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  1. Article: An Online Mindfulness Program for Teachers: A Feasibility Study of the DeStress Monday at School Program.

    Mendelson, Tamar / Webb, Lindsey / Artola, Arabiye / Molinaro, Maria / Sibinga, Erica

    Mindfulness

    2023  , Page(s) 1–16

    Abstract: Objectives: Stress has deleterious effects on teachers' well-being and interactions with students. While in-person mindfulness programs have demonstrated benefits for teachers' mental health, in-person classes are often not feasible due to teachers' ... ...

    Abstract Objectives: Stress has deleterious effects on teachers' well-being and interactions with students. While in-person mindfulness programs have demonstrated benefits for teachers' mental health, in-person classes are often not feasible due to teachers' busy schedules. This study assessed four components of feasibility (implementation, demand, acceptability, and limited-efficacy testing) for an online mindfulness intervention for teachers.
    Method: A volunteer sample of 50 primary school teachers was recruited across three urban public schools and was offered a 9-week online mindfulness program (DeStress Monday at School). The program provided weekly mindfulness practices for (1) self-care and (2) classroom use to promote teacher and student stress management. Surveys and focus group discussions assessed program feasibility. Paired
    Results: Most participants had no technical problems, providing general support for implementation. Support for program demand was mixed; while 85% of participants used practices at least once, some never used practices, and over half used practices only 1-3 times. Those who used practices generally rated their acceptability favorably. Qualitative analyses showed significant pre-post improvements in work-related and overall stress, depressive and anxiety symptoms, and sleep; those who used practices reported more benefits than those who did not. Qualitative data corroborated these findings, with teachers describing improved stress- and emotion-management following program use.
    Conclusions: Our findings suggest mindfulness can be delivered online to teachers and may enhance mental health and wellness. Next steps include conducting more rigorous research with a control condition to better understand potential program impact.
    Preregistration: This study is not preregistered.
    Supplementary information: The online version contains supplementary material available at 10.1007/s12671-023-02142-3.
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2543424-X
    ISSN 1868-8535 ; 1868-8527
    ISSN (online) 1868-8535
    ISSN 1868-8527
    DOI 10.1007/s12671-023-02142-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sex Differences in Cognitive Abilities Among Children With the Autosomal Dominant Alzheimer Disease Presenilin 1 E280A Variant From a Colombian Cohort.

    Fox-Fuller, Joshua T / Artola, Arabiye / Chen, Kewei / Pulsifer, Margaret / Ramirez, Dora / Londono, Natalia / Aguirre-Acevedo, Daniel C / Vila-Castelar, Clara / Baena, Ana / Martinez, Jairo / Arboleda-Velasquez, Joseph F / Langbaum, Jessica B / Tariot, Pierre N / Reiman, Eric M / Lopera, Francisco / Quiroz, Yakeel T

    JAMA network open

    2021  Volume 4, Issue 8, Page(s) e2121697

    Abstract: Importance: We previously reported that children with the autosomal dominant Alzheimer disease (ADAD) presenilin 1 (PSEN1) E280A variant had early life plasma biomarker findings consistent with amyloid β overproduction. However, the cognitive ... ...

