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Article: An HLA map of the world: A comparison of HLA frequencies in 200 worldwide populations reveals diverse patterns for class I and class II.

Arrieta-Bolaños, Esteban / Hernández-Zaragoza, Diana Iraíz / Barquera, Rodrigo

2023 Volume 14, Page(s) 866407

Abstract: HLA frequencies show widespread variation across human populations. Demographic factors as well as selection are thought to have shaped HLA variation across continents. In this study, a worldwide comparison of HLA class I and class II diversity was ... ...

Abstract	HLA frequencies show widespread variation across human populations. Demographic factors as well as selection are thought to have shaped HLA variation across continents. In this study, a worldwide comparison of HLA class I and class II diversity was carried out. Multidimensional scaling techniques were applied to 50
Language	English
Publishing date	2023-03-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2023.866407
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Article ; Online: Learning the next-generation sequencing alphabet of immune reconstitution: factors determining CD8

Arrieta-Bolaños, Esteban / Fleischhauer, Katharina

Haematologica

2019 Volume 104, Issue 3, Page(s) 422–425

MeSH term(s)	CD8-Positive T-Lymphocytes ; Hematopoietic Stem Cell Transplantation ; High-Throughput Nucleotide Sequencing ; Immune Reconstitution ; Receptors, Antigen, T-Cell, alpha-beta/genetics
Chemical Substances	Receptors, Antigen, T-Cell, alpha-beta
Language	English
Publishing date	2019-03-22
Publishing country	Italy
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2018.209130
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Article ; Online: Differential admixture, human leukocyte antigen diversity, and hematopoietic cell transplantation in Latin America: challenges and opportunities.

Arrieta-Bolaños, Esteban / Oliveira, Danielli Cristina / Barquera, Rodrigo

Bone marrow transplantation

2019 Volume 55, Issue 3, Page(s) 496–504

MeSH term(s)	HLA Antigens ; Hematopoietic Stem Cell Transplantation ; Humans ; Latin America
Chemical Substances	HLA Antigens
Language	English
Publishing date	2019-11-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	632854-4
ISSN	1476-5365 ; 0268-3369 ; 0951-3078
ISSN (online)	1476-5365
ISSN	0268-3369 ; 0951-3078
DOI	10.1038/s41409-019-0737-4
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Zs.A 2168: Show issues

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Article ; Online: Combined Analysis of Early CD4

Leserer, Saskia / Arrieta-Bolaños, Esteban / Buttkereit, Ulrike / Beelen, Dietrich W / Turki, Amin T

Cells

2021 Volume 10, Issue 12

Abstract: The incidence and severity of viral complications after cellular therapy are highly variable. Recent publications describe relevant interactions between the human Cytomegalovirus (CMV) and host immunity in recipients of allogeneic hematopoietic cell ... ...

Abstract	The incidence and severity of viral complications after cellular therapy are highly variable. Recent publications describe relevant interactions between the human Cytomegalovirus (CMV) and host immunity in recipients of allogeneic hematopoietic cell transplantation (HCT). Although immune monitoring is routinely performed in HCT patients, validated cut-off levels correlating with transplant outcomes such as survival or CMV reactivation are mostly limited to day +100, which is later than the median time for CMV reactivation in the absence of medical prophylaxis. To address this gap in early risk assessment, we applied an unsupervised machine learning technique based on clustering of day +30 CD4
MeSH term(s)	Adolescent ; Adult ; Aged ; CD4-Positive T-Lymphocytes/immunology ; Cytomegalovirus/immunology ; Cytomegalovirus Infections/epidemiology ; Cytomegalovirus Infections/immunology ; Cytomegalovirus Infections/therapy ; Cytomegalovirus Infections/virology ; Female ; Hematopoietic Stem Cell Transplantation ; Humans ; Incidence ; Lymphocyte Count ; Male ; Middle Aged ; Prognosis ; Risk Assessment ; Transplantation, Homologous ; Young Adult
Language	English
Publishing date	2021-11-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10123318
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Article ; Online: Time series clustering of T cell subsets dissects heterogeneity in immune reconstitution and clinical outcomes among MUD-HCT patients receiving ATG or PTCy.

