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Article ; Online: Ein nicht alltäglicher Herdbefund in der Brustdiagnostik.

Ruiu, A / Stuppner, S / Mone, A / Armatura, G / Marinello, P / Lüthy, M / Neri, S / Vismara, G / Zago, M / Ferro, F

Radiologie (Heidelberg, Germany)

2022 Volume 62, Issue 8, Page(s) 675–678

Title translation	An unusual focal finding in breast diagnostics.
MeSH term(s)	Breast/diagnostic imaging
Language	German
Publishing date	2022-05-25
Publishing country	Germany
Document type	Journal Article
ISSN	2731-7056
ISSN (online)	2731-7056
DOI	10.1007/s00117-022-01013-7
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Article ; Online: Seltene Raumforderung der Brust.

Ruiu, A / Stuppner, S / Bertelli, G / Armatura, G / Luethy, M / Damiani, D / Cagini, A / Steinkasserer, M / Lusso, M R / Ferro, F

Der Radiologe

2021 Volume 61, Issue 11, Page(s) 1020–1023

Title translation	Rare mass in the breast.
MeSH term(s)	Breast/diagnostic imaging ; Breast Neoplasms/diagnostic imaging ; Female ; Humans
Language	German
Publishing date	2021-07-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	505520-9
ISSN	1432-2102 ; 0033-832X
ISSN (online)	1432-2102
ISSN	0033-832X
DOI	10.1007/s00117-021-00888-2
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Ue I Zs.274: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: The role of splenectomy in myelofibrosis with myeloid metaplasia.

Barugola, G / Cavallini, A / Lipari, G / Armatura, G / Mantovani, W / Baggio, E

Minerva chirurgica

2010 Volume 65, Issue 6, Page(s) 619–625

Abstract: Aim: In this paper we retrospectively analyzed prospectively-collected data on our myelofibrosis with myeloid metaplasia (MMM) patients who underwent splenectomy. The aim was to ascertain the hematological response and any resolution of symptoms ... ...

Abstract	Aim: In this paper we retrospectively analyzed prospectively-collected data on our myelofibrosis with myeloid metaplasia (MMM) patients who underwent splenectomy. The aim was to ascertain the hematological response and any resolution of symptoms existing prior to splenectomy; redefining timing and role of splenectomy in the treatment of MMM. Methods: This prospective study considered 31 patients with MMM who underwent splenectomy for transfusion-dependent anemia, thrombocytopenia, abdominal swelling and pain. Postoperative work-up consisting in laboratory tests and clinical evaluation performing a quality of life (QoL) test based on EORTC QLQ-C30 questionnaire. Follow-up data were collected for one year after surgery. Statistical analysis used Student's t-test, the Mann-Whitney rank sum, Fisher's exact test, the Friedman test and the Wilcoxon test. Results: Mortality was 3.2%. Respiratory symptomatic complications occurred in 35.4%. In all patients the need for blood transfusions was significantly reduced (P=0.005). An improvement in the painful symptoms was reported and a significant improve of postoperative quality of life was observed at one year after surgery. Conclusion: In our experience splenectomy is associated with limited perioperative mortality and morbidity. Acute complications are almost exclusively limited to respiratory tract. The removal of spleen seems can be recommended to increase the QoL and to palliate hematological disorders in patients no more responder to chemotherapy.
MeSH term(s)	Humans ; Middle Aged ; Primary Myelofibrosis/complications ; Primary Myelofibrosis/surgery ; Prospective Studies ; Retrospective Studies ; Splenectomy
Language	English
Publishing date	2010-12
Publishing country	Italy
Document type	Journal Article
ZDB-ID	123603-9
ISSN	1827-1626 ; 0026-4733
ISSN (online)	1827-1626
ISSN	0026-4733
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Zs.A 25: Show issues

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Article: Low neutrophil-to-lymphocyte ratio and pan-immune-inflammation-value predict nodal pathologic complete response in 1274 breast cancer patients treated with neoadjuvant chemotherapy: a multicenter analysis.