    Abstract Importance: We previously reported that children with the autosomal dominant Alzheimer disease (ADAD) presenilin 1 (PSEN1) E280A variant had early life plasma biomarker findings consistent with amyloid β overproduction. However, the cognitive functioning of children with this variant has not been characterized vs those without the variant.
    Objective: To test whether cognitive functioning of children with and without the PSEN1 E280A variant in the same ADAD cohort differed by genetic status (ie, PSEN1 variant) and sex.
    Design, setting, and participants: This cohort study was conducted among 1354 children (including 265 children with the variant) aged 6 to 16 years recruited from the Alzheimer Prevention Initiative Colombia Registry. Participants from the city of Medellín and surrounding suburban areas traveled to the University of Antioquia to undergo all procedures. Participants were administered a Spanish version of the Wechsler Intelligence Scale for Children, Fourth Edition (WISC-IV) to measure general cognitive functioning. Data were analyzed from July through November 2020.
    Main outcomes and measures: Univariate general linear models were used to characterize differences on WISC-IV cognitive performance by genetic status, sex, and the interaction of genetic status with sex. Urbanity, socioeconomic status, and education were entered as covariates.
    Results: Among 1354 children with ADAD (695 [51.3%] girls; mean [SD] age, 11.64 [2.64] years), there were 265 children with the variant (19.6%) and 1089 children without the variant (80.4%). Children with and without the variant did not differ by demographic variables or performance on WISC-IV indices. Irrespective of genetic status, boys had statistically significantly decreased mean scores on indices for working memory (90.27 [95% CI, 89.21-91.34] vs 92.99 [95% CI, 91.98-93.99]; mean difference = -2.72; P < .001), perceptual reasoning (91.56 [95% CI, 90.47-92.65] vs. 93.27 [95% CI, 91.23-94.30]; mean difference = -1.71; P = .03), and verbal comprehension (88.69 [95% CI, 87.54-89.84] vs. 90.81 [95% CI, 89.73-91.90]; mean difference = -2.12; P = .009) compared with girls. In the interaction between sex and genetic status, boys with the variant had worse mean working memory index performance (88.78 [95% CI, 86.86-90.70]) than girls with the variant (93.75 [95% CI, 91.95-95.55]; mean difference = -4.97; P = .001), as well as boys (91.77 [95% CI, 90.85-92.70]; mean difference = -2.99; P = .04) and girls (92.22 [95% CI, 91.32-93.13]; mean difference = -3.44; P = .009) without the variant.
    Conclusions and relevance: This study found that boys with the PSEN1 variant had decreased working memory abilities compared with girls with the variant and boys and girls without the variant, suggesting a sex-specific genetic risk in early life cognitive performance among individuals with the PSEN1 variant. This increased risk of future cognitive difficulties among boys with the variant may have important downstream implications for learning and academic achievement and could be associated with sex differences seen in adulthood on episodic memory measures.
    MeSH term(s) Adolescent ; Adult ; Age of Onset ; Alzheimer Disease/blood ; Alzheimer Disease/genetics ; Biomarkers/blood ; Child ; Cognition Disorders/blood ; Cognition Disorders/genetics ; Cohort Studies ; Colombia ; Female ; Genetic Predisposition to Disease ; Healthy Volunteers ; Humans ; Male ; Predictive Value of Tests ; Presenilins/blood ; Presenilins/genetics ; Sex Factors
    Chemical Substances Biomarkers ; Presenilins
    Language English
    Publishing date 2021-08-02
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2021.21697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Associative memory and in vivo brain pathology in asymptomatic presenilin-1 E280A carriers.

    Guzmán-Vélez, Edmarie / Martínez, Jairo / Papp, Kate / Baena, Ana / Vila-Castelar, Clara / Artola, Arabiye / Schultz, Aaron P / Bocanegra, Yamile / Sanchez, Justin / Rentz, Dorene / Tariot, Pierre N / Reiman, Eric M / Sperling, Reisa / Johnson, Keith A / Lopera, Francisco / Quiroz, Yakeel T

    Neurology

    2020  Volume 95, Issue 10, Page(s) e1312–e1321

    Abstract: Objective: To determine whether performance on the Free and Cued Selective Reminding Test (FCSRT) is associated with PET in vivo markers of brain pathology and whether it can distinguish those who will develop dementia later in life due to autosomal- ... ...

    Abstract Objective: To determine whether performance on the Free and Cued Selective Reminding Test (FCSRT) is associated with PET in vivo markers of brain pathology and whether it can distinguish those who will develop dementia later in life due to autosomal-dominant Alzheimer disease (AD) from age-matched controls.
    Methods: Twenty-four cognitively unimpaired Presenilin-1 E280A carriers (mean age 36 years) and 28 noncarriers (mean age 37 years) underwent Pittsburg compound B-PET (amyloid), flortaucipir-PET (tau), and cognitive testing, including the FCSRT (immediate and delayed free and cued recall scores). Linear regressions were used to examine the relationships among FCSRT scores, age, mean cortical amyloid, and regional tau burden.
    Results: Free and total recall scores did not differ between cognitively unimpaired mutation carriers and noncarriers. Greater age predicted lower free recall and delayed free and total recall scores in carriers. In cognitively impaired carriers, delayed free recall predicted greater amyloid burden and entorhinal tau, while worse immediate free recall scores predicted greater tau in the inferior temporal and entorhinal cortices. In turn, in all carriers, lower free and total recall scores predicted greater amyloid and regional tau pathology.
    Conclusions: FCSRT scores were associated with in vivo markers of AD-related pathology in cognitively unimpaired individuals genetically determined to develop dementia. Difficulties on free recall, particularly delayed recall, were evident earlier in the disease trajectory, while difficulties on cued recall were seen only as carriers neared the onset of dementia, consistent with the pathologic progression of the disease. Findings suggest that the FCSRT can be a useful measure to track disease progression in AD.
    MeSH term(s) Adult ; Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Brain/pathology ; Female ; Genetic Predisposition to Disease/genetics ; Heterozygote ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Mental Recall ; Middle Aged ; Positron-Emission Tomography ; Presenilin-1/genetics ; Young Adult
    Chemical Substances PSEN1 protein, human ; Presenilin-1
    Language English
    Publishing date 2020-07-01
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000010177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Cortical thickness across the lifespan in a Colombian cohort with autosomal-dominant Alzheimer's disease: A cross-sectional study.

