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Book ; Online ; E-Book: Advances in crop production and climate change

Yadav, A. S. / Kumar, Narendra / Arora, Sanjay / Srivastava, D. S. / Pant, Hemlata

2021

Abstract: Cover -- Half Title -- Title -- Copyright -- Foreword -- Preface -- Contents -- List of Contributors -- 1. Advances in Rice Production Technologies -- 2. Advances in Wheat and Barley Production Technologies -- 3. Advances in Maize Production Technologies ...

Author's details	A. S. Yadav, Narendra Kumar, Sanjay Arora, D. S. Srivastava, Hemlata Pant
Abstract	Cover -- Half Title -- Title -- Copyright -- Foreword -- Preface -- Contents -- List of Contributors -- 1. Advances in Rice Production Technologies -- 2. Advances in Wheat and Barley Production Technologies -- 3. Advances in Maize Production Technologies -- 4. Improved Technologies for Pearl Millet Cultivation -- 5. Advances in Pulses Production Technologies: A Holistic Approach for New Millennium -- 6. Advances in Oilseeds Production Technologies -- 7. Advance Production Technologies of Sugarcane: A Step Towards Higher Productivity -- 8. Advances in Vegetable Production Technologies -- 9. Advances in Medicinal and Aromatic Crop Production Technologies -- 10. Advances in Forage Crop Production Technologies -- 11. Restoration of Degraded Sodic Lands Through Agroforestry Practices -- 12. Advances in Farm Mechanization in India -- 13. Resource Conservation Techniques for Sustaining Crop Production in Rainfed Foothills Under Changing Climate -- 14. Advances in Reclamation and Management of Salt Affected Soils for Sustainable Crop Production -- 15. Physio-molecular Mechanisms of Drought Tolerance in Crop -- 16. Soil Biodiversity and Its Management for Sustainable Agriculture -- 17. Impact of Climate Change in Crop Protection -- 18. Analysis of Field Experimental Data Using Statistical Calculator.
Keywords	Electronic books
Language	English
Size	1 Online-Ressource (506 Seiten)
Publisher	Taylor & Francis Group
Publishing place	Boca Raton ; London ; New York
Publishing country	United States
Document type	Book ; Online ; E-Book
Note	Description based on publisher supplied metadata and other sources
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer ; https://www.livivo.de/getdoc/EBC/7185639
HBZ-ID	HT021725128
ISBN	978-1-00-057252-0 ; 9781032024295 ; 1-00-057252-8 ; 1032024291
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: In vitro and in vivo optimization of liposomal nanoparticles based brain targeted vgf gene therapy.

Arora, Sanjay / Singh, Jagdish

International journal of pharmaceutics

2021 Volume 608, Page(s) 121095

Abstract: Vgf (non-acronymic), a neurotrophin stimulated protein which plays a crucial role in learning, synaptic activity, and neurogenesis, is markedly downregulated in the brain of Alzheimer's disease (AD) patients. However, since vgf is a large polar protein, ... ...

Abstract	Vgf (non-acronymic), a neurotrophin stimulated protein which plays a crucial role in learning, synaptic activity, and neurogenesis, is markedly downregulated in the brain of Alzheimer's disease (AD) patients. However, since vgf is a large polar protein, a safe and efficient gene delivery vector is critical for its delivery across the blood brain barrier (BBB). This research work demonstrates brain-targeted liposomal nanoparticles optimized for delivering plasmid encoding vgf across BBB and transfecting brain cells. Brain targeting was achieved by surface functionalization using glucose transporter-1 targeting ligand (mannose) and brain targeted cell-penetrating peptides (chimeric rabies virus glycoprotein fragment, rabies virus derived peptide, penetratin peptide, or CGNHPHLAKYNGT peptide). The ligands were conjugated to lipid via nucleophilic substitution reaction resulting in >75% binding efficiency. The liposomes were formed by film hydration technique demonstrating size <200 nm, positive zeta potential (15-20 mV), and polydispersity index <0.3. The bifunctionalized liposomes demonstrated ∼3 pg/µg protein vgf transfection across in vitro BBB, and ∼80 pg/mg protein in mice brain which was 1.5-2 fold (p < 0.05) higher compared to untreated control. The nanoparticles were also biocompatible in vitro and in vivo, suggesting a safe and efficient gene delivery system to treat AD.
MeSH term(s)	Animals ; Blood-Brain Barrier ; Brain ; Genetic Therapy ; Liposomes ; Mice ; Nanoparticles ; Nerve Growth Factors
Chemical Substances	Liposomes ; Nerve Growth Factors ; VGF protein, human
Language	English
Publishing date	2021-09-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2021.121095
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Article: Functionalized nanoparticles for brain targeted BDNF gene therapy to rescue Alzheimer's disease pathology in transgenic mouse model