Gasparri, Maria Luisa / Albasini, Sara / Truffi, Marta / Favilla, Karin / Tagliaferri, Barbara / Piccotti, Francesca / Bossi, Daniela / Armatura, Giulia / Calcinotto, Arianna / Chiappa, Corrado / Combi, Francesca / Curcio, Annalisa / Della Valle, Angelica / Ferrari, Guglielmo / Folli, Secondo / Ghilli, Matteo / Listorti, Chiara / Mancini, Stefano / Marinello, Peter /

Mele, Simone / Pertusati, Anna / Roncella, Manuela / Rossi, Lorenzo / Rovera, Francesca / Segattini, Silvia / Sgarella, Adele / Tognali, Daniela / Corsi, Fabio

Therapeutic advances in medical oncology

2023 Volume 15, Page(s) 17588359231193732

Abstract: Background: Systemic inflammatory markers draw great interest as potential blood-based prognostic factors in several oncological settings.: Objectives: The aim of this study is to evaluate whether neutrophil-to-lymphocyte ratio (NLR) and pan-immune- ... ...

Abstract	Background: Systemic inflammatory markers draw great interest as potential blood-based prognostic factors in several oncological settings. Objectives: The aim of this study is to evaluate whether neutrophil-to-lymphocyte ratio (NLR) and pan-immune-inflammation value (PIV) predict nodal pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) in node-positive (cN+) breast cancer (BC) patients. Design: Clinically, cN+ BC patients undergoing NAC followed by breast and axillary surgery were enrolled in a multicentric study from 11 Breast Units. Methods: Pretreatment blood counts were collected for the analysis and used to calculate NLR and PIV. Logistic regression analyses were performed to evaluate independent predictors of nodal pCR. Results: A total of 1274 cN+ BC patients were included. Nodal pCR was achieved in 586 (46%) patients. At multivariate analysis, low NLR [odds ratio (OR) = 0.71; 95% CI, 0.51-0.98; Conclusion: This study found that low NLR and PIV levels predict axillary pCR in patients with BC undergoing NAC. Registration: Eudract number NCT05798806.
Language	English
Publishing date	2023-09-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2503443-1
ISSN	1758-8359 ; 1758-8340
ISSN (online)	1758-8359
ISSN	1758-8340
DOI	10.1177/17588359231193732
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Article ; Online: Development of a novel nomogram-based online tool to predict axillary status after neoadjuvant chemotherapy in cN+ breast cancer: A multicentre study on 1,950 patients.

Corsi, Fabio / Albasini, Sara / Sorrentino, Luca / Armatura, Giulia / Carolla, Claudia / Chiappa, Corrado / Combi, Francesca / Curcio, Annalisa / Della Valle, Angelica / Ferrari, Guglielmo / Gasparri, Maria Luisa / Gentilini, Oreste / Ghilli, Matteo / Listorti, Chiara / Mancini, Stefano / Marinello, Peter / Meani, Francesco / Mele, Simone / Pertusati, Anna /

Roncella, Manuela / Rovera, Francesca / Sgarella, Adele / Tazzioli, Giovanni / Tognali, Daniela / Folli, Secondo

Breast (Edinburgh, Scotland)

2021 Volume 60, Page(s) 131–137

Abstract: Background: Type of axillary surgery in breast cancer (BC) patients who convert from cN + to ycN0 after neoadjuvant chemotherapy (NAC) is still debated. The aim of the present study was to develop and validate a preoperative predictive nomogram to ... ...

Abstract	Background: Type of axillary surgery in breast cancer (BC) patients who convert from cN + to ycN0 after neoadjuvant chemotherapy (NAC) is still debated. The aim of the present study was to develop and validate a preoperative predictive nomogram to select those patients with a low risk of residual axillary disease after NAC, in whom axillary surgery could be minimized. Patients and methods: 1950 clinically node-positive BC patients from 11 Breast Units, treated by NAC and subsequent surgery, were included from 2005 to 2020. Patients were divided in two groups: those who achieved nodal pCR vs. those with residual nodal disease after NAC. The cohort was divided into training and validation set with a geographic separation criterion. The outcome was to identify independent predictors of axillary pathologic complete response (pCR). Results: Independent predictive factors associated to nodal pCR were axillary clinical complete response (cCR) after NAC (OR 3.11, p < 0.0001), ER-/HER2+ (OR 3.26, p < 0.0001) or ER+/HER2+ (OR 2.26, p = 0.0002) or ER-/HER2- (OR 1.89, p = 0.009) BC, breast cCR (OR 2.48, p < 0.0001), Ki67 > 14% (OR 0.52, p = 0.0005), and tumor grading G2 (OR 0.35, p = 0.002) or G3 (OR 0.29, p = 0.0003). The nomogram showed a sensitivity of 71% and a specificity of 73% (AUC 0.77, 95%CI 0.75-0.80). After external validation the accuracy of the nomogram was confirmed. Conclusion: The accuracy makes this freely-available, nomogram-based online tool useful to predict nodal pCR after NAC, translating the concept of tailored axillary surgery also in this setting of patients.
MeSH term(s)	Axilla ; Breast Neoplasms/drug therapy ; Breast Neoplasms/surgery ; Chemotherapy, Adjuvant ; Female ; Humans ; Lymph Nodes ; Mastectomy ; Neoadjuvant Therapy ; Nomograms ; Sentinel Lymph Node Biopsy
Language	English
Publishing date	2021-10-02
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study
ZDB-ID	1143210-x
ISSN	1532-3080 ; 0960-9776
ISSN (online)	1532-3080
ISSN	0960-9776
DOI	10.1016/j.breast.2021.09.013
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Zs.A 3620: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 588: Show issues

