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Article ; Online: Telomeres: New players in immune-mediated inflammatory diseases?

Heba, Anne-Charlotte / Toupance, Simon / Arnone, Djésia / Peyrin-Biroulet, Laurent / Benetos, Anthanase / Ndiaye, Ndeye Coumba

Journal of autoimmunity

2021 Volume 123, Page(s) 102699

Abstract: Telomeres are repetitive DNA sequences located at the ends of linear chromosomes that preserve the integrity and stability of the genome. Telomere dysfunctions due to short telomeres or altered telomere structures can ultimately lead to replicative ... ...

Abstract	Telomeres are repetitive DNA sequences located at the ends of linear chromosomes that preserve the integrity and stability of the genome. Telomere dysfunctions due to short telomeres or altered telomere structures can ultimately lead to replicative cellular senescence and chromosomal instability, both mechanisms being hallmarks of ageing. Chronic inflammation, oxidative stress and finally telomere length (TL) dynamics have been shown to be involved in various age-related non-communicable diseases (NCDs). Immune-mediated inflammatory diseases (IMIDs), including affections such as inflammatory bowel disease, psoriasis, rheumatoid arthritis, spondyloarthritis and uveitis belong to this group of age-related NCDs. Although in recent years, we have witnessed the emergence of studies in the literature linking these IMIDs to TL dynamics, the causality between these diseases and telomere attrition is still unclear and controversial. In this review, we provide an overview of available studies on telomere dynamics and discuss the utility of TL measurements in immune-mediated inflammatory diseases.
MeSH term(s)	Arthritis, Rheumatoid/etiology ; Humans ; Inflammation/etiology ; Inflammation/immunology ; Inflammatory Bowel Diseases/etiology ; Psoriasis/etiology ; Spondylarthritis/etiology ; Telomere/physiology ; Uveitis/etiology
Language	English
Publishing date	2021-07-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	639452-8
ISSN	1095-9157 ; 0896-8411
ISSN (online)	1095-9157
ISSN	0896-8411
DOI	10.1016/j.jaut.2021.102699
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Article ; Online: Food avoidance and fasting in patients with inflammatory bowel disease: Experience from the Nancy IBD nutrition clinic.

Bonsack, Olivier / Caron, Bénédicte / Baumann, Cedric / Heba, Anne Charlotte / Vieujean, Sophie / Arnone, Djesia / Netter, Patrick / Danese, Silvio / Quilliot, Didier / Peyrin-Biroulet, Laurent

United European gastroenterology journal

2023 Volume 11, Issue 4, Page(s) 361–370

Abstract: Background: Patients with inflammatory bowel disease (IBD) consider that their diet is important for controlling symptoms and frequently ask their physician for additional guidance on this matter. The objectives of the present study of patients with IBD ...

Abstract	Background: Patients with inflammatory bowel disease (IBD) consider that their diet is important for controlling symptoms and frequently ask their physician for additional guidance on this matter. The objectives of the present study of patients with IBD were to characterize the prevalence of exclusion diets and fasting and to identify associated risk factors. Methods: Using an anonymous questionnaire, we screened patients attending our IBD nutrition clinic between November 2021 and April 2022 for exclusion diets. The avoidance of a food category completely was defined as total exclusion and avoidance most of the time was defined as partial exclusion. We also asked patients whether they fasted totally, intermittently, or partially. Result: A total of 434 patients with IBD were included. On inclusion, 159 patients (36.6%) totally excluded at least one food category and 271 (62.4%) partially excluded at least one food. Intermittent, total, or partial fasting was reported by 30.8% of the patients. Disease activity (odds ratio (OR) [95% confidence interval] = 1.7 [1.1-2.7], p = 0.0130) and treatment with a small-molecule or an investigational drug (OR = 4.0 [1.5-10.6], p = 0.0059) were independently associated with an exclusion diet. A history of stenosis (OR = 2.0 [1.2-3.2], p = 0.0063) and active disease (OR = 1.9 [1.2-3.1], p = 0.0059) were associated with fasting. Conclusion: In this real-world study, approximately two-thirds of our patients with IBD reported the partial or total exclusion of at least one food category and one third reported fasting. A systematic nutritional evaluation might improve clinical management and quality of care for patients with IBD both Crohn's disease and ulcerative colitis.
MeSH term(s)	Humans ; Inflammatory Bowel Diseases/therapy ; Inflammatory Bowel Diseases/complications ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/therapy ; Colitis, Ulcerative/complications ; Crohn Disease/therapy ; Crohn Disease/complications ; Food ; Fasting
Language	English
Publishing date	2023-04-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2728585-6
ISSN	2050-6414 ; 2050-6406
ISSN (online)	2050-6414
ISSN	2050-6406
DOI	10.1002/ueg2.12385
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Article ; Online: Calorie Restriction as a New Treatment of Inflammatory Diseases.