Leserer, Saskia / Graf, Theresa / Franke, Martina / Bogdanov, Rashit / Arrieta-Bolaños, Esteban / Buttkereit, Ulrike / Leimkühler, Nils / Fleischhauer, Katharina / Reinhardt, Hans Christian / Beelen, Dietrich W / Turki, Amin T

Frontiers in immunology

2023 Volume 14, Page(s) 1082727

Abstract: Introduction: Anti-T-lymphocyte globulin (ATG) or post-transplant cyclophosphamide (PTCy) prevent graft-versus-host disease (GVHD) after hematopoietic cell transplantation (HCT), yet individual patients benefit differentially.: Methods: Given the ... ...

Abstract	Introduction: Anti-T-lymphocyte globulin (ATG) or post-transplant cyclophosphamide (PTCy) prevent graft-versus-host disease (GVHD) after hematopoietic cell transplantation (HCT), yet individual patients benefit differentially. Methods: Given the sparse comparative data on the impact of cellular immune reconstitution in this setting, we studied flow cytometry and clinical outcomes in 339 recipients of 10/10 matched-unrelated donor (MUD) HCT using either ATG (n=304) or PTCy (n=35) for Results: Consistent with published studies, no significant differences in clinical outcomes were observed at the cohort level between MUD-ATG and MUD-PTCy. However, cellular reconstitution revealed preferences for distinct T cell subpopulations associating with GVHD protection in each setting. Starting early after HCT, MUD-PTCy patients had higher regulatory T cell levels after HCT (p <0.0001), while MUD-ATG patients presented with higher levels of γδ T- or NKT cells (both p <0.0001). Time-series clustering further dissected the patient population's heterogeneity revealing distinct immune reconstitution clusters. Importantly, it identified phenotypes that reproducibly associated with impaired clinical outcomes within the same Discussion: The improved understanding of the heterogeneity of cellular reconstitution in MUD patients with T cell manipulation both at the cohort and individual level may support clinicians in managing HCT complications.
MeSH term(s)	Humans ; Time Factors ; Immune Reconstitution ; Antilymphocyte Serum ; Hematopoietic Stem Cell Transplantation/adverse effects ; Cyclophosphamide ; Graft vs Host Disease ; T-Lymphocyte Subsets
Chemical Substances	Antilymphocyte Serum ; Cyclophosphamide (8N3DW7272P)
Language	English
Publishing date	2023-03-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1082727
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Article ; Online: Impact of the HLA Immunopeptidome on Survival of Leukemia Patients After Unrelated Donor Transplantation.

Crivello, Pietro / Arrieta-Bolaños, Esteban / He, Meilun / Wang, Tao / Fingerson, Stephanie / Gadalla, Shahinaz M / Paczesny, Sophie / Marsh, Steven G E / Lee, Stephanie J / Spellman, Stephen R / Bolon, Yung-Tsi / Fleischhauer, Katharina

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2023 Volume 41, Issue 13, Page(s) 2416–2427

Abstract: Purpose: Immunopeptidome divergence between mismatched HLA-DP is a determinant of T-cell alloreactivity and clinical tolerability after fully HLA-A, -B, -C, -DRB1, -DQB1 matched unrelated donor hematopoietic cell transplantation (UD-HCT). Here, we ... ...