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Article: Traitement des anévrismes du tronc coeliaque: expérience personnelle et revue de la littérature.

Lipari, G / Migliara, B / Cavallini, A / Barugola, G / Armatura, G / Partelli, S / Baggio, E

Journal des maladies vasculaires

2006 Volume 31, Issue 2, Page(s) 72–75

Abstract: Introduction: Celiac trunk aneurysms represent 4% of all splanchnic artery aneurysms. These lesions are thus extremely rare but yet have a significant clinical importance. Mortality, mainly related to site characteristics, is a significant risk (14%) in ...

Title translation	Treatment of celiac trunk aneurysms: personal experience and review of the literature.
Abstract	Introduction: Celiac trunk aneurysms represent 4% of all splanchnic artery aneurysms. These lesions are thus extremely rare but yet have a significant clinical importance. Mortality, mainly related to site characteristics, is a significant risk (14%) in the event of rupture. Patients and methods: We put forward our experience in both diagnosis and treatment in three patients, two women and one man (average age 55.3 years, range 35-74), presenting aneurysms involving the celiac trunk. The preoperative diagnosis was established successively with ultrasonography, CT scan and angiography. Two patients were treated via an open surgical approach while endovascular percutaneous treatment was performed for the third patient. Results: Mortality was null at 13 days on average from admission for the surgical patients and 4 days for the patient treated endovascularly. Postoperative complications were modest: pulmonary thickening with pleural effusion for the two surgical patients (spontaneous resolution), while for the third patient treated with an endovascular method, the stent migrated to a splanchnic arterial branch, with no consequence for the spleen. The average follow-up was 19 months (range 14-24). Full exclusion of the aneurysm was maintained at four months for the aneurysm treated percutaneously. A patent celiac was also maintained for the patients treated surgically. Conclusions: Considering the largely unforeseeable outcome and the high risk of rupture, we suggest that all the patients presenting this type of aneurysmal lesion should be treated. This attitude is widely advocated in the literature. Moreover, we noted null mortality in our small series, with only one percutaneous "re-do" case; resolutive at last control. With the present improvement in stent technology, endovascular treatment should be preferred. Patients should be treated surgically only if a percutaneous procedure would be risky or technically unfeasible due to the size of the aneurysm or its anatomic features.
MeSH term(s)	Adult ; Aged ; Aneurysm/diagnosis ; Aneurysm/mortality ; Aneurysm/surgery ; Angiography ; Celiac Artery ; Embolization, Therapeutic ; Female ; Humans ; Male ; Middle Aged ; Splanchnic Circulation
Language	French
Publishing date	2006-05-23
Publishing country	France
Document type	Case Reports ; English Abstract ; Journal Article ; Review
ZDB-ID	752965-x
ISSN	0398-0499
ISSN	0398-0499
DOI	10.1016/s0398-0499(06)76521-0
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Zs.A 1351: Show issues

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Article: Anévrismes de l'artère carotide interne extra-crânienne: à propos de 2 cas.

Lipari, G / Riva, F / Muselli, P / Armatura, G / Lino, M / Shamale, A / Baggio, E

Journal des maladies vasculaires

2001 Volume 31, Issue 3, Page(s) 152–158

Abstract: Introduction: Aneurysms of the extracranial portion of the internal carotid artery (ICA) are rare (accounting for only 0.1-2% of all surgical procedures affecting the ICA, 0.4-1% of all arterial aneurysms, and 4% of all aneurysms involving peripheral ... ...

