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Article ; Online: Dysmenorrhea among 12-year-old teenagers from different socioeconomic backgrounds.

Defert, Coralie / Cousin, Ianis / Marchand, Isabelle Chauvet-Le / Burgazzi, Catherine / Pabic, Estelle Le / Arnaud, Alexis P

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

2024 Volume 31, Issue 2, Page(s) 141–147

Abstract: Background: The age of menarche has been gradually declining since the end of the 20th century. Few studies have been carried out about dysmenorrhea in Europe and they mainly included girls over the age of 15 years.: Methods: We conducted an ... ...

Abstract	Background: The age of menarche has been gradually declining since the end of the 20th century. Few studies have been carried out about dysmenorrhea in Europe and they mainly included girls over the age of 15 years. Methods: We conducted an observational study among sixth-grade schoolgirls (usually 11-12 years) during the 2020 academic year in 72 randomly selected public schools in a French region (approval number #20.94). Results: Among 1712 girls interviewed, 257 (23 %) had reached menarche. Overall, 83 % of these teenagers had dysmenorrhea. Symptoms were reported to occur since the first periods in 59 % of the girls. School absenteeism was positively correlated with severe abdominal pain (p = 0.001). Median age at menarche was 11 years (10.7-11.5). Periods lasted less than 3 days, 3-8 days, and more than 8 days in, respectively, 18 %, 70 %, and 7 % of the girls. Symptoms were significantly more frequent and more severe in the urban group than the rural group (p = 0.005). Symptoms were abdominal pain (70 %), fatigue (48 %), difficulty in concentrating (26 %), headache (25 %), digestive disorders (16 %), and breast discomfort (11 %). Of the girls with dysmenorrhea, 61 % took painkillers; 10 % were uncomfortable despite taking painkillers. Sport exemption was more frequent in the urban group (p = 0.003) and among girls with severe abdominal pain (p = 0.001). Conclusions: The duration of the menstrual cycle was similar between the various socioeconomic groups, but symptoms and ways of coping were significantly different. Dysmenorrhea is definitely an issue that has to be raised with teenagers as soon as menarche occurs or even before that. Easy access to skilled health practitioners should be widespread.
MeSH term(s)	Female ; Adolescent ; Humans ; Child ; Dysmenorrhea/epidemiology ; Menarche ; Menstrual Cycle ; Abdominal Pain/epidemiology ; Abdominal Pain/etiology ; Socioeconomic Factors ; Surveys and Questionnaires ; Prevalence
Language	English
Publishing date	2024-01-24
Publishing country	France
Document type	Observational Study ; Journal Article
ZDB-ID	1181947-9
ISSN	1769-664X ; 0929-693X
ISSN (online)	1769-664X
ISSN	0929-693X
DOI	10.1016/j.arcped.2023.09.018
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Article ; Online: Invited Response on: Comment on "Lipo-Body Lift Reconstruction Following Massive Weight Loss-Our Experience with 100 Consecutive Cases".

Berkane, Yanis / Arnaud, Alexis P / Gandolfi, Silvia / Bertheuil, Nicolas

Aesthetic plastic surgery

2021 Volume 46, Issue 1, Page(s) 579–580

MeSH term(s)	Abdominoplasty ; Humans ; Weight Loss
Language	English
Publishing date	2021-05-26
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	532791-x
ISSN	1432-5241 ; 0364-216X
ISSN (online)	1432-5241
ISSN	0364-216X
DOI	10.1007/s00266-021-02316-1
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Zs.A 1296: Show issues

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Article ; Online: Transperitoneal Versus Retroperitoneal Robotic-assisted Laparoscopic Pyeloplasty for Ureteropelvic Junction Obstruction in Children. A Multicentre, Prospective Study.

Blanc, Thomas / Abbo, Olivier / Vatta, Fabrizio / Grosman, Julien / Marquant, Fabienne / Elie, Caroline / Juricic, Mélodie / Laraqui, Samia / Broch, Aline / Arnaud, Alexis

European urology open science

2022 Volume 41, Page(s) 134–140

Abstract: Background: Robotic-assisted laparoscopic pyeloplasty (RALP) has been gaining acceptance among paediatric urologists.: Objective: To compare surgical variables and clinical outcomes, including complications and success rate, with RALP using the ... ...