Kökten, Tunay / Hansmannel, Franck / Ndiaye, Ndeye Coumba / Heba, Anne-Charlotte / Quilliot, Didier / Dreumont, Natacha / Arnone, Djésia / Peyrin-Biroulet, Laurent

Advances in nutrition (Bethesda, Md.)

2021 Volume 12, Issue 4, Page(s) 1558–1570

Abstract: Immoderate calorie intake coupled with a sedentary lifestyle are major determinants of health issues and inflammatory diseases in modern society. The balance between energy consumption and energy expenditure is critical for longevity. Excessive energy ... ...

Abstract	Immoderate calorie intake coupled with a sedentary lifestyle are major determinants of health issues and inflammatory diseases in modern society. The balance between energy consumption and energy expenditure is critical for longevity. Excessive energy intake and adiposity cause systemic inflammation, whereas calorie restriction (CR) without malnutrition, exerts a potent anti-inflammatory effect. The objective of this review was to provide an overview of different strategies used to reduce calorie intake, discuss physiological mechanisms by which CR might lead to improved health outcomes, and summarize the present knowledge about inflammatory diseases. We discuss emerging data of observational studies and randomized clinical trials on CR that have been shown to reduce inflammation and improve human health.
MeSH term(s)	Adiposity ; Caloric Restriction ; Energy Intake ; Humans ; Longevity ; Obesity
Language	English
Publishing date	2021-01-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2583634-1
ISSN	2156-5376 ; 2156-5376
ISSN (online)	2156-5376
ISSN	2156-5376
DOI	10.1093/advances/nmaa179
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Article: Calorie Restriction as a New Treatment of Inflammatory Diseases

Kökten, Tunay / Hansmannel, Franck / Ndiaye, Ndeye Coumba / Heba, Anne-Charlotte / Quilliot, Didier / Dreumont, Natacha / Arnone, Djésia / Peyrin-Biroulet, Laurent

Advances in nutrition. 2021 Feb. 08, v. 12, no. 4

2021

Abstract	Immoderate calorie intake coupled with a sedentary lifestyle are major determinants of health issues and inflammatory diseases in modern society. The balance between energy consumption and energy expenditure is critical for longevity. Excessive energy intake and adiposity cause systemic inflammation, whereas calorie restriction (CR) without malnutrition, exerts a potent anti-inflammatory effect. The objective of this review was to provide an overview of different strategies used to reduce calorie intake, discuss physiological mechanisms by which CR might lead to improved health outcomes, and summarize the present knowledge about inflammatory diseases. We discuss emerging data of observational studies and randomized clinical trials on CR that have been shown to reduce inflammation and improve human health.
Keywords	adiposity ; anti-inflammatory activity ; energy expenditure ; energy intake ; human health ; inflammation ; longevity ; low calorie diet ; malnutrition ; sedentary lifestyle
Language	English
Dates of publication	2021-0208
Size	p. 1558-1570.
Publishing place	Oxford University Press
Document type	Article
ZDB-ID	2583634-1
ISSN	2156-5376
ISSN	2156-5376
DOI	10.1093/advances/nmaa179
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Article ; Online: The role of platelets and von Willebrand factor in the procoagulant phenotype of inflammatory bowel disease.