Title translation	Internal carotid artery aneurisms: two cases.
Abstract	Introduction: Aneurysms of the extracranial portion of the internal carotid artery (ICA) are rare (accounting for only 0.1-2% of all surgical procedures affecting the ICA, 0.4-1% of all arterial aneurysms, and 4% of all aneurysms involving peripheral arteries), but they are nonetheless clinically significant because of the high related risk of cerebral thromboembolism. Given the rarity of these lesions, it seems worthwhile to report on two extracranial ICA aneurysms, one of atherosclerotic, the other of fibrodysplastic etiology that came under our observation. Patients and methods: Our experience concerns just two cases, treated at the Department of Surgical and Gastroenterological Sciences of the Policlinico G.B. Rossi in Verona, presenting with very different clinical and instrumental findings, and requiring a different surgical treatment. The former underwent resection of the aneurysm and end-to-end reconstruction; in the latter, we performed a carotid transposition with internalization of the external carotid artery. Results: Neither patient suffered from any major or minor neurological complications during or after surgery, and the follow-up confirmed a normal extracranial carotid patency. Conclusions: Based on our, albeit limited experience and an analysis of the literature, we make a few points concerning the diagnostic approach (which differs from the case of stenosing carotid lesions), the indications and type of treatment for extracranial ICA aneurysms.
MeSH term(s)	Aged ; Aged, 80 and over ; Aneurysm/diagnostic imaging ; Aneurysm/pathology ; Aneurysm/surgery ; Angiography ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/pathology ; Carotid Artery Diseases/surgery ; Female ; Humans ; Treatment Outcome
Language	French
Publishing date	2001-01-10
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	752965-x
ISSN	0398-0499
ISSN	0398-0499
DOI	10.1016/s0398-0499(06)76535-0
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Article ; Online: Safety and feasibility of Irreversible Electroporation (IRE) in patients with locally advanced pancreatic cancer: results of a prospective study.

Paiella, Salvatore / Butturini, Giovanni / Frigerio, Isabella / Salvia, Roberto / Armatura, Giulia / Bacchion, Matilde / Fontana, Martina / D'Onofrio, Mirko / Martone, Enrico / Bassi, Claudio

Digestive surgery

2015 Volume 32, Issue 2, Page(s) 90–97

Abstract: Purpose: To evaluate the safety of the NanoKnife Low Energy Direct Current (LEDC) System (Irreversible Electroporation, IRE) in order to treat patients with unresectable pancreatic adenocarcinoma.: Methods: Prospective, nonrandomized, single-center ... ...

Abstract	Purpose: To evaluate the safety of the NanoKnife Low Energy Direct Current (LEDC) System (Irreversible Electroporation, IRE) in order to treat patients with unresectable pancreatic adenocarcinoma. Methods: Prospective, nonrandomized, single-center clinical evaluation of ten patients with a cytohystological diagnosis of unresectable locally advanced pancreatic cancer (LAPC) that was no further responsive to standard treatments. The primary outcome was the rate of procedure-related abdominal complications. The secondary endpoints included the evaluation of the short-term efficacy of IRE through the evaluation of tumor reduction at imaging and biological tumor response as shown by CA 19-9, clinical assessments and patient quality of life. Results: Ten patients (5 males, 5 females) were enrolled, with a median age of 66 and median tumor size of 30 mm. All patients were treated successfully with a median procedure time of 79.5 min. Two procedure-related complications were described in one patient (10%): a pancreatic abscess with a pancreoduodenal fistula. Three patients had early progression of disease: one patient developed pulmonary metastases 30 days post-IRE and two patients had liver metastases 60 days after the procedure. We registered an overall survival of 7.5 months (range: 2.9-15.9). Conclusions: IRE is a safe procedure in patients with LAPC and may represent a new technological option in the treatment and multimodality management of this disease.
MeSH term(s)	Adenocarcinoma/surgery ; Aged ; Electroporation ; Feasibility Studies ; Female ; Follow-Up Studies ; Humans ; Male ; Pancreatic Neoplasms/surgery ; Postoperative Complications ; Prospective Studies ; Quality of Life ; Treatment Outcome
Language	English
Publishing date	2015
Publishing country	Switzerland
Document type	Clinical Trial ; Journal Article
ZDB-ID	605888-7
ISSN	1421-9883 ; 0253-4886
ISSN (online)	1421-9883
ISSN	0253-4886
DOI	10.1159/000375323
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Zs.A 2004: Show issues

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Article ; Online: Clinical and patient-reported outcomes after pancreatoduodenectomy for different diseases: a follow-up study.

