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Book ; Online: Feminist Futures of Work

Arora, Payal / Raman, Usha / König, René

Reimagining Labour in the Digital Economy

(Digital Studies)

2023

Series title	Digital Studies
Keywords	Industrial arbitration & negotiation ; Gender studies: women ; Media studies ; Future of Work, Global South, Digitization, Feminism, Informal Labour
Language	English
Size	1 electronic resource (348 pages)
Publisher	Amsterdam University Press
Publishing place	Amsterdam
Document type	Book ; Online
Note	English
HBZ-ID	HT030375964
ISBN	9789463728386 ; 9463728384
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: How the next billion users are challenging global tech assessment

Julia Hahn / Arora Payal

TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis, Vol 31, Iss

Interview by Julia Hahn

2022 Volume 1

Keywords	digitalization ; science and technology ; ethics ; data governance ; big data ; Social sciences (General) ; H1-99 ; Technology (General) ; T1-995
Language	German
Publishing date	2022-04-01T00:00:00Z
Publisher	oekom verlag GmbH
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Antireproductive changes instigated by efficient drug delivery via papaya seed chloroform extract-based nanoparticles in male rat Bandicota bengalensis.

Arora, Payal / Thukral, Ruchika / Singla, Neena / Bansal, Neelam

Pesticide biochemistry and physiology

2023 Volume 192, Page(s) 105408

Abstract: Anti-reproductive potential of papaya seed chloroform extract-based solid lipid nanoparticles (PSCEN) was investigated for the first time in lesser bandicoot rat, Bandicota bengalensis. Mature male rats (n = 30 per group) were fed bait (loose mixture of ... ...

Abstract	Anti-reproductive potential of papaya seed chloroform extract-based solid lipid nanoparticles (PSCEN) was investigated for the first time in lesser bandicoot rat, Bandicota bengalensis. Mature male rats (n = 30 per group) were fed bait (loose mixture of cracked wheat, powdered sugar, and groundnut oil in the ratio 88:10:2) containing two different concentrations of PSCEN (5% and 10%) in a bi-choice condition for 15 days with one group as vehicle control. The ingestion of active ingredient in 15 days treatment was significantly (P ≤ 0.05) higher by rats treated with 10% PSCEN (39.17-58.70 g/kg body weight) as compared to rats treated with 5% PSCEN (21.30-33.23 g/kg body weight). A dose dependent significant (P ≤ 0.05) decrease was observed in the level of testosterone, FSH, LH and GnRH in plasma of treated rats. A significant (P ≤ 0.05) decrease was also observed in level of total soluble proteins, total lipids, phospholipids and cholesterol in both plasma and testicular tissue, and level of 17β-HSD and 3β-HSD in testicular tissue indicating anti-reproductive effects of PSCEN treatment. There was observed significant (P ≤ 0.05) effect of treatment on histomorphology of testis and cauda epididymis in the form of reduced tubular diameter, germinal epithelial thickness, number of germ cells and dissociation of epithelial cycle in seminiferous tubules, and reduced tubular diameter, increased epithelial thickness, vacuolization, loose contact of principle cells and reduced number of spermatozoa in the cauda epididymal tubules. Maximum antifertility effect was observed with 10% PSCEN treatment, which was not reversed upto 105 days of treatment withdrawal indicating long-term efficacy. The current investigation suggests the use of PSCEN in the management of reproduction of B. bengalensis by exerting influence on testicular and cauda epididymal functions and biochemical parameters.
MeSH term(s)	Animals ; Male ; Rats ; Body Weight ; Carica ; Chloroform/pharmacology ; Murinae ; Nanoparticles ; Spermatozoa ; Testis ; Testosterone/pharmacology ; Reproduction/drug effects
Chemical Substances	Chloroform (7V31YC746X) ; Testosterone (3XMK78S47O)
Language	English
Publishing date	2023-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	184819-7
ISSN	1095-9939 ; 0048-3583 ; 0048-3575
ISSN (online)	1095-9939
ISSN	0048-3583 ; 0048-3575
DOI	10.1016/j.pestbp.2023.105408
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Article ; Online: Antireproductive changes instigated by efficient drug delivery via papaya seed chloroform extract-based nanoparticles in male rat Bandicota bengalensis