Abstract	Purpose: Immunopeptidome divergence between mismatched HLA-DP is a determinant of T-cell alloreactivity and clinical tolerability after fully HLA-A, -B, -C, -DRB1, -DQB1 matched unrelated donor hematopoietic cell transplantation (UD-HCT). Here, we tested this concept in HLA-A, -B, and -C disparities after single class I HLA-mismatched UD-HCT. Patients and methods: We studied 2,391 single class I HLA-mismatched and 14,426 fully HLA-matched UD-HCT performed between 2008 and 2018 for acute leukemia or myelodysplastic syndromes. Hierarchical clustering of experimentally determined peptide-binding motifs (PBM) was used as a proxy for immunopeptidome divergence of HLA-A, -B, or -C disparities, allowing us to classify 1,629/2,391 (68.1%) of the HLA-mismatched UD-HCT as PBM-matched or PBM-mismatched. Risks associated with PBM-matching status were assessed by Cox proportional hazards models, with overall survival (OS) as the primary end point. Results: Relative to full matches, bidirectional or unidirectional PBM mismatches in graft-versus-host (GVH) direction (PBM-GVH mismatches, 60.7%) were associated with significantly lower OS (hazard ratio [HR], 1.48; Conclusion: PBM-GVH mismatches inform mortality risks after single class I HLA-mismatched UD-HCT, suggesting that prospective consideration of directional PBM-matching status might improve outcome. These findings highlight immunopeptidome divergence between mismatched HLA as a driver of clinical tolerability in UD-HCT.
MeSH term(s)	Humans ; Unrelated Donors ; Prospective Studies ; Hematopoietic Stem Cell Transplantation ; Leukemia, Myeloid, Acute ; HLA-A Antigens ; Graft vs Host Disease ; Histocompatibility Testing ; Retrospective Studies ; HLA Antigens
Chemical Substances	HLA-A Antigens ; HLA Antigens
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.22.01229
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 650: Show issues

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Article ; Online: A core group of structurally similar HLA-DPB1 alleles drives permissiveness after hematopoietic cell transplantation.

Arrieta-Bolaños, Esteban / Crivello, Pietro / He, Meilun / Wang, Tao / Gadalla, Shahinaz M / Paczesny, Sophie / Marsh, Steven G E / Lee, Stephanie J / Spellman, Stephen R / Bolon, Yung-Tsi / Fleischhauer, Katharina

Blood

2022 Volume 140, Issue 6, Page(s) 659–663

MeSH term(s)	Alleles ; HLA-DP Antigens ; HLA-DP beta-Chains/genetics ; Hematopoietic Stem Cell Transplantation ; Histocompatibility Testing ; Permissiveness
Chemical Substances	HLA-DP Antigens ; HLA-DP beta-Chains ; HLA-DPB1 antigen
Language	English
Publishing date	2022-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2022015708
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Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 364: Show issues

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Article ; Online: Cytomegalovirus kinetics after hematopoietic cell transplantation reveal peak titers with differential impact on mortality, relapse and immune reconstitution.

Leserer, Saskia / Bayraktar, Evren / Trilling, Mirko / Bogdanov, Rashit / Arrieta-Bolaños, Esteban / Tsachakis-Mück, Nikolaos / Crivello, Pietro / Koldehoff, Michael / Maaßen, Fabienne / Ross, Rudolf Stefan / Fleischhauer, Katharina / Beelen, Dietrich W / Turki, Amin T

American journal of hematology

2021 Volume 96, Issue 4, Page(s) 436–445

Abstract: Even in the era of PCR-based monitoring, prophylaxis, and preemptive therapy, Cytomegalovirus (CMV) viremia remains a relevant cause of non-relapse mortality (NRM) after allogeneic hematopoietic cell transplantation (HCT). However, studies using binary ... ...

Abstract	Even in the era of PCR-based monitoring, prophylaxis, and preemptive therapy, Cytomegalovirus (CMV) viremia remains a relevant cause of non-relapse mortality (NRM) after allogeneic hematopoietic cell transplantation (HCT). However, studies using binary analysis (presence/absence of CMV) reported contradicting data for NRM, overall survival and leukemia relapse. Here, we analyzed CMV replication kinetics in 11 508 whole blood PCR samples of 705 patients with HCT between 2012 and 2017. Using two independent models based on CMV peak titers and on the time point of first CMV reactivation, we stratified patients into risk cohorts. Each cohort had distinct cellular immune reconstitution profiles and differentiated for relevant clinical outcomes. Patients with high CMV peak titers had significantly reduced overall survival (HR 2.13, 95% CI 1.53-2.96; p < .0001), due to high NRM. Early impaired T cell reconstitution was a risk factor for high CMV peak titers, however relevant CMV viremia also related to boosted T cell reconstitution. Importantly, intermediate CMV peak titers associated with a significantly reduced relapse probability (HR 0.53, 95% CI 0.31-0.91; p = .022). In short, CMV kinetics models distinguished relevant clinical outcome cohorts beyond the R+ serostatus with distinct immune reconstitution patterns and resolve in part contradicting results of previous studies exclusively focused on the presence or absence of CMV.
MeSH term(s)	Adolescent ; Adult ; Aged ; Allografts ; Cytomegalovirus/isolation & purification ; Cytomegalovirus/physiology ; Cytomegalovirus Infections/immunology ; Cytomegalovirus Infections/virology ; Female ; Follow-Up Studies ; Hematopoietic Stem Cell Transplantation ; Humans ; Immune Reconstitution ; Kaplan-Meier Estimate ; Kinetics ; Male ; Middle Aged ; Proportional Hazards Models ; Recurrence ; Retrospective Studies ; Viral Load ; Viremia/immunology ; Viremia/virology ; Virus Activation ; Young Adult
Language	English
Publishing date	2021-02-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.26094
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Article ; Online: 4-Locus high-resolution HLA allele and haplotype frequencies in Amerindians from Costa Rica.

