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  1. Article ; Online: Risks and Burdens of Unplanned Heart Failure Readmissions: How to Cut a Gordian Knot?

    Nolan, Mark / Arnott, Clare

    Heart, lung & circulation

    2023  Volume 32, Issue 8, Page(s) 891–893

    MeSH term(s) Humans ; Patient Readmission ; Heart Failure/therapy
    Language English
    Publishing date 2023-09-04
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 2020980-0
    ISSN 1444-2892 ; 1443-9506
    ISSN (online) 1444-2892
    ISSN 1443-9506
    DOI 10.1016/j.hlc.2023.08.002
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    Zs.A 4988: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Good for your heart and safe for your toes: a patient-level meta-analysis of DAPA-HF and DELIVER.

    Arnott, Clare / Neal, Bruce

    European heart journal

    2023  Volume 44, Issue 24, Page(s) 2184–2186

    MeSH term(s) Humans ; Heart Failure ; Heart ; Toes ; Peripheral Arterial Disease
    Chemical Substances dapagliflozin (1ULL0QJ8UC)
    Language English
    Publishing date 2023-05-23
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad315
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    Zs.A 1563: Show issues Location:
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    Zs.MO 640: Show issues

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  3. Article ; Online: Management of chronic breathlessness in primary care: what do GPs, non-GP specialists, and allied health professionals think?

    Sunjaya, Anthony / Martin, Allison / Arnott, Clare / Jenkins, Christine

    Australian journal of primary health

    2023  Volume 29, Issue 4, Page(s) 375–384

    Abstract: Background: To explore the perspectives of GPs, non-GP specialists, and allied health professionals on the role of primary care in diagnosing and managing chronic breathlessness, the barriers faced, and the resources needed to optimise care of patients ... ...

    Abstract Background: To explore the perspectives of GPs, non-GP specialists, and allied health professionals on the role of primary care in diagnosing and managing chronic breathlessness, the barriers faced, and the resources needed to optimise care of patients with chronic breathlessness.
    Methods: This was a qualitative study involving focus group discussions that included 35GPs, non-GP specialists, and allied health professionals. Topics explored included: (1) views on the role of primary care in diagnosing and managing chronic breathlessness; (2) barriers to optimal assessment in primary care; and (3) facilitators to further optimise the care of patients with chronic breathlessness.
    Results: All participants considered that primary care has a central role to play in the assessment and management of chronic breathlessness, but greater access to referral services, suitable funding structures, and upskilling on the use of diagnostic tests such as spirometry and electrocardiography are required for this to be realised. Both GPs and non-GP specialists described great potential for developing better linkages, including new ways of referral and online consultations, greater ease of referral to allied health services, even if conducted virtually, for patients with functional causes of breathlessness. Participants identified a need to develop integrated breathlessness clinics for patients referred by GPs, which would ensure patients receive optimal care in the shortest possible time frame.
    Conclusions: GPs are crucial to achieving optimal care for breathless patients, especially given the multifactorial and multimorbid nature of breathlessness; however, there are significant gaps in services and resources at present that limit their ability to perform this role.
    MeSH term(s) Humans ; Dyspnea/diagnosis ; Dyspnea/therapy ; Allied Health Personnel ; Qualitative Research ; Referral and Consultation ; Primary Health Care ; General Practitioners
    Language English
    Publishing date 2023-01-22
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2566332-X
    ISSN 1836-7399 ; 1448-7527
    ISSN (online) 1836-7399
    ISSN 1448-7527
    DOI 10.1071/PY22018
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  4. Article ; Online: Reassurance for parents with children bornvia assisted reproductive technology or too soon to tell?

    Lawley, Claire M / Arnott, Clare / Figtree, Gemma A

    European heart journal

    2023  Volume 44, Issue 16, Page(s) 1474–1476

    MeSH term(s) Humans ; Child ; Reproductive Techniques, Assisted ; Parents ; Cohort Studies ; Cardiovascular Diseases
    Language English
    Publishing date 2023-03-09
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehac827
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    Zs.A 1563: Show issues Location:
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  5. Article ; Online: Prediction of new-onset heart failure in patients with type 2 diabetes derived from ALTITUDE and CANVAS.

