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  1. Article ; Online: A piglet model of iatrogenic rectosigmoid hypoganglionosis reveals the impact of the enteric nervous system on gut barrier function and microbiota postnatal development.

    Arnaud, Alexis Pierre / Hascoet, Juliette / Berneau, Pauline / LeGouevec, Francis / Georges, Julien / Randuineau, Gwenaelle / Formal, Michèle / Henno, Sébastien / Boudry, Gaelle

    Journal of pediatric surgery

    2020  Volume 56, Issue 2, Page(s) 337–345

    MeSH term(s) Animals ; Enteric Nervous System ; Female ; Hirschsprung Disease/etiology ; Iatrogenic Disease ; Microbiota ; Models, Animal ; Swine
    Language English
    Publishing date 2020-06-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2020.06.018
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    Zs.A 607: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Post-natal co-development of the microbiota and gut barrier function follows different paths in the small and large intestine in piglets.

    Arnaud, Alexis Pierre / Rome, Véronique / Richard, Marion / Formal, Michèle / David-Le Gall, Sandrine / Boudry, Gaëlle

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2019  Volume 34, Issue 1, Page(s) 1430–1446

    Abstract: Gut microbiota and intestinal barrier co-develop after birth, establishing a homeostatic state whereby mucosal cells cohabit with commensal bacteria. We hypothesized that this post-natal co-development follows different timings depending on the ... ...

    Abstract Gut microbiota and intestinal barrier co-develop after birth, establishing a homeostatic state whereby mucosal cells cohabit with commensal bacteria. We hypothesized that this post-natal co-development follows different timings depending on the intestinal site considered. Jejunal, ileal, and colonic luminal contents and mucosa were sampled in suckling piglets at post-natal day (PND) 0, 2, 7, 14, and 28. Jejunal, ileal, and colonic luminal microbiota (evaluated by 16S DNA sequencing followed by beta-diversity analysis) clustered at PND2 but colonic microbiota diverge afterwards (P < .05). Mucosal permeability, evaluated in Ussing chambers, increased with age in the jejunum and ileum (P < .05) but not the colon. Expression of pattern recognition receptor (PRR) exhibited different patterns (gradual or sharp increase, decrease, or no change with age, P < .05) depending on PRR and intestinal site considered. Principal component analysis of mucosa data revealed clear clustering of colonic samples, irrespective of the age and clustering of jejunal and ileal samples, with gradual changes with age. Correlation analysis highlighted three families correlating with mucosal parameters: Enterobacteriaceae in the jejunum, Peptostreptococcaceae in the ileum, and Micrococcaceae in the colon. In conclusion, small and large intestine display close microbiota composition early in life but distinct mucosal phenotype and follow very different post-natal development.
    MeSH term(s) Animals ; Bacteria/classification ; Bacteria/growth & development ; Colon/microbiology ; Gastrointestinal Microbiome/physiology ; Ileum/microbiology ; Intestinal Mucosa/microbiology ; Jejunum/microbiology ; Swine
    Language English
    Publishing date 2019-12-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.201902514R
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    Zs.A 2266: Show issues Location:
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    Zs.MO 296: Show issues

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  3. Article ; Online: An Unusual Intussusception.

    Merdrignac, Aude / Proisy, Maia / Fremond, Benjamin / Habonimana, Edouard / Nardi, Nicolas / Arnaud, Alexis Pierre

    The Journal of pediatrics

    2016  Volume 175, Page(s) 240–240.e1

    MeSH term(s) Appendix/pathology ; Appendix/surgery ; Barium Enema/methods ; Child ; Humans ; Intussusception/diagnosis ; Intussusception/surgery ; Laparoscopy/methods ; Laparotomy/methods ; Male ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2016-05-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2016.04.034
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  4. Article ; Online: A Preoperative Scoring System for Adnexal Mass in Children and Adolescents to Preserve Their Future Fertility.

