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  1. Article ; Online: Correction

    Siméon Pierre Chegaing Fodouop / Sedric Donald Tala / Lunga Paul Keilah / Norbert Kodjio / Mefokou Didiane Yemele / Armel Herve Nwabo Kamdje / Bridget Nji-kah / Joseph Tchoumboue / Donatien Gatsing

    BMC Complementary Medicine and Therapies, Vol 23, Iss 1, Pp 1-

    Effects of Vitellaria paradoxa (C.F. Gaertn.) Aqueous leaf extract administration on Salmonella typhimurium-infected rats

    2023  Volume 1

    Keywords Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Estimation of Reference Values of Biochemical Parameters Exploring the Renal Function in Adults in Ngaoundere, Cameroon

    Armel Herve Nwabo Kamdje / Gaetan Nkem / Haverie Ghislaine Ateba Mimfoumou

    International Biological and Biomedical Journal (2018)

    2018  

    Abstract: Clinical examinations are accompanied by biological analyzes to guide or confirm the clinical diagnosis. The results of these analyzes are interpreted by comparison with reference values. Studies on the biological norms of Africans are rare if not quasi- ... ...

    Abstract Clinical examinations are accompanied by biological analyzes to guide or confirm the clinical diagnosis. The results of these analyzes are interpreted by comparison with reference values. Studies on the biological norms of Africans are rare if not quasi-nonexistent. The aim of this study was to establish population-specific reference values for biochemical indices serving as renal function biomarkers in adults living in Ngaoundere, Cameroon. 205 presumed healthy subjects (118 women and 87 men) residing in the city of Ngaoundere aged 18 to 50 years from various socio-cultural backgrounds, were included in this study. Blood urea and creatinine were tested under standard conditions. Reference intervals varied between 10-44 mg/dl and 0.6-1.4 mg/dl for urea and creatinine, respectively. Urea mean values (27.93± 8.15 mg/dl) were higher in males in comparison with females (23.56± 7.14 mg/dl) (P= 0.02). Similarly, creatinine mean values (1.11 ± 0.13 mg/dl) were higher in males in comparison with females (0.82± 0.11 mg/dl) (P= 0.04). Also, an increase in uraemia was observed with age. The gender differences for creatinemia and uraemia may be related to anthropometric features differences such as the muscle mass. The increase of uraemia with age could be explained by the increase of poor hygiene, notably the consumption of alcohol, tobacco and meat, which is mostly a male habit. The results of this study may help to a better interpretation of the biochemical indices of African subjects, and avoid errors of appreciation by excess or by default.
    Keywords Biology (General) ; QH301-705.5
    Subject code 630
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher 1001 Medical Association
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Breast cancer awareness and screening practice amongst health personnel and general population of the littoral region of Cameroon

    Mohamadou Halmata / Richard Simo Tagne / Grace Nganwa Kembaou / Erika Myriam Baiguerel / Lydiane C.C. Ndopwang / Armel Herve Nwabo Kamdje / Phelix Bruno Telefo / Charlette Nangue / Elias Nchiwan Nukenine

    Heliyon, Vol 7, Iss 7, Pp e07534- (2021)

    2021  

    Abstract: Introduction: Late diagnosis has been observed as the hallmark of breast cancer in Cameroonian women where over 70% of patients report with either stage III or IV of the disease, with high mortality and dire socioeconomic consequences. The present study ... ...

    Abstract Introduction: Late diagnosis has been observed as the hallmark of breast cancer in Cameroonian women where over 70% of patients report with either stage III or IV of the disease, with high mortality and dire socioeconomic consequences. The present study was undertaken to assess the awareness of breast cancer, warning signs and screening methods among Health professionals and general population of Douala. Methods: Participants included in this study were health practitioners and women randomly selected and enrolled in six health facilities in the city of Douala, Littoral Region, Cameroon. A self-administered questionnaire was designed for each group and aimed at assessing their knowledge about breast cancer, warning signs and screening practices. Then, 616 women underwent breast palpation, followed by fine needle aspiration (FNA) when a nodule was found. Results: Out of a total of 737 participants (121 health personnel and 616 women) interviewed, a majority (96.3%) were aware of the disease with the main source of information being the hospital (76.0%), media (47.1%) and vocational training schools (45.4%) for health personnel; medias (39.9%), health professionals (26.1%) and their entourage (21.9%) for the population. Health workforce presented suitable awareness of the risk factors for breast cancer and its clinical signs even though 37.1% of them had misconceptions and myth-based ideas on the origin of the disease. Both the population and health personnel were aware of the possibility of early screening for breast cancer and cited breast self-examination, clinical breast examination and mammography as screening techniques. Nonetheless, screening practice amongst all women is very poor and mainly due to ignorance, high cost of mammography, together with a lack of mastery of the BSE technique and the fear of actually discovering signs of the disease. Conclusion: Our findings show lack of awareness and low practice of breast cancer screening amongst women in Douala and highlight the need to raise awareness and ...
    Keywords Breast cancer awareness ; Screening practices ; Fine needle aspiration ; Littoral Region ; Cameroon ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 610
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Sensitivity and Specificity of Visual Inspection with Acetic Acid (VIA) and with Lugol Iodine (VILI) in the Diagnosis of Cervical Cancer in the Northern Region of Cameroon

