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Article ; Online: Lacrimal sac massage for congenital nasolacrimal duct obstruction: a multicentre randomised controlled trial.

Asano, Mizuki / Takeuchi, Masaki / Ohno, Tomoko / Nakamura, Jutaro / Mizuki, Nobuhisa / Matsumura, Nozomi

2024

Abstract: Aim: Congenital nasolacrimal duct obstruction (CNLDO) is the most common cause of epiphora and mucous discharge in the newborn. We conducted a multicentre randomised controlled trial to determine whether Crigler massage promotes the resolution of CNLDO ... ...

Abstract	Aim: Congenital nasolacrimal duct obstruction (CNLDO) is the most common cause of epiphora and mucous discharge in the newborn. We conducted a multicentre randomised controlled trial to determine whether Crigler massage promotes the resolution of CNLDO in infants under 1 year of age. Methods: A total of 102 infants aged 3-11 months with unilateral CNLDO were enrolled in the study. Patients were randomly assigned to the massage and non-massage groups (n=51/group). As an allocation adjustment factor, the patients were divided into age groups of 3-5, 6-8 and 9-11 months. In the massage group, the guardian performed 10 strokes two times per day for each day until resolution or 1 month. The primary endpoint was a comparison of the 1-month resolution rate in the massage and non-massage groups. Results: This study included 49 male and 53 female patients with a mean age of 6.4±2.4 months. Overall, in this study, the resolution rate was not significantly different between the massage and non-massage groups (31.4% and 33.3%, respectively). However, the resolution rate was higher in the massage group in the 3-5 months age group among the protocol-compliant patients after excluding those with insufficient massage frequency (the massage group, 68.8% and the non-massage group, 28.6%, p=0.022). Conclusions: There was no increase in the resolution rate after 1 month of lacrimal sac massage in patients 3-11 months old with unilateral CNLDO. However, in protocol-compliant younger age groups, Crigler massage may be effective. Trial registration number: UMIN Clinical Trial Registry (UMIN000032840; www.umin.ac.jp/).
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	80078-8
ISSN	1468-2079 ; 0007-1161
ISSN (online)	1468-2079
ISSN	0007-1161
DOI	10.1136/bjo-2023-324595
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Article ; Online: Comparing the effectiveness of two surgical techniques for treating lower lid epiblepharon in children: a randomized controlled trial.

Takeuchi, Masaki / Matsumura, Nozomi / Ohno, Tomoko / Fujita, Takeshi / Asano, Mizuki / Mizuki, Nobuhisa

Scientific reports

2023 Volume 13, Issue 1, Page(s) 5857

Abstract: A multicenter randomized controlled trial was conducted to compare the effectiveness of incisional and nonincisional surgical techniques for treating lower lid epiblepharon in children. The study included 89 eyes from 50 children aged 3-15 years (mean, 7. ...

Abstract	A multicenter randomized controlled trial was conducted to compare the effectiveness of incisional and nonincisional surgical techniques for treating lower lid epiblepharon in children. The study included 89 eyes from 50 children aged 3-15 years (mean, 7.5 ± 2.4 years) with moderate lower lid epiblepharon. Patients were randomly assigned to either incisional (modified Hotz procedure with lid margin splitting; 45 eyes of 25 patients) or nonincisional (44 eyes of 25 patients) surgery groups. Treatment outcomes and changes in astigmatism were evaluated 6 months after surgery. Incisional surgery provided a significantly higher percentage (77.8%) of well-corrected treatment results (P = 0.026; odds ratio, 2.88; 95% confidence interval, 1.07-8.22) than nonincisional surgery (55.4%). The mean change in astigmatism 6 months after surgery was - 0.24 ± 0.42 and - 0.01 ± 0.47 D in the incisional and nonincisional surgery groups, respectively. The improvement in astigmatism was significantly higher in the incisional surgery group than in the nonincisional surgery group (P = 0.008). The incisional surgical treatment for moderate epiblepharon in children resulted in a higher number of well-corrected patients, indicating an absence of both ciliary touch and superficial keratitis as well as statistically significant improvements in astigmatism correction.
MeSH term(s)	Humans ; Child ; Astigmatism ; Retrospective Studies ; Treatment Outcome ; Eyelashes ; Cornea ; Surgical Wound
Language	English
Publishing date	2023-04-11
Publishing country	England
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-32050-4
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Article ; Online: Retraction notice to "Impaired neural reward processing in children and adolescents with reactive attachment disorder: A pilot study" Asian J. Psychiatry 17 (2015) 89-93.

