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Article ; Online: Double dissociation of dopamine and subthalamic nucleus stimulation on effortful cost/benefit decision making.

Pagnier, Guillaume J / Asaad, Wael F / Frank, Michael J

2024 Volume 34, Issue 3, Page(s) 655–660.e3

Abstract: Deep brain stimulation (DBS) and dopaminergic therapy (DA) are common interventions for Parkinson's disease (PD). Both treatments typically improve patient outcomes, and both can have adverse side effects on decision making (e.g., impulsivity). ...

Abstract	Deep brain stimulation (DBS) and dopaminergic therapy (DA) are common interventions for Parkinson's disease (PD). Both treatments typically improve patient outcomes, and both can have adverse side effects on decision making (e.g., impulsivity).
MeSH term(s)	Humans ; Dopamine/therapeutic use ; Subthalamic Nucleus/physiology ; Deep Brain Stimulation ; Neuropsychological Tests ; Parkinson Disease/therapy ; Decision Making/physiology
Chemical Substances	Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2023.12.045
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Article: Exploring the Role of the Pulvinar Nucleus of the Thalamus in Occipital Lobe Epilepsy: A Case Report.

Abdulrazeq, Hael / Kimata, Anna R / Blum, Andrew / Malik, Athar N / Asaad, Wael F

Cureus

2024 Volume 16, Issue 1, Page(s) e52534

Abstract: Understanding the role of the pulvinar nucleus may be critical for guiding circuit-targeted neurosurgical intervention in some patients. In this report, a 33-year-old female presented with focal onset occipital epilepsy with secondary generalization and ... ...

Abstract	Understanding the role of the pulvinar nucleus may be critical for guiding circuit-targeted neurosurgical intervention in some patients. In this report, a 33-year-old female presented with focal onset occipital epilepsy with secondary generalization and with a previously radiated arteriovenous malformation within the right primary visual cortex. Phase II monitoring demonstrated the pulvinar nucleus was not involved in subclinical seizures restricted to the primary visual cortex, but it did become involved in clinical events with more extensive seizure spread into higher visual cortical regions. She underwent responsive neurostimulation (RNS) with implantation of leads within the primary visual cortex. This case demonstrates the late propagation of epileptic activity from the visual cortex to the pulvinar nucleus and illustrates the pulvinar nucleus' connections with higher-order visual areas.
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.52534
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Article ; Online: Automated artifact injection into sensing-capable brain modulation devices for neural-behavioral synchronization and the influence of device state.

Alarie, Michaela E / Provenza, Nicole R / Herron, Jeffrey A / Asaad, Wael F

Brain stimulation

2023 Volume 16, Issue 5, Page(s) 1358–1360

MeSH term(s)	Artifacts ; Brain ; Deep Brain Stimulation ; Head
Language	English
Publishing date	2023-09-09
Publishing country	United States
Document type	Letter ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2394410-9
ISSN	1876-4754 ; 1935-861X
ISSN (online)	1876-4754
ISSN	1935-861X
DOI	10.1016/j.brs.2023.09.005
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Zs.A 6740: Show issues

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Article ; Online: The temporal cost of deploying attention limits accurate target identification in rapid serial visual presentation.

Kimata, Anna R / Zheng, Bryan / Watanabe, Takeo / Asaad, Wael F

Scientific reports

2023 Volume 13, Issue 1, Page(s) 3590

Abstract: Lag-1 sparing is a common exception to the attentional blink, where a target presented directly after T1 can be identified and reported accurately. Prior work has proposed potential mechanisms for lag 1 sparing, including the boost and bounce model and ... ...