    Georges Kalgong / Armel Herve Nwabo Kamdje / Tagne Simo Richard / Charlette Nangue

    International Biological and Biomedical Journal (2017)

    2017  

    Abstract: Cervical cancer is one of the major causes of women death worldwide. The aim of this study was to test the sensitivity and specificity of visual inspection with acetic acid (VIA) and visual inspection with lugol iodine (VILI) as a diagnostic test for ... ...

    Abstract Cervical cancer is one of the major causes of women death worldwide. The aim of this study was to test the sensitivity and specificity of visual inspection with acetic acid (VIA) and visual inspection with lugol iodine (VILI) as a diagnostic test for cervical cancer in comparison with Pap smear in the North Cameroon region. 309 women aged between 20 to 62 years were recruited in this study. 307 were included in the statistical analyzes. Each woman was screened for cervical cancer by a conventional smear and visual inspection with acetic acid 5% and the lugol solution. The prevalence of precancerous lesions of cervix was 12.70%. The risk factors of cervical cancer identified were age, matrimonial status, age of first sexual intercourse, and parity. The association of VIA and VILI showed sensitivity, specificity, positive and negative predictive values of 93.58%, 97.01%, 82.01%, and 99.04%, respectively. VIA-VILI were revealed as good screening tests for cervical cancer in the present context. Early detection and treatment of cervical lesions and also faith against the risk factors should help to reduce the mortality and morbidity of this pathology.
    Keywords Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2017-03-01T00:00:00Z
    Publisher 1001 Medical Association
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Comparison of epithelial differentiation and immune regulatory properties of mesenchymal stromal cells derived from human lung and bone marrow.

    Mario Ricciardi / Giorgio Malpeli / Francesco Bifari / Giulio Bassi / Luciano Pacelli / Armel Hervé Nwabo Kamdje / Marco Chilosi / Mauro Krampera

    PLoS ONE, Vol 7, Iss 5, p e

    2012  Volume 35639

    Abstract: Mesenchymal stromal cells (MSCs) reside in many organs including lung, as shown by their isolation from fetal lung tissues, bronchial stromal compartment, bronchial-alveolar lavage and transplanted lung tissues. It is still controversial whether lung ... ...

    Abstract Mesenchymal stromal cells (MSCs) reside in many organs including lung, as shown by their isolation from fetal lung tissues, bronchial stromal compartment, bronchial-alveolar lavage and transplanted lung tissues. It is still controversial whether lung MSCs can undergo mesenchymal-to-epithelial-transition (MET) and possess immune regulatory properties. To this aim, we isolated, expanded and characterized MSCs from normal adult human lung (lung-hMSCs) and compared with human bone marrow-derived MSCs (BM-hMSCs). Our results show that lung-MSCs reside at the perivascular level and do not significantly differ from BM-hMSCs in terms of immunophenotype, stemness gene profile, mesodermal differentiation potential and modulation of T, B and NK cells. However, lung-hMSCs express higher basal level of the stemness-related marker nestin and show, following in vitro treatment with retinoic acid, higher epithelial cell polarization, which is anyway partial when compared to a control epithelial bronchial cell line. Although these results question the real capability of acquiring epithelial functions by MSCs and the feasibility of MSC-based therapeutic approaches to regenerate damaged lung tissues, the characterization of this lung-hMSC population may be useful to study the involvement of stromal cell compartment in lung diseases in which MET plays a role, such as in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Bio-guided fractionation of methanol extract of Ziziphus mauritiana Lam. (bark) and effect of the most active fraction on cancer cell lines

    Richard Simo Tagne / Bruno Phelix Telefo / Emmanuel Talla / Jean Noel Nyemb / Sylvain Nguedia Njina / Mudassir Asrar / Farah Mukhtar / Armel Hervé Nwabo Kamdje / Paul Fewou Moundipa / Ahsana Dar Farooq / M. Iqbal Choudhary

    Asian Pacific Journal of Tropical Disease, Vol 5, Iss 4, Pp 307-

    2015  Volume 312

    Abstract: Objective: To investigate the anticancer and antioxidant potential of methanol bark extract of Ziziphus mauritiana (Z. mauritiana), which is used by traditional healers to cure some cases of cancer in Cameroon. Methods: The methanol crude extract of Z. ... ...

