LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Arun Kumar S"
  2. AU="Dahlsjö, Cecilia A L"
  3. AU="Gavigan, Patrick"
  4. AU="Liu, Ye"
  5. AU="Changyang Xing"
  6. AU="Sarovich, Derek S"
  7. AU="Joseph P. Zackular"
  8. AU="Maes, Evelyn"
  9. AU="Haixiang Zhou"
  10. AU="Choi, Jinyong"
  11. AU="González-Mansilla, Ana"
  12. AU="Cho Kilwon"
  13. AU="Rachide Onadja, Palamanga Abdoul"
  14. AU="Bertacca, Sofia"
  15. AU="Bansal, Ayush"
  16. AU="Liao, Naikai"
  17. AU="Gomes, Lux Attiê Santos"
  18. AU="İdil Su Canıtez"
  19. AU="Baptiste Duceau"
  20. AU="Pedro Seoane-Zonjic"
  21. AU="Guthridge, Carla J"
  22. AU=Meena Netra P.
  23. AU="Boustany, Tara"

Suchergebnis

Treffer 1 - 10 von insgesamt 47

Suchoptionen

  1. Artikel ; Online: Review on Deep Learning-Based CAD Systems for Breast Cancer Diagnosis.

    Arun Kumar, S / Sasikala, S

    Technology in cancer research & treatment

    2023  Band 22, Seite(n) 15330338231177977

    Abstract: Breast Cancer (BC) is a major health issue in women of the age group above 45. Identification of BC at an earlier stage is important to reduce the mortality rate. Image-based noninvasive methods are used for early detection and for providing appropriate ... ...

    Abstract Breast Cancer (BC) is a major health issue in women of the age group above 45. Identification of BC at an earlier stage is important to reduce the mortality rate. Image-based noninvasive methods are used for early detection and for providing appropriate treatment. Computer-Aided Diagnosis (CAD) schemes can support radiologists in making correct decisions. Computational intelligence paradigms such as Machine Learning (ML) and Deep Learning (DL) have been used in the recent past in CAD systems to accelerate diagnosis. ML techniques are feature driven and require a high amount of domain expertise. However, DL approaches make decisions directly from the image. The current advancement in DL approaches for early diagnosis of BC is the motivation behind this review. This article throws light on various types of CAD approaches used in BC detection and diagnosis. A survey on DL, Transfer Learning, and DL-based CAD approaches for the diagnosis of BC is presented in detail. A comparative study on techniques, datasets, and performance metrics used in state-of-the-art literature in BC diagnosis is also summarized. The proposed work provides a review of recent advancements in DL techniques for enhancing BC diagnosis.
    Mesh-Begriff(e) Female ; Humans ; Breast Neoplasms/diagnostic imaging ; Deep Learning ; Diagnosis, Computer-Assisted/methods ; Machine Learning ; Mammography/methods
    Sprache Englisch
    Erscheinungsdatum 2023-06-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2146365-7
    ISSN 1533-0338 ; 1533-0346
    ISSN (online) 1533-0338
    ISSN 1533-0346
    DOI 10.1177/15330338231177977
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  2. Artikel ; Online: The shifting therapeutic paradigm for relapsed/refractory mantle cell lymphoma.

    Arun Kumar, Sumukh / Gao, Jenny / Patel, Shyam A

    Leukemia research

    2023  Band 134, Seite(n) 107385

    Abstract: Mantle cell lymphoma (MCL) is a heterogeneous subtype of non-Hodgkin lymphoma that has been historically associated with poor 5-year overall survival rates, especially for aggressive variants. Traditional cytotoxic chemotherapy had been a mainstay of ... ...

    Abstract Mantle cell lymphoma (MCL) is a heterogeneous subtype of non-Hodgkin lymphoma that has been historically associated with poor 5-year overall survival rates, especially for aggressive variants. Traditional cytotoxic chemotherapy had been a mainstay of therapy for relapsed/refractory (R/R) MCL for many years until the advent of molecularly targeted therapies and cell-based approaches. However, a significant concern is the lack of definitive consensus guidelines for management of R/R MCL. The managerial conundrum partly stems from the absence of head-to-head comparisons of novel therapies, with conclusions drawn from cross-trial comparisons. In this evidence-based review, we discuss the current therapeutic options for R/R MCL, including the most recent data from the BRUIN study that led to the approval of the first-in-class non-covalent reversible Bruton's tyrosine kinase (BTK) inhibitor pirtobrutinib in 2023, as well as the recent removal of ibrutinib from the market. We discuss outlooks for targeted therapy and tolerability considerations for novel agents, including unique considerations for the elderly population. We highlight emerging data that support the curative potential of chimeric antigen receptor-T (CAR-T) therapy from ZUMA-2, relative to other promising investigational agents in the pipeline, including glofitamab, epcoritamab, and zilovertamab vedotin. We summarize management recommendations based upon the most rigorous clinical evidence to date.
    Mesh-Begriff(e) Aged ; Adult ; Humans ; Lymphoma, Mantle-Cell/drug therapy ; Antineoplastic Agents/therapeutic use ; Antibodies, Bispecific
    Chemische Substanzen glofitamab (06P3KLK2J8) ; pirtobrutinib ; Antineoplastic Agents ; Antibodies, Bispecific
    Sprache Englisch
    Erscheinungsdatum 2023-09-01
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2023.107385
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  3. Artikel: Incidentally Detected Solitary Metastatic Melanoma of the Spleen Without Known Primary: A Case Report.