Abstract	Lag-1 sparing is a common exception to the attentional blink, where a target presented directly after T1 can be identified and reported accurately. Prior work has proposed potential mechanisms for lag 1 sparing, including the boost and bounce model and the attentional gating model. Here, we apply a rapid serial visual presentation task to investigate the temporal limitations of lag 1 sparing by testing three distinct hypotheses. We found that endogenous engagement of attention to T2 requires between 50 and 100 ms. Critically, faster presentation rates yielded lower T2 performance, whereas decreased image duration did not impair T2 detection and report. These observations were reinforced by subsequent experiments controlling for short-term learning and capacity-dependent visual processing effects. Thus, lag-1 sparing was limited by the intrinsic dynamics of attentional boost engagement rather than by earlier perceptual bottlenecks such as insufficient exposure to images in the stimulus stream or visual processing capacity limitations. Taken together, these findings support the boost and bounce theory over earlier models that focus only on attentional gating or visual short-term memory storage, informing our understanding of how the human visual system deploys attention under challenging temporal constraints.
MeSH term(s)	Humans ; Attentional Blink ; Learning ; Memory, Short-Term ; Rivers ; Visual Perception
Language	English
Publishing date	2023-03-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-30748-z
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Article ; Online: Bilateral thalamic responsive neurostimulation for multifocal, bilateral frontotemporal epilepsy: illustrative case.

Phillips, Ronald K / Aghagoli, Ghazal / Blum, Andrew S / Asaad, Wael F

Journal of neurosurgery. Case lessons

2022 Volume 3, Issue 12

Abstract: Background: Patients with refractory, bilateral, multifocal epilepsy have few treatment options that typically include a combination of antiseizure medications (ASMs) and vagus nerve stimulation (VNS). A man in his 40s presented with epilepsy refractory ...

Abstract	Background: Patients with refractory, bilateral, multifocal epilepsy have few treatment options that typically include a combination of antiseizure medications (ASMs) and vagus nerve stimulation (VNS). A man in his 40s presented with epilepsy refractory to a combination of five ASMs plus VNS; he was still experiencing 7-10 seizures per week. His seizure network involved multiple foci in both frontal and temporal lobes. Bilateral depth electrodes were implanted into the centromedian/parafascicular (CM/PF) complex of the thalamus and connected to the responsive neurostimulation (RNS) system for closed-loop stimulation and neurophysiological monitoring. Observations: The patient reported clear improvement in his seizures since the procedure, with a markedly reduced number of seizures and decreased seizure intensity. He also reported stretches of seizure freedom not typical of his preoperative baseline, and his remaining seizures were milder, more often with preserved awareness. Generalized seizures with loss of consciousness have decreased to about one per month. RNS data confirmed a right-sided predominance of the bilateral seizure onsets. Lessons: In this patient with multifocal, bilateral frontotemporal epilepsy, RNS of the CM/PF thalamic complex combined with VNS was found to be beneficial. The RNS device was able to detect seizures propagating through the thalamus, and stimulation produced a decrease in seizure burden and intensity.
Language	English
Publishing date	2022-03-21
Publishing country	United States
Document type	Journal Article
ISSN	2694-1902
ISSN (online)	2694-1902
DOI	10.3171/CASE21672
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Article ; Online: Al-Zahrawi (936-1013 AD): On the Surgical Treatment of Neurological Disorders by the Father of Operative Surgery.

Abdulrazeq, Hael F / Ali, Rohaid / Najib, Hebah / Doberstein, Curt / Oyelese, Adetokunbo / Gokaslan, Ziya / Malik, Athar N / Asaad, Wael F / Greenblatt, Samuel

World neurosurgery

2024 Volume 184, Page(s) 236–240.e1

Abstract: Background: Medical knowledge during the medieval ages flourished under the influence of great scholars of the Islamic Golden age such as Ibn Sina (Latinized as Avicenna), Abu Bakr al-Razi (Rhazes), and Abu al-Qasim Khalaf ibn al-Abbas al-Zahrawi, known ...

