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Article: Identification of RNAi hypoallergic bread wheat lines for wheat-dependent exercise-induced anaphylaxis patients.

Guzmán-López, María H / Ruipérez, Violeta / Marín-Sanz, Miriam / Ojeda-Fernández, Isabel / Ojeda-Fernández, Pedro / Garrote-Adrados, José Antonio / Arranz-Sanz, Eduardo / Barro, Francisco

Frontiers in nutrition

2024 Volume 10, Page(s) 1319888

Abstract: Wheat-dependent exercise-induced anaphylaxis (WDEIA) is one of the most severe forms of wheat allergy. It occurs in patients when they exercise after ingesting wheat-containing foods. Nowadays, the only possible alternative for WDEIA patients is to avoid ...

Abstract	Wheat-dependent exercise-induced anaphylaxis (WDEIA) is one of the most severe forms of wheat allergy. It occurs in patients when they exercise after ingesting wheat-containing foods. Nowadays, the only possible alternative for WDEIA patients is to avoid such foods. This study investigated the potential of six RNA of interference (RNAi) wheat lines with low-prolamin content as alternatives for WDEIA patients. For that purpose, a high performance-liquid chromatography (HPLC) analysis was performed to evaluate differences in gluten protein fractions among these lines. Next, western blots were conducted to measure the immunoglobulin E (IgE) reactivity to wheat proteins in sera from five WDEIA patients. Additionally, monoclonal antibodies (moAb) recognition sites and the IgE binding sites were searched in all peptides identified by LC-MS/MS after protein digestion. The results showed a 61.4%-81.2% reduction in the gliadin content of the RNAi lines, accompanied by an increase in their high-molecular weight (HMW) glutenin content compared to the wild type bread wheat line (WT). In all cases, the reduction in gliadin content correlated with a decrease in IgE reactivity observed in the sera of WDEIA patients, highlighting the E82 and H320 lines. These two RNAi lines exhibited a ≤90% reduction in IgE reactivity. This reduction could be attributed to an absence of IgE binding sites associated with α- and ω5-gliadins, which were present in the WT. Overall, these lines offer a potential alternative for foodstuff for individuals with WDEIA.
Language	English
Publishing date	2024-01-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1319888
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Article ; Online: Sublingual immunotherapy is safe in children, but the challenge is how to increase its efficiency?

Blanco Quirós, A / Arranz Sanz, E

Allergologia et immunopathologia

2011 Volume 39, Issue 3, Page(s) 119–121

MeSH term(s)	Animals ; Antigens, Dermatophagoides/administration & dosage ; Asthma/prevention & control ; Desensitization, Immunologic/methods ; Female ; Humans ; Hypersensitivity/prevention & control ; Male ; Pyroglyphidae/immunology ; Rhinitis, Allergic, Perennial/prevention & control
Chemical Substances	Antigens, Dermatophagoides
Language	English
Publishing date	2011-05
Publishing country	Spain
Document type	Comment ; Editorial
ZDB-ID	193144-1
ISSN	1578-1267 ; 0301-0546
ISSN (online)	1578-1267
ISSN	0301-0546
DOI	10.1016/j.aller.2011.04.003
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Article: Early infections and later allergic diseases.

Blanco Quirós, A / Arranz Sanz, E

Allergologia et immunopathologia

2009 Volume 37, Issue 6, Page(s) 279–280

MeSH term(s)	Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Communicable Diseases/complications ; Communicable Diseases/immunology ; Humans ; Hypersensitivity/etiology ; Hypersensitivity/genetics ; Hypersensitivity/immunology ; Immune System/drug effects ; Immune System/growth & development ; Immune System/immunology ; Infant, Newborn ; Models, Immunological ; Risk Factors ; Sepsis/drug therapy ; Sepsis/immunology ; Th1 Cells/immunology ; Th2 Cells/immunology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2009-11
Publishing country	Spain
Document type	Comment ; Editorial
ZDB-ID	193144-1
ISSN	1578-1267 ; 0301-0546
ISSN (online)	1578-1267
ISSN	0301-0546
DOI	10.1016/j.aller.2009.10.002
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Article: Genes and populations in susceptibility to celiac disease.

Garrote-Adrados, José Antonio / Arranz-Sanz, Eduardo

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

2013 Volume 104, Issue 11, Page(s) 563–565

MeSH term(s)	Celiac Disease/epidemiology ; Celiac Disease/genetics ; Female ; Humans ; Male ; Myosins/genetics
Chemical Substances	myosin IXB ; Myosins (EC 3.6.4.1)
Language	English
Publishing date	2013-01-23
Publishing country	Spain
Document type	Editorial ; Comment
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.4321/s1130-01082012001100002
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Article: Duodenal lymphogram as a complementary tool in the diagnosis of celiac disease in adults.