    Depoers, Charlotte / Martin, Flore-Anne / Nyangoh Timoh, Krystel / Morcet, Jeff / Proisy, Maia / Henno, Sebastien / Lavoue, Vincent / Arnaud, Alexis Pierre

    Journal of pediatric and adolescent gynecology

    2018  Volume 32, Issue 1, Page(s) 57–63

    Abstract: Study objective: To develop a predictive score for ovarian malignancy to avoid unnecessary adnexectomy in cases of adnexal mass in pediatric and adolescent girls.: Design: A population-based retrospective study on girls who underwent surgery for an ... ...

    Abstract Study objective: To develop a predictive score for ovarian malignancy to avoid unnecessary adnexectomy in cases of adnexal mass in pediatric and adolescent girls.
    Design: A population-based retrospective study on girls who underwent surgery for an ovarian mass with normal levels of human chorionic gonadotrophin and alpha fetoprotein between 1996 and 2016.
    Setting: Rennes University Hospital, Rennes, France.
    Participants: Eighty-one patients who received surgery for ovarian tumor.
    Main outcome measures: The main outcome measure was the rate of malignant and borderline tumor. A preoperative scoring system was constructed after multivariate analysis.
    Results: The rate of malignant ovarian tumor was 6/81 (7%), borderline tumor was 7/81 (9%) (ie, outcome measure: 16%), and benign tumor was 84%. In a univariate analysis, the characteristics significantly associated with malignancy were early puberty, palpable mass, size and content of the tumor, and positive epithelial tumor markers (carcinoma antigen 125, carcinoembryonic antigen, and carcinoma antigen 19-9). The predictive malignancy score was on the basis of 2 variables obtained after multivariate analysis: tumor size and cystic content. The score defined 3 groups at risk for malignancy: low risk, middle-risk, and high-risk. The sensitivity for detecting malignancy was 1.3% (95% confidence interval [CI], 0.1-18.4), 26.2% (95% CI, 11.6-49.0), and 53.1% (95% CI, 29.1-75.8), respectively.
    Conclusion: We set up a simple predictive score of malignancy on the basis of objective criteria to help decision-making on whether or not ovarian-sparing surgery is feasible in case of children and adolescents with ovarian tumors and normal human chorionic gonadotrophin and alpha fetoprotein levels while ensuring oncologic safety.
    MeSH term(s) Adnexal Diseases/diagnosis ; Adnexal Diseases/pathology ; Adnexal Diseases/surgery ; Adolescent ; Adult ; Biomarkers, Tumor/blood ; Child ; Child, Preschool ; Female ; Fertility Preservation/methods ; France ; Humans ; Infant ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/surgery ; Preoperative Care/methods ; Retrospective Studies ; Sensitivity and Specificity ; Young Adult
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2018-09-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1325079-6
    ISSN 1873-4332 ; 1083-3188
    ISSN (online) 1873-4332
    ISSN 1083-3188
    DOI 10.1016/j.jpag.2018.08.009
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    Zs.A 2337: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Laparoscopic Ladd's procedure for malrotation in infants and children is still a controversial approach.

    Arnaud, Alexis Pierre / Suply, Etienne / Eaton, Simon / Blackburn, Simon C / Giuliani, Stefano / Curry, Joe Igniatius / Cross, Kate M / De Coppi, Paolo

    Journal of pediatric surgery

    2018  Volume 54, Issue 9, Page(s) 1843–1847

    Abstract: Background: Open Ladd's procedure is the gold standard for the correction of intestinal malrotation and laparoscopic approach remains controversial. This study aimed to evaluate our experience in laparoscopic management of malrotation.: Methods: ... ...

