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  1. AU="Arnaud Gautier"
  2. AU="Leary Peter"
  3. AU="Currò, Mariaconcetta"
  4. AU=Schulte Ryan T
  5. AU=Wichmann D
  6. AU="Arora, Prateek"
  7. AU="Junqueira, Helena Couto"
  8. AU="Kataria, Saurabh"
  9. AU=Wang Xia AU=Wang Xia
  10. AU="Tonnesen, Morten"
  11. AU="Ebrahimi-Fakhari, Darius"
  12. AU="Kalinich, Chaney C"
  13. AU="O'Neal, David N"
  14. AU="Bennett, Matthew R"
  15. AU="Chagas, Mariana W"

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  1. Artikel ; Online: Author Correction

    Alison G. Tebo / Arnaud Gautier

    Nature Communications, Vol 10, Iss 1, Pp 1-

    A split fluorescent reporter with rapid and reversible complementation

    2019  Band 2

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-08-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: A split fluorescent reporter with rapid and reversible complementation

    Alison G. Tebo / Arnaud Gautier

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 8

    Abstract: Monitoring protein-protein interactions via bimolecular fluorescence complementation is often limited by the slow kinetics and irreversibility of the complementation. Here the authors introduce a fluorescent reporter for real-time monitoring of ... ...

    Abstract Monitoring protein-protein interactions via bimolecular fluorescence complementation is often limited by the slow kinetics and irreversibility of the complementation. Here the authors introduce a fluorescent reporter for real-time monitoring of reversible interactions based on complementation and binding of an exogenous chromophore.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-06-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: A split fluorescent reporter with rapid and reversible complementation

    Alison G. Tebo / Arnaud Gautier

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 8

    Abstract: Monitoring protein-protein interactions via bimolecular fluorescence complementation is often limited by the slow kinetics and irreversibility of the complementation. Here the authors introduce a fluorescent reporter for real-time monitoring of ... ...

    Abstract Monitoring protein-protein interactions via bimolecular fluorescence complementation is often limited by the slow kinetics and irreversibility of the complementation. Here the authors introduce a fluorescent reporter for real-time monitoring of reversible interactions based on complementation and binding of an exogenous chromophore.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-06-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Author Correction

    Alison G. Tebo / Arnaud Gautier

    Nature Communications, Vol 10, Iss 1, Pp 1-

    A split fluorescent reporter with rapid and reversible complementation

    2019  Band 2

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-08-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Acceptability of mandatory vaccination against influenza, measles, pertussis and varicella by workers in healthcare facilities

    Sophie Vaux / Laure Fonteneau / Muriel Péfau / Anne-Gaëlle Venier / Arnaud Gautier / Sophan Soing Altrach / Pierre Parneix / Daniel Levy-Bruhl

    Archives of Public Health, Vol 81, Iss 1, Pp 1-

    a national cross-sectional study, France, 2019

    2023  Band 14

    Abstract: Abstract Background Vaccination of healthcare workers (HCW) aims to protect them and to reduce transmission to susceptible patients. Influenza, measles, pertussis, and varicella vaccinations are recommended but not mandatory for HCW in France. ... ...

    Abstract Abstract Background Vaccination of healthcare workers (HCW) aims to protect them and to reduce transmission to susceptible patients. Influenza, measles, pertussis, and varicella vaccinations are recommended but not mandatory for HCW in France. Insufficient vaccine coverage for these diseases in HCW has raised the question of introducing mandatory vaccination. We conducted a survey to estimate acceptability of mandatory vaccination for these four vaccines by HCW working in healthcare facilities (HCF) in France, and to identify associated determinants. Methods In 2019, we performed a cross-sectional survey of physicians, nurses, midwives and nursing assistants working in HCF in France using a randomised stratified three-stage sampling design (HCF type, ward category, HCW category). Data were collected in face-to-face interviews using a tablet computer. We investigated the possible determinants of acceptability of mandatory vaccination using univariate and multivariate Poisson regressions, and estimated prevalence ratios (PR). Results A total of 8594 HCW in 167 HCF were included. For measles, pertussis, and varicella, self-reported acceptability of mandatory vaccination (very or quite favourable) was 73.1% [CI95%: 70.9–75.1], 72.1% [69.8–74.3], and 57.5% [54.5–57.7], respectively. Acceptability varied according to i) HCW and ward category for these three vaccinations, ii) age group for measles and pertussis, and iii) sex for varicella. For mandatory influenza vaccination, acceptability was lower (42.7% [40.6–44.9]), and varied greatly between HCW categories (from 77.2% for physicians to 32.0% for nursing assistants). Conclusion HCW acceptability of mandatory vaccination was high for measles, pertussis and varicella but not as high for influenza. Vaccination for COVID-19 is mandatory for HCW in France. Replication of this study after the end of the COVID-19 crisis would help assess whether the pandemic had an impact on their acceptability of mandatory vaccination, in particular for influenza.
    Schlagwörter Mandatory vaccination ; Acceptability ; Measles ; Varicella ; Pertussis ; Influenza ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 380
    Sprache Englisch
    Erscheinungsdatum 2023-04-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Increased awareness and knowledge of Lyme Borreliosis and tick bite prevention among the general population in France

