Article ; Online: IL-33 and ST2 as predictors of disease severity in children with viral acute lower respiratory infection.
2020 Volume 127, Page(s) 154965
Abstract: Background: Mechanisms influencing severity of acute lower respiratory infection (ALRI) in children are not established. We aimed to assess the role of inflammatory markers and respiratory viruses in ALRI severity.: Methods: Concentrations of ... ...
| Abstract | Background: Mechanisms influencing severity of acute lower respiratory infection (ALRI) in children are not established. We aimed to assess the role of inflammatory markers and respiratory viruses in ALRI severity. Methods: Concentrations of interleukin(IL)-33, soluble suppression of tumorigenicity (sST)2, IL-1ß, tumor necrosis factor α, IL-4, IL-6 and IL- 8 and types of respiratory viruses were evaluated in children at the first and fifth days after hospital admission. Disease severity was defined as need for mechanical ventilation. Results: Seventy-nine children <5 years-old were included; 33(41.8%) received mechanical ventilation. No associations between virus type, viral load or co-detections and severity of disease were observed. Detection of IL-33 and sST2 in nasopharyngeal aspirates (NPA) on admission were associated with higher risk for mechanical ventilation (RR = 2.89 and RR = 4.57, respectively). IL-6 and IL-8 concentrations were higher on Day 5 in mechanically ventilated children. IL-6 NPA concentrations decreased from Day 1 to Day 5 in children who did not receive mechanical ventilation. Increase in sST2 NPA concentrations from Day 1 to Day 5 was associated with longer hospital length of stay (p < 0.01). Conclusions: An exacerbated local activation of the IL-33/ST2 axis and persistently high sST2 concentrations over time were associated with severity of viral ALRI in children. |
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| MeSH term(s) | Biomarkers/metabolism ; Child, Preschool ; Female ; Hospitalization ; Humans ; Interleukin-1 Receptor-Like 1 Protein/metabolism ; Interleukin-33/metabolism ; Interleukin-6/metabolism ; Interleukin-8/metabolism ; Male ; Prospective Studies ; Respiratory Syncytial Virus Infections/metabolism ; Respiratory Syncytial Virus Infections/pathology ; Respiratory Tract Infections/metabolism ; Respiratory Tract Infections/pathology ; Severity of Illness Index |
| Chemical Substances | Biomarkers ; IL1RL1 protein, human ; IL33 protein, human ; Interleukin-1 Receptor-Like 1 Protein ; Interleukin-33 ; Interleukin-6 ; Interleukin-8 |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-01-03 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1018055-2 |
| ISSN | 1096-0023 ; 1043-4666 |
| ISSN (online) | 1096-0023 |
| ISSN | 1043-4666 |
| DOI | 10.1016/j.cyto.2019.154965 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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