    Said, Fatema / Arnott, Clare / Voors, Adriaan A / Heerspink, Hiddo J L / Ter Maaten, Jozine M

    Diabetes, obesity & metabolism

    2024  

    Abstract: Aim: To create and validate a prediction model to identify patients with type 2 diabetes (T2D) at high risk of new-onset heart failure (HF), including those treated with a sodium-glucose cotransporter-2 (SGLT2) inhibitor.: Methods: A prediction model ...

    Abstract Aim: To create and validate a prediction model to identify patients with type 2 diabetes (T2D) at high risk of new-onset heart failure (HF), including those treated with a sodium-glucose cotransporter-2 (SGLT2) inhibitor.
    Methods: A prediction model was developed from the Aliskiren Trial in Type 2 Diabetes Using Cardiorenal Endpoints (ALTITUDE), a trial in T2D patients with albuminuria or cardiovascular disease. We included 5081 patients with baseline N-terminal pro B-type natriuretic peptide (NT-proBNP) measurement and no history of HF. The model was developed using Cox regression and validated externally in the placebo arm of the Canagliflozin Cardiovascular Assessment Study (CANVAS), which included 996 participants with T2D and established cardiovascular disease or high cardiovascular risk, and in patients treated with canagliflozin.
    Results: ALTITUDE participants (mean age 64 ± 9.8 years) had a median serum NT-proBNP level of 157 (25th-75th percentile 70-359) pg/mL. Higher NT-proBNP level, troponin T (TnT) level and body mass index (BMI) emerged as significant and independent predictors of new-onset HF in both cohorts. The model further contained urinary albumin-to-creatinine ratio, glycated haemoglobin, age, haematocrit, and use of calcium channel blockers. A prediction model including these variables had a C-statistic of 0.828 (95% confidence interval [CI] 0.801-0.855) in ALTITUDE and 0.800 (95% CI 0.720-0.880) in CANVAS. The C-statistic of this model increased to 0.847 (95% CI 0.792-0.902) in patients after 1 year of canagliflozin treatment.
    Conclusion: In patients with T2D, higher NT-proBNP level, TnT level and BMI are independent and externally validated predictors of new-onset HF, including patients using an SGLT2 inhibitor. This newly developed model may identify patients at high risk of new-onset HF, contributing to early recognition and possibly prevention.
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.15592
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    Zs.A 5442: Show issues Location:
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  6. Article ; Online: "It's like a forgotten issue sometimes …": Qualitative study of individuals living and caring for people with chronic breathlessness.

    Sunjaya, Anthony / Martin, Allison / Arnott, Clare / Marks, Guy / Jenkins, Christine

    The clinical respiratory journal

    2023  Volume 17, Issue 7, Page(s) 694–700

    Abstract: Introduction: This study aims to explore the perspectives of patients and carers with chronic breathlessness on current provision of care, care expectations, and self-management needs to develop relevant health services and resources to improve clinical ...

    Abstract Introduction: This study aims to explore the perspectives of patients and carers with chronic breathlessness on current provision of care, care expectations, and self-management needs to develop relevant health services and resources to improve clinical outcomes.
    Methods: In-depth semistructured interviews were conducted on patients living with chronic breathlessness and carers.
    Results: Thirteen patients (cardiac, respiratory, and noncardiorespiratory) and two carers were interviewed (mean age 57 years, 47% female, median duration with breathlessness 5 years). Four main themes were identified: (1) living with breathlessness, (2) diagnosis delays, misdiagnosis, and knowledge gaps, (3) beyond curing disease: symptom relief and improving quality of life, and (4) self-management and limited support for it.
    Conclusion: Breathlessness has a high personal impact but remains a neglected condition in Australia. Patients suffer from lack of personal, community, and provider awareness, discontinuity of care, and too few clinical and self-management options.
    MeSH term(s) Humans ; Female ; Middle Aged ; Male ; Quality of Life ; Dyspnea/diagnosis ; Dyspnea/etiology ; Dyspnea/therapy ; Caregivers ; Australia/epidemiology ; Qualitative Research ; Pulmonary Disease, Chronic Obstructive/therapy
    Language English
    Publishing date 2023-06-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2442214-9
    ISSN 1752-699X ; 1752-6981
    ISSN (online) 1752-699X
    ISSN 1752-6981
    DOI 10.1111/crj.13652
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  7. Article: Sodium Glucose Cotransporter 2 Inhibitors, Amputation Risk, and Fracture Risk.