Abstract	Background: Robotic-assisted laparoscopic pyeloplasty (RALP) has been gaining acceptance among paediatric urologists. Objective: To compare surgical variables and clinical outcomes, including complications and success rate, with RALP using the transperitoneal (T-RALP) and retroperitoneal (R-RALP) approaches. Design setting and participants: We performed a multicentre, prospective, cohort study (NCT03274050) between November 2016 and October 2021 in three paediatric urology teaching centres (transperitoneal approach, Intervention: We performed dismembered pyeloplasty using running monofilament 6-0 absorbable suture. Outcome measurements and statistical analysis: We assessed intra- and postoperative morbidity (primary outcome) and success (secondary outcome). Data were expressed as medians and interquartile range (25th and 75th percentiles) for quantitative variables, and analysed comparatively. Results and limitations: We operated on 106 children (T-RALP, Conclusions: In selected children, RALP is safe and effective using either the transperitoneal or the retroperitoneal approach, with a shorter hospital stay after R-RALP. Patient summary: In our multicentre, prospective study, we compared the results and complications of robotic-assisted laparoscopic pyeloplasty (RALP) using the transperitoneal and retroperitoneal approaches. We found that RALP is safe and effective using either approach, with a shorter hospital stay after R-RALP.
Language	English
Publishing date	2022-06-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3040546-4
ISSN	2666-1683 ; 2058-4881
ISSN (online)	2666-1683
ISSN	2058-4881
DOI	10.1016/j.euros.2022.05.009
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Article ; Online: Meconium Concentrations of Pesticides and Risk of Hypospadias: A Case-Control Study in Brittany, France.

Rouget, Florence / Bihannic, Adèle / Le Bot, Barbara / Mercier, Fabien / Gilles, Erwann / Garlantezec, Ronan / Multigner, Luc / Cordier, Sylvaine / Arnaud, Alexis / Pladys, Patrick / Chevrier, Cécile

Epidemiology (Cambridge, Mass.)

2023 Volume 35, Issue 2, Page(s) 185–195

Abstract: Background: Hypospadias is a male genital tract defect for which an increase in prevalence has been documented over the last few decades. A role for environmental risk factors is suspected, including prenatal exposure to pesticides.: Objectives: To ... ...

Abstract	Background: Hypospadias is a male genital tract defect for which an increase in prevalence has been documented over the last few decades. A role for environmental risk factors is suspected, including prenatal exposure to pesticides. Objectives: To study the risk of hypospadias in association with multiple pesticide measurements in meconium samples. Methods: The Brittany Registry of Congenital Anomalies (France) conducted a case-control study between 2012 and 2018. Cases were hypospadias, ascertained by a pediatrician and a pediatric surgeon, excluding genetic conditions, following European Surveillance of Congenital Anomalies guidelines (N = 69). Controls (N = 135) were two male infants without congenital anomaly born after each case in the same maternity unit. Mothers in the maternity units completed a self-administered questionnaire, we collected medical data from hospital records, and medical staff collected meconium samples. We performed chemical analysis of 38 pesticides (parent compound and/or metabolite) by UHPLC/MS/MS following strict quality assurance/quality control criteria and blind to case-control status. We carried out logistic regression accounting for frequency-matching variables and major risk factors. Results: Among the 38 pesticides measured, 16 (42%) were never detected in the meconium samples, 18 (47%) were in <5% of samples, and 4 (11%) in ≥5% of the samples. We observed an association between the detection of fenitrothion in meconium and the risk of hypospadias (OR = 2.6 [1.0-6.3] with n cases = 13, n controls = 21), but not the other pesticides. Conclusions: Our small study provides a robust assessment of fetal exposure. Fenitrothion's established antiandrogenic activities provide biologic plausibility for our observations. Further studies are needed to confirm this hypothesis.
MeSH term(s)	Infant, Newborn ; Infant ; Child ; Humans ; Male ; Female ; Pregnancy ; Hypospadias/chemically induced ; Hypospadias/epidemiology ; Meconium/chemistry ; Pesticides/toxicity ; Maternal Exposure/adverse effects ; Case-Control Studies ; Tandem Mass Spectrometry ; Fenitrothion/analysis ; France/epidemiology
Chemical Substances	Pesticides ; Fenitrothion (W8M4X3Y7ZY)
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1053263-8
ISSN	1531-5487 ; 1044-3983
ISSN (online)	1531-5487
ISSN	1044-3983
DOI	10.1097/EDE.0000000000001688
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Zs.A 3121: Show issues

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Article: Financial and relational impact of having a boy with posterior urethral valves.