Mizuno, Kei / Takiguchi, Shinichiro / Yamazaki, Mika / Asano, Mizuki / Kato, Shiho / Kuriyama, Kikuko / Watanabe, Yasuyoshi / Sadato, Norihiro / Tomoda, Akemi

Asian journal of psychiatry

2023 Volume 89, Page(s) 103794

Language	English
Publishing date	2023-10-04
Publishing country	Netherlands
Document type	Journal Article ; Retraction of Publication
ZDB-ID	2456678-0
ISSN	1876-2026 ; 1876-2018
ISSN (online)	1876-2026
ISSN	1876-2018
DOI	10.1016/j.ajp.2023.103794
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Article ; Online: Bilateral Incomplete Atypical Femur Fractures with Severe Bowing Treated Using Elastic Intramedullary Nails: A Case Report.

Okubo, Naoki / Yoshida, Takashi / Tanaka, Kazuya / Asano, Mizuki / Nakazawa, Taku / Ohara, Masato / Hosoi, Kunihiko / Takahashi, Kenji

JBJS case connector

2022 Volume 12, Issue 2

Abstract: Case: A 77-year-old woman with bilateral symptomatic atypical femoral fractures (AFFs) and severe anterolateral bowing due to long-term bisphosphonate administration was treated using stainless elastic intramedullary nails. Weight-bearing pain ... ...

Abstract	Case: A 77-year-old woman with bilateral symptomatic atypical femoral fractures (AFFs) and severe anterolateral bowing due to long-term bisphosphonate administration was treated using stainless elastic intramedullary nails. Weight-bearing pain disappeared immediately after surgery. Radiographs obtained 1 year postoperatively showed fracture healing. Conclusion: Although intramedullary nail insertion has been recommended for symptomatic incomplete AFFs, in cases of severe bowing, rigid nail insertion was often challenging, and the complication rates were higher than those with mild bowing. The advantage of our method is easy insertion, suggesting effective treatment.
MeSH term(s)	Aged ; Bone Nails ; Female ; Femoral Fractures/diagnostic imaging ; Femoral Fractures/surgery ; Femur ; Fracture Fixation, Intramedullary ; Fracture Healing ; Humans
Language	English
Publishing date	2022-06-08
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	2160-3251
ISSN (online)	2160-3251
DOI	e22.00191
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Article: Persistent Hyperplastic Primary Vitreous with Microphthalmia and Coloboma in a Patient with Okur-Chung Neurodevelopmental Syndrome.

Murakami, Hiroaki / Uehara, Tomoko / Enomoto, Yumi / Nishimura, Naoto / Kumaki, Tatsuro / Kuroda, Yukiko / Asano, Mizuki / Aida, Noriko / Kosaki, Kenjiro / Kurosawa, Kenji

Molecular syndromology

2021 Volume 13, Issue 1, Page(s) 75–79

Abstract: Okur-Chung neurodevelopmental syndrome is a rare autosomal dominant disorder caused by pathogenic variants ... ...

Abstract	Okur-Chung neurodevelopmental syndrome is a rare autosomal dominant disorder caused by pathogenic variants in
Language	English
Publishing date	2021-09-22
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2546218-0
ISSN	1661-8777 ; 1661-8769
ISSN (online)	1661-8777
ISSN	1661-8769
DOI	10.1159/000517977
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Article ; Online: Effects of ramelteon on refractory behavioral and psychological symptoms of dementia in Alzheimer disease.

Asano, Mizuki / Ishitobi, Makoto / Tanaka, Yuji / Wada, Yuji

Journal of clinical psychopharmacology

2013 Volume 33, Issue 4, Page(s) 579–581

MeSH term(s)	Aged ; Alzheimer Disease/diagnosis ; Alzheimer Disease/drug therapy ; Alzheimer Disease/physiopathology ; Alzheimer Disease/psychology ; Circadian Rhythm/drug effects ; Drug Resistance ; Humans ; Hypnotics and Sedatives/therapeutic use ; Indenes/therapeutic use ; Male ; Sleep/drug effects ; Sleep Wake Disorders/diagnosis ; Sleep Wake Disorders/drug therapy ; Sleep Wake Disorders/physiopathology ; Sleep Wake Disorders/psychology ; Treatment Outcome
Chemical Substances	Hypnotics and Sedatives ; Indenes ; ramelteon (901AS54I69)
Language	English
Publishing date	2013-08
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	604631-9
ISSN	1533-712X ; 0271-0749
ISSN (online)	1533-712X
ISSN	0271-0749
DOI	10.1097/JCP.0b013e3182946702
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Article ; Online: Ramelteon monotherapy for insomnia and impulsive behavior in high-functioning autistic disorder.