    Alexandra Septfons / Julie Figoni / Arnaud Gautier / Noémie Soullier / Henriette de Valk / Jean-Claude Desenclos

    BMC Public Health, Vol 21, Iss 1, Pp 1-

    2016 and 2019 health barometer survey

    2021  Band 15

    Abstract: Abstract Background Lyme borreliosis (LB) is the most frequent tick-borne disease in France. In the absence of a vaccine, LB prevention mainly relies on reducing tick bites. In 2016, the French Ministry of Health launched a national plan against tick- ... ...

    Abstract Abstract Background Lyme borreliosis (LB) is the most frequent tick-borne disease in France. In the absence of a vaccine, LB prevention mainly relies on reducing tick bites. In 2016, the French Ministry of Health launched a national plan against tick-borne infections, including a prevention component. To evaluate the impact of this prevention strategy, we assessed knowledge and practices of tick bite prevention using the 2016 and 2019 national surveys on health attitudes and beliefs known as the French Health Barometer. Methods The Health Barometer is a repeated nationwide phone survey conducted annually on a random sample aged 18 to 75 years living in mainland France. In 2016 and 2019, participants were asked, among others, about their exposure to ticks, their behavior and practices regarding tick bites, and their knowledge about LB and its prevention. Results In 2019, 30% of the population reported a lifetime tick bite and 6% in the last year, an increase from 25% and 4%, respectively, in 2016 (p < 0.001). In 2019, 25% of the population felt exposed to tick bites compared to 23% in 2016 (p < 0.001). The proportion of participants who had heard about LB and who considered themselves well informed respectively increased from 66% and 29% in 2016 to 79% and 41% in 2019, (p < 0.001). In 2019 compared to 2016, a greater part of the French population applied protective measures against tick bites, particularly wearing protective clothing (74% vs 66%, p < 0.001) and regular tick checks and prompt tick removal after exposure (54% vs 47%, p < 0.001). Conclusions A substantial proportion of French residents are exposed to tick bites and apply protective measures. Our findings indicate a trend toward an increased knowledge and awareness of tick bites and LB between 2016 and 2019 in France. Our results can be used to target future information campaigns to specific age groups or at-risk areas in addition to the general population. However, we need to further study the barriers to the use of preventive ...
    Schlagwörter Lyme Borreliosis ; Tick bites ; Epidemiology ; Prevention ; Knowledge ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2021-10-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Influenza vaccination coverage of professionals working in nursing homes in France and related determinants, 2018–2019 season

    Sophie Vaux / Laure Fonteneau / Anne-Gaëlle Venier / Arnaud Gautier / Sophan Soing Altrach / Pierre Parneix / Daniel Lévy-Bruhl

    BMC Public Health, Vol 22, Iss 1, Pp 1-

    a cross-sectional survey

    2022  Band 11

    Abstract: Abstract Background The burden of influenza morbidity and mortality in nursing homes (NH) is high. Vaccination of residents and professionals working in NH is the main prevention strategy. Despite recommendations, vaccination coverage among professionals ...

    Abstract Abstract Background The burden of influenza morbidity and mortality in nursing homes (NH) is high. Vaccination of residents and professionals working in NH is the main prevention strategy. Despite recommendations, vaccination coverage among professionals is generally low. Methods We performed a nationwide cross-sectional survey of NH using a single-stage stratified random sampling design to estimate influenza vaccination coverage in NH healthcare workers (HCW) and non-medical professionals in France during the 2018–2019 season, and to identify measures likely to increase it. For each NH, a questionnaire was completed with aggregated data by one member of the management team. A multivariate analysis was performed using a negative binomial regression. Results Five-hundred and eighty nine NH filled in the study questionnaire (response rate: 49.5%). When considering all professionals (i.e., HCW and non-medical professionals), overall vaccination coverage was 30.6% (95%CI [28.2–33.0], range: 1.6–96.2). Overall influenza vaccination coverage in HCW was 31.9% [29.7–34.1]. It varied according to occupational category: 75.5% [69.3–81.7] for physicians, 42.9% [39.4–46.4] for nurses, 26.7% [24.5–29.0] for nursing assistants, and 34.0% [30.1–38.0] for other paramedical personnel. Vaccination coverage was higher i) in private nursing homes (RRa: 1.3, [1.1–1.5]), ii) in small nursing homes (0.9 [0.8–0.9]), iii) when vaccination was offered free of charge (1.4, [1.1–1.8]), iv) when vaccination promotion for professionals included individual (1.6 [1.1–2.1]) or collective (1.3 [1.1–1.5]) information sessions, videos or games (1.4 [1.2–1.6], v) when information on influenza vaccines was provided (1.2 [1.0–1.3], and finally, vi) when a vaccination point of contact—defined as an HCW who could provide reliable information on vaccination—was nominated within the nursing home (1.7 [1.3–2.2]). Conclusions Urgent and innovative actions are required to increase coverage in HCW. Vaccination programmes should include free on-site ...
    Schlagwörter Vaccination ; Influenza ; Nursing homes ; Healthcare workers ; Vaccine coverage ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Fluorogenic Labeling Strategies for Biological Imaging

