LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Arslan, Habibe Sema"
  2. AU="Sarjanoja, E (Länsi-Pohja Central Hospital)"
  3. AU=Cohen Irun R
  4. AU="Mo, Zhao-Hui"
  5. AU="Bahar, Fahmi"
  6. AU="Stambouli, Sarra"
  7. AU="Held, Susanne"
  8. AU="Warit, Saradee"
  9. AU="Songco, Annabel" AU="Songco, Annabel"
  10. AU="Nezbeda, Ivo"
  11. AU="Bair, Henry"
  12. AU="Lingala Santosh Kumar"

Suchergebnis

Treffer 1 - 3 von insgesamt 3

Suchoptionen

  1. Artikel: New markers for predictions of acute and chronic rejection and graft outcomes in kidney transplant recipients; HLA-G gene 3′UTR 14 bp polymorphism and sHLA-G

    Darbas, Sule / Yilmaz, Vural Taner / Kocak, Huseyin / Kisaoglu, Abdullah / Demiryilmaz, Ismail / Aydinli, Bulent / Arslan, Habibe Sema / Ucar, Fahri

    Gene. 2021 July 20, v. 790

    2021  

    Abstract: The aim of this study was to evaluate the relation of Human Leukocyte Antigen-G (HLA-G) 14 bp ins/del (insertion/deletion) polymorphism and soluble HLA-G (sHLA-G) level with rejection in kidney transplant recipients.The study was planned as a case- ... ...

    Abstract The aim of this study was to evaluate the relation of Human Leukocyte Antigen-G (HLA-G) 14 bp ins/del (insertion/deletion) polymorphism and soluble HLA-G (sHLA-G) level with rejection in kidney transplant recipients.The study was planned as a case-control study involving two hundred fifty kidney transplant recipients. The case group consisted of 125 (female/male: 56/69) kidney transplant recipients diagnosed with acute (n = 52) and chronic rejection (n = 73). The control group consisted of one hundred twenty-five kidney transplant patients with no acute or chronic rejection matched by gender and age in the case group. The sHLA-G level in the recipient's plasma (at the time of rejection for the case, the same time as the case after the transplant for control) was analyzed by Enzyme-Linked Immunosorbent Assay (ELISA). HLA-G 3′ untranslated region (3′UTR) polymorphism of recipient and donor was determined using agarose gel electrophoresis and DNA sequencing method.In our study, it was shown that acute rejection rate increased 1.06 times and chronic rejection rate increased 1.14 times in kidney transplant recipients with low serum sHLA-G levels. The rejection patients with the HLA-G 14 bp del/del genotype had higher sHLA-G levels post-transplantation. The frequency of acute rejection was lower in patients with HLA-G 14 bp del/del polymorphism than those with ins/ins and ins/del polymorphisms.This study proposes that HLA-G 3′UTR polymorphism and sHLA-G level might be useful in prediction of rejection in kidney transplant recipients.
    Schlagwörter DNA ; agar gel electrophoresis ; blood serum ; case-control studies ; enzyme-linked immunosorbent assay ; females ; genes ; genotype ; humans ; kidney transplant ; leukocytes ; males ; prediction
    Sprache Englisch
    Erscheinungsverlauf 2021-0720
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2021.145712
    Datenquelle NAL Katalog (AGRICOLA)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Bonn

    Z 79/715: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  2. Artikel ; Online: New markers for predictions of acute and chronic rejection and graft outcomes in kidney transplant recipients; HLA-G gene 3'UTR 14 bp polymorphism and sHLA-G.

    Darbas, Sule / Yilmaz, Vural Taner / Kocak, Huseyin / Kisaoglu, Abdullah / Demiryilmaz, Ismail / Aydinli, Bulent / Arslan, Habibe Sema / Ucar, Fahri

    Gene

    2021  Band 790, Seite(n) 145712

    Abstract: The aim of this study was to evaluate the relation of Human Leukocyte Antigen-G (HLA-G) 14 bp ins/del (insertion/deletion) polymorphism and soluble HLA-G (sHLA-G) level with rejection in kidney transplant recipients. The study was planned as a case- ... ...