Schellenberg, Célia / Lagrange, Jérémy / Ahmed, Muhammad Usman / Arnone, Djésia / Campoli, Philippe / Louis, Huguette / Touly, Nina / Caron, Bénédicte / Plénat, François / Perrin, Julien / Lenting, Peter J / Regnault, Véronique / Lacolley, Patrick / Denis, Cécile V / Peyrin-Biroulet, Laurent

Journal of Crohn's & colitis

2023

Abstract: Objective: Although the risk for thrombosis is well documented for inflammatory bowel disease (IBD) patients, the underlying pathological mechanism seems to be different from other thrombotic conditions. Deciphering the actors responsible for the ... ...

Abstract	Objective: Although the risk for thrombosis is well documented for inflammatory bowel disease (IBD) patients, the underlying pathological mechanism seems to be different from other thrombotic conditions. Deciphering the actors responsible for the increased risk of thrombosis in IBD would help to improve management of this frequent complication. Design: We studied the interplay between platelets, coagulation, and von Willebrand factor (VWF) in 193 IBD patients and in experimental models (acute and chronic) of colitis in wild-type and VWF-deficient mice. Results: We found a platelet-dependent increase in thrombin generation in IBD patients and in our mouse model of colitis. Agglutinated platelets were present in the blood of patients and mice. Interestingly, we observed not only a significant increase in total VWF antigen, but we were able to detect the presence of active VWF (VWF in its platelet-binding conformation; 3.2±2.7µg/ml) in the plasma of 30% of all IBD patients. In healthy controls, active VWF levels were below 0.3µg/ml. This led us to further explore experimental colitis in VWF-deficient mice and we observed that these mice were protected against the procoagulant state triggered by the colitis. Unexpectedly, these mice also manifested a significant worsening of colitis severity both in acute and chronic models. Conclusion: Platelets and VWF (including its active form) appear to be central players in the procoagulant phenotype in IBD. We observed that the role of VWF in hemostasis differs from its role in colic tissue healing, potentially opening new therapeutic avenues for a life-threatening complication in IBD patients.
Language	English
Publishing date	2023-11-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2390120-2
ISSN	1876-4479 ; 1873-9946
ISSN (online)	1876-4479
ISSN	1873-9946
DOI	10.1093/ecco-jcc/jjad198
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Article ; Online: Deep Dive Into MicroRNAs in Inflammatory Bowel Disease.

Alfaifi, Jaber / Germain, Adeline / Heba, Anne-Charlotte / Arnone, Djésia / Gailly, Laura / Ndiaye, Ndeye Coumba / Viennois, Emilie / Caron, Bénédicte / Peyrin-Biroulet, Laurent / Dreumont, Natacha

Inflammatory bowel diseases

2022 Volume 29, Issue 6, Page(s) 986–999

Abstract: Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, is thought to develop in genetically predisposed individuals as a consequence of complex interactions between dysregulated inflammatory stimuli, immunological ... ...

