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  1. AU="Armando Vilchis-Ordoñez"
  2. AU="Zhongfu Lu"
  3. AU="Lo, Hong-Yip"
  4. AU="Ziman Xiong"
  5. AU="Oakes, Allison H"
  6. AU="Ma, Shaotong"
  7. AU="Zang, Lili"
  8. AU="Adams Brian D"
  9. AU="Maria Papaioannou"
  10. AU="Kollia, Georgia"
  11. AU="Auxiette, Catherine"
  12. AU="Guzmán, Luis"
  13. AU="Alipour, Elnaz"
  14. AU="Queiroz, Dayanna Joyce Marques"
  15. AU="Ramamurthy, Santosh"
  16. AU="Xueying Huang"
  17. AU="Cromwell, Howard C"
  18. AU="Spence, John C H"
  19. AU="Chapinal, Libertad"
  20. AU=Rohaim Mohammed A AU=Rohaim Mohammed A
  21. AU=Hempel Cornelius

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  1. Artikel ; Online: Analytical recommendations for SARS-CoV-2 identification by RT-PCR in pediatric patients

    Israel Parra-Ortega / Armando Vilchis-Ordoñez / Briceida López-Martínez / Tania Ángeles-Floriano

    Boletín Médico del Hospital Infantil de México, Vol 78, Iss

    2021  Band 3

    Abstract: Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome 2 coronavirus (SARS-CoV-2) and is currently listed as a global public health emergency. Timely identification and protocol implementations for molecular detection of ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome 2 coronavirus (SARS-CoV-2) and is currently listed as a global public health emergency. Timely identification and protocol implementations for molecular detection of this virus are vital for medical decision-making. Identification of SARS-CoV-2 infection cases is based on detection of the virus RNA by molecular tests, particularly real-time reverse transcription-polymerase chain reaction (RT-PCR). Technical and operational details specific to each center must be considered to perform the molecular diagnosis of SARS-CoV-2 in pediatric patients. The term “qualified laboratories” involves laboratories in which all users, analysts, and anyone reporting results are trained to develop and interpret results through a procedure implemented previously by an instructor. Such knowledge is essential in detecting and identifying errors during each of its phases: pre-analytical, analytical, and post-analytical, which allow the establishment of continuous improvement policies to ensure the quality of the results, but above all, the physical integrity of health workers.
    Schlagwörter COVID-19. SARS-CoV-2. RT-PCR ; Pediatrics ; RJ1-570 ; Public aspects of medicine ; RA1-1270
    Sprache Englisch
    Erscheinungsdatum 2021-07-01T00:00:00Z
    Verlag Permanyer
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Cell surface expression of GRP78 and CXCR4 is associated with childhood high-risk acute lymphoblastic leukemia at diagnostics

    Tania Angeles-Floriano / Guadalupe Rivera-Torruco / Paulina García-Maldonado / Esmeralda Juárez / Yolanda Gonzalez / Israel Parra-Ortega / Armando Vilchis-Ordoñez / Briceida Lopez-Martinez / Lourdes Arriaga-Pizano / Dario Orozco-Ruíz / José Refugio Torres-Nava / Paula Licona-Limón / Francisco López-Sosa / Alhelí Bremer / Lourdes Alvarez-Arellano / Ricardo Valle-Rios

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Band 11

    Abstract: Abstract Acute lymphocytic leukemia is the most common type of cancer in pediatric individuals. Glucose regulated protein (GRP78) is an endoplasmic reticulum chaperone that facilitates the folding and assembly of proteins and regulates the unfolded ... ...

    Abstract Abstract Acute lymphocytic leukemia is the most common type of cancer in pediatric individuals. Glucose regulated protein (GRP78) is an endoplasmic reticulum chaperone that facilitates the folding and assembly of proteins and regulates the unfolded protein response pathway. GRP78 has a role in survival of cancer and metastasis and cell-surface associated GRP78 (sGRP78) is expressed on cancer cells but not in normal cells. Here, we explored the presence of sGRP78 in pediatric B-ALL at diagnosis and investigated the correlation with bona fide markers of leukemia. By using a combination of flow cytometry and high multidimensional analysis, we found a distinctive cluster containing high levels of sGRP78, CD10, CD19, and CXCR4 in bone marrow samples obtained from High-risk leukemia patients, which was absent in the compartment of Standard-risk leukemia. We confirmed that sGRP78+CXCR4+ blood-derived cells were more frequent in High-risk leukemia patients. Finally, we analyzed the dissemination capacity of sGRP78 leukemia cells in a model of xenotransplantation. sGRP78+ cells emigrated to the bone marrow and lymph nodes, maintaining the expression of CXCR4. Testing the presence of sGRP78 and CXCR4 together with conventional markers may help to achieve a better categorization of High and Standard-risk pediatric leukemia at diagnosis.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Bone Marrow Cells in Acute Lymphoblastic Leukemia Create a Proinflammatory Microenvironment Influencing Normal Hematopoietic Differentiation Fates

    Armando Vilchis-Ordoñez / Adriana Contreras-Quiroz / Eduardo Vadillo / Elisa Dorantes-Acosta / Alfonso Reyes-López / Henry Martin Quintela-Nuñez del Prado / Jorge Venegas-Vázquez / Hector Mayani / Vianney Ortiz-Navarrete / Briceida López-Martínez / Rosana Pelayo

    BioMed Research International, Vol

    2015  Band 2015

    Abstract: B-cell acute lymphoblastic leukemia (B-ALL) is a serious public health problem in the pediatric population worldwide, contributing to 85% of deaths from childhood cancers. Understanding the biology of the disease is crucial for its clinical management ... ...

    Abstract B-cell acute lymphoblastic leukemia (B-ALL) is a serious public health problem in the pediatric population worldwide, contributing to 85% of deaths from childhood cancers. Understanding the biology of the disease is crucial for its clinical management and the development of therapeutic strategies. In line with that observed in other malignancies, chronic inflammation may contribute to a tumor microenvironment resulting in the damage of normal processes, concomitant to development and maintenance of neoplastic cells. We report here that hematopoietic cells from bone marrow B-ALL have the ability to produce proinflammatory and growth factors, including TNFα, IL-1β, IL-12, and GM-CSF that stimulate proliferation and differentiation of normal stem and progenitor cells. Our findings suggest an apparently distinct CD13+CD33+ population of leukemic cells contributing to a proinflammatory microenvironment that may be detrimental to long-term normal hematopoiesis within B-ALL bone marrow.
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2015-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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