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Article ; Online: Best Practices in Hematology and Oncology Care.

Aggarwal, Anita / Ascensao, Joao

Federal practitioner : for the health care professionals of the VA, DoD, and PHS

2017 Volume 33, Issue Suppl 1, Page(s) 13S–14S

Language	English
Publishing date	2017-12-12
Publishing country	United States
Document type	Journal Article
ISSN	1945-337X
ISSN (online)	1945-337X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Massive blood loss from urethrorrhage in a 16-year-old boy: Case report and review of two rare causes.

Ascensão, João / Sobral, Maria Carolina / Lima, Sofia / Silva, Aline Vaz / Vital, Vanda Pratas / Cardoso, Dinorah / Alves, Fátima / Alves, Rui

Urology case reports

2023 Volume 51, Page(s) 102529

Abstract: Urethral varices and hemangiomas are rare, underreported conditions that can be asymptomatic or present with intermittent urethrorrhage that can start or worsen with erection, sexual intercourse and ejaculation. Diagnosis can be made with urethroscopy ... ...

Abstract	Urethral varices and hemangiomas are rare, underreported conditions that can be asymptomatic or present with intermittent urethrorrhage that can start or worsen with erection, sexual intercourse and ejaculation. Diagnosis can be made with urethroscopy and there are a wide variety of possible treatments that can suit both conditions. We present a case of a pediatric patient with severe blood loss from urethral varices that was treated with electrofulguration after laser treatment with Holmium failed.
Language	English
Publishing date	2023-08-26
Publishing country	United States
Document type	Case Reports
ZDB-ID	2745459-9
ISSN	2214-4420
ISSN	2214-4420
DOI	10.1016/j.eucr.2023.102529
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Article ; Online: Hairy Cell Leukemia and Ground Water Contamination With Industrial Solvents: a Case Report.

Green-Lott, Ashley-Marie / Singaraju, Raj / Liu, Min-Ling / Ascensao, Joao

Military medicine

2020 Volume 185, Issue 7-8, Page(s) e1338–e1340

Abstract: The industrial solvents benzene and trichloroethylene (TCE) are known carcinogens, and these solvents contaminated the drinking water at Marine Corps Base Camp Lejeune from the 1950s to 1980s. Benzene and TCE are linked to the hematopoietic cancers acute ...

Abstract	The industrial solvents benzene and trichloroethylene (TCE) are known carcinogens, and these solvents contaminated the drinking water at Marine Corps Base Camp Lejeune from the 1950s to 1980s. Benzene and TCE are linked to the hematopoietic cancers acute myelocytic and lymphocytic leukemia and chronic lymphocytic leukemia. We report the case of a veteran stationed at Marine Corps Base Camp Lejeune during this period who developed hairy cell leukemia (HCL), a rare form of lymphocytic leukemia. We review his presentation, medical history, solvent exposure, and literature on the carcinogenicity of benzene and TCE. This patient represents a possible link of TCE or benzene to HCL. The case also informs clinicians of the updated epidemiology with regards to clinical findings for HCL.
MeSH term(s)	Drinking Water ; Groundwater ; Humans ; Leukemia, Hairy Cell/chemically induced ; Solvents/toxicity ; Trichloroethylene
Chemical Substances	Drinking Water ; Solvents ; Trichloroethylene (290YE8AR51)
Language	English
Publishing date	2020-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	391061-1
ISSN	1930-613X ; 0026-4075
ISSN (online)	1930-613X
ISSN	0026-4075
DOI	10.1093/milmed/usz484
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Article ; Online: Lineage frequency time series reveal elevated levels of genetic drift in SARS-CoV-2 transmission in England

Yu, QinQin / Ascensao, Joao / Okada, Takashi / The COVID-19 Genomics UK (COG-UK) consortium / Boyd, Olivia / Volz, Erik / Hallatschek, Oskar

bioRxiv

Abstract: Random genetic drift in the population-level dynamics of an infectious disease outbreak results from the randomness of inter-host transmission and the randomness of host recovery or death. The strength of genetic drift has been found to be high for SARS- ... ...