Arora, Sanjay / Kanekiyo, Takahisa / Singh, Jagdish

International journal of biological macromolecules. 2022 May 31, v. 208

2022

Abstract: Brain-derived neurotrophic factor (BDNF) is actively produced and utilized in cortical circuits throughout life to sustain neuronal function and synaptic plasticity. In animal models of Alzheimer's Disease (AD), highly invasive BDNF gene therapy using ... ...

Abstract	Brain-derived neurotrophic factor (BDNF) is actively produced and utilized in cortical circuits throughout life to sustain neuronal function and synaptic plasticity. In animal models of Alzheimer's Disease (AD), highly invasive BDNF gene therapy using viral vectors has successfully shown enhanced synaptic protein expression, proliferation of neurons and attenuation of amyloidogenic processes. However, to eliminate virus-related safety issues and invasive procedures, our present study has explored brain-targeted lipid-based nanoparticles that can deliver plasmid encoding BDNF to brain in a safe and efficient manner. Efficacy of these nanoparticles was tested in early (6-months) and advanced stage (9-months) transgenic APP/PS1 AD mice. Liposomes were surface-functionalized with brain targeting ligand, mannose, and cell-penetrating peptides (rabies virus-derived peptide or penetratin). These bifunctionalized nanoparticles enhanced BDNF expression by ~2 times and resulted in >40% (p < 0.05) reduction in toxic amyloid-beta peptides in 6- and 9-months old APP/PS1 mice brains compared to their age-matched untreated controls. Plaque load was reduced ~7 and ~3 times (p < 0.05), respectively, whereas synaptic proteins, synaptophysin and PSD-95, were found to be increased >90% (p < 0.05) in both age groups of transgenic mice treated with bifunctionalized nanoparticles. No untoward adverse effects were observed throughout treatment, suggesting a safe and effective strategy to rescue AD pathology.
Keywords	Alzheimer disease ; brain ; gene therapy ; ligands ; mannose ; mice ; neurons ; neuroplasticity ; plasmids ; protein synthesis ; rabies ; toxicity
Language	English
Dates of publication	2022-0531
Size	p. 901-911.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.03.203
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Implementation and Evaluation of an Automated Text Message-Based Diabetes Prevention Program for Adults With Pre-diabetes.

Arora, Sanjay / Lam, Chun Nok / Burner, Elizabeth / Menchine, Michael

Journal of diabetes science and technology

2023 , Page(s) 19322968231162601

Abstract: Background: Despite the efficacy of diabetes prevention programs, only an estimated 5% of people with pre-diabetes actually participate. Mobile health (mHealth) holds promise to engage patients with pre-diabetes into lifestyle modification programs by ... ...

Abstract	Background: Despite the efficacy of diabetes prevention programs, only an estimated 5% of people with pre-diabetes actually participate. Mobile health (mHealth) holds promise to engage patients with pre-diabetes into lifestyle modification programs by decreasing the referral burden, centralizing remote enrollment, removing the physical requirement of a brick-and-mortar location, lowering operating costs through automation, and reducing time and transportation barriers. Methods: Non-randomized implementation study enrolling patients with pre-diabetes from a large health care organization. Patients were exposed to a text message-based program combining live human coaching guidance and support with automated scheduled, interactive, data-driven, and on-demand messages. The primary analysis examined predicted weight outcomes at 6 and 12 months. Secondary outcomes included predicted changes in HbA1c and minutes of exercise at 6 and 12 months. Results: Of the 163 participants included in the primary analysis, participants had a mean predicted weight loss of 5.5% at six months ( Conclusions: In this real-world implementation of the myAgileLife Diabetes Prevention Program among patients with pre-diabetes, we observed significant decreases in weight and HbA1c at 6 and 12 months. mHealth may represent an effective and easily scalable potential solution to deliver impactful diabetes prevention curricula to large numbers of patients.
Language	English
Publishing date	2023-03-22
Publishing country	United States
Document type	Journal Article
ISSN	1932-2968
ISSN (online)	1932-2968
DOI	10.1177/19322968231162601
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Article ; Online: Rationalizing mineral gypsum use through microbially enriched municipal solid waste compost for amelioration and regaining productivity potential of degraded alkali soils.