Harper, Luke / Botto, Nathalie / Peycelon, Matthieu / Michel, Jean-Luc / Leclair, Marc-David / Garnier, Sarah / Clermidi, Pauline / Arnaud, Alexis / Dariel, Anne / Dobremez, Eric / Faure, Alice / Fourcade, Laurent / Boudaoud, Nadia / Chaussy, Yann / Huiart, Laetitia / Bocquet, Valery / Ferdynus, Cyril / Sauvat, Frédérique

Frontiers in pediatrics

2023 Volume 11, Page(s) 1228248

Abstract: Introduction: Childhood chronic diseases affect family functioning and well-being. The aim of this study was to measure the impact of caring for a child with PUV, and the factors that most impact the burden of care.: Patients and method: We gave a ... ...

Abstract	Introduction: Childhood chronic diseases affect family functioning and well-being. The aim of this study was to measure the impact of caring for a child with PUV, and the factors that most impact the burden of care. Patients and method: We gave a questionnaire on the familial impact of having a child with posterior urethral valves to all parents of a child included in the CIRCUP trial from 2015 onwards. The questionnaire included questions about the parents' demographics, health, professional, financial and marital status and how these evolved since the child's birth as well as the "impact on family scale" (IOFS), which gives a total score ranging from 15 (no impact) to 60 (maximum impact). We then analyzed both the results of the specific demographic questions as well as the factors which influenced the IOFS score. Results: We retrieved answers for 38/51 families (74.5% response rate). The average IOFS score was 23.7 (15-51). We observed that the child's creatinine level had an effect on the IOFS score ( Conclusion: In conclusion, having a boy with PUV significantly impacts families. The risk of parental separation and decrease in revenue is significant. Strategies aiming to decrease these factors should be put in place as soon as possible.
Language	English
Publishing date	2023-08-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1228248
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Article ; Online: Can separation of the scrotal sac in proximal hypospadias reliably predict the need for urethral plate transection?

Arnaud, Alexis / Ferdynus, Cyril / Harper, Luke

Journal of pediatric urology

2015 Volume 12, Issue 2, Page(s) 121.e1–5

Abstract: Introduction: One of the main challenges in proximal hypospadias repair is correcting curvature. The best technique to achieve this remains the object of debate. Indeed, some authors believe the urethral plate should be kept and used as often as ... ...

Abstract	Introduction: One of the main challenges in proximal hypospadias repair is correcting curvature. The best technique to achieve this remains the object of debate. Indeed, some authors believe the urethral plate should be kept and used as often as possible. In some cases, however, even after extensive mobilization and dorsal plication, significant curvature remains and it is necessary to transect the urethral plate. Having a reliable pre-dissection marker of the need for urethral transection would be useful in choosing a technique.We wanted to determine if presence of marked separation of the scrotal sac (SSS), also referred to as bifid scrotum, could reliably predict the need for urethral plate transection. Study design: We prospectively enrolled a series of boys with proximal hypospadias. We noted age, degree of hypospadias, meatal position, presence of cryptorchidism, and presence or absence of SSS. During surgery we fully degloved the penile shaft, freeing all ventral tissues, and radically dissected the more proximal bulbar urethra. We then performed an erection test. If there was residual curvature <30° we performed a dorsal plication, if it was >30° we transected the urethral plate. Results: Twenty-nine patients were included, of whom 18 presented SSS. The average age was comparable in both groups, as was type of hypospadias and meatal position. We estimated transection of the urethral plate to be necessary in 15 out of the 18 children with SSS, and 2 out of the 11 children without SSS. The relative risk for requiring urethral plate transection in case of SSS in this series was 4.58. Conclusion: Techniques that commit to urethral plate transection are criticized because they preclude using the urethral plate. In our study presence of SSS was predictive for the need to transect the plate. Obviously one can decide to keep the urethral plate at all cost, and mobilize it more than we did, or accept more residual curvature, but in reality our aim was to determine a preoperative marker allowing us to define a patient category. We believe presence of SSS is a marker of severity, and that this "severity" translates into "a less usable urethra". As recent studies caution us about the evolution of the reconstructed native urethra and the possibility that it may not grow as well as the other penile tissues, we believe this extra information could influence the surgeon's decision as to the most appropriate technique for each patient.
MeSH term(s)	Child, Preschool ; Follow-Up Studies ; Humans ; Hypospadias/surgery ; Male ; Prospective Studies ; Reconstructive Surgical Procedures/methods ; Scrotum/surgery ; Treatment Outcome ; Urethra/surgery ; Urologic Surgical Procedures, Male/methods
Language	English
Publishing date	2015-12-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2237683-5
ISSN	1873-4898 ; 1477-5131
ISSN (online)	1873-4898
ISSN	1477-5131
DOI	10.1016/j.jpurol.2015.10.011
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Article ; Online: A piglet model of iatrogenic rectosigmoid hypoganglionosis reveals the impact of the enteric nervous system on gut barrier function and microbiota postnatal development.