    Fox-Fuller, Joshua T / Torrico-Teave, Heirangi / d'Oleire Uquillas, Federico / Chen, Kewei / Su, Yi / Chen, Yinghua / Brickhouse, Michael / Sanchez, Justin S / Aguero, Cinthya / Jacobs, Heidi I L / Hampton, Olivia / Guzmán-Vélez, Edmarie / Vila-Castelar, Clara / Aguirre-Acevedo, Daniel C / Baena, Ana / Artola, Arabiye / Martinez, Jairo / Pluim, Celina F / Alvarez, Sergio /
    Ochoa-Escudero, Martin / Reiman, Eric M / Sperling, Reisa A / Lopera, Francisco / Johnson, Keith A / Dickerson, Bradford C / Quiroz, Yakeel T

    Alzheimer's & dementia (Amsterdam, Netherlands)

    2021  Volume 13, Issue 1, Page(s) e12233

    Abstract: Introduction: Cortical thinning is a marker of neurodegeneration in Alzheimer's disease (AD). We investigated the age-related trajectory of cortical thickness across the lifespan (9-59 years) in a Colombian kindred with autosomal dominant AD (ADAD).: ... ...

    Abstract Introduction: Cortical thinning is a marker of neurodegeneration in Alzheimer's disease (AD). We investigated the age-related trajectory of cortical thickness across the lifespan (9-59 years) in a Colombian kindred with autosomal dominant AD (ADAD).
    Methods: Two hundred eleven participants (105 presenilin-1 [
    Results: Unimpaired carriers exhibited elevated cortical thickness compared to non-carriers, and thickness more negatively correlated with age and cognition in carriers relative to non-carriers. We found increased cortical thickness in child carriers, after which thickness steadied compared to non-carriers prior to a rapid reduction in the decade leading up to the expected age at cognitive impairment in carriers.
    Discussion: Findings suggest that cortical thickness may fluctuate across the ADAD lifespan, from early-life increased thickness to atrophy proximal to clinical onset.
    Language English
    Publishing date 2021-09-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2832898-X
    ISSN 2352-8729
    ISSN 2352-8729
    DOI 10.1002/dad2.12233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Association of subjective cognitive decline with markers of brain pathology in preclinical autosomal dominant Alzheimer's disease.

    Gatchel, Jennifer R / Lopera, Francisco / Norton, Daniel J / Baena, Ana / Guzman-Velez, Edmarie / Sanchez, Justin S / d'Oleire Uquillas, Federico / Schultz, Aaron / Vannini, Patrizia / Artola, Arabiye / Amariglio, Rebecca E / Rentz, Dorene M / Tariot, Pierre N / Reiman, Eric M / Johnson, Keith A / Sperling, Reisa A / Marshall, Gad A / Quiroz, Yakeel T

    Journal of neurology, neurosurgery, and psychiatry

    2019  Volume 91, Issue 3, Page(s) 330–332

    MeSH term(s) Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Alzheimer Disease/psychology ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/pathology ; Humans ; Mutation/genetics ; Presenilin-1/genetics ; Self Report
    Chemical Substances PSEN1 protein, human ; Presenilin-1
    Language English
    Publishing date 2019-12-24
    Publishing country England
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2019-321205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder.

