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  1. Article ; Online: Genetic Polymorphism on Chromosome 4q25 (rs17570669) May Predict Recurrence After Successful Electrical Cardioversion in Patients with Persistent Atrial Fibrillation.

    Ulus, Taner / Aliyev, İlkin / Arslan, Serap / Çilingir, Oğuz / Çolak, Ertuğrul

    Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir

    2024  Volume 51, Issue 8, Page(s) 550–556

    Abstract: Objective: Direct current electrical cardioversion (DCCV) is an effective rhythm-control option for patients with atrial fibrillation (AF). Despite initial success, a high recurrence rate remains a significant challenge. There is limited data on the ... ...

    Title translation Kromozom 4q25 (Rs17570669) Üzerindeki Genetik Polimorfizm Dirençli Atriyal Fibrilasyon Hastalarında Başarılı Elektriksel Kardiyoversiyon Sonrası Nüksü Belirleyebilir.
    Abstract Objective: Direct current electrical cardioversion (DCCV) is an effective rhythm-control option for patients with atrial fibrillation (AF). Despite initial success, a high recurrence rate remains a significant challenge. There is limited data on the genetic predictors of AF recurrence following successful DCCV. In this study, we aimed to evaluate whether 11 single nucleotide polymorphisms (SNPs) previously associated with AF are also linked to recurrence after DCCV in the Turkish population.
    Methods: Seventy-five patients with persistent AF, who achieved stable sinus rhythm following DCCV, were included in the study. The patients were prospectively monitored for the onset of AF recurrence. Clinical characteristics and SNPs were analyzed and compared between patients who experienced recurrence and those who did not.
    Results: The average age of the patients was 61.9 ± 11.5, and 33 (44%) were female. Over an average follow-up period of 17.0 (11.0-25.0) months, AF recurrence was observed in 38 patients (50.7%). A SNP in the PITX2 gene (rs17570669) (OR: 9.00, 95% Confidence Interval (CI): 1.28-63.02) and another in the ZFHX3 gene (rs2106261) (OR: 8.96, 95% CI: 1.03-77.66) were notably associated with AF recurrence in the additive model (P = 0.027 and 0.047, respectively). Multivariate Cox regression analysis revealed that the rs17570669 SNP was the sole independent predictor of AF recurrence (Hazard Ratio (HR): 3.59, 95% CI: 1.05-12.21, P = 0.040).
    Conclusion: The SNP in the paired-like homeodomain 2 (PITX2) gene (rs17570669) emerges as an independent predictor for AF recurrence after successful electrical cardioversion.
    MeSH term(s) Humans ; Female ; Male ; Atrial Fibrillation/genetics ; Atrial Fibrillation/therapy ; Electric Countershock ; Polymorphism, Single Nucleotide ; Chromosomes ; Recurrence
    Language English
    Publishing date 2024-03-27
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1215217-1
    ISSN 1308-4488 ; 1016-5169
    ISSN (online) 1308-4488
    ISSN 1016-5169
    DOI 10.5543/tkda.2023.37679
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  2. Article ; Online: IL-15 Gene Polymorphism in Celiac Disease Patients and Their Siblings.

    Kara, Yalçın / Eren, Makbule / Arslan, Serap / Çilingir, Oğuz

    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

    2021  Volume 32, Issue 4, Page(s) 349–356

    Abstract: Background: Celiac disease (CD) is an immune-mediated enteropathy characterized by lifelong gluten intolerance. Interleukin-15 (IL- 15) is a proinflammatory cytokine that is considered a key component in the immune reaction triggered by gluten. Our aim ... ...