    Abstract Background: Open Ladd's procedure is the gold standard for the correction of intestinal malrotation and laparoscopic approach remains controversial. This study aimed to evaluate our experience in laparoscopic management of malrotation.
    Methods: Single center retrospective study including patients who underwent a laparoscopic assessment of intestinal malrotation with correction if appropriate between 2007 and 2017.
    Results: Sixty-five patients (median age 7 months) had a laparoscopic assessment with and without correction of malrotation. Forty-five (69%) were symptomatic, including 16 (25%) with a midgut volvulus. The procedure was completed laparoscopically in 55 (86%) patients in 110 min (30-190). Conversions happened more frequently at the beginning of the experience. With a follow-up of 12.5 months (8 days-5.3 years), morbidity rate was 15% and 4 (6%) patients underwent a redo surgery, all in the first 5 months after surgery, compared with 3/53 (6%) in a contemporaneous group undergoing open Ladd's.
    Conclusion: This is the largest series reported so far of the laparoscopic management of malrotation. Laparoscopic Ladd's procedure is reliable but still exposes to open conversion which may be in part owing to a learning curve. A low conversion threshold is important in cases with volvulus. The redo rate is similar to that of the open procedure.
    Level of evidence: Level III retrospective comparative treatment study.
    MeSH term(s) Child, Preschool ; Digestive System Surgical Procedures/adverse effects ; Digestive System Surgical Procedures/methods ; Digestive System Surgical Procedures/statistics & numerical data ; Humans ; Infant ; Intestinal Volvulus/surgery ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Laparoscopy/statistics & numerical data ; Postoperative Complications ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2018-10-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2018.09.023
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    Zs.A 607: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Transvesical Intra-Abdominal Pressure Measurement in Newborn: What Is the Optimal Saline Volume Instillation?

    Defontaine, Anne / Tirel, Olivier / Costet, Nathalie / Beuchée, Alain / Ozanne, Bruno / Gaillot, Théophile / Arnaud, Alexis Pierre / Wodey, Eric

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2016  Volume 17, Issue 2, Page(s) 144–149

    Abstract: Objective: To determine the optimal saline volume bladder instillation to measure intravesical pressure in critically ill newborns weighing less than 4.5 kg, and to establish a reference of intra-abdominal pressure value in this population.: Design: ... ...

    Abstract Objective: To determine the optimal saline volume bladder instillation to measure intravesical pressure in critically ill newborns weighing less than 4.5 kg, and to establish a reference of intra-abdominal pressure value in this population.
    Design: Prospective monocentric study.
    Setting: Neonatal ICU and PICU.
    Patients: Newborns, premature or not, weighing less than 4.5 kg who required a urethral catheter.
    Measurements and main results: Patients were classified into two groups according to whether they presented a risk factor for intra-abdominal hypertension. Nine intravesical pressure measures per patient were performed after different volume saline instillation. The first one was done without saline instillation and then by increments of 0.5 mL/kg to a maximum of 4 mL/kg. Linear models for repeated measurements of intravesical pressure with unstructured covariance were used to analyze the variation of intravesical pressure measures according to the conditions of measurement (volume instilled). Pairwise comparisons of intravesical pressure adjusted mean values between instillation volumes were done using Tukey tests, corrected for multiple testing to determine an optimal instillation volume. Forty-seven patients with completed measures (nine instillations volumes) were included in the analysis. Mean intravesical pressure values were not significantly different when measured after instillation of 0.5, 1, or 1.5 mL/kg, whereas measures after instillation of 2 mL/kg or more were significantly higher. The median intravesical pressure value in the group without intra-abdominal hypertension risk factor after instillation of 1 mL/kg was 5 mm Hg (2-6 mm Hg).
    Conclusions: The optimal saline volume bladder instillation to measure intra-abdominal pressure in newborns weighing less than 4.5 kg was 1 mL/kg. Reference intra-abdominal pressure in this population was found to be 5 mm Hg (2-6 mm Hg).
    MeSH term(s) Abdomen/physiology ; Administration, Intravesical ; Critical Illness ; Female ; Humans ; Infant, Newborn ; Intensive Care Units, Neonatal ; Male ; Pressure ; Prospective Studies ; Reference Values ; Sodium Chloride/administration & dosage ; Urinary Bladder/physiopathology
    Chemical Substances Sodium Chloride (451W47IQ8X)
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000000580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 472: Show issues

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