    Zhu, Shanshan / Cordner, Zachary A / Xiong, Jiali / Chiu, Chi-Tso / Artola, Arabiye / Zuo, Yanning / Nelson, Andrew D / Kim, Tae-Yeon / Zaika, Natalya / Woolums, Brian M / Hess, Evan J / Wang, Xiaofang / Chuang, De-Maw / Pletnikov, Mikhail M / Jenkins, Paul M / Tamashiro, Kellie L / Ross, Christopher A

    Proceedings of the National Academy of Sciences of the United States of America

    2017  Volume 114, Issue 39, Page(s) 10479–10484

    Abstract: Genome-wide association studies have implicated ... ...

    Abstract Genome-wide association studies have implicated the
    MeSH term(s) Animals ; Ankyrins/genetics ; Bipolar Disorder/drug therapy ; Bipolar Disorder/genetics ; Bipolar Disorder/physiopathology ; Disease Models, Animal ; GABAergic Neurons/pathology ; Lithium/pharmacology ; Methylphenidate/pharmacology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Potassium Channels, Voltage-Gated/genetics ; Prosencephalon/physiopathology ; Proto-Oncogene Proteins c-fyn/biosynthesis ; Synapses/pathology ; Valproic Acid/pharmacology ; Voltage-Gated Sodium Channels/genetics
    Chemical Substances Ank3 protein, mouse ; Ankyrins ; Potassium Channels, Voltage-Gated ; Voltage-Gated Sodium Channels ; Methylphenidate (207ZZ9QZ49) ; Valproic Acid (614OI1Z5WI) ; Lithium (9FN79X2M3F) ; Proto-Oncogene Proteins c-fyn (EC 2.7.10.2)
    Language English
    Publishing date 2017-09-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1700689114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report.

    Arboleda-Velasquez, Joseph F / Lopera, Francisco / O'Hare, Michael / Delgado-Tirado, Santiago / Marino, Claudia / Chmielewska, Natalia / Saez-Torres, Kahira L / Amarnani, Dhanesh / Schultz, Aaron P / Sperling, Reisa A / Leyton-Cifuentes, David / Chen, Kewei / Baena, Ana / Aguillon, David / Rios-Romenets, Silvia / Giraldo, Margarita / Guzmán-Vélez, Edmarie / Norton, Daniel J / Pardilla-Delgado, Enmanuelle /
    Artola, Arabiye / Sanchez, Justin S / Acosta-Uribe, Juliana / Lalli, Matthew / Kosik, Kenneth S / Huentelman, Matthew J / Zetterberg, Henrik / Blennow, Kaj / Reiman, Rebecca A / Luo, Ji / Chen, Yinghua / Thiyyagura, Pradeep / Su, Yi / Jun, Gyungah R / Naymik, Marcus / Gai, Xiaowu / Bootwalla, Moiz / Ji, Jianling / Shen, Lishuang / Miller, John B / Kim, Leo A / Tariot, Pierre N / Johnson, Keith A / Reiman, Eric M / Quiroz, Yakeel T

    Nature medicine

    2019  Volume 25, Issue 11, Page(s) 1680–1683

    Abstract: We identified a PSEN1 (presenilin 1) mutation carrier from the world's largest autosomal dominant Alzheimer's disease kindred, who did not develop mild cognitive impairment until her seventies, three decades after the expected age of clinical onset. The ... ...

    Abstract We identified a PSEN1 (presenilin 1) mutation carrier from the world's largest autosomal dominant Alzheimer's disease kindred, who did not develop mild cognitive impairment until her seventies, three decades after the expected age of clinical onset. The individual had two copies of the APOE3 Christchurch (R136S) mutation, unusually high brain amyloid levels and limited tau and neurodegenerative measurements. Our findings have implications for the role of APOE in the pathogenesis, treatment and prevention of Alzheimer's disease.
    MeSH term(s) Aged ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid/genetics ; Amyloid/metabolism ; Apolipoprotein E2/genetics ; Apolipoprotein E3/genetics ; Brain/diagnostic imaging ; Brain/metabolism ; Brain/pathology ; Cognitive Dysfunction/genetics ; Cognitive Dysfunction/pathology ; Female ; Homozygote ; Humans ; Male ; Mutation/genetics ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Pedigree ; Presenilin-1/genetics
    Chemical Substances Amyloid ; Apolipoprotein E2 ; Apolipoprotein E3 ; PSEN1 protein, human ; Presenilin-1
    Language English
    Publishing date 2019-11-04
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-019-0611-3
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