    Abstract Objective: To investigate the anticancer and antioxidant potential of methanol bark extract of Ziziphus mauritiana (Z. mauritiana), which is used by traditional healers to cure some cases of cancer in Cameroon. Methods: The methanol crude extract of Z. mauritiana has the antiproliferative activity on four cancer cell lines and its antioxidant activity. The extract was partitioned in five different solvents, and each fraction was tested. The effect of the most antiproliferative fraction on cell cycle was determined. Bio-guided fractionation was performed on the fraction with the highest antiproliferative and the highest antioxidant activities. Results: Z. mauritiana methanol extract was active on all tested cells, and showed promising antioxidant activity. All fractions except hexane fraction were active with the dichloromethane fraction being the most active and showed S and G2-M phase arrest (P<0.01) on cell cycle progression of NCI-H460 and MCF-7, respectively. Bio-guided fractionation of the dichloromethane fraction led to lupeol and betulinic acid. The greatest antioxidant activity was recorded with ethyl acetate fraction and its fractionation led to catechin and epigallocatechin. Conclusions: Overall, this study showed that Z. mauritiana barks has benefits as a chemoprevention agent cancer.
    Keywords Ziziphus mauritiana ; Anticancer ; Antioxidant ; Betulinic acid ; Catechin. ; Medicine ; R ; Arctic medicine. Tropical medicine ; RC955-962
    Subject code 500
    Language English
    Publishing date 2015-04-01T00:00:00Z
    Publisher Asian Pacific Journal of Tropical Disease Editorial Office
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: In vivo anti-androgenic, anti-estrogenic and antioxidant activities of the aqueous extract of Eremomastax speciosa

    Richard Simo Tagne / Bruno Phelix Telefo / Sylvain Nguedia Njina / Bayala Bala / Stéphanie Marie Chekem Goka / Didiane Mefokou Yemele / Landry Lienou Lienou / Gildas Tetaping Mbemya / Nathalie Jiatsa Donfack / Armel Hervé Nwabo Kamdje / Paul Fewou Moundipa

    Asian Pacific Journal of Tropical Disease, Vol 4, Iss Sup 2, Pp 952-

    2014  Volume 956

    Abstract: Objective: To evaluate the in vivo anti-androgenic, antioxidant activity and anti-estrogenic activities of Eremomastax speciosa (E. speciosa) in order to find new method for fighting against chronic diseases such as cancer. Methods: Evaluations of ... ...

    Abstract Objective: To evaluate the in vivo anti-androgenic, antioxidant activity and anti-estrogenic activities of Eremomastax speciosa (E. speciosa) in order to find new method for fighting against chronic diseases such as cancer. Methods: Evaluations of antiandrogenic and antioxidant activities were carried out on male rate receiving simultaneous daily administration of testosterone and different doses of aqueous extract of E. speciosa, during a period of 10 d. The evaluation of antiestrogenic activity was carried out on mature ovariectomized female rats receiving simultaneous daily administration of estradiol and different doses of extract, for a week. Then reproductive organs were weighted, levels of prostatic acid phosphatase, superoxide dismutase and catalase as well as some hematologic parameters were measured. Results: The treatment significantly reduced (P<0.01 ) the weight of ventral prostate, penis, Cowper’s gland and the level of serum prostatic acid phosphatase; while a significant decrease (P<0.01) of the catalase activity was observed. A significant increase (P<0.05) in the lymphocyte number and significant decrease of monocyte (P<0.05) were noticed. The uterine relative weight were significantly reduced (P<0.01). Conclusions: Generally, these results denote the antiandrogenic, antiestrogenic and immunomodulatory potential of E. speciosa.
    Keywords Eremomastax speciosa ; Prostate cancer ; Antiandrogenic activity ; Antiestrogenic activity ; Medicine ; R ; Arctic medicine. Tropical medicine ; RC955-962
    Subject code 630
    Language English
    Publishing date 2014-09-01T00:00:00Z
    Publisher Asian Pacific Journal of Tropical Disease Editorial Office
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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