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  1. Article: The Forgotten Disease: A Case of Lemierre's Syndrome with Distal Extremity Involvement.

    Gaskill, John / Aronson, Michael

    Case reports in infectious diseases

    2020  Volume 2020, Page(s) 4346937

    Abstract: Once coined the "Forgotten Disease," Lemierre's syndrome is a rare condition that results from oropharyngeal infection with the gram-negative, ... ...

    Abstract Once coined the "Forgotten Disease," Lemierre's syndrome is a rare condition that results from oropharyngeal infection with the gram-negative, anaerobic
    Language English
    Publishing date 2020-03-16
    Publishing country Egypt
    Document type Case Reports
    ZDB-ID 2627642-2
    ISSN 2090-6633 ; 2090-6625
    ISSN (online) 2090-6633
    ISSN 2090-6625
    DOI 10.1155/2020/4346937
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  2. Article ; Online: Reduction of Raman scattering and fluorescence from anvils in high pressure Raman scattering.

    Dierker, S B / Aronson, M C

    The Review of scientific instruments

    2018  Volume 89, Issue 5, Page(s) 53902

    Abstract: We describe a new design and use of a high pressure anvil cell that significantly reduces the Raman scattering and fluorescence from the anvils in high pressure Raman scattering experiments. The approach is particularly useful in Raman scattering studies ...

    Abstract We describe a new design and use of a high pressure anvil cell that significantly reduces the Raman scattering and fluorescence from the anvils in high pressure Raman scattering experiments. The approach is particularly useful in Raman scattering studies of opaque, weakly scattering samples. The effectiveness of the technique is illustrated with measurements of two-magnon Raman scattering in La
    Language English
    Publishing date 2018-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209865-9
    ISSN 1089-7623 ; 0034-6748
    ISSN (online) 1089-7623
    ISSN 0034-6748
    DOI 10.1063/1.5027722
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  3. Article: Transgalactosidation during lactose hydrolysis.

    ARONSON, M

    Archives of biochemistry and biophysics

    2003  Volume 39, Issue 2, Page(s) 370–378

    MeSH term(s) Animals ; Carbohydrate Metabolism ; Hydrolysis ; Lactose/metabolism
    Chemical Substances Lactose (J2B2A4N98G)
    Language English
    Publishing date 2003-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 523-x
    ISSN 1096-0384 ; 0003-9861
    ISSN (online) 1096-0384
    ISSN 0003-9861
    DOI 10.1016/0003-9861(52)90346-9
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  4. Article: Biallelic EPCAM deletions induce tissue-specific DNA repair deficiency and cancer predisposition.

    Forster, V J / Aronson, M / Zhang, C / Chung, J / Sudhaman, S / Galati, M A / Kelly, J / Negm, L / Ercan, A B / Stengs, L / Durno, C / Edwards, M / Komosa, M / Oldfield, L E / Nunes, N M / Pedersen, S / Wellum, J / Siddiqui, I / Bianchi, V /
    Weil, B R / Fox, V L / Pugh, T J / Kamihara, J / Tabori, U

    NPJ precision oncology

    2024  Volume 8, Issue 1, Page(s) 69

    Abstract: We report a case of Mismatch Repair Deficiency (MMRD) caused by germline homozygous EPCAM deletion leading to tissue-specific loss of MSH2. Through the use of patient-derived cells and organoid technologies, we performed stepwise in vitro differentiation ...

    Abstract We report a case of Mismatch Repair Deficiency (MMRD) caused by germline homozygous EPCAM deletion leading to tissue-specific loss of MSH2. Through the use of patient-derived cells and organoid technologies, we performed stepwise in vitro differentiation of colonic and brain organoids from reprogrammed EPCAM
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article
    ISSN 2397-768X
    ISSN 2397-768X
    DOI 10.1038/s41698-024-00537-6
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  5. Article ; Online: Evaluating colonoscopy screening intervals in patients with Lynch syndrome from a large Canadian registry.

    Aronson, Melyssa / Gryfe, Robert / Choi, Yun-Hee / Semotiuk, Kara / Holter, Spring / Ward, Thomas / Gallinger, Steve / Cohen, Zane / Briollais, Laurent

    Journal of the National Cancer Institute

    2023  Volume 115, Issue 7, Page(s) 778–787

    Abstract: Background: Lynch syndrome (LS) screening guidelines originally recommended colonoscopy every 1 to 2 years, beginning between the ages of 20 and 25 years. Recent studies have questioned the benefits of these short screening intervals in preventing ... ...

