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  1. Article ; Online: A 37-Year-Old Woman with Hypertrophic Cardiomyopathy with a Dual-Chamber Implantable Cardioverter-Defibrillator Requiring Percutaneous Transvenous Lead Extraction and Multidisciplinary Management.

    Dhawan, Rahul / Khan, Faris / Samant, Saurabhi / Asawaeer, Majid / Merritt Genore, HelenMari / Erickson, Christopher C

    The American journal of case reports

    2021  Volume 22, Page(s) e932073

    Abstract: BACKGROUND Percutaneous transvenous lead extraction (TLE) of cardiac implantable electronic devices can be performed with a high success rate. However, TLE has its limitations and challenges. Recognizing the challenges at an early stage during the ... ...

    Abstract BACKGROUND Percutaneous transvenous lead extraction (TLE) of cardiac implantable electronic devices can be performed with a high success rate. However, TLE has its limitations and challenges. Recognizing the challenges at an early stage during the procedure is vital for appropriate patient management. We present a challenging case of implantable cardioverter-defibrillator (ICD) lead extraction in which we aborted TLE in favor of elective surgical extraction (SE). This potentially prevented a major catastrophic complication of vascular tear, which would have required an emergent thoracotomy. CASE REPORT A 37-year-old woman with history of hypertrophic cardiomyopathy had a primary prevention dual-chamber ICD implant in 2001 and underwent right ventricular ICD lead revision in 2009 due to lead fracture. In 2019, she was again found to have right ventricular ICD lead malfunction. TLE was attempted, but no meaningful progression could be made despite using multiple extraction tools. Therefore, TLE was aborted in favor of SE. During elective SE, significant adhesions were noted, and the innominate vein was completely avulsed during removal of the leads, requiring venous reconstruction by the vascular surgery team. After SE and vascular reconstruction, an epicardial ICD system was placed, and the patient had an uneventful postoperative recovery. CONCLUSIONS This case report highlights the limitations of TLE and the importance of recognizing them in a timely manner. In all challenging cases, conversion to elective SE should be considered to avoid potential injuries warranting emergent surgical repair.
    MeSH term(s) Adult ; Cardiomyopathy, Hypertrophic/complications ; Cardiomyopathy, Hypertrophic/therapy ; Defibrillators, Implantable/adverse effects ; Device Removal ; Female ; Humans ; Tissue Adhesions ; Treatment Outcome
    Language English
    Publishing date 2021-10-22
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.932073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A rare case of granulomatosis with polyangiitis-induced burnout cardiomyopathy: role of combined viability and metabolic imaging.

    Asawaeer, Majid / Sayyed, Samer / Chatzizisis, Yiannis S

    European heart journal cardiovascular Imaging

    2018  Volume 19, Issue 5, Page(s) 584

    MeSH term(s) Burnout, Psychological ; Cardiomyopathies/complications ; Cardiomyopathies/diagnostic imaging ; Cardiomyopathies/physiopathology ; Echocardiography/methods ; Follow-Up Studies ; Granulomatosis with Polyangiitis/complications ; Granulomatosis with Polyangiitis/diagnostic imaging ; Granulomatosis with Polyangiitis/drug therapy ; Heart Failure/diagnosis ; Heart Failure/etiology ; Humans ; Immunosuppressive Agents/therapeutic use ; Magnetic Resonance Imaging, Cine/methods ; Male ; Middle Aged ; Multimodal Imaging/methods ; Rare Diseases ; Stroke Volume/physiology ; Time Factors
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2018-02-15
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jey001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Recurrent Spontaneous Coronary Artery Dissection Presenting with STEMI, Once is Never Enough!

    Al Emam, Abdel R / Akkad, Haysam / Asawaeer, Majid / Pompili, Vincent

    Current cardiology reviews

    2019  Volume 17, Issue 4, Page(s) e310521172093

    Abstract: Background: Spontaneous coronary artery dissection (SCAD) is an under-recognized cause of acute coronary syndrome in women.: Case presentation: We present a 40-year-old female who presented with recurrent STEMI due to recurrent SCAD 10 days after the ...