    Chenge Li / Alison G. Tebo / Arnaud Gautier

    International Journal of Molecular Sciences, Vol 18, Iss 7, p

    2017  Band 1473

    Abstract: The spatiotemporal fluorescence imaging of biological processes requires effective tools to label intracellular biomolecules in living systems. This review presents a brief overview of recent labeling strategies that permits one to make protein and RNA ... ...

    Abstract The spatiotemporal fluorescence imaging of biological processes requires effective tools to label intracellular biomolecules in living systems. This review presents a brief overview of recent labeling strategies that permits one to make protein and RNA strongly fluorescent using synthetic fluorogenic probes. Genetically encoded tags selectively binding the exogenously applied molecules ensure high labeling selectivity, while high imaging contrast is achieved using fluorogenic chromophores that are fluorescent only when bound to their cognate tag, and are otherwise dark. Beyond avoiding the need for removal of unbound synthetic dyes, these approaches allow the development of sophisticated imaging assays, and open exciting prospects for advanced imaging, particularly for multiplexed imaging and super-resolution microscopy.
    Schlagwörter fluorogenic probes ; protein labeling ; RNA labeling ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2017-07-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Fluorescent secreted bacterial effectors reveal active intravacuolar proliferation of Listeria monocytogenes in epithelial cells.

    Caroline Peron-Cane / José-Carlos Fernandez / Julien Leblanc / Laure Wingertsmann / Arnaud Gautier / Nicolas Desprat / Alice Lebreton

    PLoS Pathogens, Vol 16, Iss 10, p e

    2020  Band 1009001

    Abstract: Real-time imaging of bacterial virulence factor dynamics is hampered by the limited number of fluorescent tools suitable for tagging secreted effectors. Here, we demonstrated that the fluorogenic reporter FAST could be used to tag secreted proteins, and ... ...

    Abstract Real-time imaging of bacterial virulence factor dynamics is hampered by the limited number of fluorescent tools suitable for tagging secreted effectors. Here, we demonstrated that the fluorogenic reporter FAST could be used to tag secreted proteins, and we implemented it to monitor infection dynamics in epithelial cells exposed to the human pathogen Listeria monocytogenes (Lm). By tracking individual FAST-labelled vacuoles after Lm internalisation into cells, we unveiled the heterogeneity of residence time inside entry vacuoles. Although half of the bacterial population escaped within 13 minutes after entry, 12% of bacteria remained entrapped over an hour inside long term vacuoles, and sometimes much longer, regardless of the secretion of the pore-forming toxin listeriolysin O (LLO). We imaged LLO-FAST in these long-term vacuoles, and showed that LLO enabled Lm to proliferate inside these compartments, reminiscent of what had been previously observed for Spacious Listeria-containing phagosomes (SLAPs). Unexpectedly, inside epithelial SLAP-like vacuoles (eSLAPs), Lm proliferated as fast as in the host cytosol. eSLAPs thus constitute an alternative replication niche in epithelial cells that might promote the colonization of host tissues.
    Schlagwörter Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2020-10-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel: Use of an Air-Stable Cu(I)-NHC Catalyst for the Synthesis of Peptidotriazoles

    Bruyat, Pierrick / Arnaud Gautier / Ludovic Jean / Pierre-Yves Renard

    Journal of organic chemistry. 2018 Oct. 03, v. 83, no. 21

    2018  

    Abstract: We report the use of air-stable Cu(I)-NHC complex 4a as a catalyst for the efficient microwave-assisted synthesis of peptidotriazoles on solid phase. Compared with the usual conditions (CuI or CuSO4/NaAsc), catalyst 4a allowed the preparation of a series ...

    Abstract We report the use of air-stable Cu(I)-NHC complex 4a as a catalyst for the efficient microwave-assisted synthesis of peptidotriazoles on solid phase. Compared with the usual conditions (CuI or CuSO4/NaAsc), catalyst 4a allowed the preparation of a series of peptidomimetic compounds containing a 1,2,3-triazole ring in their backbone without the oxidation of common side-chains. Overall, the peptidotriazoles were obtained in good yields (61–87%), in excellent purity (higher than 94%) and with low copper contamination.
    Schlagwörter catalysts ; chemical structure ; copper ; microwave treatment ; organic chemistry ; oxidation ; triazoles
    Sprache Englisch
    Erscheinungsverlauf 2018-1003
    Umfang p. 13515-13522.
    Erscheinungsort American Chemical Society
    Dokumenttyp Artikel
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.8b01490
    Datenquelle NAL Katalog (AGRICOLA)

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