    Abstract Background: Lynch syndrome (LS) screening guidelines originally recommended colonoscopy every 1 to 2 years, beginning between the ages of 20 and 25 years. Recent studies have questioned the benefits of these short screening intervals in preventing colorectal cancer (CRC). Our goal is to determine how colonoscopy screening intervals impact CRC in patients with LS.
    Methods: We analyzed the demographics, screening practices, and outcomes of patients with LS identified through the clinic based Familial Gastrointestinal Cancer Registry at the Zane Cohen Centre, Sinai Health System, Toronto, Canada.
    Results: A total of 429 patients with LS were identified with median follow-up of 9.2 years; 44 developed CRC. We found a positive trend between shorter screening intervals and the number of adenomas detected during colonoscopy. Any new adenoma detected at screening decreased 10-year CRC incidence by 11.3%. For MLH1 carriers, a screening interval of 1-2 years vs 2-3 years led to a 20-year cumulative CRC risk reduction of 28% and 14% in females and males, respectively. For MSH2 carriers, this risk reduction was 29% and 17%, respectively, and for male MSH6 carriers 18%. Individuals without any adenomas detected (53.4% of LS carriers) had an increased 20-year CRC risk of 25.7% and 57.2% for women and men, respectively, compared with those diagnosed with adenomas at screening.
    Conclusions: The recommended colonoscopy screening interval of 1-2 years is efficient at detecting adenomas and reducing CRC risk. The observation that 53.4% of LS patients never had an adenoma warrants further investigation about a possible adenoma-free pathway.
    MeSH term(s) Humans ; Male ; Female ; Young Adult ; Adult ; Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis ; Colorectal Neoplasms, Hereditary Nonpolyposis/epidemiology ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/prevention & control ; Canada/epidemiology ; Colonoscopy ; Adenoma/diagnosis ; Adenoma/epidemiology ; Adenoma/prevention & control ; Registries
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djad058
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    Uh III Zs.131: Show issues Location:
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  6. Article ; Online: Genetic counseling for hereditary colorectal cancer: ethical, legal, and psychosocial issues.

    Aronson, Melyssa

    Surgical oncology clinics of North America

    2009  Volume 18, Issue 4, Page(s) 669–685

    Abstract: The impression that genetic testing for an inherited colorectal cancer syndrome involves a simple blood test masks the complex issues that surround this type of testing. This article explores the ethical, legal, and psychosocial implications of genetic ... ...

    Abstract The impression that genetic testing for an inherited colorectal cancer syndrome involves a simple blood test masks the complex issues that surround this type of testing. This article explores the ethical, legal, and psychosocial implications of genetic testing and the role of genetic counseling through the genetic testing process.
    MeSH term(s) Colorectal Neoplasms/genetics ; Ethics, Medical ; Genetic Counseling/ethics ; Genetic Counseling/legislation & jurisprudence ; Humans ; Legislation, Medical ; Psychology
    Language English
    Publishing date 2009-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196919-2
    ISSN 1558-5042 ; 1055-3207
    ISSN (online) 1558-5042
    ISSN 1055-3207
    DOI 10.1016/j.soc.2009.07.001
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  7. Article: Quantum critical behavior in Ce(Fe

    Montfrooij, Wouter / Heitmann, Tom / Qiu, Yiming / Watson, Shannon / Erwin, Ross / Chen, Wangchun / Zhao, Yang / Aronson, Meigan / Huang, Yingkai / de Visser, Anne

    Physical review. B

    2024  Volume 99, Issue 19

    Abstract: Systems with embedded magnetic ions that exhibit a competition between magnetic order and disorder down to absolute zero can display unusual low-temperature behaviors of the resistivity, susceptibility, and specific heat. Moreover, the dynamic response ... ...

    Abstract Systems with embedded magnetic ions that exhibit a competition between magnetic order and disorder down to absolute zero can display unusual low-temperature behaviors of the resistivity, susceptibility, and specific heat. Moreover, the dynamic response of such a system can display hyperscaling behavior in which the relaxation back to equilibrium when an amount of energy
    Language English
    Publishing date 2024-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209770-9
    ISSN 1095-3795 ; 1550-235X ; 2469-9950 ; 1098-0121 ; 0163-1829 ; 0556-2805
    ISSN (online) 1095-3795 ; 1550-235X
    ISSN 2469-9950 ; 1098-0121 ; 0163-1829 ; 0556-2805
    DOI 10.1103/PhysRevB.99.195113
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    In stock of ZB MED Bonn / Germany

    Z 72/712: Show issues

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  8. Article: BRIGE FORMATION AND CYTOPLASMIC FLOW BETWEEN PHAGOCYTIC CELLS.