Abstract	Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, is thought to develop in genetically predisposed individuals as a consequence of complex interactions between dysregulated inflammatory stimuli, immunological responses, and environmental factors. The pathogenesis of IBD has yet to be fully understood. The global increase in the incidence of IBD suggests a gap in the current understanding of the disease. The development of a new diagnostic tool for inflammatory bowel disease that is both less invasive and more cost-effective would allow for better management of this condition. MicroRNAs (miRNAs) are a class of noncoding RNAs with important roles as posttranscriptional regulators of gene expression, which has led to new insights into understanding IBD. Using techniques such as microarrays and real-time polymerase chain reactions, researchers have investigated the patterns in which patients with Crohn's disease and ulcerative colitis show alterations in the expression of miRNA in tissue, blood, and feces. These miRNAs are found to be differentially expressed in IBD and implicated in its pathogenesis through alterations in autophagy, intestinal barrier, and immune homeostasis. In this review, we discuss the miRNA expression profiles associated with IBD in tissue, peripheral blood, and feces and provide an overview of the miRNA mechanisms involved in IBD.
MeSH term(s)	Humans ; MicroRNAs/metabolism ; Colitis, Ulcerative/diagnosis ; Crohn Disease/diagnosis ; Inflammatory Bowel Diseases/diagnosis ; Intestines
Chemical Substances	MicroRNAs
Language	English
Publishing date	2022-12-19
Publishing country	England
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1093/ibd/izac250
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Zs.A 4530: Show issues

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Article ; Online: Genomic and molecular alterations in human inflammatory bowel disease-associated colorectal cancer.

Muller, Marie / Hansmannel, Franck / Arnone, Djesia / Choukour, Myriam / Ndiaye, Ndeye Coumba / Kokten, Tunay / Houlgatte, Rémi / Peyrin-Biroulet, Laurent

United European gastroenterology journal

2020 Volume 8, Issue 6, Page(s) 675–684

Abstract: Patients with inflammatory bowel disease are at increased risk of colorectal cancer, which has worse prognosis than sporadic colorectal cancer. Until recently, understanding of pathogenesis in inflammatory bowel disease-associated colorectal cancer was ... ...

Abstract	Patients with inflammatory bowel disease are at increased risk of colorectal cancer, which has worse prognosis than sporadic colorectal cancer. Until recently, understanding of pathogenesis in inflammatory bowel disease-associated colorectal cancer was restricted to the demonstration of chromosomic/microsatellite instabilities and aneuploidy. The advance of high-throughput sequencing technologies has highlighted the complexity of the pathobiology and revealed recurrently mutated genes involved in the RTK/RAS, PI3K, WNT, and TGFβ pathways, leading to potentially new targetable mutations. Moreover, alterations of mitochondrial DNA and the dysregulation of non-coding sequences have also been described, as well as several epigenetic modifications. Although recent studies have brought new insights into pathobiology and raised the prospect of innovative therapeutic approaches, the understanding of colorectal carcinogenesis in inflammatory bowel disease and how it differs from sporadic colorectal cancer remains not fully elucidated. Further studies are required to better understand the pathogenesis and molecular alterations leading to human inflammatory bowel disease-associated colorectal cancer.
MeSH term(s)	Biomarkers, Tumor/genetics ; Carcinogenesis/genetics ; Carcinogenesis/immunology ; Carcinogenesis/pathology ; Colitis, Ulcerative/complications ; Colitis, Ulcerative/genetics ; Colitis, Ulcerative/immunology ; Colitis, Ulcerative/microbiology ; Colitis-Associated Neoplasms/genetics ; Colitis-Associated Neoplasms/immunology ; Colitis-Associated Neoplasms/microbiology ; Colitis-Associated Neoplasms/pathology ; Crohn Disease/complications ; Crohn Disease/genetics ; Crohn Disease/immunology ; Crohn Disease/microbiology ; DNA Mutational Analysis ; DNA, Mitochondrial/genetics ; Epigenesis, Genetic ; Gastrointestinal Microbiome/genetics ; Gastrointestinal Microbiome/immunology ; High-Throughput Nucleotide Sequencing ; Host Microbial Interactions/genetics ; Host Microbial Interactions/immunology ; Humans ; Intestinal Mucosa/immunology ; Intestinal Mucosa/microbiology ; Intestinal Mucosa/pathology ; Mutation ; RNA, Untranslated/genetics ; Signal Transduction/genetics ; Signal Transduction/immunology
Chemical Substances	Biomarkers, Tumor ; DNA, Mitochondrial ; RNA, Untranslated
Language	English
Publishing date	2020-04-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2728585-6
ISSN	2050-6414 ; 2050-6406
ISSN (online)	2050-6414
ISSN	2050-6406
DOI	10.1177/2050640620919254
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Article ; Online: Sugars and Gastrointestinal Health.