Arora, Payal / Thukral, Ruchika / Singla, Neena / Bansal, Neelam

Pesticide Biochemistry and Physiology. 2023 May, v. 192 p.105408-

2023

Abstract	Anti-reproductive potential of papaya seed chloroform extract-based solid lipid nanoparticles (PSCEN) was investigated for the first time in lesser bandicoot rat, Bandicota bengalensis. Mature male rats (n = 30 per group) were fed bait (loose mixture of cracked wheat, powdered sugar, and groundnut oil in the ratio 88:10:2) containing two different concentrations of PSCEN (5% and 10%) in a bi-choice condition for 15 days with one group as vehicle control. The ingestion of active ingredient in 15 days treatment was significantly (P ≤ 0.05) higher by rats treated with 10% PSCEN (39.17–58.70 g/kg body weight) as compared to rats treated with 5% PSCEN (21.30–33.23 g/kg body weight). A dose dependent significant (P ≤ 0.05) decrease was observed in the level of testosterone, FSH, LH and GnRH in plasma of treated rats. A significant (P ≤ 0.05) decrease was also observed in level of total soluble proteins, total lipids, phospholipids and cholesterol in both plasma and testicular tissue, and level of 17β-HSD and 3β-HSD in testicular tissue indicating anti-reproductive effects of PSCEN treatment. There was observed significant (P ≤ 0.05) effect of treatment on histomorphology of testis and cauda epididymis in the form of reduced tubular diameter, germinal epithelial thickness, number of germ cells and dissociation of epithelial cycle in seminiferous tubules, and reduced tubular diameter, increased epithelial thickness, vacuolization, loose contact of principle cells and reduced number of spermatozoa in the cauda epididymal tubules. Maximum antifertility effect was observed with 10% PSCEN treatment, which was not reversed upto 105 days of treatment withdrawal indicating long-term efficacy. The current investigation suggests the use of PSCEN in the management of reproduction of B. bengalensis by exerting influence on testicular and cauda epididymal functions and biochemical parameters.
Keywords	Bandicota bengalensis ; active ingredients ; antifertility effect ; body weight ; chloroform ; cholesterol ; dissociation ; dose response ; epididymis ; epithelium ; ingestion ; males ; nanoparticles ; peanut oil ; pesticides ; phospholipids ; rats ; reproduction ; sugars ; testes ; testosterone ; wheat ; Antireproductive effects ; Biochemicals ; Chloroform extract ; Hormones and enzymes ; Histomorphology ; Solid lipid nanoparticles ; Papaya seed
Language	English
Dates of publication	2023-05
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	184819-7
ISSN	1095-9939 ; 0048-3583 ; 0048-3575
ISSN (online)	1095-9939
ISSN	0048-3583 ; 0048-3575
DOI	10.1016/j.pestbp.2023.105408
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Formulation and evaluation of solid lipid nanoparticles loaded with papaya seed chloroform extract for long-term antifertility effects on the male rat,

Thukral, Ruchika / Arora, Payal / Sharma, Sunidhi / Choudhury, Diptiman / Singla, Neena

Drug and chemical toxicology

2023 , Page(s) 1–11

Abstract: The study is the first to formulate and investigate potential of papaya seed chloroform extract based solid lipid nanoparticles (PSCEN) as antifertility agents on ... ...

Abstract	The study is the first to formulate and investigate potential of papaya seed chloroform extract based solid lipid nanoparticles (PSCEN) as antifertility agents on male
Language	English
Publishing date	2023-07-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	548368-2
ISSN	1525-6014 ; 0148-0545
ISSN (online)	1525-6014
ISSN	0148-0545
DOI	10.1080/01480545.2023.2240542
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Article: Inflammation in Periodontal Disease: Possible Link to Vascular Disease.

Paul, Oindrila / Arora, Payal / Mayer, Michael / Chatterjee, Shampa

Frontiers in physiology

2021 Volume 11, Page(s) 609614

Abstract: Inflammation is a well-organized protective response to pathogens and consists of immune cell recruitment into areas of infection. Inflammation either clears pathogens and gets resolved leading to tissue healing or remains predominantly unresolved ... ...