    Abstract Background: Spontaneous coronary artery dissection (SCAD) is an under-recognized cause of acute coronary syndrome in women.
    Case presentation: We present a 40-year-old female who presented with recurrent STEMI due to recurrent SCAD 10 days after the index presentation in a different coronary territory. She was successfully treated both times with drug eluting stents. MRI showed an evidence of transmural infarction but her ejection fraction was only mildly reduced. She had good short term outcome.
    Conclusion: High index of suspicion is crucial for early diagnosis and prompt medical and interventional management in patients with SCAD.
    MeSH term(s) Adult ; Coronary Angiography ; Coronary Vessel Anomalies/diagnosis ; Coronary Vessel Anomalies/diagnostic imaging ; Dissection ; Female ; Humans ; Percutaneous Coronary Intervention ; Recurrence ; ST Elevation Myocardial Infarction/diagnostic imaging ; ST Elevation Myocardial Infarction/etiology ; Vascular Diseases/diagnostic imaging
    Language English
    Publishing date 2019-05-07
    Publishing country United Arab Emirates
    Document type Case Reports
    ISSN 1875-6557
    ISSN (online) 1875-6557
    DOI 10.2174/1573403X15666190513101614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Left Ventricular Assist Device Outflow Cannula Obstruction: Importance of Multimodality Imaging.

    Asawaeer, Majid / Kadir, Sajid / Albulushi, Arif / Castleberry, Anthony W / Chatzizisis, Yiannis S

    JACC. Case reports

    2020  Volume 2, Issue 10, Page(s) 1454–1456

    Abstract: One of the dreaded complications of left ventricular assist device implantation is mechanical obstruction of the device secondary to pump thrombosis or mechanical outflow cannula obstruction. We describe a case of outflow cannula obstruction caused by ... ...

    Abstract One of the dreaded complications of left ventricular assist device implantation is mechanical obstruction of the device secondary to pump thrombosis or mechanical outflow cannula obstruction. We describe a case of outflow cannula obstruction caused by kinking and twisting of the outflow graft after surgical manipulation of the pump. (
    Language English
    Publishing date 2020-08-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2020.05.065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Tyrosine Kinase Inhibitor-Induced Acute Myocarditis, Myositis, and Cardiogenic Shock.

    Asawaeer, Majid / Barton, David / Radio, Stanley / Chatzizisis, Yiannis S

    Methodist DeBakey cardiovascular journal

    2018  Volume 14, Issue 3, Page(s) e5–e6

    MeSH term(s) Acute Disease ; Antineoplastic Agents/adverse effects ; Biopsy ; Cardiotoxicity ; Coronary Angiography ; Echocardiography ; Female ; Humans ; Middle Aged ; Myocarditis/chemically induced ; Myocarditis/diagnosis ; Myocarditis/therapy ; Myocardium/pathology ; Myositis/chemically induced ; Myositis/diagnosis ; Myositis/therapy ; Protein Kinase Inhibitors/adverse effects ; Shock, Cardiogenic/chemically induced ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/therapy ; Sorafenib/adverse effects
    Chemical Substances Antineoplastic Agents ; Protein Kinase Inhibitors ; Sorafenib (9ZOQ3TZI87)
    Language English
    Publishing date 2018-11-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2544079-2
    ISSN 1947-6108 ; 1947-6094
    ISSN (online) 1947-6108
    ISSN 1947-6094
    DOI 10.14797/mdcj-14-3-e5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Infliximab Treatment of Refractory Cardiac Sarcoidosis.

    Asawaeer, Majid / Widener, Benjamin / Singhal, Varda / DeVries, Matthew J / Romberger, Debra J / Erickson, Alan R / Chatzizisis, Yiannis S

    JACC. Case reports

    2020  Volume 2, Issue 10, Page(s) 1553–1557

    Abstract: Treatment of cardiac sarcoidosis is challenging, as the disease can be refractory to traditional treatment with steroids. Infliximab, a tumor necrosis factor-α inhibitor, has been reportedly used in cardiac sarcoidosis, but published evidence is limited. ...

    Abstract Treatment of cardiac sarcoidosis is challenging, as the disease can be refractory to traditional treatment with steroids. Infliximab, a tumor necrosis factor-α inhibitor, has been reportedly used in cardiac sarcoidosis, but published evidence is limited. The potential cardiotoxicity of infliximab and the Food and Drug Administration black-box warning for patients with heart failure have hindered the use of this agent in cardiac sarcoidosis. Here, we report a case of refractory cardiac sarcoidosis successfully treated with infliximab and discuss the important role of fluorine-18-fluorodeoxyglucose positron emission tomography in prognostication and guidance of therapy. (
    Language English
    Publishing date 2020-08-19
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2020.06.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The role of thromboprophylaxis in patients with permanent immobility.