    Abstract Background: Celiac disease (CD) is an immune-mediated enteropathy characterized by lifelong gluten intolerance. Interleukin-15 (IL- 15) is a proinflammatory cytokine that is considered a key component in the immune reaction triggered by gluten. Our aim of this study was to evaluate the influence of IL-15 gene polymorphisms on CD development and clinical presentation.
    Methods: The study was enrolled-with 90 CD patients (49 female/41 male, median years of age 11), their 38 siblings (20 female/18 male, median years of age 8), and 99 healthy controls (66 female/33 male, median years of age 13). Their demographic findings, symptoms, and signs histopathological grade, Human Leukocyte Antigen (HLA) types were recorded. IL-15 gene polymorphisms rs2857261, rs10519613, and rs1057972 were analyzed through PCR.
    Results: There was a significantly higher frequency of GG genotype in rs2857972 polymorphisms and TT genotype in rs1057972 polymorphisms in celiac families compared to controls [41% vs. 23% (P = .0008), 36% vs. 11% (P = .001), respectively]. Without considering their HLA status, there was not any difference between celiacs and healthy siblings. However, when stratified according to their HLADQ2 status, rs2857972 GG polymorphism was 1.5 times prominent in celiacs than siblings at homozygous state, whereas rs1057972 TT genotype was found to be 2.5 times prominent in celiac siblings at heterozygous state. There was no association between these polymorphisms and clinical presentation.
    Conclusion: rs2857972 GG and rs1057972 TT variants of IL 15 are more prominent in celiac families than controls. However, the impact of IL-15 gene polymorphism on CD development is dependent on HLADQ2 status.
    MeSH term(s) Adolescent ; Case-Control Studies ; Celiac Disease/diagnosis ; Celiac Disease/genetics ; Child ; Child, Preschool ; Cohort Studies ; Female ; Genetic Predisposition to Disease/genetics ; Genotype ; Glutens ; Humans ; Interleukin-15/genetics ; Male ; Polymorphism, Genetic ; Prospective Studies ; Siblings
    Chemical Substances Interleukin-15 ; Glutens (8002-80-0)
    Language English
    Publishing date 2021-07-06
    Publishing country Turkey
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1340275-4
    ISSN 2148-5607 ; 1300-4948
    ISSN (online) 2148-5607
    ISSN 1300-4948
    DOI 10.5152/tjg.2021.19083
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  3. Article: Association of eleven single nucleotide polymorphisms with refractive disorders from Eskisehir, Turkey.

    Unlu, Nadir / Erzurumluoglu Gokalp, Ebru / Arslan, Serap / Cilingir, Oguz / Bilgin, Muzaffer / Yildirim, Engin / Gursoy, Huseyin

    International journal of ophthalmology

    2021  Volume 14, Issue 6, Page(s) 812–817

    Abstract: Aim: To investigate relationship between refractive errors and eleven single nucleotide polymorphisms (SNPs) in : Methods: A group of 212 participants with myopia (: Results: The patients in this study consists of 47 female/44 male (age: 23.47±4 ... ...

    Abstract Aim: To investigate relationship between refractive errors and eleven single nucleotide polymorphisms (SNPs) in
    Methods: A group of 212 participants with myopia (
    Results: The patients in this study consists of 47 female/44 male (age: 23.47±4.30) patients with myopia, 20 female/25 male (age: 31.20±8.02) with hyperopia and 33 female/43 male (age: 25.22±6.60) with emmetropia. The genotype distribution of the rs7618348 polymorphism, which was the only statistically significant one between myopia and emmetropia group. The genotype distribution of the rs3819545, rs3735520, rs7041, and rs2239182 polymorphisms, which were statistically significant between hyperopia and emmetropia groups.
    Conclusion: The importance of genetic predisposition to refractive errors with respect to etiology of the disease is revealed. It is known that polymorphism studies may differ because of genetic diversity among populations so larger cohort studies are required in different populations to enlighten the etiology of the refractive errors.
    Language English
    Publishing date 2021-06-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2663246-9
    ISSN 2227-4898 ; 2222-3959
    ISSN (online) 2227-4898
    ISSN 2222-3959
    DOI 10.18240/ijo.2021.06.05
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  4. Article: Patient with Mal de Meleda in whom a Novel Gene Mutation was Identified.

    Gurel, Gulhan / Cilingir, Oguz / Kutluay, Ozden / Arslan, Serap / Sahin, Sevinc / Colgecen, Emine

    The Eurasian journal of medicine

    2018  Volume 51, Issue 2, Page(s) 206–208

    Abstract: Mal de Meleda, also known as keratoderma palmoplantaris transgrediens, is a rare type of autosomal recessive palmoplantar keratoderma. A 19-year-old male presented with a congenital yellowish discoloration and thickening of both palms and soles of the ... ...