Abstract	Inflammation is a well-organized protective response to pathogens and consists of immune cell recruitment into areas of infection. Inflammation either clears pathogens and gets resolved leading to tissue healing or remains predominantly unresolved triggering pathological processes in organs. Periodontal disease (PD) that is initiated by specific bacteria also triggers production of inflammatory mediators. These processes lead to loss of tissue structure and function. Reactive oxygen species and oxidative stress play a role in susceptibility to periodontal pathogenic bacterial infections. Periodontal inflammation is a risk factor for systemic inflammation and eventually cardiovascular disease (CVD). This review discusses the role of inflammation in PD and its two way association with other health conditions such as diabetes and CVD. Some of the mechanisms underpinning the links between inflammation, diabetes, CVD and PD are also discussed. Finally, we review available epidemiological data and other reports to assess possible links between oral health and CVD.
Language	English
Publishing date	2021-01-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2020.609614
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Thiolutin has complex effects in vivo but is a direct inhibitor of RNA polymerase II in vitro.

Qiu, Chenxi / Arora, Payal / Malik, Indranil / Laperuta, Amber J / Pavlovic, Emily M / Ugochukwu, Scott / Naik, Mandar / Kaplan, Craig D

Nucleic acids research

2024 Volume 52, Issue 5, Page(s) 2546–2564

Abstract: Thiolutin is a natural product transcription inhibitor with an unresolved mode of action. Thiolutin and the related dithiolopyrrolone holomycin chelate Zn2+ and previous studies have concluded that RNA Polymerase II (Pol II) inhibition in vivo is ... ...

Abstract	Thiolutin is a natural product transcription inhibitor with an unresolved mode of action. Thiolutin and the related dithiolopyrrolone holomycin chelate Zn2+ and previous studies have concluded that RNA Polymerase II (Pol II) inhibition in vivo is indirect. Here, we present chemicogenetic and biochemical approaches to investigate thiolutin's mode of action in Saccharomyces cerevisiae. We identify mutants that alter sensitivity to thiolutin. We provide genetic evidence that thiolutin causes oxidation of thioredoxins in vivo and that thiolutin both induces oxidative stress and interacts functionally with multiple metals including Mn2+ and Cu2+, and not just Zn2+. Finally, we show direct inhibition of RNA polymerase II (Pol II) transcription initiation by thiolutin in vitro in support of classical studies that thiolutin can directly inhibit transcription in vitro. Inhibition requires both Mn2+ and appropriate reduction of thiolutin as excess DTT abrogates its effects. Pause prone, defective elongation can be observed in vitro if inhibition is bypassed. Thiolutin effects on Pol II occupancy in vivo are widespread but major effects are consistent with prior observations for Tor pathway inhibition and stress induction, suggesting that thiolutin use in vivo should be restricted to studies on its modes of action and not as an experimental tool.
MeSH term(s)	Pyrrolidinones/pharmacology ; RNA Polymerase II/antagonists & inhibitors ; Saccharomyces cerevisiae/drug effects ; Saccharomyces cerevisiae/enzymology ; Saccharomyces cerevisiae Proteins/genetics ; Transcription, Genetic ; Zinc
Chemical Substances	acetopyrrothine (02C005Q20B) ; Pyrrolidinones ; RNA Polymerase II (EC 2.7.7.-) ; Saccharomyces cerevisiae Proteins ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkad1258
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Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: Enhancement of innate immunity in gingival epithelial cells by vitamin D and HDAC inhibitors.

Figgins, Erika L / Arora, Payal / Gao, Denny / Porcelli, Emily / Ahmed, Rabab / Daep, Carlo Amorin / Keele, Garrett / Ryan, Lisa K / Diamond, Gill

Frontiers in oral health

2024 Volume 5, Page(s) 1378566

Abstract: Introduction: The human host defense peptide LL-37 is a component of the innate immune defense mechanisms of the oral cavity against colonization by microbes associated with periodontal disease. We have previously shown that the active form of vitamin D, ...

Abstract	Introduction: The human host defense peptide LL-37 is a component of the innate immune defense mechanisms of the oral cavity against colonization by microbes associated with periodontal disease. We have previously shown that the active form of vitamin D, 1,25(OH) Methods: We treated 3-dimensional primary cultures of GEC topically with the inactive form of vitamin D, in the presence and absence of selected histone deacetylase (HDAC) inhibitors. LL-37 mRNA levels were quantified by quantitative RT-PCR, and inhibition of invasion of bacteria was measured by fluorescence microscopy. Results: Vitamin D treatment led to an induction of LL-37 mRNA levels, as well as an inhibition of pro-inflammatory cytokine secretion. This effect was further enhanced by HDAC inhibitors, most strongly when the HDAC inhibitor, phenyl butyrate (PBA) was combined with Vitamin D Conclusions: Our results demonstrate that a combination of inactive vitamin D and sodium butyrate could be developed as a safe treatment for periodontal disease.
Language	English
Publishing date	2024-03-14
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-4842
ISSN (online)	2673-4842
DOI	10.3389/froh.2024.1378566
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Determination of Oxidized Lipids in Commonly Consumed Foods and a Preliminary Analysis of Their Binding Affinity to PPARγ.