Arnone, Djésia / Chabot, Caroline / Heba, Anne-Charlotte / Kökten, Tunay / Caron, Bénédicte / Hansmannel, Franck / Dreumont, Natacha / Ananthakrishnan, Ashwin N / Quilliot, Didier / Peyrin-Biroulet, Laurent

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

2021 Volume 20, Issue 9, Page(s) 1912–1924.e7

Abstract: Sugar overconsumption is linked to a rise in the incidence of noncommunicable diseases such as diabetes, cardiovascular diseases, and cancer. This increased incidence is becoming a real public health problem that is more severe than infectious diseases, ... ...

Abstract	Sugar overconsumption is linked to a rise in the incidence of noncommunicable diseases such as diabetes, cardiovascular diseases, and cancer. This increased incidence is becoming a real public health problem that is more severe than infectious diseases, contributing to 35 million deaths annually. Excessive intake of free sugars can cause many of the same health problems as excessive alcohol consumption. Many recent international recommendations have expressed concerns about sugar consumption in Westernized societies, as current consumption levels represent quantities with no precedent during hominin evolution. In both adults and children, the World Health Organization strongly recommends reducing free sugar intake to <10% of total energy intake and suggests a further reduction to below 5%. Most studies have focused on the deleterious effects of Western dietary patterns on global health and the intestine. Whereas excessive dietary fat consumption is well studied, the specific impact of sugar is poorly described, while refined sugars represent up to 40% of caloric intake within industrialized countries. However, high sugar intake is associated with multiple tissue and organ dysfunctions. Both hyperglycemia and excessive sugar intake disrupt the intestinal barrier, thus increasing gut permeability and causing profound gut microbiota dysbiosis, which results in a disturbance in mucosal immunity that enhances infection susceptibility. This review aims to highlight the roles of different types of dietary carbohydrates and the consequences of their excessive intake for intestinal homeostasis.
MeSH term(s)	Adult ; Cardiovascular Diseases ; Child ; Energy Intake ; Gastrointestinal Tract ; Humans ; Sugars
Chemical Substances	Sugars
Language	English
Publishing date	2021-12-10
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2119789-1
ISSN	1542-7714 ; 1542-3565
ISSN (online)	1542-7714
ISSN	1542-3565
DOI	10.1016/j.cgh.2021.12.011
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Zs.A 5836: Show issues

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Article ; Online: Characteristics of Lymphoma in Patients with Inflammatory Bowel Disease: A Systematic Review.

Muller, Marie / Broséus, Julien / Feugier, Pierre / Thieblemont, Catherine / Beaugerie, Laurent / Danese, Silvio / Arnone, Djésia / Ndiaye, Ndeye Coumba / Kokten, Tunay / Houlgatte, Rémi / Peyrin-Biroulet, Laurent

Journal of Crohn's & colitis

2020 Volume 15, Issue 5, Page(s) 827–839

Abstract: Background: Lymphoma is a dreaded complication of inflammatory bowel diseases [IBD]. Knowledge about lymphoma in patients with IBD is limited to epidemiological data and the description of risk factors. We performed a systematic review to describe the ... ...