Arrieta-Bolaños, Esteban / Madrigal-Sánchez, Juan José / Stein, Jeremy E / Salazar-Sánchez, Lizbeth / Madrigal, J Alejandro / Marsh, Steven G E / Shaw, Bronwen E

Human immunology

2019 Volume 80, Issue 7, Page(s) 409–410

Abstract: A total of 125 Costa Ricans of Amerindian descent were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, and -DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as ... ...

Abstract	A total of 125 Costa Ricans of Amerindian descent were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, and -DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequent extended haplotype identified was A24:02:01-B40:02:01-C03:05-DRB104:07:01G, with an estimated frequency of 8.26%. A deviation from Hardy-Weinberg Equilibrium was detected at the DRB1 locus (p = 0.099). The HLA genotypic data of the population sample reported here are available publicly in the Allele Frequencies Net Database under the population name "Costa Rica Amerindians" and the identifier AFN3608.
Language	English
Publishing date	2019-05-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	801524-7
ISSN	1879-1166 ; 0198-8859
ISSN (online)	1879-1166
ISSN	0198-8859
DOI	10.1016/j.humimm.2019.05.008
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Article ; Online: Human leukocyte antigen profiles of latin american populations: differential admixture and its potential impact on hematopoietic stem cell transplantation.

Arrieta-Bolaños, Esteban / Madrigal, J Alejandro / Shaw, Bronwen E

Bone marrow research

2012 Volume 2012, Page(s) 136087

Abstract: The outcome of hematopoietic stem cell transplantation (HSCT) is shaped by both clinical and genetic factors that determine its success. Genetic factors including human leukocyte antigen (HLA) and non-HLA genetic variants are believed to influence the ... ...

Abstract	The outcome of hematopoietic stem cell transplantation (HSCT) is shaped by both clinical and genetic factors that determine its success. Genetic factors including human leukocyte antigen (HLA) and non-HLA genetic variants are believed to influence the risk of potentially fatal complications after the transplant. Moreover, ethnicity has been proposed as a factor modifying the risk of graft-versus-host disease. The populations of Latin America are a complex array of different admixture processes with varying degrees of ancestral population proportions that came in different migration waves. This complexity makes the study of genetic risks in this region complicated unless the extent of this variation is thoroughly characterized. In this study we compared the HLA-A and HLA-B allele group profiles for 31 Latin American populations and 61 ancestral populations from Iberia, Italy, Sub-Saharan Africa, and America. Results from population genetics comparisons show a wide variation in the HLA profiles from the Latin American populations that correlate with different admixture proportions. Populations in Latin America seem to be organized in at least three groups with (1) strong Amerindian admixture, (2) strong Caucasian component, and (3) a Caucasian-African gradient. These results imply that genetic risk assessment for HSCT in Latin America has to be adapted for different population subgroups rather than as a pan-Hispanic/Latino analysis.
Language	English
Publishing date	2012-11-18
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2623734-9
ISSN	2090-3006 ; 2090-2999 ; 2090-2999
ISSN (online)	2090-3006 ; 2090-2999
ISSN	2090-2999
DOI	10.1155/2012/136087
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