    Arun Kumar, Sumukh / Ramasamy, Chidambaram / Syed, Masood Pasha / Agarwal, Archana

    Cureus

    2023  Band 15, Heft 5, Seite(n) e38530

    Abstract: Splenic masses could be secondary to infection or due to benign and malignant cancers. Due to its anatomy and microenvironment, the spleen is relatively protected from cancer spread. However, melanomas are one of the few cancers that metastasize to the ... ...

    Abstract Splenic masses could be secondary to infection or due to benign and malignant cancers. Due to its anatomy and microenvironment, the spleen is relatively protected from cancer spread. However, melanomas are one of the few cancers that metastasize to the spleen, but only 2% of these metastasize as solitary splenic masses. Among such a small fraction, only a handful have been reported without a known primary. Our patient, an elderly male in his early 60s, was diagnosed with metastatic melanoma of the spleen following a biopsy of the incidentally detected isolated splenic mass. Complete ocular, oral, and dermatological inspections were unremarkable for a probable primary. He responded well to immunotherapy and total splenectomy with no recurrence. Due to advanced imaging modalities in the modern era, the probability of isolated splenic masses as an initial presentation will increase, and a high index of clinical suspicion should be maintained for metastatic cancer as one of the differentials.
    Sprache Englisch
    Erscheinungsdatum 2023-05-04
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.38530
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  4. Artikel ; Online: Primary cardiac large B cell lymphoma.

    Arun Kumar, Sumukh / Mishra, Rahul / Malempati, Sarat Chandra / Bindal, Poorva

    BMJ case reports

    2023  Band 16, Heft 12

    Abstract: A female patient in her mid-60s presented with progressive shortness of breath, pleuritic chest pain and bilateral leg swelling for 1 week. Initial diagnostic workup revealed pericardial effusion, and a localised pericardial tubular mass on CT chest. ... ...

    Abstract A female patient in her mid-60s presented with progressive shortness of breath, pleuritic chest pain and bilateral leg swelling for 1 week. Initial diagnostic workup revealed pericardial effusion, and a localised pericardial tubular mass on CT chest. Pericardial fluid analysis showed elevated white cells, with predominance of medium-large sized atypical lymphoid cells. Atypical lymphocytes stained positive for CD79a, CD10, PAX-5, BCL-2 and BCL6. Fluorescence in situ hybridisation testing demonstrated MYC and BCL6 rearrangements without BCL2 gene rearrangement. The overall morphological, immunohistochemical and cytogenetic findings supported a diagnosis of high-grade B cell lymphoma with MYC and BCL6 rearrangements. After extensive staging workup, localised disease involving the pericardium with a diagnosis of primary cardiac large B cell lymphoma was established. She was treated with dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin and rituximab chemotherapy. Rituximab was discontinued owing to largely absent CD20 expression. Interim positron emission tomography-CT after three cycles revealed a complete response, and the patient completed six cycles of therapy.
    Mesh-Begriff(e) Humans ; Female ; Rituximab/therapeutic use ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-bcl-6/genetics ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/genetics ; Cyclophosphamide/therapeutic use ; Vincristine/therapeutic use ; Prednisone/therapeutic use ; Doxorubicin/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Chemische Substanzen Rituximab (4F4X42SYQ6) ; Proto-Oncogene Proteins c-myc ; Proto-Oncogene Proteins c-bcl-6 ; Cyclophosphamide (8N3DW7272P) ; Vincristine (5J49Q6B70F) ; Prednisone (VB0R961HZT) ; Doxorubicin (80168379AG)
    Sprache Englisch
    Erscheinungsdatum 2023-12-26
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-256167
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  5. Artikel: A study of life cycle conversion efficiency and CO2 role in the pyramid shape solar stills – Comparative analysis

    Arun Kumar, S / Suresh Mohan Kumar, P / Sathyamurthy, Ravishankar / Manokar, A. Muthu

    Groundwater for sustainable development. 2020 Oct., v. 11

    2020  

    Abstract: The comparative analysis of the Conventional Pyramid Still (CPS) with the Shaded Pyramid Still (SPS) is fabricated and experimented in estimating the carbon dioxide (CO₂) emission and embodied energy. The single basin square pyramid shape solar still is ... ...