Asano, Mizuki / Ishitobi, Makoto / Kosaka, Hirotaka / Hiratani, Michio / Wada, Yuji

Journal of clinical psychopharmacology

2014 Volume 34, Issue 3, Page(s) 402–403

MeSH term(s)	Adolescent ; Autistic Disorder/complications ; Autistic Disorder/drug therapy ; Humans ; Impulsive Behavior/drug effects ; Indenes/therapeutic use ; Male ; Sleep Initiation and Maintenance Disorders/drug therapy ; Sleep Initiation and Maintenance Disorders/etiology ; Treatment Outcome
Chemical Substances	Indenes ; ramelteon (901AS54I69)
Language	English
Publishing date	2014-06
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	604631-9
ISSN	1533-712X ; 0271-0749
ISSN (online)	1533-712X
ISSN	0271-0749
DOI	10.1097/JCP.0000000000000137
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Article ; Online: Quetiapine responsive catatonia in an autistic patient with comorbid bipolar disorder and idiopathic basal ganglia calcification.

Ishitobi, Makoto / Kawatani, Masao / Asano, Mizuki / Kosaka, Hirotaka / Goto, Takashi / Hiratani, Michio / Wada, Yuji

Brain & development

2014 Volume 36, Issue 9, Page(s) 823–825

Abstract: Background: Bipolar disorder (BD) has been linked with the manifestation of catatonia in subjects with autism spectrum disorders (ASD). Idiopathic basal ganglia calcification (IBGC) is characterized by movement disorders and various neuropsychiatric ... ...

Abstract	Background: Bipolar disorder (BD) has been linked with the manifestation of catatonia in subjects with autism spectrum disorders (ASD). Idiopathic basal ganglia calcification (IBGC) is characterized by movement disorders and various neuropsychiatric disturbances including mood disorder. Case: We present a patient with ASD and IBGC who developed catatonia presenting with prominent dystonic feature caused by comorbid BD, which was treated effectively with quetiapine. Conclusion: In addition to considering the possibility of neurodegenerative disease, careful psychiatric interventions are important to avoid overlooking treatable catatonia associated with BD in cases of ASD presenting with both prominent dystonic features and apparent fluctuation of the mood state.
MeSH term(s)	Adolescent ; Autistic Disorder/complications ; Autistic Disorder/diagnosis ; Autistic Disorder/pathology ; Basal Ganglia/pathology ; Bipolar Disorder/complications ; Bipolar Disorder/diagnosis ; Bipolar Disorder/pathology ; Brain Diseases/complications ; Brain Diseases/diagnosis ; Brain Diseases/pathology ; Calcinosis/chemically induced ; Calcinosis/complications ; Calcinosis/pathology ; Catatonia/complications ; Catatonia/diagnosis ; Catatonia/drug therapy ; Catatonia/pathology ; Diagnosis, Differential ; Dibenzothiazepines/therapeutic use ; Humans ; Magnetic Resonance Imaging ; Male ; Quetiapine Fumarate ; Tomography, X-Ray Computed
Chemical Substances	Dibenzothiazepines ; Quetiapine Fumarate (2S3PL1B6UJ)
Language	English
Publishing date	2014-10
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	604822-5
ISSN	1872-7131 ; 0387-7604
ISSN (online)	1872-7131
ISSN	0387-7604
DOI	10.1016/j.braindev.2013.12.005
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Zs.A 1788: Show issues

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Article ; Online: Impaired neural reward processing in children and adolescents with reactive attachment disorder: A pilot study.

Mizuno, Kei / Takiguchi, Shinichiro / Yamazaki, Mika / Asano, Mizuki / Kato, Shiho / Kuriyama, Kikuko / Watanabe, Yasuyoshi / Sadato, Norihiro / Tomoda, Akemi

publication RETRACTED

Asian journal of psychiatry

2015 Volume 17, Page(s) 89–93

Abstract: Reactive attachment disorder (RAD) is characterized by markedly disturbed and developmentally inappropriate social relatedness due to parental maltreatment. RAD patients often display a high number of comorbid attention deficit/hyperactivity disorder ( ... ...