Abstract	Random genetic drift in the population-level dynamics of an infectious disease outbreak results from the randomness of inter-host transmission and the randomness of host recovery or death. The strength of genetic drift has been found to be high for SARS-CoV-2 due to superspreading, and this is expected to substantially impact the disease epidemiology and evolution. Noise that results from the measurement process, such as biases in data collection across time, geographical areas, etc., can potentially confound estimates of genetic drift as both processes contribute "noise" to the data. To address this challenge, we develop and validate a method to jointly infer genetic drift and measurement noise from time-series lineage frequency data. We apply this method to over 490,000 SARS-CoV-2 genomic sequences from England collected between March 2020 and December 2021 by the COVID-19 Genomics UK (COG-UK) consortium. We find that even after correcting for measurement noise, the strength of genetic drift is consistently, throughout time, higher than that expected from the observed number of COVID-19 positive individuals in England by 1 to 3 orders of magnitude. Corrections taking into account epidemiological dynamics (susceptible-infected-recovered or susceptible-exposed-infected-recovered models) do not explain the discrepancy. Moreover, the levels of genetic drift that we observe are higher than the estimated levels of superspreading found by modeling studies that incorporate data on actual contact statistics in England. We discuss how even in the absence of superspreading, high levels of genetic drift can be generated via community structure in the host contact network. Our results suggest that further investigations of heterogeneous host contact structure may be important for understanding the high levels of genetic drift observed for SARS-CoV-2 in England.
Keywords	covid19
Language	English
Publishing date	2022-11-22
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2022.11.21.517390
Database	COVID19

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Article ; Online: Familial myeloma and monoclonal gammopathy: a report of eight African American families.

Jain, Maneesh / Ascensao, Joao / Schechter, Geraldine P

American journal of hematology

2009 Volume 84, Issue 1, Page(s) 34–38

Abstract: Previous descriptions of familial myeloma have been mainly of Caucasian families. We report here eight African American families with familial multiple myeloma and monoclonal gammopathy identified over a 30 year period. Six patients with multiple myeloma ...

Abstract	Previous descriptions of familial myeloma have been mainly of Caucasian families. We report here eight African American families with familial multiple myeloma and monoclonal gammopathy identified over a 30 year period. Six patients with multiple myeloma (MM) and two with monoclonal gammopathy of unknown significance (MGUS) reported a family history of MM or had family members with MGUS found on screening. A pedigree compiled for each family included a history of other cancers. In the eight families, 21 of 58 first degree relatives had a plasma cell dyscrasia including 12 MM, eight MGUS, and one amyloidosis patient(s). The age of the MM patients ranged from 50 to 78 years (median 61 years). Four families had two members with MM, including one mother-son and three sibling pairs. Two MM families each had two additional first degree relatives with MGUS, with three generations involved in one family. Anticipation was suggested in two families with parent-child pairs with monoclonal gammopathy. The eight pedigrees had 66 members, 21 of whom had a diagnosis of cancer, including non-Hodgkin lymphoma and Hodgkin disease, or a clonal myeloproliferative disorder other than MM. Although the mode of genetic transmission and anticipation cannot be confirmed due to the small sample size, the increased number of MM and MGUS family members suggests underlying genetic susceptibility factors for plasma cell dyscrasias and possibly for other cancers in these families.
MeSH term(s)	Adult ; African Americans/genetics ; Aged ; Female ; Genetic Predisposition to Disease ; Hodgkin Disease/genetics ; Humans ; Lymphoma, Non-Hodgkin/genetics ; Male ; Middle Aged ; Monoclonal Gammopathy of Undetermined Significance/genetics ; Multiple Myeloma/genetics ; Pedigree
Language	English
Publishing date	2009-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.21325
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Zs.A 1251: Show issues

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Article: Immunological reconstitution: chimerism and the mechanisms for tolerance following transplantation of hemopoietic cells.

