Article ; Online: ERCC6L2 mitigates replication stress and promotes centromere stability.
2023 Volume 42, Issue 4, Page(s) 112329
Abstract: Structurally complex genomic regions, such as centromeres, are inherently difficult to duplicate. The mechanism behind centromere inheritance is not well understood, and one of the key questions relates to the reassembly of centromeric chromatin ... ...
Abstract | Structurally complex genomic regions, such as centromeres, are inherently difficult to duplicate. The mechanism behind centromere inheritance is not well understood, and one of the key questions relates to the reassembly of centromeric chromatin following DNA replication. Here, we define ERCC6L2 as a key regulator of this process. ERCC6L2 accumulates at centromeres and promotes deposition of core centromeric factors. Interestingly, ERCC6L2 |
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MeSH term(s) | Humans ; Chromatin ; Centromere/metabolism ; DNA/chemistry ; DNA Replication ; DNA Repair ; DNA Helicases/metabolism |
Chemical Substances | Chromatin ; DNA (9007-49-2) ; ERCC6L2 protein, human (EC 3.6.4.12) ; DNA Helicases (EC 3.6.4.-) |
Language | English |
Publishing date | 2023-04-03 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2649101-1 |
ISSN | 2211-1247 ; 2211-1247 |
ISSN (online) | 2211-1247 |
ISSN | 2211-1247 |
DOI | 10.1016/j.celrep.2023.112329 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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