    Abstract Mal de Meleda, also known as keratoderma palmoplantaris transgrediens, is a rare type of autosomal recessive palmoplantar keratoderma. A 19-year-old male presented with a congenital yellowish discoloration and thickening of both palms and soles of the feet. His family history revealed that there was no consanguinity between the mother and the father and that the patient had three healthy brothers. The second- and third-degree relatives, five females and one male, also exhibited similar skin findings. From the isolated DNA samples, the extrinsic regions of the SLURP1 gene were screened using the sequence analysis and the Sanger sequencing was performed with the 3130 Sequence Analyzer. Results of this analysis show that a p.Arg 96 Pro (R96P) (c.287 CGA>CCA) homozygous missense point mutation was detected on the SLURP 1 (a secreted toxin-like mammalian lymphocyte antigen 6/urokinase-type plasminogen activator receptor-related protein 1) gene of the patients, while heterozygous p.Arg 96 Pro (R96P) (c.287 CGA>CCA) mutation was detected in the mother, father, and brothers. Our search of the Human Genome Mutation Database and previous literature revealed no reports of this mutation in mal de Meleda. We report this case due to the identification of a novel gene mutation in a patient with mal de Meleda, a palmoplantar keratoderma.
    Language English
    Publishing date 2018-11-30
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2577670-8
    ISSN 1308-8742 ; 1308-8734
    ISSN (online) 1308-8742
    ISSN 1308-8734
    DOI 10.5152/eurasianjmed.2018.18215
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  5. Article ; Online: Serum beta 2-microglobulin as a biomarker in inflammatory bowel disease.

    Yılmaz, Bülent / Köklü, Seyfettin / Yüksel, Osman / Arslan, Serap

    World journal of gastroenterology

    2014  Volume 20, Issue 31, Page(s) 10916–10920

    Abstract: Aim: To investigate the diagnostic utility of beta 2 microglobulin (B2-M) levels and analyze this correlation with the activity of inflammatory bowel disease (IBD).: Methods: Overall, 78 IBD patients and 30 healthy controls were enrolled in the study. ...

    Abstract Aim: To investigate the diagnostic utility of beta 2 microglobulin (B2-M) levels and analyze this correlation with the activity of inflammatory bowel disease (IBD).
    Methods: Overall, 78 IBD patients and 30 healthy controls were enrolled in the study. We examined B2-M serum levels in 43 ulcerative colitis (UC) patients, 35 with Crohn's disease (CD) and 30 control subjects, using an enzymatic method. Patients were divided into two groups according to two disease types: active and in remission. Subjects were also divided into two subgroups according to extent of the disease: left-side and pancolitis for UC and ileitis and ileocolitis for CD. All groups were compared for mean serum B2-M levels and also examined to see whether there was a correlation between serum B2-M levels and other inflammatory markers.
    Results: The mean serum B2-M levels in the control group, UC and CD were 1.71, 2.41 and 2.24 respectively. B2-M values ≥ 1.96 mg/L had a 62% sensitivity, 76% specificity, a 79% positive predictive value, and a 58% negative predictive value for UC patients. B2-M values ≥ 1.70 mg/L had 80% sensitivity, 53% specificity, 66% positive predictive value, and 69% negative predictive value for CD patients. Mean B2-M values were significantly higher in ulcerative colitis and Crohn's disease patients than in healthy controls (UC 2.41 ± 0.87 vs 1.71 ± 0.44, P = 0.002; CD 2.24 ± 1.01 vs 1.71 ± 0.44, P = 0.033). Also, mean B2-M values were significantly higher in active disease when compared to patients in remission (UC 2.66 ± 0.92 vs 1.88 ± 0.41, P = 0.004; CD 2.50 ± 1.15 vs 1.73 ± 0.31, P = 0.033). The difference between groups (UC and CD) in terms of serum B2-M levels was statistically insignificant (2.41 ± 0.87 vs 2.24 ± 1.01, P > 0.05 respectively).
    Conclusion: Serum B2-M levels may be used as an activity parameter in IBD.
    MeSH term(s) Adult ; Biomarkers/blood ; Case-Control Studies ; Colitis, Ulcerative/blood ; Colitis, Ulcerative/diagnosis ; Crohn Disease/blood ; Crohn Disease/diagnosis ; Female ; Humans ; Inflammation Mediators/blood ; Male ; Middle Aged ; Predictive Value of Tests ; Remission Induction ; beta 2-Microglobulin/blood
    Chemical Substances Biomarkers ; Inflammation Mediators ; beta 2-Microglobulin
    Language English
    Publishing date 2014-07-24
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v20.i31.10916
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  6. Article: Retrospective evaluation of pregnant women with celiac disease.

    Beksaç, Kemal / Örgül, Gökçen / Çağan, Murat / Karaağaoğlu, Ergun / Arslan, Serap / Beksaç, Mehmet Sinan

    Journal of the Turkish German Gynecological Association

    2017  Volume 18, Issue 1, Page(s) 56–59

    Abstract: Objective: To show celiac disease (CD) and its poor pregnancy outcome relationship, and to demonstrate the importance of a gluten-free diet together with low-dose low-molecular-weight heparin (LMWH) and low-dose corticosteroid (LDC) in the management of ...