    Abstract The comparative analysis of the Conventional Pyramid Still (CPS) with the Shaded Pyramid Still (SPS) is fabricated and experimented in estimating the carbon dioxide (CO₂) emission and embodied energy. The single basin square pyramid shape solar still is used for experiments. The daily production of distilled water was measured from both the still for the analysis. The cumulative yield from the CPS is 2.6 kg/day, and SPS is 1.7 kg/day. The outcome of the investigation shows that the CO₂ emission and embodied energy was decreased in CPS as compared with SPS and energy production factor, Life Cycle Conversion Efficiency (LCCE), CO₂ mitigation, and Carbon credit was increased in the CPS compared with the SPS. The LCCE for CPS was 30.39%, and for SPS was 19.98% at 30 years life. Similarly, the CO₂ mitigation for CPS was 20.07 tons and for SPS was 13.19 tons. The distilled water can be sold at Rs. 23.28 per kg for CPS and Rs. 22.67 per kg for SPS and the payback year of both the still were 0.52 and 0.82 years, respectively concerning carbon credit for the expected life year of still is 30 years.
    Schlagwörter basins ; carbon dioxide ; carbon markets ; embodied energy ; greenhouse gas emissions ; groundwater ; solar still ; sustainable development
    Sprache Englisch
    Erscheinungsverlauf 2020-10
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ISSN 2352-801X
    DOI 10.1016/j.gsd.2020.100413
    Datenquelle NAL Katalog (AGRICOLA)

    Zusatzmaterialien

    Kategorien

  6. Artikel ; Online: Aseptic presentation of interventricular septal abscess with progressive heart block: a case report.

    Arun Kumar, Pramukh / Patel, Boskey / Dasari, Mahati / Arun Kumar, Sumukh / Shah, Neeta / Laidlaw, Douglas

    Journal of medical case reports

    2023  Band 17, Heft 1, Seite(n) 131

    Abstract: Background: Infective endocarditis can progress to an intracardiac abscess in 20% to 30% of cases, with interventricular septal abscess (IVSA) being one of the rare complications usually presenting with sepsis. We present a case of IVSA presenting with ... ...

    Abstract Background: Infective endocarditis can progress to an intracardiac abscess in 20% to 30% of cases, with interventricular septal abscess (IVSA) being one of the rare complications usually presenting with sepsis. We present a case of IVSA presenting with a new-onset second-degree heart block, which rapidly progressed to a complete heart block.
    Case presentation: A 80-year-old Caucasian female with a past medical history of hypertension and hyperlipidemia presented with exertional chest pain, lightheadedness, and shortness of breath with telemetry and electrocardiogram revealing persistent Mobitz type II second degree atrioventricular block. The rest of the vitals were normal. As she was being planned for a pacemaker placement, she spiked a temperature of 103F. Blood cultures grew methicillin-sensitive Staphylococcus aureus, and appropriate antibiotics were initiated. Transthoracic echocardiogram was grossly normal. However, transesophageal echocardiogram revealed a heterogeneous extension of an echodensity from the aortic root, along the aorto-mitral cushion and into the interventricular septum, indicating an interventricular septal abscess. Her course was complicated by altered mental status, with computed tomography of the brain revealing hypodense regions in the left lentiform nucleus and anterior caudate nucleus representing acute/subacute stroke. Surgery was deferred as she was deemed a poor candidate. She succumbed to her illness on day 6 of hospitalization.
    Conclusion: Intracardiac abscesses should be considered a possible initial differential in patients with progressive heart block despite aseptic presentation and no risk factors.
    Mesh-Begriff(e) Humans ; Female ; Aged, 80 and over ; Abscess/etiology ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/diagnostic imaging ; Endocarditis/complications ; Echocardiography/adverse effects ; Heart Block/therapy ; Heart Block/complications
    Sprache Englisch
    Erscheinungsdatum 2023-04-10
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-023-03846-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  7. Artikel ; Online: Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform.

    Arun Kumar, Shreedevi / Lee, Jihui / Bishop, Corey J

    Journal of visualized experiments : JoVE

    2020  , Heft 164

    Abstract: Vaccine delivery strategies that can limit the exposure of cargo to organic solvent while enabling novel release profiles are crucial for improving immunization coverage worldwide. Here, a novel injectable, ultraviolet- curable and delayed burst release- ...