Ascensao, J l

Blood cells

1991 Volume 17, Issue 2, Page(s) 403–406

MeSH term(s)	Fetal Tissue Transplantation/immunology ; Follow-Up Studies ; HLA Antigens/analysis ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/immunology ; Histocompatibility Testing ; Humans ; Immune Tolerance ; Infant, Newborn ; Liver Transplantation/immunology ; Male ; Severe Combined Immunodeficiency/immunology ; Severe Combined Immunodeficiency/surgery ; Thymus Gland/embryology ; Thymus Gland/immunology ; Thymus Gland/transplantation
Chemical Substances	HLA Antigens
Language	English
Publishing date	1991
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	125304-9
ISSN	0340-4684
ISSN	0340-4684
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Zs.A 1138: Show issues

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Article ; Online: Multiple bony amyloidomas as an initial presentation of myeloma.

Kirkel, Dean M / Paal, Edina / Ascensao, Joao / Schechter, Geraldine P

Clinical lymphoma & myeloma

2009 Volume 9, Issue 5, Page(s) E18–20

Abstract: Amyloidosis complicating multiple myeloma is an uncommon but well-recognized phenomenon. Multiple bone amyloidomas are rare as the initial presenting feature of myeloma. Solitary bone amyloidomas share common features with those of patients who have ... ...

Abstract	Amyloidosis complicating multiple myeloma is an uncommon but well-recognized phenomenon. Multiple bone amyloidomas are rare as the initial presenting feature of myeloma. Solitary bone amyloidomas share common features with those of patients who have solitary plasmacytomas and progression to disseminated myeloma is common. We report a case of an elderly man who presented with extensive amyloid deposition in multiple plasmacytoma sites as well as evidence of amyloid in a fat pad aspirate but with none of the usual organ damage associated with systemic amyloidosis. This presentation is similar to a subset of patients said to have macrofocal myeloma. These patients are typically aged < 40 years, have no bone marrow involvement, and have a good prognosis. This report may represent the first description of macrofocal myeloma associated with amyloid deposition in an older individual.
MeSH term(s)	Aged, 80 and over ; Amyloidosis/diagnosis ; Amyloidosis/diagnostic imaging ; Amyloidosis/pathology ; Bone Diseases/diagnosis ; Bone Diseases/pathology ; Disease Progression ; Humans ; Male ; Multiple Myeloma/diagnosis ; Multiple Myeloma/diagnostic imaging ; Multiple Myeloma/pathology ; Radiography
Language	English
Publishing date	2009-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2228154-X
ISSN	1938-0712 ; 1557-9190
ISSN (online)	1938-0712
ISSN	1557-9190
DOI	10.3816/CLM.2009.n.078
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Zs.A 5903: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 488: Show issues

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Article: Pulmonary alveolar proteinosis with myeloproliferative syndrome with myelodysplasia: bronchoalveolar lavage reduces white blood cell count.

Pollack, Seth M / Gutierrez, Guillermo / Ascensao, Joao

American journal of hematology

2006 Volume 81, Issue 8, Page(s) 634–638

Abstract: Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by surfactant component accumulation in the alveolar space. Primary PAP is likely an autoimmune disorder caused by antibodies to granulocyte-macrophage colony stimulating factor (GM- ... ...

Abstract	Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by surfactant component accumulation in the alveolar space. Primary PAP is likely an autoimmune disorder caused by antibodies to granulocyte-macrophage colony stimulating factor (GM-CSF). When an underlying disease causes PAP, this is called secondary PAP. Hematologic malignancies are an important cause of secondary PAP. As the pathogenesis of primary PAP has become more fully understood, improvements in diagnostic and therapeutic approaches have followed. However, when PAP is secondary to an underlying hematologic malignancy, much remains unclear. Here we describe for the first time a patient with hybrid myelodysplastic syndrome/myeloproliferative syndrome and PAP who had a marked decrease in her white blood cell count following a transbronchial biopsy accompanied by bronchoalveolar lavage (BAL). Similar significant decreases in WBC count accompanied clinical improvement following two unilateral BALs. Given that patients with pulmonary alveolar proteinosis frequently have elevated GM-CSF in bronchoalveolar fluid, this observation provides a unique vantage point to understand the pathophysiology of secondary PAP.
MeSH term(s)	Adult ; Bronchoalveolar Lavage/methods ; Female ; Humans ; Leukocyte Count ; Myelodysplastic Syndromes/complications ; Myelodysplastic Syndromes/diagnosis ; Myeloproliferative Disorders/complications ; Myeloproliferative Disorders/diagnosis ; Pulmonary Alveolar Proteinosis/complications ; Pulmonary Alveolar Proteinosis/diagnosis ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2006-08
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.20670
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Article: Bases do ensino de oncologia.