Arnaud, Alexis Pierre / Hascoet, Juliette / Berneau, Pauline / LeGouevec, Francis / Georges, Julien / Randuineau, Gwenaelle / Formal, Michèle / Henno, Sébastien / Boudry, Gaelle

Journal of pediatric surgery

2020 Volume 56, Issue 2, Page(s) 337–345

MeSH term(s)	Animals ; Enteric Nervous System ; Female ; Hirschsprung Disease/etiology ; Iatrogenic Disease ; Microbiota ; Models, Animal ; Swine
Language	English
Publishing date	2020-06-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	80165-3
ISSN	1531-5037 ; 0022-3468
ISSN (online)	1531-5037
ISSN	0022-3468
DOI	10.1016/j.jpedsurg.2020.06.018
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Zs.A 607: Show issues

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Article: Douleurs abdomninales chirurgicales de l'enfant.

Arnaud, Alexis / Sauvat, Frédérique

La Revue du praticien

2011 Volume 61, Issue 5, Page(s) 626–629

Abstract: Abdominal pain in child could be related to surgical pathologies in 10 to 20 % of cases. The more frequent etiology remains appendicitis. Regarding to clinical presentation, age and medical history, intestinal intussusception, incarcerated hernia, ... ...

Title translation	Surgical abdominal pain in children.
Abstract	Abdominal pain in child could be related to surgical pathologies in 10 to 20 % of cases. The more frequent etiology remains appendicitis. Regarding to clinical presentation, age and medical history, intestinal intussusception, incarcerated hernia, adhesive occlusion and Meckel's diverticulum could be evocated. But the most dreadful diagnosis is malrotation with volvulus, because of mortality and morbidities induced by bowel necrosis. Usually, medical history and clinical exam allowed diagnosis. Ultrasound remains the more helpful exam in children with surgical pathologies and in some selected cases, CT scan and others biological and/or radiological exams could be performed.
MeSH term(s)	Abdominal Pain/diagnosis ; Abdominal Pain/etiology ; Child ; Humans ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology
Language	French
Publishing date	2011-05
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	205365-2
ISSN	2101-017X ; 0035-2640
ISSN (online)	2101-017X
ISSN	0035-2640
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Ua VI Zs.433: Show issues

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Article ; Online: A multicenter review of undescended testis torsion: A plea for early management.

Dupond-Athénor, Adrien / Peycelon, Matthieu / Abbo, Olivier / Rod, Julien / Haraux, Elodie / Scalabre, Aurélien / Arnaud, Alexis / Guérin, Florent / Irtan, Sabine

Journal of pediatric urology

2020 Volume 17, Issue 2, Page(s) 191.e1–191.e6

Abstract: Introduction: Torsion of an undescended testis (UT) is a surgical emergency, difficult to diagnose, whose prognosis depends on a quick management.: Aim of the study: To evaluate the management and outcome of these patients.: Study design: We ... ...