Singh, Yash Pal / Arora, Sanjay / Mishra, Vinay Kumar / Singh, Atul Kumar

Scientific reports

2023 Volume 13, Issue 1, Page(s) 11816

Abstract: Reclamation of alkali soils to harness their productivity potential is more complex due to the presence of excess sodium ions, poor hydraulic conductivity and infiltration rate, resulting in poor plant growth and crop productivity. Sodic soil reclamation ...

Abstract	Reclamation of alkali soils to harness their productivity potential is more complex due to the presence of excess sodium ions, poor hydraulic conductivity and infiltration rate, resulting in poor plant growth and crop productivity. Sodic soil reclamation using inorganic ameliorants like mineral gypsum or phosphogypsum is beyond the reach of small and marginal farmers having alkali soils because of their higher market prices and shortage of availability. Conjoint use of inorganic and organic amendments can be a pragmatic solution for improving soil physico-chemical and biological properties and sustaining crop productivity. Municipal solid waste compost (MSWC) available in abundant quantity if enriched with the efficient halophilic microbial consortium and used in conjunction with a reduced dose of gypsum can be a cost-effective approach for sustainable reclamation of alkali soils and harnessing their productivity potential. Hence, a field experiment was conducted on a high alkali soil (pH
MeSH term(s)	Calcium Sulfate ; Solid Waste ; Composting ; Minerals ; Alkalies ; Carbon ; Sodium
Chemical Substances	Calcium Sulfate (WAT0DDB505) ; Solid Waste ; Minerals ; Alkalies ; Carbon (7440-44-0) ; Sodium (9NEZ333N27)
Language	English
Publishing date	2023-07-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-37823-5
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Article ; Online: Functionalized nanoparticles for brain targeted BDNF gene therapy to rescue Alzheimer's disease pathology in transgenic mouse model.

Arora, Sanjay / Kanekiyo, Takahisa / Singh, Jagdish

International journal of biological macromolecules

2022 Volume 208, Page(s) 901–911

Abstract	Brain-derived neurotrophic factor (BDNF) is actively produced and utilized in cortical circuits throughout life to sustain neuronal function and synaptic plasticity. In animal models of Alzheimer's Disease (AD), highly invasive BDNF gene therapy using viral vectors has successfully shown enhanced synaptic protein expression, proliferation of neurons and attenuation of amyloidogenic processes. However, to eliminate virus-related safety issues and invasive procedures, our present study has explored brain-targeted lipid-based nanoparticles that can deliver plasmid encoding BDNF to brain in a safe and efficient manner. Efficacy of these nanoparticles was tested in early (6-months) and advanced stage (9-months) transgenic APP/PS1 AD mice. Liposomes were surface-functionalized with brain targeting ligand, mannose, and cell-penetrating peptides (rabies virus-derived peptide or penetratin). These bifunctionalized nanoparticles enhanced BDNF expression by ~2 times and resulted in >40% (p < 0.05) reduction in toxic amyloid-beta peptides in 6- and 9-months old APP/PS1 mice brains compared to their age-matched untreated controls. Plaque load was reduced ~7 and ~3 times (p < 0.05), respectively, whereas synaptic proteins, synaptophysin and PSD-95, were found to be increased >90% (p < 0.05) in both age groups of transgenic mice treated with bifunctionalized nanoparticles. No untoward adverse effects were observed throughout treatment, suggesting a safe and effective strategy to rescue AD pathology.
MeSH term(s)	Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Alzheimer Disease/therapy ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Animals ; Brain/metabolism ; Brain-Derived Neurotrophic Factor/genetics ; Disease Models, Animal ; Genetic Therapy ; Mice ; Mice, Transgenic ; Nanoparticles
Chemical Substances	Amyloid beta-Peptides ; Brain-Derived Neurotrophic Factor
Language	English
Publishing date	2022-04-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.03.203
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Book ; Online: Yuga

Nitin, Vikram / Mulhern, Anne / Arora, Sanjay / Ray, Baishakhi

Automatically Detecting Lifetime Annotation Bugs in the Rust Language

2023

Abstract: The Rust programming language is becoming increasingly popular among systems programmers due to its efficient performance and robust memory safety guarantees. Rust employs an ownership model to ensure this guarantee by allowing each value to be owned by ... ...