    Abstract The aim of this study was to evaluate the relation of Human Leukocyte Antigen-G (HLA-G) 14 bp ins/del (insertion/deletion) polymorphism and soluble HLA-G (sHLA-G) level with rejection in kidney transplant recipients. The study was planned as a case-control study involving two hundred fifty kidney transplant recipients. The case group consisted of 125 (female/male: 56/69) kidney transplant recipients diagnosed with acute (n = 52) and chronic rejection (n = 73). The control group consisted of one hundred twenty-five kidney transplant patients with no acute or chronic rejection matched by gender and age in the case group. The sHLA-G level in the recipient's plasma (at the time of rejection for the case, the same time as the case after the transplant for control) was analyzed by Enzyme-Linked Immunosorbent Assay (ELISA). HLA-G 3' untranslated region (3'UTR) polymorphism of recipient and donor was determined using agarose gel electrophoresis and DNA sequencing method. In our study, it was shown that acute rejection rate increased 1.06 times and chronic rejection rate increased 1.14 times in kidney transplant recipients with low serum sHLA-G levels. The rejection patients with the HLA-G 14 bp del/del genotype had higher sHLA-G levels post-transplantation. The frequency of acute rejection was lower in patients with HLA-G 14 bp del/del polymorphism than those with ins/ins and ins/del polymorphisms. This study proposes that HLA-G 3'UTR polymorphism and sHLA-G level might be useful in prediction of rejection in kidney transplant recipients.
    Mesh-Begriff(e) 3' Untranslated Regions ; Adolescent ; Adult ; Aged ; Biomarkers/analysis ; Case-Control Studies ; Female ; Graft Rejection/diagnosis ; Graft Rejection/etiology ; HLA-G Antigens/genetics ; Humans ; Kidney Transplantation/adverse effects ; Male ; Middle Aged ; Polymorphism, Genetic ; Renal Insufficiency, Chronic/pathology ; Renal Insufficiency, Chronic/surgery ; Young Adult
    Chemische Substanzen 3' Untranslated Regions ; Biomarkers ; HLA-G Antigens
    Sprache Englisch
    Erscheinungsdatum 2021-05-11
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2021.145712
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1357: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel ; Online: Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population.

    Darbas, Sule / Inan, Dilara / Kilinc, Yahya / Arslan, Habibe Sema / Ucar, Fahri / Boylubay, Ozaydin / Koksoy, Sadi / Mutlu, Esvet / Yucel, Burcu / Ekinci, Nurten Sayin

    Northern clinics of Istanbul

    2022  Band 10, Heft 1, Seite(n) 67–73

    Abstract: Objective: Many human leukocyte antigen (HLA)-B alleles are associated with an increased risk of Acquired Immune Deficiency Syndrome (AIDS) and Human Immunodeficiency Virus (HIV) progression; however, their distribution varies among different racial/ ... ...

    Abstract Objective: Many human leukocyte antigen (HLA)-B alleles are associated with an increased risk of Acquired Immune Deficiency Syndrome (AIDS) and Human Immunodeficiency Virus (HIV) progression; however, their distribution varies among different racial/ethnic groups. Abacavir used in the treatment of AIDS significantly increases the risk of hypersensitivity reactions in patients with HLA-B*57:01. The aim of this study was to determine the distribution of HIV-associated HLA-B subgroups (high and low resolution) and HLA-B*57:01 associated with Abacavir sensitivity in Turkiye.
    Methods: This retrospective case-control study consisted of 416 (F/M:111/305) HIV positive patients and 416 (F/M:111/305) healthy controls. HLA-B alleles were identified using Luminex based low-resolution method and further subgrouped by sequence-based high-resolution typing.
    Results: Our data showed that in patients with HIV-1 infection, HLA-B*15, *35, and *51 allele frequencies were higher, while the HLA-B*07, *14 and *55 allele frequencies were lower as compared to the controls. It was determined that HLA-B*15:01, *35:01, *35:08, and *51:01 alleles frequencies were higher in the patients with HIV-1 infection compared to the controls as HLA-B*07:02, *14:01, *44:01, and *55:01 allele frequencies were detected low. HLA-B*57:01 allele positivity, which is important in Abacavir hypersensitivity, was lower than controls, and this difference was not statistically significant.
    Conclusion: Our results suggest that, HLA-B*07, *14, and *55 alleles and HLA-B*07:02, *14:01, *44:01, and *55:01 subgroups might have a protective effect, while HLA-B*15, *35, and *51 alleles and HLA-B*15:01, *35:01, *35:08, and *51:01 subgroups might play a role in susceptibility to HIV-1 infection.
    Sprache Englisch
    Erscheinungsdatum 2022-12-13
    Erscheinungsland Turkey
    Dokumenttyp Journal Article
    ZDB-ID 3031921-3
    ISSN 2536-4553 ; 2148-4902
    ISSN (online) 2536-4553
    ISSN 2148-4902
    DOI 10.14744/nci.2021.00018
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang