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  1. Article ; Online: Promising role for pleural vent in pneumothorax following CT-guided biopsy of lung lesions.

    Ball, Michael / Babu, Suresh / Wallis, Adam / Asciak, Rachelle

    The British journal of radiology

    2022  Volume 95, Issue 1135, Page(s) 20210965

    Abstract: Objectives: To evaluate the safety, effectiveness and cost-benefit of ambulatory pleural vent compared to conventional chest drain for pneumothorax following CT-guided biopsy of lung lesions (CTGB).: Methods: We retrospectively analysed electronic ... ...

    Abstract Objectives: To evaluate the safety, effectiveness and cost-benefit of ambulatory pleural vent compared to conventional chest drain for pneumothorax following CT-guided biopsy of lung lesions (CTGB).
    Methods: We retrospectively analysed electronic hospital records of patients requiring intervention for pneumothorax following CTGB. All patients treated with pleural vent over a 2-year period (August 2017-July 2019) were included and compared to a control group of all patients treated with chest drain over a previous 2-year period (August 2014-July 2016).
    Results: Patients managed with a pleural vent had a shorter length of hospital stay compared to the chest drain group (median 0 days
    Conclusion: Pleural vent can be a safe and effective alternative to conventional chest drain for the management of CTGB-related pneumothorax which allows patients to be managed on an outpatient basis with reduced hospital stays and lower associated healthcare costs.
    Advances in knowledge: To the best of our knowledge, this is the first study demonstrating the safety and effectiveness of pleural vent for CTGB-related pneumothorax.
    MeSH term(s) Humans ; Image-Guided Biopsy/adverse effects ; Lung/diagnostic imaging ; Lung/pathology ; Pneumothorax/etiology ; Retrospective Studies ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20210965
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  2. Article ; Online: Update on biology and management of mesothelioma.

    Asciak, Rachelle / George, Vineeth / Rahman, Najiib M

    European respiratory review : an official journal of the European Respiratory Society

    2021  Volume 30, Issue 159

    Abstract: Malignant pleural mesothelioma is an aggressive, incurable cancer that is usually caused by asbestos exposure several decades before symptoms arise. Despite widespread prohibition of asbestos production and supply, its incidence continues to increase. It ...

    Abstract Malignant pleural mesothelioma is an aggressive, incurable cancer that is usually caused by asbestos exposure several decades before symptoms arise. Despite widespread prohibition of asbestos production and supply, its incidence continues to increase. It is heterogeneous in its presentation and behaviour, and diagnosis can be notoriously difficult. Identification of actionable gene mutations has proven challenging and current treatment options are largely ineffective, with a median survival of 10-12 months.However, the past few years have witnessed major advances in our understanding of the biology and pathogenesis of mesothelioma. This has also revealed the limitations of existing diagnostic algorithms and identified new treatment targets.Recent clinical trials have re-examined the role of surgery, provided new options for the management of associated pleural effusions and heralded the addition of targeted therapies. The increasing complexity of mesothelioma management, along with a desperate need for further research, means that a multidisciplinary team framework is essential for the delivery of contemporary mesothelioma care.This review provides a synthesised overview of the current state of knowledge and an update on the latest research in the field.
    MeSH term(s) Asbestos/adverse effects ; Biology ; Humans ; Mesothelioma/diagnosis ; Mesothelioma/genetics ; Mesothelioma/therapy ; Mesothelioma, Malignant ; Pleural Neoplasms/diagnosis ; Pleural Neoplasms/epidemiology ; Pleural Neoplasms/etiology
    Chemical Substances Asbestos (1332-21-4)
    Language English
    Publishing date 2021-01-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0226-2020
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  3. Article ; Online: Malignant Pleural Effusion: From Diagnostics to Therapeutics.

    Asciak, Rachelle / Rahman, Najib M

    Clinics in chest medicine

    2017  Volume 39, Issue 1, Page(s) 181–193

    Abstract: Malignant pleural effusion is a common complication of cancer and denotes a poor prognosis. It usually presents with dyspnea and a unilateral large pleural effusion. Thoracic computed tomography scans and ultrasound are helpful in distinguishing ... ...