Abstract	The Rust programming language is becoming increasingly popular among systems programmers due to its efficient performance and robust memory safety guarantees. Rust employs an ownership model to ensure this guarantee by allowing each value to be owned by only one identifier at a time. Additionally, it introduces the concept of borrowing and lifetimes to enable other variables to borrow the values under certain conditions temporarily. Despite its benefits, security vulnerabilities have been reported in Rust projects, often attributed to the use of "unsafe" Rust code. These vulnerabilities, in part, arise from incorrect lifetime annotations on function signatures. However, existing tools fail to detect these bugs, primarily because such bugs are rare, challenging to detect through dynamic analysis, and require explicit memory models. To overcome these limitations, first, we characterize incorrect lifetime annotations as a source of memory safety bugs and leverage this understanding to devise a novel static analysis tool, Yuga, to detect potential lifetime annotation bugs. Yuga uses a multi-phase analysis approach, starting with a quick pattern-matching algorithm to identify potential buggy components and then conducting a flow and field-sensitive alias analysis to confirm the bugs. We also curate new datasets of lifetime annotation bugs. Yuga successfully detects bugs with good precision on these datasets, and we make the code and datasets publicly available for review.
Keywords	Computer Science - Software Engineering
Subject code	005
Publishing date	2023-10-12
Publishing country	us
Document type	Book ; Online
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Article ; Online: A Review of Brain-Targeted Nonviral Gene-Based Therapies for the Treatment of Alzheimer's Disease.

Arora, Sanjay / Sharma, Divya / Layek, Buddhadev / Singh, Jagdish

Molecular pharmaceutics

2021 Volume 18, Issue 12, Page(s) 4237–4255

Abstract: Diseases of the central nervous system (CNS) are difficult to treat owing to the complexity of the brain and the presence of a natural blood-brain-barrier (BBB). Alzheimer's disease (AD) is one of the major progressive and currently incurable ... ...

Abstract	Diseases of the central nervous system (CNS) are difficult to treat owing to the complexity of the brain and the presence of a natural blood-brain-barrier (BBB). Alzheimer's disease (AD) is one of the major progressive and currently incurable neurodegenerative disorders of the CNS, which accounts for 60-80% of cases of dementia. The pathophysiology of AD involves the accumulation of amyloid beta (Aβ) plaques and neurofibrillary tangles (NFTs) in the brain. Additionally, synaptic loss and imbalance of neuronal signaling molecules are characterized as important markers of AD. Existing treatments of AD help in the management of its symptoms and aim toward the maintenance of cognitive functions, behavior, and attenuation of gradual memory loss. Over the past decade, nonviral gene therapy has attracted increasing interest due to its various advantages over its viral counterparts. Moreover, advancements in nonviral gene technology have led to their increasing contributions in clinical trials. However, brain-targeted nonviral gene delivery vectors come across various extracellular and intracellular barriers, limiting their ability to transfer the therapeutic gene into the target cells. Chief barriers to nonviral gene therapy have been discussed briefly in this review. We have also highlighted the rapid advancement of several nonviral gene therapies for AD, which are broadly categorized into physical and chemical methods. These methods aim to modulate Aβ, beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1), apolipoprotein E, or neurotrophic factors' expression in the CNS. Overall, this review discusses challenges and recent advancements of nonviral gene therapy for AD.
MeSH term(s)	Alzheimer Disease/etiology ; Alzheimer Disease/therapy ; Biolistics ; Blood-Brain Barrier ; Brain/metabolism ; Dendrimers ; Electroporation ; Gene Transfer Techniques ; Genetic Therapy/methods ; Humans ; Nanoparticle Drug Delivery System ; Polymers/chemistry
Chemical Substances	Dendrimers ; Nanoparticle Drug Delivery System ; Polymers
Language	English
Publishing date	2021-10-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.1c00611
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Article ; Online: Indigenous Practices of Soil and Water Conservation for Sustainable Hill Agriculture and Improving Livelihood Security.