    Abstract Objective: To show celiac disease (CD) and its poor pregnancy outcome relationship, and to demonstrate the importance of a gluten-free diet together with low-dose low-molecular-weight heparin (LMWH) and low-dose corticosteroid (LDC) in the management of pregnancies with CD.
    Material and methods: This study consisted of 2 groups of patients. Six patients with CD (control group) on a gluten-free diet were monitored during their first pregnancies within the framework of antenatal care program and their pregnancy outcomes were compared with eight poorly-treated pregnant patients with CD (study group) who were referred from other medical institutions. LMWH (enoxaparine 1x2000 Anti-XA IU/0.2 mL/day), and LDC (methylprednisolone 1x4 mg p.o/day) were used in the control group. Their obstetric histories and outcomes of their last pregnancies were compared. The patients' obstetric risk levels were evaluated using the "Beksac Obstetrics Index" (BOI).
    Results: There were miscarriages in 50% of the study group. There were also 50% and 75% preterm deliveries in the control and study groups, respectively. The BOI of the study group was significantly worse than the control group (1.31 vs. 0.31±0.21, p<0.01). There were no statistically significant differences between age (24±4.7 vs 31.7±6 years, p=0.448), gestational day of birth (259.3±8.5 vs 246.6±24.3), birthweight (2691±698 vs 2262±359 g, p=0.394), and cesarean section rates (p=0.118).
    Conclusion: CD is a risk factor for adverse pregnancy outcome. Miscarriage and preterm labor are critical complications in pregnancies complicated by CD. A gluten-free diet is important in the treatment. LMWH and LDC seem to be helpful in the management of pregnant women with CD.
    Language English
    Publishing date 2017-05-16
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2425806-4
    ISSN 1309-0380 ; 1303-9695 ; 1309-0399
    ISSN (online) 1309-0380 ; 1303-9695
    ISSN 1309-0399
    DOI 10.4274/jtgga.2016.0198
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  7. Article ; Online: Genetic variants associated with atrial fibrillationand long-term recurrence after catheter ablation for atrialfibrillation in Turkish patients.

    Ulus, Taner / Dural, Muhammet / Meşe, Pelin / Yetmiş, Furkan / Mert, Kadir Uğur / Görenek, Bülent / Çilingir, Oğuz / Erzurumluoglu Gökalp, Ebru / Arslan, Serap / Artan, Sevilhan / Aykaç, Özlem / Çolak, Ertuğrul / Yorgun, Hikmet / Canpolat, Uğur / Aytemir, Kudret

    Anatolian journal of cardiology

    2021  Volume 25, Issue 2, Page(s) 129–138

    Abstract: Objective: Genome-wide association studies have revealed that single nucleotide polymorphisms (SNPs) are associated with atrial fibrillation (AF) and can predict AF recurrence after catheter ablation in different populations. However, there exists no ... ...

    Abstract Objective: Genome-wide association studies have revealed that single nucleotide polymorphisms (SNPs) are associated with atrial fibrillation (AF) and can predict AF recurrence after catheter ablation in different populations. However, there exists no such data for the Turkish population. We aimed to investigate whether 11 SNPs in the PITX2, ZFHX3, EPHX2, CAV1, TBX5, TGF-1, and SCN10A were related to AF and whether these SNPs can predict long-term atrial tachyarrhythmia (ATa) recurrence after pulmonary vein isolation (PVI) for AF in Turkish patients.
    Methods: A total of 245 consecutive patients with non-valvular AF (44.9% men, mean age: 60.2±13.2 years, 65.3% paroxysmal AF) and 50 age- and sex-matched controls were included in this analysis. The clinical features and genetic variants were compared between the 2 groups. Of the 245 patients, 128 who underwent PVI with second-generation cryoballoon were further examined for long-term recurrence after the procedure.
    Results: Four SNPs in PITX2 were significantly associated with AF (rs10033464_T: OR 3.29, 95%CI: 1.38-7.82, p=0.007; rs6838973_T: OR 3.06, 95% CI 1.36-6.87, p=0.007; rs3853445_C: OR 2.84, 95%CI: 1.27-6.36, p=0.011; rs17570669_T: OR 4.03, 95% CI: 1.71-9.51, p=0.001). Among these patients who underwent PVI, one locus in CAV1 (rs3807989_G: OR 4.50, 95% CI 1.04-19.31, p=0.043) and early recurrence (OR: 8.06, 95% CI: 2.12-30.55, p=0.002) predicted long-term AF recurrence after catheter ablation.
    Conclusion: Significant associations exists between 4 SNPs in PITX2 and AF (rs10033464, rs6838973, rs3853445, and rs17570669) in Turkish patients. In addition, 1 genetic variant in CAV1 (rs3807989) and early recurrence can predict long-term ATa recurrence after catheter ablation.
    MeSH term(s) Aged ; Atrial Fibrillation/genetics ; Atrial Fibrillation/surgery ; Catheter Ablation ; Female ; Genome-Wide Association Study ; Humans ; Male ; Middle Aged ; NAV1.8 Voltage-Gated Sodium Channel ; Pulmonary Veins/surgery ; Recurrence ; Treatment Outcome
    Chemical Substances NAV1.8 Voltage-Gated Sodium Channel ; SCN10A protein, human
    Language English
    Publishing date 2021-02-12
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2278670-3
    ISSN 2149-2271 ; 2149-2271
    ISSN (online) 2149-2271
    ISSN 2149-2271
    DOI 10.14744/AnatolJCardiol.2020.44082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The relationship of retinopathy of prematurity with brain-derivated neurotrophic factor, vascular endotelial growth factor-A, endothelial PAD domain protein 1 and nitric oxide synthase 3 gene polymorphisms.