    Abstract Malignant pleural effusion is a common complication of cancer and denotes a poor prognosis. It usually presents with dyspnea and a unilateral large pleural effusion. Thoracic computed tomography scans and ultrasound are helpful in distinguishing malignant from benign effusions. Pleural fluid cytology is diagnostic in about 60% of cases. In cytology-negative disease, pleural biopsies are helpful. Current management is palliative. Previously, first-line treatment for recurrent symptomatic malignant pleural effusion was chest drain insertion and talc pleurodesis, with indwelling pleural catheter insertion reserved for patients with trapped lung or failed talc pleurodesis. However, catheter insertion is an increasingly acceptable first-line treatment.
    MeSH term(s) Aged ; Female ; Humans ; Male ; Middle Aged ; Pleural Effusion, Malignant/diagnosis ; Pleural Effusion, Malignant/pathology ; Pleural Effusion, Malignant/therapy
    Language English
    Publishing date 2017-12-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 447455-7
    ISSN 1557-8216 ; 0272-5231
    ISSN (online) 1557-8216
    ISSN 0272-5231
    DOI 10.1016/j.ccm.2017.11.004
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  4. Article ; Online: British Thoracic Society Clinical Statement on pleural procedures.

    Asciak, Rachelle / Bedawi, Eihab O / Bhatnagar, Rahul / Clive, Amelia O / Hassan, Maged / Lloyd, Heather / Reddy, Raja / Roberts, Helen / Rahman, Najib M

    Thorax

    2023  Volume 78, Issue Suppl 3, Page(s) s43–s68

    Language English
    Publishing date 2023-07-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thorax-2022-219371
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  5. Article: Respiratory medicine training in Malta.

    Asciak, Rachelle / Montefort, Stephen / Fsadni, Peter

    Breathe (Sheffield, England)

    2017  Volume 13, Issue 3, Page(s) 245–246

    Abstract: In Malta, respiratory medicine is quite a popular speciality. It is attractive because of the interesting case mix and the interventional element of the speciality. ...

    Abstract In Malta, respiratory medicine is quite a popular speciality. It is attractive because of the interesting case mix and the interventional element of the speciality.
    Language English
    Publishing date 2017-08-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2562899-9
    ISSN 2073-4735 ; 1810-6838
    ISSN (online) 2073-4735
    ISSN 1810-6838
    DOI 10.1183/20734735.009417
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  6. Article ; Online: Sex differences in the efficacy, safety, and tolerability of omalizumab after 1 year in Maltese patients with asthma.

    Gouder, Caroline / Asciak, Rachelle / Montefort, Stephen

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2017  Volume 118, Issue 4, Page(s) 513–514

    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2017.01.019
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  7. Article ; Online: The Impact of COVID-19 on Hospitalised COPD Exacerbations in Malta.

    Farrugia, Yvette / Spiteri Meilak, Bernard Paul / Grech, Neil / Asciak, Rachelle / Camilleri, Liberato / Montefort, Stephen / Zammit, Christopher

    Pulmonary medicine

    2021  Volume 2021, Page(s) 5533123

    Abstract: Method: Data was collected retrospectively from electronic hospital records during the periods 1st March until 10th May in 2019 and 2020.: Results: There was a marked decrease in AECOPD admissions in 2020, with a 54.2% drop in admissions (: ... ...

    Abstract Method: Data was collected retrospectively from electronic hospital records during the periods 1st March until 10th May in 2019 and 2020.
    Results: There was a marked decrease in AECOPD admissions in 2020, with a 54.2% drop in admissions (
    Conclusions: There was a decrease in the number of admissions with AECOPD in 2020 during the COVID-19 pandemic, when compared to 2019. The year 2020 proved to be a significant predictor for inpatient mortality, with a significant increase in mortality in 2020. The decrease in nebuliser and controlled oxygen treatment noted in the study period did not prove to be a significant predictor of mortality when corrected for other variables. Therefore, the difference in mortality cannot be explained with certainty in this retrospective cohort study.
    MeSH term(s) Aged ; COVID-19 ; Cross-Sectional Studies ; Disease Progression ; Female ; Hospitalization/statistics & numerical data ; Humans ; Male ; Malta ; Pulmonary Disease, Chronic Obstructive/therapy ; Retrospective Studies
    Language English
    Publishing date 2021-06-23
    Publishing country Egypt
    Document type Journal Article ; Observational Study
    ZDB-ID 2603580-7
    ISSN 2090-1844 ; 2090-1844
    ISSN (online) 2090-1844
    ISSN 2090-1844
    DOI 10.1155/2021/5533123
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  8. Article ; Online: Physical Activity and Sedentary Behaviour in Patients With Malignant Pleural Effusion Undergoing Therapeutic Pleural Interventions (The ASPIRE Study).

