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Article ; Online: Inflammatory Myofibroblastic Tumor of the Anus: A Case Report.

Takayama, Tetsuyoshi / Nakame, Ayako / Suzuki, Masaomi / Asano, Hiroshi / Jin, Ling

Journal of the anus, rectum and colon

2024 Volume 8, Issue 1, Page(s) 39–42

Abstract: Inflammatory myofibroblastic tumors (IMTs) are neoplastic lesions characterized by the proliferation of spindle cells with myofibroblastic features and lymphocyte infiltration. Primary lesions can develop in several locations but rarely arise in the ... ...

Abstract	Inflammatory myofibroblastic tumors (IMTs) are neoplastic lesions characterized by the proliferation of spindle cells with myofibroblastic features and lymphocyte infiltration. Primary lesions can develop in several locations but rarely arise in the colon as described herein. The present case was that of a 69-year-old woman who visited our hospital with complaints of bloody bowel discharge and a prolapsed mass from the anus. A 20-mm tumor was identified on visual and digital examination. Lower gastrointestinal endoscopy revealed a pedunculated, elevated lesion above the dentate line, which showed contrast enhancement on abdominal computed tomography. The patient was preoperatively diagnosed with an anal polyp, which was resected transanally. During the procedure, a mobile tumor coated by anal epithelium was observed at the 11 o'clock position above the dentate line. Deeper parts of the tumor were contiguous with the internal anal sphincter (IAS) muscle. Suspecting a neoplastic lesion, we resected the mass
Language	English
Publishing date	2024-01-25
Publishing country	Japan
Document type	Case Reports
ISSN	2432-3853
ISSN (online)	2432-3853
DOI	10.23922/jarc.2022-043
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Article: [Investigation of Factors Related to Overall Survival in Patients Treated with Gemcitabine plus Paclitaxel(Albumin Suspension)for Advanced or Recurrent Pancreatic Cancer].

Ito, Daisuke / Takenaka, Shoya / Moriya, Akihiro / Asano, Hiroki / Iwai, Mina / Usami, Eiseki

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 50, Issue 12, Page(s) 1301–1305

Abstract: In cancer chemotherapy, identifying factors that may affect overall survival is clinically beneficial. In this study, we examined the factors associated with overall survival in patients treated with gemcitabine plus paclitaxel(albumin suspension) (GN) ... ...

Abstract	In cancer chemotherapy, identifying factors that may affect overall survival is clinically beneficial. In this study, we examined the factors associated with overall survival in patients treated with gemcitabine plus paclitaxel(albumin suspension) (GN)for pancreatic cancer. We included 91 pancreatic cancer patients who underwent GN therapy as the first-line treatment from January 2015-November 2021. In addition to survival from the start of therapy, the factors surveyed were patient background(gender, age, BMI, etc), dose at the start of treatment, baseline laboratory values, presence or absence of neutrophil count reduction, and modified Glasgow Prognostic Score(mGPS). Multivariate analysis showed that a neutrophil count reduction of Grade 3 or higher(p=0.004)and mGPS≤1(p=0.004)significantly increased overall survival. Consequently, 54.9% of patients(50/91)showed a neutrophil count reduction of Grade 3 or higher, and 35.2% of patients (32/91)showed expression of the first course. The study suggests that neutrophil count reduction of Grade 3 or higher and mGPS≤1 are indicators of prolonged overall survival. In particular, neutrophil count reduction had a high incidence in the first course; therefore, appropriate management is required from early stages of treatment. In addition, nutritional support care should be considered prior to starting treatment.
MeSH term(s)	Humans ; Gemcitabine ; Leukocyte Count ; Pancreatic Neoplasms/drug therapy ; Albumins
Chemical Substances	Gemcitabine ; Albumins
Language	Japanese
Publishing date	2024-01-22
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Zs.B 2573: Show issues

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Article ; Online: Crystal structure of tick tyrosylprotein sulfotransferase reveals the activation mechanism of the tick anticoagulant protein madanin.

Yoshimura, Misa / Teramoto, Takamasa / Asano, Hirai / Iwamoto, Yuka / Kondo, Mariko / Nishimoto, Etsuko / Kakuta, Yoshimitsu

The Journal of biological chemistry

2024 Volume 300, Issue 3, Page(s) 105748

Abstract: Ticks pose a substantial public health risk as they transmit various pathogens. This concern is related to the adept blood-sucking strategy of ticks, underscored by the action of the anticoagulant, madanin, which is known to exhibit an approximately 1000- ...