Arora, Sanjay / Bhatt, Rajan / Sharma, Vikas / Hadda, Manjeet S

Environmental management

2022 Volume 72, Issue 2, Page(s) 321–332

Abstract: In the foothills of the North-West Himalayan region of India, agriculture is the main occupation of the residents. The soil and water resources are becoming the major constraints in agricultural production in the erosion-prone fragile ecosystem of the ... ...

Abstract	In the foothills of the North-West Himalayan region of India, agriculture is the main occupation of the residents. The soil and water resources are becoming the major constraints in agricultural production in the erosion-prone fragile ecosystem of the region. However, due to intensive rains and sloping lands of the region, erosion of the topsoil becoming the major problem for practicing sustainable agriculture in the region, which further dissects the lands, reduces the fertility potentials and land productivities of the region. The root cause of this huge erosion in the region is the intensive rains within a short interval of time on the bare sloping hillsides and handling this problem in both ways could reduce their erosion damage. Socio-economically the farmers are illiterate, poor, and hesitate to adopt innovative techniques of both land and water conservation. All this makes the challenge of reducing erosion losses quite difficult. Farmers in the region do have the skills to manage the problem of soil erosion which they learned from their forefathers and have faith in them. These technologies put together are termed as "Indigenous Technical Knowledge" (ITKs) and these ITKs have helped them a lot for sustainable agriculture in the region. Among different ITKs bunding of field, plowing before monsoon, filter strips, earthing-up in maize, mulching, compression of soil in sugarcane are the important ones for restoring the fertility of soils, reducing erosion losses, improving land productivity, and ultimately livelihoods in the region.
MeSH term(s)	Soil ; Conservation of Water Resources ; Ecosystem ; Conservation of Natural Resources ; Agriculture
Chemical Substances	Soil
Language	English
Publishing date	2022-02-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1478932-2
ISSN	1432-1009 ; 0364-152X
ISSN (online)	1432-1009
ISSN	0364-152X
DOI	10.1007/s00267-022-01602-1
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Article ; Online: A review of the tortuous path of nonviral gene delivery and recent progress.

Sharma, Divya / Arora, Sanjay / Singh, Jagdish / Layek, Buddhadev

International journal of biological macromolecules

2021 Volume 183, Page(s) 2055–2073

Abstract: Gene therapy encompasses the transfer of exogenous genetic materials into the patient's target cells to treat or prevent diseases. Nevertheless, the transfer of genetic material into desired cells is challenging and often requires specialized tools or ... ...

Abstract	Gene therapy encompasses the transfer of exogenous genetic materials into the patient's target cells to treat or prevent diseases. Nevertheless, the transfer of genetic material into desired cells is challenging and often requires specialized tools or delivery systems. For the past 40 years, scientists are mainly pursuing various viruses as gene delivery vectors, and the overall progress has been slow and far from the expectation. As an alternative, nonviral vectors have gained substantial attention due to their several advantages, including superior safety profile, enhanced payload capacity, and stealth abilities. Since nonviral vectors encounter multiple extra- and intra-cellular barriers limiting the transfer of genetic payload into the target cell nucleus, we have discussed these barriers in detail for this review. A direct approach, utilizing physical methods like electroporation, sonoporation, gene gun, eliminate the requirement for a specific carrier for gene delivery. In contrast, chemical methods of gene transfer exploit natural or synthetic compounds as carriers to increase cellular targeting and gene therapy effectiveness. We have also emphasized the recent advancements aimed at enhancing the current nonviral approaches. Therefore, in this review, we have focused on discussing the current evolving state of nonviral gene delivery systems and their future perspectives.
MeSH term(s)	Animals ; Humans ; Gene Transfer Techniques/adverse effects ; Genetic Therapy/adverse effects ; Lipids/chemistry ; Polymers/chemistry ; RNA, Messenger/genetics ; RNA, Messenger/therapeutic use
Chemical Substances	Lipids ; Polymers ; RNA, Messenger
Language	English
Publishing date	2021-06-01
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2021.05.192
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