    Khan, Muhammad Shahzeb / Riaz Sipra, Qurat-ul-Ain / Asawaeer, Majid / Riaz, Irbaz Bin

    The American journal of medicine

    2015  Volume 128, Issue 3, Page(s) e7–8

    MeSH term(s) Anticoagulants/therapeutic use ; Bed Rest/adverse effects ; Chemoprevention/methods ; Clinical Trials as Topic ; Disabled Persons ; Humans ; Immobility Response, Tonic ; Risk Assessment ; Thromboembolism/etiology ; Thromboembolism/prevention & control
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Letter
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2014.10.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Optimal anticoagulation duration of unfractionated and low molecular weight heparin in non-ST elevation acute coronary syndrome: a systematic review of the literature.

    Riaz, Irbaz Bin / Asawaeer, Majid / Riaz, Haris / Gabriel, Wendy M / Tabash, Ismail K / Bilal, Jawad / Alpert, Joseph S

    International journal of cardiology

    2014  Volume 177, Issue 2, Page(s) 461–466

    Abstract: Introduction: In this PCI era, non-invasive management for patients presenting with non-ST elevation acute coronary syndrome continues to be relevant in several clinical circumstances. The duration of anticoagulation in non-invasively treated group is ... ...

    Abstract Introduction: In this PCI era, non-invasive management for patients presenting with non-ST elevation acute coronary syndrome continues to be relevant in several clinical circumstances. The duration of anticoagulation in non-invasively treated group is not clear. The use of heparin can be associated with fatal side effects. Thus, defining the optimal duration of therapy has significant implications for patient safety and cost.
    Methods: Literature search was conducted using Medline (PubMed and Ovid SP), Embase, Cochrane Central Register of Controlled Clinical Trials (CENTRAL) and Cochrane Database of Systematic Review (CDSR) from the inception of these databases till present (August 2013). Only studies on humans and in English language were included. We included only published clinical trials which used UFH or LMWH as the anticoagulation agent.
    Results: Initial search revealed 548 studies with 182 meeting inclusion criteria for full review. The duration of therapy was reported in 20 of 182 studies with an average treatment duration of 2-8 days. There was a trend towards increased bleeding without significant improvement in cardiovascular outcomes when anticoagulation was continued for more than 5-7 days. No single trial directly analyzed the composite end point outcome or adverse events in correlation with the duration of anticoagulation.
    Conclusion: There is a lack of good quality evidence to define the optimal duration of anticoagulation in the management of NSTE ACS. Well-designed, methodologically rigorous database studies are required to determine the shortest duration of therapy which achieves the benefits of anticoagulants while minimizing the costs and risks associated with prolonged anticoagulant use.
    MeSH term(s) Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/drug therapy ; Acute Coronary Syndrome/epidemiology ; Anticoagulants/adverse effects ; Anticoagulants/pharmacology ; Anticoagulants/therapeutic use ; Blood Coagulation/drug effects ; Blood Coagulation/physiology ; Clinical Trials as Topic/methods ; Hemorrhage/epidemiology ; Hemorrhage/prevention & control ; Heparin/adverse effects ; Heparin/pharmacology ; Heparin/therapeutic use ; Heparin, Low-Molecular-Weight/adverse effects ; Heparin, Low-Molecular-Weight/pharmacology ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans
    Chemical Substances Anticoagulants ; Heparin, Low-Molecular-Weight ; Heparin (9005-49-6)
    Language English
    Publishing date 2014-12-15
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2014.09.105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Meta-analysis of revascularization versus medical therapy for atherosclerotic renal artery stenosis.

    Riaz, Irbaz B / Husnain, Muhammad / Riaz, Haris / Asawaeer, Majid / Bilal, Jawad / Pandit, Anil / Shetty, Ranjith / Lee, Kwan S

    The American journal of cardiology

    2014  Volume 114, Issue 7, Page(s) 1116–1123

    Abstract: The aim of the study was to compare the efficacy of revascularization versus medical therapy in patients with atherosclerotic renal artery stenosis (ARAS). ARAS is the most common cause of secondary hypertension and is associated with several ... ...

