2012-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.008821
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  6. Article ; Online: Images in clinical medicine. Trichobezoar in a four-year-old girl.

    Lanoue, John L / Arkovitz, Marc S

    The New England journal of medicine

    2003  Volume 348, Issue 13, Page(s) 1242

    MeSH term(s) Bezoars/diagnostic imaging ; Bezoars/pathology ; Child, Preschool ; Female ; Humans ; Intestine, Small/diagnostic imaging ; Radiography ; Stomach/diagnostic imaging ; Stomach/pathology
    Language English
    Publishing date 2003-03-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMicm020348
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    Ua VI Zs.34: Show issues Location:
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  7. Article ; Online: A successful neonatal repair of congenital aortic aneurysm with cleft sternum.

    Hirata, Yasutaka / Arkovitz, Marc S / Marboe, Charles C / Mosca, Ralph S

    The Journal of thoracic and cardiovascular surgery

    2009  Volume 137, Issue 3, Page(s) 769–771

    MeSH term(s) Aortic Aneurysm, Thoracic/congenital ; Aortic Aneurysm, Thoracic/surgery ; Female ; Humans ; Infant, Newborn ; Remission Induction ; Sternum/abnormalities ; Sternum/surgery ; Thoracic Surgical Procedures/methods
    Language English
    Publishing date 2009-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2008.06.037
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  8. Article ; Online: Lung development is not necessary for diaphragm development in mice.

    Arkovitz, Marc S / Hyatt, Brian A / Shannon, John M

    Journal of pediatric surgery

    2005  Volume 40, Issue 9, Page(s) 1390–1394

    Abstract: Background/purpose: Congenital diaphragmatic hernia affects approximately 1 in every 2000 live births. The etiology of these diaphragmatic defects is unknown. Using mice with a targeted deletion of fibroblast growth factor 10 (FGF10), which display a ... ...

    Abstract Background/purpose: Congenital diaphragmatic hernia affects approximately 1 in every 2000 live births. The etiology of these diaphragmatic defects is unknown. Using mice with a targeted deletion of fibroblast growth factor 10 (FGF10), which display a complete lack of lung tissue, we have examined the relationship between lung hypoplasia and diaphragmatic development.
    Methods: The diaphragms of FGF10 null mice were examined at 2 embryonic time-points and compared with their heterozygous and wild-type littermates.
    Results: FGF10 null mice had phenotypically normal diaphragms when compared with wild-type littermates at both time-points studied.
    Conclusion: Normal diaphragm development appears to occur independent of lung development in mice.
    MeSH term(s) Animals ; Diaphragm/embryology ; Fibroblast Growth Factor 10/genetics ; Hernia, Diaphragmatic/physiopathology ; Immunohistochemistry ; Lung/embryology ; Lung/pathology ; Mice ; Phenotype
    Chemical Substances Fgf10 protein, mouse ; Fibroblast Growth Factor 10
    Language English
    Publishing date 2005-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2005.05.059
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    Zs.A 607: Show issues Location:
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  9. Article ; Online: Hereditary multiple exostoses of the ribs: an unusual cause of hemothorax and pericardial effusion.

    Cowles, Robert A / Rowe, Dorothy H / Arkovitz, Marc S

    Journal of pediatric surgery

    2005  Volume 40, Issue 7, Page(s) 1197–1200

    Abstract: A 6-year-old girl with hereditary multiple exostoses presented with spontaneous hemothorax and pericardial effusion. Chest computed tomographic scan showed left-sided costal exostoses protruding into the left side of the chest. She underwent successful ... ...

    Abstract A 6-year-old girl with hereditary multiple exostoses presented with spontaneous hemothorax and pericardial effusion. Chest computed tomographic scan showed left-sided costal exostoses protruding into the left side of the chest. She underwent successful thoracoscopic resection of 3 left rib exostoses and made a full recovery. This report illustrates this rare clinical scenario and reviews the previously published reports of this complication of costal exostoses.
    MeSH term(s) Child ; Exostoses, Multiple Hereditary/complications ; Exostoses, Multiple Hereditary/surgery ; Female ; Hemothorax/etiology ; Humans ; Pericardial Effusion/etiology ; Ribs/pathology ; Ribs/surgery ; Treatment Outcome
    Language English
    Publishing date 2005-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2005.03.064
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    Zs.A 607: Show issues Location:
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  10. Article ; Online: Multivariate model for predicting recurrence in congenital diaphragmatic hernia.

    Fisher, Jason C / Haley, Mary Jo / Ruiz-Elizalde, Alejandro / Stolar, Charles J H / Arkovitz, Marc S

    Journal of pediatric surgery

    2009  Volume 44, Issue 6, Page(s) 1173–9; discussion 1179–80

    Abstract: Purpose: Risk factors that predispose children with congenital diaphragmatic hernia (CDH) to recurrence remain poorly defined. We report a large series of recurrent CDH and ask whether prenatal patient factors or postnatal treatment variables better ... ...

    Abstract Purpose: Risk factors that predispose children with congenital diaphragmatic hernia (CDH) to recurrence remain poorly defined. We report a large series of recurrent CDH and ask whether prenatal patient factors or postnatal treatment variables better predict recurrence.
    Methods: Two hundred thirty-eight neonates with unilateral CDH underwent repair from 1990 to 2006. Data were assessed by chi(2) and Mann-Whitney U tests. Multivariate regression identified independent predictors of recurrence. Statistical significance was set at P < .05.
    Results: We identified 24 recurrences (10%). Median time from repair to recurrence diagnosis was 4.9 months. Patients with recurrence were older (P = .02) and more often required abdominal wall patches at initial repair (P = .01) compared to nonrecurrence patients. Postoperative length of stay (LOS) after initial repair (P < .01) and morbidity (P = .01) were greater in recurrence patients. Use of diaphragm patch at initial repair was greater in patients with recurrence but only approached statistical significance (P = .05). Only 2 variables independently predicted recurrence by multivariate regression as follows: abdominal (not diaphragm) wall patch during initial repair (odds ratio [OR] 3.50; P = .04) and postoperative LOS (OR, 1.012; P = .01).
    Conclusion: Neonates at risk for CDH recurrence are better identified by postnatal treatment variables than by prenatal patient factors. Although age at repair and diaphragm patch use are greater in recurrence patients, the only factors to independently predict recurrence were postoperative LOS and abdominal wall patch use. These data can help optimize follow-up regimens.
    MeSH term(s) Forecasting ; Hernia, Diaphragmatic/surgery ; Hernias, Diaphragmatic, Congenital ; Humans ; Infant, Newborn ; Multivariate Analysis ; Recurrence
    Language English
    Publishing date 2009-06-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2009.02.043
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