Burgueño Gómez, Beatriz / Escudero-Hernández, Celia / de Pedro, Rodrigo / Montalvillo, Enrique / Bernardo, David / García-Lagarto, Elena / Garrote Adrados, José Antonio / Arranz Sanz, Eduardo / Fernández Salazar, Luis

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

2020 Volume 112, Issue 6, Page(s) 434–439

Abstract: Introduction: celiac disease (CD) patients have a specific pattern of lymphocytic infiltrate in the duodenal mucosa. Flow cytometry is a complementary tool for the diagnosis of CD, which allows the quantification and characterization of intraepithelial ... ...

Abstract	Introduction: celiac disease (CD) patients have a specific pattern of lymphocytic infiltrate in the duodenal mucosa. Flow cytometry is a complementary tool for the diagnosis of CD, which allows the quantification and characterization of intraepithelial lymphocytes (IELs) by what is commonly called a lymphogram. Here we describe our experience with this technique in the diagnosis of CD in adult patients. Methods: lymphograms from 157 patients performed in our center between 2009 and 2017 were retrospectively analyzed. Fourteen patients had a previous diagnosis of CD and followed a gluten-free diet (GFD), 21 had a new diagnosis of CD and the remaining were considered as non-celiac. The association of the lymphogram results (total IELs, CD3- lymphocytes and TcRγδ lymphocytes) with the CD diagnosis, compliance with the GFD, time since diagnosis and IgA anti-TG2 titer were determined. Results: the area under the ROC curve of TcRγδ lymphocytes for CD patients varied between 0.86 and 0.86. The percentage of TcRγδ lymphocytes in GFD-treated patients was lower; 12 (8.5) vs 20.5 (8.7), p = 0.0153. However, it remained high compared to non-CD; 12 (8.5) vs 6.7 (6), p = 0.135. The time since diagnosis and IgA anti-TG2 titer correlated with the lymphogram results. Helicobacter pylori infection and treatment with angiotensin receptor antagonist 2 (ARA2) were associated with differences in the lymphogram results in patients without CD. Conclusions: the duodenal lymphogram is a reliable complementary tool in adults for the diagnosis of CD. However, compliance and duration of the GFD and other factors may condition its diagnostic capacity.
MeSH term(s)	Adult ; Celiac Disease/diagnosis ; Diet, Gluten-Free ; Duodenum/diagnostic imaging ; Helicobacter Infections ; Helicobacter pylori ; Humans ; Intestinal Mucosa ; Retrospective Studies
Language	English
Publishing date	2020-02-06
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.17235/reed.2020.6391/2019
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Article: From autoimmune enteropathy to the IPEX (immune dysfunction, polyendocrinopathy, enteropathy, X-linked) syndrome.

Blanco Quirós, A / Arranz Sanz, E / Bernardo Ordiz, D / Garrote Adrados, J A

Allergologia et immunopathologia

2009 Volume 37, Issue 4, Page(s) 208–215

Abstract: The term autoimmune enteropathy (AIE) was applied to a form of "intractable diarrhoea" with serum gut autoantibodies, characterized by male predominance, early onset, poor response to parenteral nutrition and several autoimmune diseases, mainly type 1 ... ...

Abstract	The term autoimmune enteropathy (AIE) was applied to a form of "intractable diarrhoea" with serum gut autoantibodies, characterized by male predominance, early onset, poor response to parenteral nutrition and several autoimmune diseases, mainly type 1 diabetes. In recent years the vague concept of AIE has became more precise thanks to the discovery of its genetic and molecular basis. The FOXP3 molecule is crucial for the generation and maturation of regulatory T cells (Treg) expressing CD4+ and CD25+ molecules. Mutations of the FOXP3 gene, located in X chromosome, produce a syndrome with Immune dysfunction, Polyendocrinopathy, Enteropathy and X-linked inheritance (IPEX). The majority of the ancient so-called AIE cases probably correspond to the new IPEX syndrome, even in female patients who may have some autosomal genetic variants. Besides FOXP3, other molecules are likely to be involved in the generation and function of Treg and its deficiency may also enhance autoimmune disease and IPEX-like syndromes. Meanwhile, the important pathogenic role previously ascribed to gut autoantibodies has vanished, with it remaining as having only certain screening usefulness.
MeSH term(s)	Autoantibodies/blood ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Female ; Forkhead Transcription Factors/immunology ; Forkhead Transcription Factors/metabolism ; Genetic Diseases, X-Linked/diagnosis ; Genetic Diseases, X-Linked/immunology ; Humans ; Intestinal Diseases/diagnosis ; Intestinal Diseases/immunology ; Intestinal Diseases/therapy ; Male ; Polyendocrinopathies, Autoimmune/diagnosis ; Polyendocrinopathies, Autoimmune/immunology ; Polyendocrinopathies, Autoimmune/therapy ; Syndrome ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism
Chemical Substances	Autoantibodies ; FOXP3 protein, human ; Forkhead Transcription Factors
Language	English
Publishing date	2009-07
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	193144-1
ISSN	1578-1267 ; 0301-0546
ISSN (online)	1578-1267
ISSN	0301-0546
DOI	10.1016/j.aller.2009.04.002
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Article: Common variable immunodeficiency. Old questions are getting clearer.