Abstract	Background: Medical knowledge during the medieval ages flourished under the influence of great scholars of the Islamic Golden age such as Ibn Sina (Latinized as Avicenna), Abu Bakr al-Razi (Rhazes), and Abu al-Qasim Khalaf ibn al-Abbas al-Zahrawi, known as Albucasis. Much has been written on al-Zahrawi's innovation in various disciplines of medicine and surgery. In this article, we focus for on the contributions of al-Zahrawi toward the treatment of neurological disorders in the surgical chapters of his medical encyclopedia, Kitab al-Tasrif (The Method of Medicine). Methods: Excerpts from a modern copy of volume 30 of al-Zahrawi's Kitab al-Tasrif were reviewed and translated by the primary author from Arabic to English, to further provide specific details regarding his neurosurgical knowledge. In addition, a literature search was performed using PubMed and Google Scholar to review prior reports on al-Zahrawi's neurosurgical instructions. Results: In addition to what is described in the literature of al-Zahrawi's teachings in cranial and spine surgery, we provide insight into his diagnosis and management of cranial and spinal trauma, the devices he used, and prognostication of various traumatic injuries. Conclusions: Al-Zahrawi was a renowned physician during the Islamic Golden age who made significant contributions to the diagnosis and treatment of neurological conditions, particularly cranial and spinal cord injuries. He developed innovative surgical techniques for trephination and spinal traction, which are still used in modern neurosurgery. His insights make him worthy of recognition as an important figure in the history of neurological surgery.
MeSH term(s)	Humans ; Male ; Nervous System Diseases/surgery ; Neurosurgery/history ; Neurosurgical Procedures ; Spinal Injuries ; Spinal Cord Injuries ; Medicine, Arabic/history
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2024.01.169
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Zs.A 1159: Show issues

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Article ; Online: Concurrent decoding of distinct neurophysiological fingerprints of tremor and bradykinesia in Parkinson's disease.

Lauro, Peter M / Lee, Shane / Amaya, Daniel E / Liu, David D / Akbar, Umer / Asaad, Wael F

eLife

2023 Volume 12

Abstract: Parkinson's disease (PD) is characterized by distinct motor phenomena that are expressed asynchronously. Understanding the neurophysiological correlates of these motor states could facilitate monitoring of disease progression and allow improved ... ...

Abstract	Parkinson's disease (PD) is characterized by distinct motor phenomena that are expressed asynchronously. Understanding the neurophysiological correlates of these motor states could facilitate monitoring of disease progression and allow improved assessments of therapeutic efficacy, as well as enable optimal closed-loop neuromodulation. We examined neural activity in the basal ganglia and cortex of 31 subjects with PD during a quantitative motor task to decode tremor and bradykinesia - two cardinal motor signs of PD - and relatively asymptomatic periods of behavior. Support vector regression analysis of microelectrode and electrocorticography recordings revealed that tremor and bradykinesia had nearly opposite neural signatures, while effective motor control displayed unique, differentiating features. The neurophysiological signatures of these motor states depended on the signal type and location. Cortical decoding generally outperformed subcortical decoding. Within the subthalamic nucleus (STN), tremor and bradykinesia were better decoded from distinct subregions. These results demonstrate how to leverage neurophysiology to more precisely treat PD.
MeSH term(s)	Humans ; Parkinson Disease/therapy ; Tremor ; Hypokinesia/therapy ; Neurophysiology ; Basal Ganglia ; Deep Brain Stimulation/methods
Language	English
Publishing date	2023-05-30
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.84135
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Article: Predictors of Mortality in Traumatic Intracranial Hemorrhage: A National Trauma Data Bank Study.

Wu, Esther / Marthi, Siddharth / Asaad, Wael F

Frontiers in neurology

2020 Volume 11, Page(s) 587587

Abstract: Background/Objective: ...

Abstract	Background/Objective:
Language	English
Publishing date	2020-11-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2020.587587
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Article ; Online: Subthalamic-Cortical Network Reorganization during Parkinson's Tremor.

Lauro, Peter M / Lee, Shane / Akbar, Umer / Asaad, Wael F

The Journal of neuroscience : the official journal of the Society for Neuroscience

2021 Volume 41, Issue 47, Page(s) 9844–9858

Abstract: Tremor, a common and often primary symptom of Parkinson's disease, has been modeled with distinct onset and maintenance dynamics. To identify the neurophysiologic correlates of each state, we acquired intraoperative cortical and subthalamic nucleus ... ...