Skinner, Joanna / Arora, Payal / McMath, Nicole / Penumetcha, Meera

Foods (Basel, Switzerland)

2021 Volume 10, Issue 8

Abstract: Foods rich in poly unsaturated fatty acids (PUFA) are vulnerable to oxidation. While it is well established that endogenously derived oxidized lipids are ligands of the transcription factor PPARγ, the binding ability of diet-derived oxidized lipids is ... ...

Abstract	Foods rich in poly unsaturated fatty acids (PUFA) are vulnerable to oxidation. While it is well established that endogenously derived oxidized lipids are ligands of the transcription factor PPARγ, the binding ability of diet-derived oxidized lipids is unknown. Our two-fold objective was to determine the oxidized lipid content and PPARγ binding ability of commonly consumed foods. Extracted food lipids were assayed for the peroxide value, conjugated dienes, and aldehydes, and PPARγ binding was assessed by an in vitro PPARγ ligand screening assay. Oxidized lipids were present in all foods tested at the time of purchase, and oxidation did not increase during storage. The peroxide values for walnuts, sunflower seeds, and flax meal were significantly lower at the end of three months as compared to the day of purchase (peroxide value: 1.26 ± 0.13 vs. 2.32 ± 0.4; 1.65 ± 0.23 vs. 2.08 ± 0.09; 3.07 ± 0.22 vs. 9.94 ± 0.75 mEq/kg fat,
Language	English
Publishing date	2021-07-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods10081702
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Metabolic Reconfiguration Activates Stemness and Immunomodulation of PDLSCs.

Arora, Payal / Li, Wen / Huang, Xiaobin / Yu, Wenjing / Huang, Ranran / Jiang, Qian / Chen, Chider

International journal of molecular sciences

2022 Volume 23, Issue 7

Abstract: Periodontal ligament derived stem cells (PDLSC) are adult multipotent mesenchymal-like stem cells (MSCs) that can induce a promising immunomodulation to interact with immune cells for disease treatment. Metabolic reconfiguration has been shown to be ... ...

Abstract	Periodontal ligament derived stem cells (PDLSC) are adult multipotent mesenchymal-like stem cells (MSCs) that can induce a promising immunomodulation to interact with immune cells for disease treatment. Metabolic reconfiguration has been shown to be involved in the immunomodulatory activity of MSCs. However, the underlying mechanisms are largely unknown, and it remains a challenging to establish a therapeutic avenue to enhance immunomodulation of endogenous stem cells for disease management. In the present study, RNA-sequencing (RNA-seq) analysis explores that curcumin significantly promotes PDLSC function through activation of MSC-related markers and metabolic pathways. In vitro stem cell characterization further confirms that self-renewal and multipotent differentiation capabilities are largely elevated in curcumin treated PDLSCs. Mechanistically, RNA-seq reveals that curcumin activates ERK and mTOR cascades through upregulating growth factor pathways for metabolic reconfiguration toward glycolysis. Interestingly, PDLSCs immunomodulation is significantly increased after curcumin treatment through activation of prostaglandin E2-Indoleamine 2,3 dioxygenase (PGE2-IDO) signaling, whereas inhibition of glycolysis activity by 2-deoxyglucose (2-DG) largely blocked immunomodulatory capacity of PDLSCs. Taken together, this study provides a novel pharmacological approach to activate endogenous stem cells through metabolic reprogramming for immunomodulation and tissue regeneration.
MeSH term(s)	Cell Differentiation/physiology ; Cell Proliferation ; Cells, Cultured ; Curcumin/metabolism ; Curcumin/pharmacology ; Immunomodulation ; Mesenchymal Stem Cells/metabolism ; Periodontal Ligament
Chemical Substances	Curcumin (IT942ZTH98)
Language	English
Publishing date	2022-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23074038
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