da Ascensão, J L

Acta medica portuguesa

1994 Volume 7, Issue 9, Page(s) 493–499

Abstract: We define the parameters for preclinical and postgraduate teaching in oncology coupled with hematology with a view to train competent physicians in these areas as well as to encourage a restructuring of the health system to permit optimal delivery of ... ...

Title translation	Bases for the teaching of oncology.
Abstract	We define the parameters for preclinical and postgraduate teaching in oncology coupled with hematology with a view to train competent physicians in these areas as well as to encourage a restructuring of the health system to permit optimal delivery of care to all people. We analyze and define curricular changes in the medical schools to be implemented at a national level with the introduction of an intensive course in hematology-oncology during the clinical clerkships. This course would require a host of appropriate teachers, continued monitoring and a final appropriate written exam. The Oncologic training of the medical student requires an interdisciplinary approach with an emphasis on the personalized approach to the patient with cancer. The postgraduate training should follow minimal guidelines established by the ESMO, EORTC and ABIM with an emphasis on combined training in oncology/hematology, following appropriate training in internal medicine. A need for continued "recycling" of generalists in oncology is felt to be important. Other issues discussed include: methods of teaching and their evaluation; the career pathway for the scientist (docent) in oncology; preventive medicine and finally the need for continuing medical education. An evaluation of the quality of medicine and of ethical and professional conduct while not specifically linked to oncology is considered a vital part of medical care and needs to be placed in perspective.
MeSH term(s)	Curriculum ; Hematology/education ; Internal Medicine/education ; Internship and Residency ; Medical Oncology/education ; Teaching
Language	Portuguese
Publishing date	1994-09
Publishing country	Portugal
Document type	English Abstract ; Journal Article
ZDB-ID	603078-6
ISSN	0870-399X
ISSN	0870-399X
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Zs.B 2343: Show issues

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Article: Human natural killer cells.

Barão, I / Ascensão, J L

Archivum immunologiae et therapiae experimentalis

1998 Volume 46, Issue 4, Page(s) 213–229

Abstract: Human natural killer (NK) cells comprise 10 to 15% of peripheral blood lymphocytes, characterized by their morphologic appearance of large granular lymphocytes (LGLs) and phenotype CD3- CD56+ CD16+ or CD16-. Functionally, these cells are defined by their ...

Abstract	Human natural killer (NK) cells comprise 10 to 15% of peripheral blood lymphocytes, characterized by their morphologic appearance of large granular lymphocytes (LGLs) and phenotype CD3- CD56+ CD16+ or CD16-. Functionally, these cells are defined by their ability to lyse target cells without prior sensitization and without restriction by major histocompatibility (MHC) antigens. These cells play an important role in immune defenses, especially after hematopoietic transplantation. They contribute to the defenses against virus-infected cells, graft rejection, and neoplasias; they also participate in the regulation of hematopoiesis through cytokine production and cell to cell interaction. In this mini-review we attempt to summarize the most relevant findings about these cells in terms of their origin and differentiation, their cell surface characteristics including activation and their cytolytic pathways. We have also provided a brief approach of their potential clinical use. Increased knowledge of NK cell differentiation, ontogeny and regulatory mechanisms may be of use for the planning of immunotherapeutic strategies.
MeSH term(s)	Animals ; Humans ; Killer Cells, Natural/immunology ; Transplantation Immunology
Language	English
Publishing date	1998
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	282209-x
ISSN	1661-4917 ; 0004-069X
ISSN (online)	1661-4917
ISSN	0004-069X
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