Abstract	Ticks pose a substantial public health risk as they transmit various pathogens. This concern is related to the adept blood-sucking strategy of ticks, underscored by the action of the anticoagulant, madanin, which is known to exhibit an approximately 1000-fold increase in anticoagulant activity following sulfation of its two tyrosine residues, Tyr51 and Tyr54. Despite this knowledge, the molecular mechanism underlying sulfation by tick tyrosylprotein sulfotransferase (TPST) remains unclear. In this study, we successfully prepared tick TPST as a soluble recombinant enzyme. We clarified the method by which this enzyme proficiently sulfates tyrosine residues in madanin. Biochemical analysis using a substrate peptide based on madanin and tick TPST, along with the analysis of the crystal structure of the complex and docking simulations, revealed a sequential sulfation process. Initial sulfation at the Tyr51 site augments binding, thereby facilitating efficient sulfation at Tyr54. Beyond direct biochemical implications, these findings considerably improve our understanding of tick blood-sucking strategies. Furthermore, combined with the utility of modified tick TPST, our findings may lead to the development of novel anticoagulants, promising avenues for thrombotic disease intervention and advancements in the field of public health.
MeSH term(s)	Animals ; Anticoagulants/chemistry ; Sulfotransferases/chemistry ; Ticks ; Tyrosine/metabolism ; Arthropod Proteins/chemistry ; Crystallization
Chemical Substances	Anticoagulants ; protein-tyrosine sulfotransferase (EC 2.8.2.20) ; Sulfotransferases (EC 2.8.2.-) ; Tyrosine (42HK56048U) ; Arthropod Proteins
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2024.105748
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Uc I Zs.108: Show issues

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Article ; Online: Association between CDK4/6 inhibitors and drug-related osteonecrosis of the jaw: A pharmacoepidemiological study using the FDA Adverse Events Reporting System.

Go, Makiko / Noguchi, Yoshihiro / Masuda, Rikuto / Asano, Hiroki / Kimura, Michio / Usami, Eiseki / Yoshimura, Tomoaki

International journal of cancer

2024

Abstract: The most common toxicities associated with cyclin-dependent kinase (CDK) 4/6 inhibitor therapy include decreased leukopenia and neutropenia due to the inhibition of CDK6 of leukocyte and neutrophil precursors in bone marrow. These hematological ... ...

Abstract	The most common toxicities associated with cyclin-dependent kinase (CDK) 4/6 inhibitor therapy include decreased leukopenia and neutropenia due to the inhibition of CDK6 of leukocyte and neutrophil precursors in bone marrow. These hematological toxicities are more commonly observed with palbociclib administration than with abemaciclib administration, which is approximately 13 times more selective against CDK4 than CDK6. Thus, even though both successfully inhibit CDK4/6, the side effects of palbociclib and abemaciclib differ due to differences in selectivity. Recent reports have suggested an association between palbociclib and medication-related osteonecrosis of the jaw; however, reports on this association are inconsistent. This study investigated the potential association of palbociclib and abemaciclib with MRONJ using the FAERS. Signals of "Osteonecrosis of jaw" were detected only in females using palbociclib (cROR
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.34962
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 576: Show issues

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Article ; Online: Pituitary-Related Adverse Events and Onset Patterns Caused by Immune Checkpoint Inhibitors: Analysis Using the Japanese Adverse Drug Event Report Database.

Asano, Hiroki / Noguchi, Yoshihiro / Kimura, Michio / Usami, Eiseki / Yoshimura, Tomoaki

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 11

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Female ; Humans ; East Asian People ; Immune Checkpoint Inhibitors/adverse effects ; Ipilimumab/adverse effects ; Nivolumab/adverse effects ; Pituitary Diseases/chemically induced ; Pituitary Diseases/drug therapy
Chemical Substances	Immune Checkpoint Inhibitors ; Ipilimumab ; Nivolumab (31YO63LBSN)
Language	English
Publishing date	2023-11-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59111963
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Zs.A 6270: Show issues

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Article ; Online: Measuring auditory event-related potentials at the external ear canal: A demonstrative study using a new electrode and error-feedback paradigm.

Arao, Hiroshi / Suwazono, Shugo / Kimura, Akio / Asano, Hirotoshi / Suzuki, Hiroaki

The European journal of neuroscience

2023 Volume 58, Issue 11, Page(s) 4310–4327

Abstract: Although ear canal electroencephalogram (EEG) recording has received interest from basic and applied research communities, evidence on how it can be implemented in practice is limited. The present study involving eight male participants including the ... ...