    ARONSON, M

    The Journal of experimental medicine

    2000  Volume 118, Page(s) 1083–1088

    Abstract: A simple chamber was constructed for observation of cells at 37 degrees C and under high magnification. Rabbit peritoneal histiocytes observed in this chamber manifested a constant interaction, which lasted as long as the preparation itself. This ... ...

    Abstract A simple chamber was constructed for observation of cells at 37 degrees C and under high magnification. Rabbit peritoneal histiocytes observed in this chamber manifested a constant interaction, which lasted as long as the preparation itself. This interaction consisted of formation of cytoplasmic bridges and flow of cytoplasm between the cells. Lung macrophages formed bridges both between themselves, and with peritoneal histiocytes. On the other hand, no bridges were noticed between histiocytes and polymorphonuclears or fibroblasts. BCG bacteria were observed passing from one histiocyte to another. Autoradiographic studies suggest that RNA may be transferred from one cell to another. The possible significance of these observations is discussed.
    MeSH term(s) Animals ; Autoradiography ; Cell Biology ; Cytoplasm ; Fibroblasts ; Histiocytes ; Lung ; Macrophages ; Mycobacterium bovis ; Peritoneum ; Phagocytosis ; RNA ; Rabbits ; Research ; Tritium
    Chemical Substances Tritium (10028-17-8) ; RNA (63231-63-0)
    Language English
    Publishing date 2000-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.118.6.1083
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    Ua VI Zs.107: Show issues Location:
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  9. Conference proceedings: The importance of irregular movements for the elderly

    Aronson, M.

    2006  , Page(s) 06pasa116

    Event/congress Xth International EGREPA Conference; Physical activity and successful aging; Cologne; European Group for Research into Elderly and Physical Activity; 2006
    Keywords Medizin, Gesundheit
    Publishing date 2006-12-18
    Publisher German Medical Science; Düsseldorf, Köln
    Document type Conference proceedings
    Database German Medical Science

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  10. Article ; Online: MLH1 epimutation is a rare mechanism for Lynch syndrome: A case report and review of the literature.

    Zyla, Roman / Graham, Tracy / Aronson, Melyssa / Velsher, Lea / Mrkonjic, Miralem / Turashvili, Gulisa

    Genes, chromosomes & cancer

    2021  Volume 60, Issue 9, Page(s) 635–639

    Abstract: Endometrial carcinoma is one of the prototypical malignancies associated with Lynch syndrome, an inherited cancer syndrome most commonly caused by germline mutations in DNA mismatch repair (MMR) genes, although rare alternative mechanisms also exist. In ... ...

    Abstract Endometrial carcinoma is one of the prototypical malignancies associated with Lynch syndrome, an inherited cancer syndrome most commonly caused by germline mutations in DNA mismatch repair (MMR) genes, although rare alternative mechanisms also exist. In this report, we describe a patient first diagnosed with colorectal cancer at age 33, then vulvar squamous cell carcinoma, facial sebaceous adenoma/sebaceoma, and finally endometrial carcinoma at age 52. All tumors were MLH1/PMS2-deficient by immunohistochemistry, and MLH1 promoter methylation was identified in the endometrial cancer. Germline MLH1 testing was negative for pathogenic variants, but she was subsequently diagnosed with Lynch syndrome secondary to a germline monoallelic constitutional epimutation of the MLH1 promoter. Identification of patients displaying a Lynch syndrome phenotype but lacking germline MMR mutations is important to avoid delays in the diagnosis of Lynch syndrome as well as the initiation of appropriate cancer screening and genetic counseling.
    MeSH term(s) Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/pathology ; DNA Methylation ; Epigenesis, Genetic ; Female ; Germ-Line Mutation ; Humans ; Middle Aged ; MutL Protein Homolog 1/genetics ; Promoter Regions, Genetic
    Chemical Substances MLH1 protein, human ; MutL Protein Homolog 1 (EC 3.6.1.3)
    Language English
    Publishing date 2021-05-15
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1018988-9
    ISSN 1098-2264 ; 1045-2257
    ISSN (online) 1098-2264
    ISSN 1045-2257
    DOI 10.1002/gcc.22957
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