Abstract	Reactive attachment disorder (RAD) is characterized by markedly disturbed and developmentally inappropriate social relatedness due to parental maltreatment. RAD patients often display a high number of comorbid attention deficit/hyperactivity disorder (ADHD) symptoms, and certain RAD symptoms are difficult to discriminate from ADHD. One of the core characteristics of ADHD is a decrease in neural reward processing due to dopamine dysfunction. The aim of the present study was to determine whether the brain activity involved in reward processing in RAD patients is impaired in comparison with ADHD patients and typically developed controls. Five RAD patients, 17 typically developed (TD) controls and 17 ADHD patients aged 10-16 years performed tasks with high and low monetary reward while undergoing functional magnetic resonance imaging. ADHD patients were tested before and after 3 months treatment with osmotic release oral system-methylphenidate. Before treatment, ADHD patients showed that striatal and thalamus activities only in the tasks with low monetary reward were lower than TD controls. RAD patients showed decrease in activity of the caudate, putamen and thalamus during both the high and low monetary reward conditions in comparison with all the other groups. In RAD patients, the activity of the putamen was associated with the severity of posttraumatic stress and overt dissociation. Reward sensitivity was markedly decreased in children and adolescents with RAD, as evidenced by a diminished neural response during reward perception. This suggests that dopaminergic dysfunction exists in these patients, and may inform future dopaminergic treatment strategies for RAD.
MeSH term(s)	Adolescent ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Attention Deficit Disorder with Hyperactivity/metabolism ; Brain/metabolism ; Brain/physiopathology ; Child ; Child Abuse/psychology ; Dopamine Uptake Inhibitors/administration & dosage ; Dopamine Uptake Inhibitors/pharmacokinetics ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/metabolism ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Methylphenidate/administration & dosage ; Methylphenidate/pharmacokinetics ; Pilot Projects ; Reactive Attachment Disorder/diagnosis ; Reactive Attachment Disorder/metabolism ; Reactive Attachment Disorder/physiopathology ; Reactive Attachment Disorder/psychology ; Reward ; Social Behavior ; Task Performance and Analysis
Chemical Substances	Dopamine Uptake Inhibitors ; Methylphenidate (207ZZ9QZ49)
Language	English
Publishing date	2015-08-18
Publishing country	Netherlands
Document type	Journal Article ; Retracted Publication
ZDB-ID	2456678-0
ISSN	1876-2026 ; 1876-2018
ISSN (online)	1876-2026
ISSN	1876-2018
DOI	10.1016/j.ajp.2015.08.002
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Article ; Online: Distinguishing between autism spectrum disorder and attention deficit hyperactivity disorder by using behavioral checklists, cognitive assessments, and neuropsychological test battery.

Matsuura, Naomi / Ishitobi, Makoto / Arai, Sumiyoshi / Kawamura, Kaori / Asano, Mizuki / Inohara, Keisuke / Narimoto, Tadamasa / Wada, Yuji / Hiratani, Michio / Kosaka, Hirotaka

Asian journal of psychiatry

2014 Volume 12, Page(s) 50–57

Abstract: Children with attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) share many common symptoms, including attention deficit, behavioral problems, and difficulties with social skills. The aim of this study was to distinguish ... ...

Abstract	Children with attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) share many common symptoms, including attention deficit, behavioral problems, and difficulties with social skills. The aim of this study was to distinguish between ASD and ADHD by identifying the characteristic features of both the disorders, by using multidimensional assessments, including screening behavioral checklists, cognitive assessments, and comprehensive neurological battery. After screening for comorbid disorders, we carefully selected age-, sex-, IQ-, and socio-economic status-matched children with typical development (TD). In the Wechsler Intelligence Scale for children, a lower score was observed for the ASD group than for the TD group in Picture concept, which is a subscale of perceptual reasoning. A lower score was shown by the ADHD group than by the TD group in the spatial working memory test in the Cambridge Neuropsychological Test Automated Battery (CANTAB(®)). Although ASD and ADHD have many similar symptoms, they can be differentiated by focusing on the behavioral and cognitive characteristics of executive function.
MeSH term(s)	Adolescent ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/psychology ; Checklist ; Child ; Child Development Disorders, Pervasive/diagnosis ; Child Development Disorders, Pervasive/psychology ; Cognition ; Diagnosis, Differential ; Executive Function ; Female ; Humans ; Male ; Neuropsychological Tests ; Surveys and Questionnaires
Language	English
Publishing date	2014-12
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2456678-0
ISSN	1876-2026 ; 1876-2018
ISSN (online)	1876-2026
ISSN	1876-2018
DOI	10.1016/j.ajp.2014.06.011
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