    Arnott, Clare / Fletcher, Robert A / Neal, Bruce

    Heart failure clinics

    2022  Volume 18, Issue 4, Page(s) 645–654

    Abstract: Sodium glucose cotransporter 2 (SGLT2) inhibitors are associated with cardiovascular and renal benefits across a broad range of patients, with no increase in total serious adverse events. We evaluated the evidence with respect to amputation and fracture ... ...

    Abstract Sodium glucose cotransporter 2 (SGLT2) inhibitors are associated with cardiovascular and renal benefits across a broad range of patients, with no increase in total serious adverse events. We evaluated the evidence with respect to amputation and fracture risks for this drug class. Overall, SGLT2 inhibitors are not associated with an increased risk of amputation or fracture in any of the patient populations they have been tested in. The increase in amputation and fracture risks with canagliflozin observed in the CANagliflozin cardioVascular Assessment Study (CANVAS) program was not seen in the Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation trial or any study of other SGLT2 inhibitors. Extensive evaluation of amputation and fracture risks suggests that the CANVAS program findings were chance observations rather than real effects.
    MeSH term(s) Amputation/statistics & numerical data ; Canagliflozin/adverse effects ; Clinical Trials as Topic ; Fractures, Bone/epidemiology ; Humans ; Risk Assessment ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors ; Canagliflozin (0SAC974Z85)
    Language English
    Publishing date 2022-10-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2212019-1
    ISSN 1551-7136
    ISSN 1551-7136
    DOI 10.1016/j.hfc.2022.03.008
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    Zs.A 6554: Show issues Location:
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  8. Article ; Online: Radial First in Primary Percutaneous Coronary Intervention-Ensuring At-Risk Groups Aren't Left Behind.

    Toomath, Shamus / Arnott, Clare / Patel, Sanjay

    Heart, lung & circulation

    2022  Volume 31, Issue 8, Page(s) 1047–1048

    MeSH term(s) Coronary Angiography ; Femoral Artery ; Humans ; Percutaneous Coronary Intervention ; Radial Artery ; Treatment Outcome
    Language English
    Publishing date 2022-06-09
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 2020980-0
    ISSN 1444-2892 ; 1443-9506
    ISSN (online) 1444-2892
    ISSN 1443-9506
    DOI 10.1016/j.hlc.2022.05.039
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    Zs.A 4988: Show issues Location:
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  9. Article ; Online: A Novel Cardioprotective Therapy That Also Improves Glycemia.

    Neal, Bruce / Arnott, Clare

    JAMA

    2020  Volume 323, Issue 14, Page(s) 1349–1350

    MeSH term(s) Benzhydryl Compounds ; Blood Glucose ; Diabetes Mellitus ; Glucosides ; Heart Failure ; Humans
    Chemical Substances Benzhydryl Compounds ; Blood Glucose ; Glucosides ; dapagliflozin (1ULL0QJ8UC)
    Language English
    Publishing date 2020-03-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.1905
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  10. Article ; Online: Procedural Volumes in the Era of COVID: The Risk Versus Benefit Trade-Off.

    Khandkar, Chinmay / Patel, Sanjay / Arnott, Clare

    Heart, lung & circulation

    2021  Volume 30, Issue 10, Page(s) 1430–1432

    MeSH term(s) COVID-19 ; Cardiology ; Humans ; Infection Control ; SARS-CoV-2
    Language English
    Publishing date 2021-08-05
    Publishing country Australia
    Document type Editorial
    ZDB-ID 2020980-0
    ISSN 1444-2892 ; 1443-9506
    ISSN (online) 1444-2892
    ISSN 1443-9506
    DOI 10.1016/j.hlc.2021.07.012
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