    Ilguy, Serdar / Cilingir, Oguz / Bilgec, Mustafa Deger / Ozalp, Onur / Erzurumluoglu Gokalp, Ebru / Arslan, Serap / Tekin, Neslihan / Aydemir, Ozge / Erol, Nazmiye / Colak, Ertugrul / Gursoy, Huseyin

    Ophthalmic genetics

    2021  Volume 42, Issue 6, Page(s) 725–731

    Abstract: Background: In addition to risk factors such as low birth weight and uncontrolled oxygen therapy, genetic predisposition is also thought to play a role in the development of retinopathy of prematurity (ROP). In our study, we aimed to analyze single- ... ...

    Abstract Background: In addition to risk factors such as low birth weight and uncontrolled oxygen therapy, genetic predisposition is also thought to play a role in the development of retinopathy of prematurity (ROP). In our study, we aimed to analyze single-nucleotide polymorphisms (SNPs) in
    Materials and methods: Seventy-five mild-moderate and 73 severe ROP cases were included in this study. Eleven different SNPs regions that located in
    Results: Statistically significant results were obtained in 8 of the 11 SNPs. It was observed that the excess of mutant alleles in four (
    Conclusions: Considering the results of our study, it was seen that besides the known environmental and demographic factors in ROP pathogenesis, genetic predisposition also had an effect on the clinic and course of ROP. Polymorphisms of
    MeSH term(s) Alleles ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Brain-Derived Neurotrophic Factor/genetics ; Female ; Follow-Up Studies ; Gene Frequency ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Male ; Nitric Oxide Synthase Type III/genetics ; Polymorphism, Single Nucleotide/genetics ; Retinopathy of Prematurity/diagnosis ; Retinopathy of Prematurity/genetics ; Risk Factors ; Vascular Endothelial Growth Factor A/genetics
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; Brain-Derived Neurotrophic Factor ; VEGFA protein, human ; Vascular Endothelial Growth Factor A ; endothelial PAS domain-containing protein 1 (1B37H0967P) ; BDNF protein, human (7171WSG8A2) ; NOS3 protein, human (EC 1.14.13.39) ; Nitric Oxide Synthase Type III (EC 1.14.13.39)
    Language English
    Publishing date 2021-08-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1199279-7
    ISSN 1744-5094 ; 0167-6784 ; 1381-6810
    ISSN (online) 1744-5094
    ISSN 0167-6784 ; 1381-6810
    DOI 10.1080/13816810.2021.1961279
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  9. Article: Agenesis of gallbladder and multiple anomalies of the biliary tree in a patient with portal thrombosis: a case report.

    Bayraktar, Yusuf / Balaban, H Yasemin / Arslan, Serap / Balkanci, Ferhun

    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

    2006  Volume 17, Issue 3, Page(s) 212–215

    Abstract: A 55-year-old male patient was admitted to hospital because of splenomegaly. Abdominal ultrasonography and computed tomography failed to demonstrate the gallbladder. The diagnosis of right portal vein thrombosis was established by Doppler ultrasonography, ...