Blanco-Quirós, A / Solís-Sánchez, P / Garrote-Adrados, J A / Arranz-Sanz, E

Allergologia et immunopathologia

2006 Volume 34, Issue 6, Page(s) 263–275

Abstract: Common variable immunodeficiency (CVID) is a heterogeneous entity characterized by an impaired ability to produce antibodies. The failure is localized in partially mature B lymphocytes, though T lymphocyte abnormalities are occasionally present. This ... ...

Abstract	Common variable immunodeficiency (CVID) is a heterogeneous entity characterized by an impaired ability to produce antibodies. The failure is localized in partially mature B lymphocytes, though T lymphocyte abnormalities are occasionally present. This deficiency affects antibody synthesis and class switch from IgD and IgM, to IgG and IgA. CVID is related to selective IgA deficiency, and both abnormalities may coincide in one same family, and evolve from one to another in the same patient. The symptoms generally manifest in adults, but can occur at any age, even in infancy. Recurrent bacterial infections or pneumonias are frequent, and may be complicated by gastrointestinal problems, granulomas, autoimmune disorders or malignancies. A defect in memory B cells seems to condition the clinical severity. Recently, several mutations in genes encoding for molecules (CD19, TACI, ICOS) involved in B cell survival and isotype switch have been identified in patients with CVID. Nevertheless, genetic abnormalities have been found in less than 25 % of cases with CVID; the underlying mechanism thus remains unknown in the majority of CVID patients, and research in this field must continue.
MeSH term(s)	Adult ; Aged ; Animals ; Antibody Formation ; B-Cell Activating Factor/deficiency ; B-Cell Activating Factor/immunology ; B-Cell Activating Factor/physiology ; B-Lymphocytes/pathology ; CD40 Ligand/analysis ; Cell Differentiation ; Child ; Chronic Disease ; Cimetidine/therapeutic use ; Common Variable Immunodeficiency/diagnosis ; Common Variable Immunodeficiency/drug therapy ; Common Variable Immunodeficiency/epidemiology ; Common Variable Immunodeficiency/etiology ; Common Variable Immunodeficiency/genetics ; Common Variable Immunodeficiency/immunology ; Disease Models, Animal ; Granuloma/etiology ; Humans ; Immunoglobulin Class Switching ; Immunoglobulin G/therapeutic use ; Immunoglobulins/biosynthesis ; Incidence ; Infection/complications ; Lung Diseases/etiology ; Mice ; Mice, Knockout ; Middle Aged ; Transmembrane Activator and CAML Interactor Protein/deficiency ; Transmembrane Activator and CAML Interactor Protein/immunology ; Tumor Necrosis Factor Ligand Superfamily Member 13/deficiency ; Tumor Necrosis Factor Ligand Superfamily Member 13/immunology ; Tumor Necrosis Factor Ligand Superfamily Member 13/physiology
Chemical Substances	B-Cell Activating Factor ; Immunoglobulin G ; Immunoglobulins ; TNFRSF13B protein, human ; TNFSF13B protein, human ; Tnfsf13 protein, mouse ; Tnfsf13b protein, mouse ; Transmembrane Activator and CAML Interactor Protein ; Tumor Necrosis Factor Ligand Superfamily Member 13 ; CD40 Ligand (147205-72-9) ; Cimetidine (80061L1WGD)
Language	English
Publishing date	2006-12-12
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	193144-1
ISSN	1578-1267 ; 0301-0546
ISSN (online)	1578-1267
ISSN	0301-0546
DOI	10.1157/13095875
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Article: Sepsis meningocócica en pediatría. Parámetros asociados a mala evolución.

Blanco Quirós, A / Casado Flores, J / Nieto Moro, M / Garrote Adrados, J A / Arranz Sanz, E / Asensio Antón, J

Anales de pediatria (Barcelona, Spain : 2003)

2004 Volume 61, Issue 4, Page(s) 305–313

Abstract: Background: Mortality due to meningococcal sepsis continues to be extremely high. Patients with a poor prognosis require aggressive therapy and should be identified early.: Objective: To investigate the clinical and biological factors associated with ...

Title translation	Meningococcal sepsis in pediatrics. Parameters associated with poor outcome.
Abstract	Background: Mortality due to meningococcal sepsis continues to be extremely high. Patients with a poor prognosis require aggressive therapy and should be identified early. Objective: To investigate the clinical and biological factors associated with poor outcome. Patients and method: Seventy-one children aged 2 months to 13 years with meningococcal sepsis were studied. Inclusion criteria were meningococcus isolation in cultures or characteristic clinical features with purpuric exanthema. Methods: A correlational descriptive study was performed. In all patients we evaluated the Pediatric Risk of Mortality (PRISM), the Glasgow Scale for Meningococcal Sepsis (GSMS), polymorphonuclear (PMN) count and prolactin (PRL), leptin (LPT) and C-reactive protein (CRP) levels. Results: Fourteen children (19.7 %) died. Death was associated with multiple organ dysfunction syndrome (MODS) (p = 0.0001), high GSMS and PRISM scores (p = 0.0001) and to a lesser extent with shock (p = 0.01). In patients who died, the determinations showing greatest alteration at admission were PRL levels (p = 0.0009) and PMN count (p = 0.0005). CRP levels were not associated with differences in mortality but were high in patients with shock (p = 0.008). Children with high body weight percentiles were at greater risk of death and showed higher levels of PRL, PCT (p = 0.006) and LPT (p = 0.006), without differences in GSMS or PRISM scores. Age did not influence mortality or PRL levels but did influence GMSM and PRISM scores and PMN and CRP levels. These differences disappeared after the age of 2-3 years. In patients with MODS or shock, the only differences found were reduced PMN count (p = 0.0001) and elevated PRL levels (p = 0.0001). Conclusions: In meningococcal sepsis, death is more frequent in children with high body weight percentiles. Moreover, these children present elevated PRL and LPT levels, although whether these variables act independently remains to be elucidated.
MeSH term(s)	Adolescent ; Anti-Bacterial Agents/therapeutic use ; C-Reactive Protein/analysis ; Calcitonin/blood ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Leptin/blood ; Male ; Meningococcal Infections/blood ; Meningococcal Infections/drug therapy ; Meningococcal Infections/mortality ; Prognosis ; Risk Factors ; Sensitivity and Specificity ; Sepsis/blood ; Sepsis/drug therapy ; Sepsis/microbiology ; Sepsis/mortality ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; Leptin ; Calcitonin (9007-12-9) ; C-Reactive Protein (9007-41-4)
Language	Spanish
Publishing date	2004-07-21
Publishing country	Spain
Document type	Comparative Study ; English Abstract ; Journal Article
ZDB-ID	2102669-5
ISSN	1695-4033
ISSN	1695-4033
DOI	10.1016/s1695-4033(04)78393-9
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Article: Marcadores serológicos de actividad en la enfermedad celiaca (EC).

Blanco Quiros, A / Garrote, J A / Arranz Sanz, E

Anales espanoles de pediatria

1990 Volume 32, Issue 6, Page(s) 564–565

Title translation	Serological markers in active celiac disease.
MeSH term(s)	Celiac Disease/genetics ; Celiac Disease/immunology ; Child ; Genetic Markers ; Humans ; Immunoglobulin A/analysis ; Immunoglobulin G/analysis ; Immunoglobulin M/analysis ; Immunoglobulins/analysis
Chemical Substances	Genetic Markers ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; Immunoglobulins
Language	Spanish
Publishing date	1990-06
Publishing country	Spain
Document type	Corrected and Republished Article ; Journal Article
ZDB-ID	193089-8
ISSN	0302-4342
ISSN	0302-4342
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Article: Papel de la inmunología en la enfermedad celiaca.

Blanco Quirós, A / Garrote Adrados, J A / Arranz Sanz, E

Anales espanoles de pediatria

1990 Volume 33, Issue 4, Page(s) 315–324

Title translation	The role of immunology in celiac disease.
MeSH term(s)	Antibody Formation ; B-Lymphocytes/immunology ; Celiac Disease/genetics ; Celiac Disease/immunology ; Child ; HLA Antigens/immunology ; Humans ; Immunoglobulin G/immunology ; T-Lymphocytes/immunology
Chemical Substances	HLA Antigens ; Immunoglobulin G
Language	Spanish
Publishing date	1990-10
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	193089-8
ISSN	0302-4342
ISSN	0302-4342
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