    Abstract The aim of the study was to compare the efficacy of revascularization versus medical therapy in patients with atherosclerotic renal artery stenosis (ARAS). ARAS is the most common cause of secondary hypertension and is associated with several complications, such as renal failure, coronary artery disease, cardiac destabilization, and stroke. Medical therapy is the cornerstone for management of ARAS; however, numerous trials have compared medical therapy with revascularization in the form of percutaneous renal artery angioplasty (PTRA) or percutaneous renal artery angioplasty with stent placement (PTRAS). Medline (PubMed and Ovid SP), Embase, Cochrane Central Register of Controlled Clinical Trials (CENTRAL), and Cochrane Database of Systematic Review (CDSR) were searched till present (November 2013) to identify clinical trials where medical therapy was compared with revascularization (PTRA or PTRAS). We performed a meta-analysis using a random effects model. The heterogeneity was assessed using I2 values. The initial database search identified 540 studies and 7 randomized controlled trials, and 2,139 patients were included in the final analysis. Angioplasty with or without stenting was not superior to medical therapy with respect to any outcome. The incidence of nonfatal myocardial infarction was 6.74% in both the stenting and medical therapy group (odds ratio=0.998, 95% confidence interval 0.698 to 1.427, p=0.992), and incidence of renal events in stenting population was found to be 19.58% versus 20.53% in medical therapy (odds ratio=0.945, 95% confidence interval 0.755 to 1.182, p=0.620). In conclusion, PTRA or PTRAS does not improve outcomes compared with medical therapy in patients with ARAS. Future studies should investigate to identify patient subgroups that may benefit from such an intervention.
    MeSH term(s) Animals ; Atherosclerosis/complications ; Atherosclerosis/epidemiology ; Atherosclerosis/therapy ; Cardiovascular Agents/therapeutic use ; Global Health ; Humans ; Morbidity ; Renal Artery Obstruction/epidemiology ; Renal Artery Obstruction/etiology ; Renal Artery Obstruction/therapy ; Treatment Outcome ; Vascular Surgical Procedures/methods
    Chemical Substances Cardiovascular Agents
    Language English
    Publishing date 2014-10-01
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2014.06.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The impact of recently published negative erythropoiesis-stimulating agent studies on the clinical management of cancer-related anemia at a single center.

    Abdel-Razeq, Hikmat / Hijjawi, Shadi / Abdulelah, Hazem / Amarin, Rula / Asawaeer, Majid / Shaheen, Haitham

    Hematology/oncology and stem cell therapy

    2010  Volume 3, Issue 2, Page(s) 78–83

    Abstract: Background and objectives: Anemia in cancer patients is common, but often under-recognized and under-treated. Erythropoiesis stimulating agents (ESAs) are widely used to prevent and treat cancer and chemo- therapy-related anemia, but recent studies ... ...

    Abstract Background and objectives: Anemia in cancer patients is common, but often under-recognized and under-treated. Erythropoiesis stimulating agents (ESAs) are widely used to prevent and treat cancer and chemo- therapy-related anemia, but recent studies suggest a negative impact on disease progression and survival associated with their use. This retrospective study describes the prevalence of anemia in cancer patients and recent trends in its management given the negative studies.
    Patients and methods: All consecutive adult cancer patients (n=959) admitted to regular medical units over one year were reviewed. Patients with a hemoglobin (Hb) value <12 g/dL on admission were considered anemic. Information on the primary tumor, main reasons for admission and treatment given were collected.
    Results: At the time of enrollment, anemia was detected in 755 (78.7%) patients. The mean Hb value for anemic patients was 9.5 g/dL. Prevalence and severity of anemia varied according to tumor type and reason for admission. The majority (68.6%) of the anemic patients were not offered treatment. The mean Hb value at which treatment was started was 8.0 g/dL. Anemia treatment was related to its severity; treatment rates were 94.4%, 32.9%, and 5.0% in patients with severe, moderate and mild anemia, respectively (P<.0001). Blood transfusion was used the most while ESAs were rarely used. Length of hospital stay was affected by the presence of anemia (7.2 days in anemic patients vs. 4.85 days in nonanemic patients) (P<.001).
    Conclusions: Blood transfusion was used the most for cancer-related anemia, while ESAs were rarely used. The majority of patients with moderate anemia were not treated, including patients on active chemotherapy. Better guidelines addressing anemia management in this subgroup of patients are highly needed.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anemia/blood ; Anemia/etiology ; Anemia/therapy ; Blood Transfusion ; Female ; Hematinics/therapeutic use ; Hemoglobins/analysis ; Humans ; Male ; Middle Aged ; Neoplasms/blood ; Neoplasms/complications ; Neoplasms/drug therapy ; Prevalence ; Retrospective Studies
    Chemical Substances Hematinics ; Hemoglobins
    Language English
    Publishing date 2010-06-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2651893-4
    ISSN 1658-3876
    ISSN 1658-3876
    DOI 10.1016/s1658-3876(10)50039-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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