    Abstract Vaccine delivery strategies that can limit the exposure of cargo to organic solvent while enabling novel release profiles are crucial for improving immunization coverage worldwide. Here, a novel injectable, ultraviolet- curable and delayed burst release- enabling vaccine delivery platform called polybubbles is introduced. Cargo was injected into polyester-based polybubbles that were formed in 10% carboxymethycellulose -based aqueous solution. This paper includes protocols to maintain spherical shape of the polybubbles and optimize cargo placement and retention to maximize the amount of cargo within the polybubbles. To ensure safety, chlorinated solvent content within the polybubbles were analyzed using neutron activation analysis. Release studies were conducted with small molecules as cargo within the polybubble to confirm delayed burst release. To further show the potential for on-demand delivery of the cargo, gold nanorods were mixed within the polymer shell to enable near-infrared laser activation.
    Mesh-Begriff(e) Drug Carriers/chemistry ; Gold/chemistry ; Infrared Rays ; Nanotubes/chemistry ; Polyesters/chemistry ; Vaccines/administration & dosage ; Vaccines/chemistry
    Chemische Substanzen Drug Carriers ; Polyesters ; Vaccines ; Gold (7440-57-5)
    Sprache Englisch
    Erscheinungsdatum 2020-10-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/60569
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  8. Artikel: Is Resin Infiltration a Microinvasive Approach to White Lesions of Calcified Tooth Structures?: A Systemic Review.

    Manoharan, Vidya / Arun Kumar, S / Arumugam, Selva B / Anand, Vijay / Krishnamoorthy, Santham / Methippara, John J

    International journal of clinical pediatric dentistry

    2019  Band 12, Heft 1, Seite(n) 53–58

    Abstract: Aim: The treatment of white lesions should aim at arresting the lesion progression of carious lesions and improving the esthetics by diminishing the opacity of the developmental disturbances of a tooth. The objective of this review was to present the ... ...

    Abstract Aim: The treatment of white lesions should aim at arresting the lesion progression of carious lesions and improving the esthetics by diminishing the opacity of the developmental disturbances of a tooth. The objective of this review was to present the scientific basis, the principles of resin infiltration and to discuss its inherent clinical applications.
    Data sources: Data were identified by PubMed searches. Papers published in English between 2010 and 2015 were selected and most up-to-date or relevant references were chosen.
    Conclusion: The resin infiltration technique, while promising, needed more clinical evidence for conclusive findings. However, based on available laboratory and clinical studies, it seems convincing that resin infiltration of enamel lesions should aim at arresting the progression of white spot lesions. Combining this microinvasive approach with a substantial caries remineralization program may provide therapeutic benefits and significantly reduce both long term restorative needs and costs, thus complementing the concept of minimum intervention dentistry.
    How to cite this article: Manoharan V, Kumar AS,
    Sprache Englisch
    Erscheinungsdatum 2019-06-06
    Erscheinungsland India
    Dokumenttyp Journal Article ; Review
    ISSN 0974-7052
    ISSN 0974-7052
    DOI 10.5005/jp-journals-10005-1579
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  9. Artikel: The immunotherapy advancement targeting malignant blastomas in early childhood.

    Zang, Bolun / Ding, Luyue / Liu, Linlin / Arun Kumar, Senthil / Liu, Wei / Zhou, Chongchen / Duan, Yongtao

    Frontiers in oncology

    2023  Band 13, Seite(n) 1015115

    Abstract: Malignant blastomas develop relentlessly in all functional body organs inflicting severe health ailments in younger children. Malignant blastomas exhibit diverse clinical characteristics in compliance with their emergence in functional body organs. ... ...

    Abstract Malignant blastomas develop relentlessly in all functional body organs inflicting severe health ailments in younger children. Malignant blastomas exhibit diverse clinical characteristics in compliance with their emergence in functional body organs. Surprisingly, neither of these preferred treatment types (surgery, radiotherapy, and chemotherapy) showed promise or were effective in treating malignant blastomas among child patients. N ew, innovative immunotherapeutic procedures including monoclonal antibodies and chimeric-antigen based receptor (CAR) cell therapy, coupled with the clinical study of reliable therapeutic targets and immune regulatory pathways targeting malignant blastomas, have attracted the attention of clinicians recently.
    Sprache Englisch
    Erscheinungsdatum 2023-02-16
    Erscheinungsland Switzerland
    Dokumenttyp Systematic Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1015115
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  10. Buch ; Artikel ; Online: MISSION POSSIBLE

    Arun kumar, Sharma

    A 100% ORGANIC WORLD

    2017  

    Abstract: A multipronged approach encompassing documentation, policy, technology, research, marketing and govt succour, can facilitate a 100% organic world has been described in this article. ...

    Abstract A multipronged approach encompassing documentation, policy, technology, research, marketing and govt succour, can facilitate a 100% organic world has been described in this article.
    Schlagwörter "Organics" in general ; Social aspects ; Biodiversity and ecosystem services ; History of organics
    Sprache Englisch
    Erscheinungsdatum 2017-10-17
    Erscheinungsland dk
    Dokumenttyp Buch ; Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Zusatzmaterialien

    Kategorien

Zum Seitenanfang