Abstract	Tremor, a common and often primary symptom of Parkinson's disease, has been modeled with distinct onset and maintenance dynamics. To identify the neurophysiologic correlates of each state, we acquired intraoperative cortical and subthalamic nucleus recordings from 10 patients (9 male, 1 female) performing a naturalistic visual-motor task. From this task, we isolated short epochs of tremor onset and sustained tremor. Comparing these epochs, we found that the subthalamic nucleus was central to tremor onset, as it drove both motor cortical activity and tremor output. Once tremor became sustained, control of tremor shifted to cortex. At the same time, changes in directed functional connectivity across sensorimotor cortex further distinguished the sustained tremor state.
MeSH term(s)	Aged ; Electrocorticography ; Female ; Humans ; Male ; Middle Aged ; Neural Pathways/physiopathology ; Parkinson Disease/complications ; Parkinson Disease/physiopathology ; Sensorimotor Cortex/physiopathology ; Subthalamic Nucleus/physiopathology ; Tremor/etiology ; Tremor/physiopathology
Language	English
Publishing date	2021-10-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.0854-21.2021
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Zs.A 1668: Show issues

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Article ; Online: The Impact of Frailty on Traumatic Brain Injury Outcomes: An Analysis of 691 821 Nationwide Cases.

Tang, Oliver Y / Shao, Belinda / Kimata, Anna R / Sastry, Rahul A / Wu, Joshua / Asaad, Wael F

Neurosurgery

2022 Volume 91, Issue 5, Page(s) 808–820

Abstract: Background: Frailty, a decline in physiological reserve, prognosticates poorer outcomes for several neurosurgical conditions. However, the impact of frailty on traumatic brain injury outcomes is not well characterized.: Objective: To analyze the ... ...

Abstract	Background: Frailty, a decline in physiological reserve, prognosticates poorer outcomes for several neurosurgical conditions. However, the impact of frailty on traumatic brain injury outcomes is not well characterized. Objective: To analyze the association between frailty and traumatic intracranial hemorrhage (tICH) outcomes in a nationwide cohort. Methods: We identified all adult admissions for tICH in the National Trauma Data Bank from 2007 to 2017. Frailty was quantified using the validated modified 5-item Frailty Index (mFI-5) metric (range = 0-5), with mFI-5 ≥2 denoting frailty. Analyzed outcomes included in-hospital mortality, favorable discharge disposition, complications, ventilator days, and intensive care unit (ICU) and total length of stay (LOS). Multivariable regression assessed the association between mFI-5 and outcomes, adjusting for patient demographics, hospital characteristics, injury severity, and neurosurgical intervention. Results: A total of 691 821 tICH admissions were analyzed. The average age was 57.6 years. 18.0% of patients were frail (mFI-5 ≥ 2). Between 2007 and 2017, the prevalence of frailty grew from 7.9% to 21.7%. Frailty was associated with increased odds of mortality (odds ratio [OR] = 1.36, P < .001) and decreased odds of favorable discharge disposition (OR = 0.72, P < .001). Frail patients exhibited an elevated rate of complications (OR = 1.06, P < .001), including unplanned return to the ICU (OR = 1.55, P < .001) and operating room (OR = 1.17, P = .003). Finally, frail patients experienced increased ventilator days (+12%, P < .001), ICU LOS (+11%, P < .001), and total LOS (+13%, P < .001). All associations with death and disposition remained significant after stratification for age, trauma severity, and neurosurgical intervention. Conclusion: For patients with tICH, frailty predicted higher mortality and morbidity, independent of age or injury severity.
MeSH term(s)	Adult ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/epidemiology ; Brain Injuries, Traumatic/surgery ; Frailty/complications ; Frailty/epidemiology ; Hospitalization ; Humans ; Length of Stay ; Middle Aged ; Neurosurgical Procedures
Language	English
Publishing date	2022-08-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	135446-2
ISSN	1524-4040 ; 0148-396X
ISSN (online)	1524-4040
ISSN	0148-396X
DOI	10.1227/neu.0000000000002116
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Zs.A 1424: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 539: Show issues

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