    Abstract A 55-year-old male patient was admitted to hospital because of splenomegaly. Abdominal ultrasonography and computed tomography failed to demonstrate the gallbladder. The diagnosis of right portal vein thrombosis was established by Doppler ultrasonography, splenoportography and computed tomography angiography. To investigate the biliary tree and evaluate the effect on the biliary tree of portal changes, endoscopic retrograde cholangiopancreatography was performed. Endoscopic retrograde cholangiopancreatography study revealed the absence of gallbladder, cystic duct and common bile duct together with the junction of the right and left hepatic ducts at the pancreatic head, with predominant left hepatic duct. To our knowledge, this is the first reported case of multiple congenital anomalies of the extrahepatic biliary tree associated with right portal vein thrombosis. The presence of these rare pathologies in two viscera running together in a patient with right portal vein thrombosis is a very rare condition.
    MeSH term(s) Abnormalities, Multiple/diagnosis ; Bile Duct Diseases/complications ; Bile Duct Diseases/congenital ; Bile Ducts/abnormalities ; Cholangiopancreatography, Endoscopic Retrograde ; Gallbladder/abnormalities ; Humans ; Male ; Middle Aged ; Portal Vein/pathology ; Tomography, X-Ray Computed ; Ultrasonography, Doppler ; Venous Thrombosis/complications ; Venous Thrombosis/pathology
    Language English
    Publishing date 2006-09
    Publishing country Turkey
    Document type Case Reports ; Journal Article
    ZDB-ID 1340275-4
    ISSN 1300-4948
    ISSN 1300-4948
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  10. Article: How much helpful is the capsule endoscopy for the diagnosis of small bowel lesions?

    Ersoy, Osman / Sivri, Bulent / Arslan, Serap / Batman, Figen / Bayraktar, Yusuf

    World journal of gastroenterology

    2005  Volume 12, Issue 24, Page(s) 3906–3910

    Abstract: Aim: To assess the practically usefulness and diagnostic yield of this new method in a group of patients with suspected small bowel lesions.: Methods: Capsule endoscopic (CE) examination by using M2A capsule endoscope TM (Given Imaging, Yoqneam, ... ...

    Abstract Aim: To assess the practically usefulness and diagnostic yield of this new method in a group of patients with suspected small bowel lesions.
    Methods: Capsule endoscopic (CE) examination by using M2A capsule endoscope TM (Given Imaging, Yoqneam, Israel) was performed in thirty nine patients (26 males, 13 females) with suspected small intestinal lesions. The composing of the patients was as follows: obscure gastrointestinal bleeding in twenty three patients, known Crohn's disease in 6 patients, in whom CE was used to evaluate the severity and extension of the diseases, chronic diarrhea in 8 patients, abdominal pain in one patient and malignancy in one patient with unknown origin.
    Results: In two patients CE failed. Different abnormalities were revealed in 26 patients overall. Detection rate of abnormalities was highest among patients with obscure gastrointestinal bleeding and the source of bleeding was demonstrated in 17 of 23 patients with obscure bleeding (73.9%). Entero-Behcet was diagnosed in two patients by CE as a source of obscure gastrointestinal bleeding. In 6 patients with known Crohn's disease, CE revealed better evaluation of the disease extension. In 3 of 8 (37.5%) patients with chronic diarrhea; CE revealed some mucosal abnormalities as the cause of chronic diarrhea. In a patient with unexplained abdominal pain and in a cancer patient with unknown origin, CE examination was normal.
    Conclusion: In our relatively small series, we found that capsule endoscopy is a useful diagnostic tool particularly in diagnosis of obscure gastrointestinal bleeding, chronic diarrhea and in estimating the extension of Crohn's disease.
    MeSH term(s) Abdominal Pain/diagnosis ; Abdominal Pain/pathology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Capsules ; Chronic Disease ; Crohn Disease/diagnosis ; Crohn Disease/pathology ; Diarrhea/diagnosis ; Diarrhea/pathology ; Endoscopy, Gastrointestinal/methods ; Female ; Gastrointestinal Hemorrhage/diagnosis ; Gastrointestinal Hemorrhage/pathology ; Humans ; Intestinal Diseases/diagnosis ; Intestinal Diseases/pathology ; Intestinal Neoplasms/diagnosis ; Intestinal Neoplasms/pathology ; Intestine, Small/pathology ; Male ; Middle Aged ; Severity of Illness Index
    Chemical Substances Capsules
    Language English
    Publishing date 2005-07-20
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v12.i24.3906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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