Abstract	Introduction: Torsion of an undescended testis (UT) is a surgical emergency, difficult to diagnose, whose prognosis depends on a quick management. Aim of the study: To evaluate the management and outcome of these patients. Study design: We retrospectively analyzed all cases of UT torsion operated in nine French hospitals between 1997 and 2017. We divided patients in two groups: patients referred less than 6 h after the onset of symptoms (group A) or more than 6 h (group B). Main results: We collected 60 cases (17 in group A and 43 in group B). Median age was 2.2 years [IQR = 0.7-7.8] (2.3 y in group A and 2 y in group B, p = 0.76). Eleven patients (10 in group B) had neurological disorders (p = 0.15). The main reason for absence of UT treatment was the absence of surgical consultation in a normal delay (n = 44, 73%). Symptoms were pain (n = 58, 97%), inguinal mass (n = 55, 92%) and vomiting (n = 16, 27%). An inguinal mass with no palpable testis in the ipsilateral hemiscrotum was seen in 55 patients (92%). An ultrasound scan performed in 27 patients led to the diagnosis in 16 patients (59%). At surgery, an orchiectomy was performed in 4 patients (23%) of group A and 24 patients (56%) of group B (p = 0.04). After a median follow-up of 11 months [IQR = 4-23], 11 patients of group A (65%) and 7 patients of group B (16%) had a clinically normal testis (p = 0.03). The salvage rate among patients with conservative treatment was 85% for group A and 37% for group B (p = 0.01). Discussion: Our study reveals that although UT torsion is an emergency, 72% of patients are referred more than 6 h after the onset of symptoms. We mostly found classic clinical presentation of UT torsion: a painful inguinal mass with an empty ipsilateral scrotum. Ultrasound was performed in half cases, and even if the result was not significant, it still seemed to be associated with a higher rate of orchiectomy especially in group B because of the delay in care. However, when ultrasound was realized early, it led to diagnosis in all cases. This dilemma poses the problem of the role of imaging in diagnostic management. Conclusions: Early clinical diagnosis in front of a painful inguinal mass with an empty scrotum is essential to improve the salvage rate of testis in UT torsion. Early management of UT should have avoided 68% of testis loss.
MeSH term(s)	Child, Preschool ; Cryptorchidism/complications ; Cryptorchidism/diagnosis ; Cryptorchidism/surgery ; Humans ; Male ; Orchiectomy ; Retrospective Studies ; Spermatic Cord Torsion/diagnosis ; Spermatic Cord Torsion/epidemiology ; Spermatic Cord Torsion/surgery ; Testis
Language	English
Publishing date	2020-12-08
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	2237683-5
ISSN	1873-4898 ; 1477-5131
ISSN (online)	1873-4898
ISSN	1477-5131
DOI	10.1016/j.jpurol.2020.12.004
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Article ; Online: Fully Automatic Lesion Localization and Characterization: Application to Brain Tumors Using Multiparametric Quantitative MRI Data.

Arnaud, Alexis / Forbes, Florence / Coquery, Nicolas / Collomb, Nora / Lemasson, Benjamin / Barbier, Emmanuel L

IEEE transactions on medical imaging

2018 Volume 37, Issue 7, Page(s) 1678–1689

Abstract: When analyzing brain tumors, two tasks are intrinsically linked, spatial localization, and physiological characterization of the lesioned tissues. Automated data-driven solutions exist, based on image segmentation techniques or physiological parameters ... ...

Abstract	When analyzing brain tumors, two tasks are intrinsically linked, spatial localization, and physiological characterization of the lesioned tissues. Automated data-driven solutions exist, based on image segmentation techniques or physiological parameters analysis, but for each task separately, the other being performedmanually or with user tuning operations. In this paper, the availability of quantitative magnetic resonance (MR) parameters is combined with advancedmultivariate statistical tools to design a fully automated method that jointly performs both localization and characterization. Non trivial interactions between relevant physiologicalparameters are capturedthanks to recent generalized Student distributions that provide a larger variety of distributional shapes compared to the more standard Gaussian distributions. Probabilisticmixtures of the former distributions are then consideredto account for the different tissue types and potential heterogeneity of lesions. Discriminative multivariate features are extracted from this mixture modeling and turned into individual lesion signatures. The signatures are subsequently pooled together to build a statistical fingerprintmodel of the different lesion types that captures lesion characteristics while accounting for inter-subject variability. The potential of this generic procedure is demonstrated on a data set of 53 rats, with 36 rats bearing 4 different brain tumors, for which 5 quantitative MR parameters were acquired.
MeSH term(s)	Algorithms ; Animals ; Brain Neoplasms/diagnostic imaging ; Databases, Factual ; Image Interpretation, Computer-Assisted/methods ; Magnetic Resonance Imaging/methods ; Rats
Language	English
Publishing date	2018-07-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	622531-7
ISSN	1558-254X ; 0278-0062
ISSN (online)	1558-254X
ISSN	0278-0062
DOI	10.1109/TMI.2018.2794918
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