Abstract	Background: Lymphoma is a dreaded complication of inflammatory bowel diseases [IBD]. Knowledge about lymphoma in patients with IBD is limited to epidemiological data and the description of risk factors. We performed a systematic review to describe the clinical characteristics and prognosis of lymphoma in patients with IBD. Methods: Electronic databases were searched up to June 1, 2020. All published clinical characteristics of lymphoma occurring in patients with IBD were collected. Results: Eleven studies were included. A total of 589 lymphomas were described in patients with IBD. As seen in de novo lymphoma, non-Hodgkin's lymphoma [NHL] was the most common histological subtype [83.9%]. Diffuse large B-cell lymphoma [DLBCL] and follicular lymphoma were the most well-represented NHL in patients with IBD [30% and 13% respectively]. Two main differences were observed in comparison with de novo lymphoma: primary intestinal lymphoma [PIL] represented a large proportion of lymphoma in patients with IBD [22-75%] whereas mucosa-associated lymphoid tissue [MALT] lymphoma was under-represented. Epstein-Barr virus [EBV]-positive status was observed in a large proportion of tumours [44-75%]. Survival data of lymphoma in patients with IBD were similar to those of de novo lymphoma. Discussion: This systematic review first highlights that PIL [especially DLBCL subtype] is significantly more frequent in patients with IBD and represents the most common entity. Conversely, MALT lymphoma is extremely rare in the IBD population. However, the overall quality of the evidence is low. Further studies are required to better define lymphoma characteristics in patients with IBD.
MeSH term(s)	Humans ; Inflammatory Bowel Diseases/complications ; Lymphoma/etiology ; Prognosis
Language	English
Publishing date	2020-09-18
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	2390120-2
ISSN	1876-4479 ; 1873-9946
ISSN (online)	1876-4479
ISSN	1873-9946
DOI	10.1093/ecco-jcc/jjaa193
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Article ; Online: Paradoxical gastrointestinal effects of interleukin-17 blockers.

Fauny, Marine / Moulin, David / D'Amico, Ferdinando / Netter, Patrick / Petitpain, Nadine / Arnone, Djesia / Jouzeau, Jean-Yves / Loeuille, Damien / Peyrin-Biroulet, Laurent

Annals of the rheumatic diseases

2020 Volume 79, Issue 9, Page(s) 1132–1138

Abstract: Secukinumab, ixekizumab and brodalumab are monoclonal antibody therapies that inhibit interleukin (IL)-17 activity and are widely used for the treatment of psoriasis, psoriatic arthritis and ankylosing spondylitis. The promising efficacy results in ... ...

Abstract	Secukinumab, ixekizumab and brodalumab are monoclonal antibody therapies that inhibit interleukin (IL)-17 activity and are widely used for the treatment of psoriasis, psoriatic arthritis and ankylosing spondylitis. The promising efficacy results in dermatology and rheumatology prompted the evaluation of these drugs in Crohn's disease and ulcerative colitis, but the onset of paradoxical events (disease exacerbation after treatment with a theoretically curative drug) prevented their approval in patients with inflammatory bowel diseases (IBDs). To date, the pathophysiological mechanisms underlying these paradoxical effects are not well defined, and there are no clear guidelines for the management of patients with disease flare or new IBD onset after anti-IL-17 drug therapy. In this review, we summarise the literature on putative mechanisms, the clinical digestive effects after therapy with IL-17 inhibitors and provide guidance for the management of these paradoxical effects in clinical practice.
MeSH term(s)	Adult ; Antibodies, Monoclonal, Humanized/adverse effects ; Antirheumatic Agents/adverse effects ; Arthritis, Psoriatic/drug therapy ; Colitis, Ulcerative/drug therapy ; Crohn Disease/drug therapy ; Female ; Humans ; Inflammatory Bowel Diseases/chemically induced ; Interleukin-17/antagonists & inhibitors ; Male ; Middle Aged ; Psoriasis/drug therapy ; Randomized Controlled Trials as Topic ; Spondylitis, Ankylosing/drug therapy ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal, Humanized ; Antirheumatic Agents ; Interleukin-17 ; brodalumab (6ZA31Y954Z) ; ixekizumab (BTY153760O) ; secukinumab (DLG4EML025)
Keywords	covid19
Language	English
Publishing date	2020-07-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/annrheumdis-2020-217927
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