Pezzilli, Raffaele / Falconi, Massimo / Zerbi, Alessandro / Casadei, Riccardo / Valli, Luana / Varale, Roberta / Armatura, Giulia / Felicani, Cristina / Morselli-Labate, Antonio M

Pancreas

2011 Volume 40, Issue 6, Page(s) 938–945

Abstract: Objective: The objective of the study was to evaluate clinical features and quality of life (QoL) in a 2-year follow-up study in subjects who underwent pancreatic head resection (PHR).: Methods: One hundred ninety-seven patients with benign and ... ...

Abstract	Objective: The objective of the study was to evaluate clinical features and quality of life (QoL) in a 2-year follow-up study in subjects who underwent pancreatic head resection (PHR). Methods: One hundred ninety-seven patients with benign and malignant diseases who underwent PHR were studied. A dedicated clinical form and the European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire C-30 were administered at evaluation times (immediately before surgery and 6, 12, 18, and 24 months after discharge). A sample of 197 sex- and age-matched norms was also included into the study as reference group. Results: Of the 197 patients studied, 164 (83.2%) had malignant disease, and 33 had benign disease (16.8%). At initial evaluation, global health was significantly lower (P = 0.001) in the study population as compared with the norms. At the end of the study, the QoL was not significantly different from the norms, although the QoL of the 30 patients with benign disease was significantly better than that of the 72 patients with malignant disease. Conclusions: The QoL before PHR was impaired in study patients before resection as compared with the normative population, whereas in patients who survived resection, it significantly improved in the 24 months after surgery.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Pancreatic Diseases/physiopathology ; Pancreatic Diseases/psychology ; Pancreatic Diseases/surgery ; Pancreatic Neoplasms/physiopathology ; Pancreatic Neoplasms/psychology ; Pancreatic Neoplasms/surgery ; Pancreaticoduodenectomy/psychology ; Quality of Life ; Surveys and Questionnaires ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2011-08
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	632831-3
ISSN	1536-4828 ; 0885-3177
ISSN (online)	1536-4828
ISSN	0885-3177
DOI	10.1097/MPA.0b013e318216f693
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Zs.A 2160: Show issues

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Article ; Online: Differences between main-duct and branch-duct intraductal papillary mucinous neoplasms of the pancreas.

Salvia, Roberto / Crippa, Stefano / Partelli, Stefano / Armatura, Giulia / Malleo, Giuseppe / Paini, Marina / Pea, Antonio / Bassi, Claudio

World journal of gastrointestinal surgery

2010 Volume 2, Issue 10, Page(s) 342–346

Abstract: In the last decade, intraductal papillary mucinous neoplasms (IPMNs) have become commonly diagnosed. From a morphological standpoint, they are classified in main-duct IPMNs (MD-IPMNs) and branch-duct IPMNs (BD-IPMNs), depending on the type of involvement ...

Abstract	In the last decade, intraductal papillary mucinous neoplasms (IPMNs) have become commonly diagnosed. From a morphological standpoint, they are classified in main-duct IPMNs (MD-IPMNs) and branch-duct IPMNs (BD-IPMNs), depending on the type of involvement of the pancreatic ductal system by the neoplasm. Despite the fact that our understanding of their natural history is still incomplete, recent data indicate that MD-IPMNs and BD-IPMNs show significant differences in terms of biological behaviour with MD-IPMNs at higher risk of malignant degeneration. In the present paper, clinical and epidemiological characteristics, rates of malignancy and the natural history of MD-IPMNs and BD-IPMNs are analyzed. The profile of IPMNs involving both the main pancreatic duct and its side branches (combined-IPMNs) are also discussed. Finally, general recommendations for management based on these differences are given.
Language	English
Publishing date	2010-07-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573700-4
ISSN	1948-9366 ; 1948-9366
ISSN (online)	1948-9366
ISSN	1948-9366
DOI	10.4240/wjgs.v2.i10.342
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