Abstract	Although ear canal electroencephalogram (EEG) recording has received interest from basic and applied research communities, evidence on how it can be implemented in practice is limited. The present study involving eight male participants including the authors presents the utility of our ear canal electrode and method by demonstrating both comparability of ear canal EEG to those at nearby sites and distinctiveness that ear canal event-related potentials (ERPs) could have. For this purpose, we used the balanced noncephalic electrode reference and an experimental paradigm with an error-feedback sound. Clear auditory ERPs were detected at the ear canal sites with a sufficiently low noise level comparable with those at conventional sites. The N1c, a temporal maximum subcomponent, spread over the bilateral temporal sites, including the ear canals and earlobes. While consecutive signals are generally highly similar between the ear canal and the earlobe, the N1c was larger at the ear canal than the earlobe, as demonstrated by the conventional frequentist and the hierarchical Bayesian modelling approaches. Although an evident caveat is that our sample was limited in terms of size and sex, the general capability indicates that the structure of our ear canal electrode provides EEG measurement that can be used in basic and applied settings. Our experimental method can also be an ERP-based test that conveniently assesses the capability of existing and future ear canal electrodes. The distinctive nature of the ERPs to the error-feedback sound may be utilized to examine the basic aspects of auditory ERPs and to test the processes involved in feedback-guided behaviour of participants.
MeSH term(s)	Humans ; Male ; Ear Canal ; Feedback ; Bayes Theorem ; Evoked Potentials ; Electrodes
Language	English
Publishing date	2023-10-24
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645180-9
ISSN	1460-9568 ; 0953-816X
ISSN (online)	1460-9568
ISSN	0953-816X
DOI	10.1111/ejn.16175
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Zs.A 2548: Show issues

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Article: [Possibility of Using ELF Score as Index for Hepatic Fibrosis Evaluation].

Asano, Hiromichi

Rinsho byori. The Japanese journal of clinical pathology

2015 Volume 63, Issue 1, Page(s) 78–83

Abstract: Liver fibrosis, most commonly caused by hepatitis virus (such as HBV and HCV) infections, excessive alcohol consumption, and obesity-induced steatosis, is characterized by the excessive accumulation of extracellular matrix proteins (including collagen) ... ...

Abstract	Liver fibrosis, most commonly caused by hepatitis virus (such as HBV and HCV) infections, excessive alcohol consumption, and obesity-induced steatosis, is characterized by the excessive accumulation of extracellular matrix proteins (including collagen) and an increase in connective-tissue (liver fibrogenesis) in the human liver. Today, while the reference standard for detecting and assessing liver fibrosis is needle biopsy of the liver, this invasive procedure can cause physical and emotional distress for patients. On the other hand, medical imaging systems and various blood markers have been developed and become available for routine laboratory practices. These non-invasive procedures, as well as pathological biopsy, have significantly contributed to assessing liver fibrosis. The Enhanced Liver Fibrosis (ELF) test is a simple blood test to create an ELF score by combining three markers: hyaluronic acid (HA), amino-terminal propeptide of type III procollagen (PIIINP), and tissue inhibitor of metalloproteinase 1 (TIMP-1). The ELF test is one of the promising techniques for diagnosing patients with liver fibrosis.
MeSH term(s)	Biomarkers/blood ; Fatty Liver/complications ; Hematologic Tests/methods ; Hepatitis, Viral, Human/complications ; Humans ; Hyaluronic Acid/blood ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/etiology ; Liver Diseases, Alcoholic/complications ; Peptide Fragments/blood ; Procollagen/blood ; Severity of Illness Index ; Tissue Inhibitor of Metalloproteinase-1/blood
Chemical Substances	Biomarkers ; Peptide Fragments ; Procollagen ; Tissue Inhibitor of Metalloproteinase-1 ; procollagen Type III-N-terminal peptide ; Hyaluronic Acid (9004-61-9)
Language	Japanese
Publishing date	2015-01
Publishing country	Japan
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	604196-6
ISSN	0047-1860 ; 0485-1404
ISSN	0047-1860 ; 0485-1404
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Zs.B 437: Show issues

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Article ; Online: Risk factors for the recurrence of stage II perforated colorectal cancer: A retrospective observational study.

Asano, Hiroshi / Fukano, Hiroyuki / Takagi, Makoto / Takayama, Tetsuyoshi

Asian journal of surgery

2022

Abstract: Background: Patients with perforated colorectal cancer (PCRC) experience higher recurrence rates than those with non-perforated tissue. We identified the promoting factors of stage II PCRC recurrence after R0 surgery.: Method: This retrospective ... ...