    Hassan, Maged / Banka, Radhika / Castro-Añón, Olalla / Mercer, Rachel M / Bedawi, Eihab O / Asciak, Rachelle / Stradling, John / Rahman, Najib M

    Archivos de bronconeumologia

    2021  Volume 57, Issue 10, Page(s) 656–658

    MeSH term(s) Exercise ; Humans ; Pleura ; Pleural Effusion/etiology ; Pleural Effusion/therapy ; Pleural Effusion, Malignant/drug therapy ; Pleurodesis ; Sedentary Behavior
    Language English
    Publishing date 2021-08-26
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbr.2020.09.013
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    Zs.B 2655: Show issues Location:
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  9. Article ; Online: A diagnostic dilemma in a case of pulmonary inflammatory myofibroblastic tumour.

    Asciak, Rachelle / Gouder, Caroline / Bilocca, David / Montefort, Stephen

    BMJ case reports

    2016  Volume 2016, Page(s) 10.1136/bcr–2016–215168

    Abstract: An 18-year-old man presented to the local hospital in Malta, with dyspnoea, cough, mild haemoptysis, chest pain and night sweats. CT revealed a right hilar mass. Pleural tap, bronchoscopy and open lung biopsy were inconclusive. Biopsies obtained at ... ...

    Abstract An 18-year-old man presented to the local hospital in Malta, with dyspnoea, cough, mild haemoptysis, chest pain and night sweats. CT revealed a right hilar mass. Pleural tap, bronchoscopy and open lung biopsy were inconclusive. Biopsies obtained at repeat bronchoscopy and endobronchial ultrasound (EBUS) revealed a likely diagnosis of inflammatory myofibroblastic tumour (IMT). The patient subsequently underwent right pneumonectomy, and histology revealed the presence of two further nodules apart from the main tumour. Follow-up with positron emission tomography (PET)/CT showed the development of a right basal paracardial lesion due to recurrence and the presence of lymph node, pleural and skeletal disease. Despite radiotherapy to the recurrent nodule and chemotherapy, there was skeletal disease progression. Treatment with an anaplastic lymphoma kinase inhibitor, ceritinib, resulted in very good metabolic response. This case report highlights the importance of keeping IMT in mind when the diagnosis of lung tumours is difficult, as delayed diagnosis may lead to worsened prognosis.
    MeSH term(s) Adolescent ; Biopsy ; Bronchoscopy ; Diagnosis, Differential ; Humans ; Lung/pathology ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/surgery ; Male ; Neoplasms, Muscle Tissue/diagnostic imaging ; Neoplasms, Muscle Tissue/surgery ; Pneumonectomy ; Positron-Emission Tomography ; Tomography, X-Ray Computed
    Language English
    Publishing date 2016-04-18
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2016-215168
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  10. Article ; Online: Computed tomography abnormalities antedating mesothelioma diagnosis: a perspective on the natural history.

    Hassan, Maged / Tsikrika, Stamatoula / Asciak, Rachelle / Mercer, Rachel M / El-Ganady, Anwar / Rahman, Najib M

    The European respiratory journal

    2019  Volume 53, Issue 2

    MeSH term(s) Aged ; Aged, 80 and over ; Disease Progression ; Early Detection of Cancer ; Female ; Humans ; Lung Neoplasms ; Male ; Mesothelioma/complications ; Mesothelioma/diagnostic imaging ; Mesothelioma, Malignant ; Middle Aged ; Pleural Effusion/complications ; Pleural Effusion/diagnostic imaging ; Precancerous Conditions/diagnostic imaging ; Radiography, Thoracic ; Retrospective Studies ; Tomography, X-Ray Computed
    Language English
    Publishing date 2019-02-28
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00935-2018
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    Zs.MO 292: Show issues

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