Abstract	Background: Patients with perforated colorectal cancer (PCRC) experience higher recurrence rates than those with non-perforated tissue. We identified the promoting factors of stage II PCRC recurrence after R0 surgery. Method: This retrospective observational study included patients treated for colorectal cancer at a single facility between 2007 and 2016, and compared the clinicopathological features of patients with perforating versus non-perforating stage II tumors who underwent R0 resection, while focusing on recurrences. Results: Thirty-two and 112 patients (predominantly men) with perforating and non-perforating tumors, respectively, were included. The perforated group had significantly higher proportions of T4 tumors than the non-perforated group (44% vs. 15%). The perforated group had significantly lower numbers of resected lymph nodes than the non-perforated group (6 vs. 17). Seven of 17 patients with follow-up data in the perforated group experienced recurrence (41%), versus 19 of 104 in the non-perforated group (18%). In the non-perforated group, male sex (89% vs. 60%, p = 0.030), T4 stage (32% vs. 9%, p = 0.029), and fewer resected lymph nodes (12.5 vs. 18.6, p = 0.003) were significantly associated with recurrence; however, no such influences on recurrence were observed in the perforated group. The recurrence sites in the perforated group were mostly local (6 patients, 86%). Conversely, recurrences in the non-perforated group were mostly distant; 8 of 19 patients (42%) had liver metastasis and 1 (5%) had lung metastasis. Conclusion: Patients with stage II PCRC experienced higher recurrence rates regardless of clinicopathological features and had high local recurrence rates indicating possible local tumor cell dispersal owing to perforation.
Language	English
Publishing date	2022-03-21
Publishing country	China
Document type	Journal Article
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.03.026
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Article: Effectiveness of Acupuncture for Nonspecific Chronic Low Back Pain: A Systematic Review and Meta-Analysis.

Asano, Hitomi / Plonka, Derek / Weeger, Jacqueline

Medical acupuncture

2022 Volume 34, Issue 2, Page(s) 96–106

Abstract: Objective: This systematic review and meta-analysis assess the effectiveness of acupuncture as an adjunct to standard therapy in the management of nonspecific chronic low back pain (NScLBP), compared with standard therapy alone.: Methods: A ... ...

Abstract	Objective: This systematic review and meta-analysis assess the effectiveness of acupuncture as an adjunct to standard therapy in the management of nonspecific chronic low back pain (NScLBP), compared with standard therapy alone. Methods: A systematic literature search of full-text articles of randomized controlled trials in the date range of 2000-2020, utilizing PubMed and EBSCO databases, was performed to evaluate the efficacy of acupuncture treatment for nonspecific chronic lower back pain. The outcomes of interest were pain intensity and disability. The methodological quality of each study was evaluated using Cochrane risk-of-bias criteria. The studies were combined using meta-analysis when statistical pooling of data was possible. Results: This systematic review included 5 studies of which 4 were included in the meta-analysis. Acupuncture as an adjunct to standard therapy had clinically meaningful reduction in self-reported pain at post-treatment (mean difference = -1.04 [95% confidence interval (CI), -1.59 to -0.49], Conclusion: Both the systematic review and meta-analysis demonstrate that acupuncture as an adjunct to standard therapy is a safe and effective method in reducing pain and disability among adults with NScLBP.
Language	English
Publishing date	2022-04-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2296110-0
ISSN	1933-6594 ; 1933-6586
ISSN (online)	1933-6594
ISSN	1933-6586
DOI	10.1089/acu.2021.0057
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Book ; Online: Counterfactual Fairness Filter for Fair-Delay Multi-Robot Navigation

Asano, Hikaru / Yonetani, Ryo / Nishimura, Mai / Kozuno, Tadashi

2023

Abstract: Multi-robot navigation is the task of finding trajectories for a team of robotic agents to reach their destinations as quickly as possible without collisions. In this work, we introduce a new problem: fair-delay multi-robot navigation, which aims not ... ...

Abstract	Multi-robot navigation is the task of finding trajectories for a team of robotic agents to reach their destinations as quickly as possible without collisions. In this work, we introduce a new problem: fair-delay multi-robot navigation, which aims not only to enable such efficient, safe travels but also to equalize the travel delays among agents in terms of actual trajectories as compared to the best possible trajectories. The learning of a navigation policy to achieve this objective requires resolving a nontrivial credit assignment problem with robotic agents having continuous action spaces. Hence, we developed a new algorithm called Navigation with Counterfactual Fairness Filter (NCF2). With NCF2, each agent performs counterfactual inference on whether it can advance toward its goal or should stay still to let other agents go. Doing so allows us to effectively address the aforementioned credit assignment problem and improve fairness regarding travel delays while maintaining high efficiency and safety. Our extensive experimental results in several challenging multi-robot navigation environments demonstrate the greater effectiveness of NCF2 as compared to state-of-the-art fairness-aware multi-agent reinforcement learning methods. Our demo videos and code are available on the project webpage: https://omron-sinicx.github.io/ncf2/ Comment: To appear in the International Conference on Autonomous Agents and Multiagent Systems (AAMAS 2023)
Keywords	Computer Science - Multiagent Systems ; Computer Science - Robotics
Subject code	629
Publishing date	2023-05-19
Publishing country	us
Document type	Book ; Online
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