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  1. AU="Asemani, Yahya"
  2. AU="Ketomäki, Tuomo"
  3. AU=Cavallini Giorgio
  4. AU="Saha, Aakash"
  5. AU="Noguchi, J"
  6. AU="Löhr, B."
  7. AU="Lokie, Kelsey B"

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  1. Artikel ; Online: The influence of occupational heat stress on serum inflammatory cytokines among traditional bakery workers in Iran.

    Mirsanei, Zahra / Asemani, Yahya / Derakhshanjazari, Milad / Gharibi, Vahid / Norouzi, Pirasteh / Mahdavi, Sepideh / Cousins, Rosanna

    PloS one

    2024  Band 19, Heft 5, Seite(n) e0302847

    Abstract: Heat exposure exceeding the ISO7243:1989 standard limit can contribute to health problems among employees in a variety of workplaces. Ignoring heat standard requirements in hot working conditions such as bakeries results in physiologic and health ... ...

    Abstract Heat exposure exceeding the ISO7243:1989 standard limit can contribute to health problems among employees in a variety of workplaces. Ignoring heat standard requirements in hot working conditions such as bakeries results in physiologic and health problems, as well as an elevated risk of later illnesses. In this analytical case-control study, the serum levels of four inflammatory factors (interleukin-1 beta, interleukin-6, tumor necrosis factor-α, and C-reactive protein) were assessed using an enzyme-linked immunosorbent assay. 105 male artisan bakers (in four job classifications in bakeries and staff) were compared based on demographic characteristics and inflammatory factors. The findings of the study showed correlations between serum interleukin-1β, interleukin-6, and C-reactive protein levels and thermal exposure in the occupational environment and employment type. Moreover, some differences in serum level of interleukin-1β and job type were observed. Heat overexposure affected the increase of interleukin-1β and C-reactive protein secretion. As a result of years of working in high-temperature conditions, inflammation can lead to subsequent diseases in workers. To protect their health from this occupational hazard, additional safeguards are needed. Our recommendations could also be applied to overly hot work environments that may cause heat stress in workers.
    Mesh-Begriff(e) Humans ; Male ; Iran/epidemiology ; Adult ; Occupational Exposure/adverse effects ; Case-Control Studies ; Cytokines/blood ; C-Reactive Protein/metabolism ; C-Reactive Protein/analysis ; Interleukin-1beta/blood ; Middle Aged ; Hot Temperature ; Heat Stress Disorders/blood ; Heat Stress Disorders/epidemiology ; Interleukin-6/blood ; Inflammation/blood ; Occupational Diseases/blood ; Occupational Diseases/epidemiology ; Heat-Shock Response
    Chemische Substanzen Cytokines ; C-Reactive Protein (9007-41-4) ; Interleukin-1beta ; Interleukin-6
    Sprache Englisch
    Erscheinungsdatum 2024-05-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0302847
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: A review of potential anti-cancer properties of some selected medicinal plants grown in Iran

    Hamedi, Azadeh / Bayat, Maryam / Asemani, Yahya / Amirghofran, Zahra

    Journal of herbal medicine. 2022 June, v. 33

    2022  

    Abstract: The increasing number of cancer patients, together with the side effects of current chemical treatments have encouraged the exploration of the potential of Iranian medicinal plants as a rich source of anticancer compounds. In the current review, 114 ... ...

    Abstract The increasing number of cancer patients, together with the side effects of current chemical treatments have encouraged the exploration of the potential of Iranian medicinal plants as a rich source of anticancer compounds. In the current review, 114 medicinal plant species grown in Iran were selected and their major constituents, animal or cell targets, as well as possible anticancer mechanisms, were ascertained through searching pertinent keywords in the Scientific Information Database (SID), IranMedex, PubMed, Medline, Google Scholar, Science Direct, Web of Knowledge and Scopus databases. Of the 114 species (with more emphasis on Asteraceae, Lamiaceae and Fabaceae as major plant families in Iran) that were reviewed, some were endemic plants of Iran, with others found in other countries. Besides valuable and well-known anticancer plants such as Taxus baccata and Catharanthus roseus, other species were included. Several compounds of these plants, such as organo-sulfur compounds, terpenoids, polyphenols, alkaloids, saponins, phenylethanoids, coumarins and polysaccharides have been proposed to exhibit anticancer effects. In general, apoptosis, cytotoxicity, cell cycle arrest, mitochondrial suppression, reductiob of DNA damage, vital enzyme inhibition and/or blocking angiogenesis were considered as the proposed mechanisms for the anticancer potential of the studied plants. Investigating the bioactive anticancer components of Iranian medicinal plants, especially the endemic species, seems to be beneficial for achieving novel potential anticancer drugs that are better equipped to fight cancer.
    Schlagwörter Asteraceae ; Catharanthus roseus ; DNA damage ; Fabaceae ; Lamiaceae ; Taxus baccata ; angiogenesis ; animals ; apoptosis ; cell cycle checkpoints ; coumarins ; cytotoxicity ; databases ; enzyme inhibition ; herbal medicines ; indigenous species ; medicinal plants ; mitochondria ; polyphenols ; polysaccharides ; saponins ; terpenoids ; Iran
    Sprache Englisch
    Erscheinungsverlauf 2022-06
    Erscheinungsort Elsevier GmbH
    Dokumenttyp Artikel
    ISSN 2210-8033
    DOI 10.1016/j.hermed.2022.100557
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  3. Artikel ; Online: Oleuropein reduces LPS-induced inflammation via stimulating M2 macrophage polarization.

    Mirsanei, Zahra / Heidari, Neda / Hazrati, Ali / Asemani, Yahya / Niknam, Bahare / Yousefi, Zahra / Jafari, Reza

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Band 163, Seite(n) 114857

    Abstract: Oleuropein (OLEU) is the most prevalent phenolic component in olive varieties, and it has been considered for its powerful antioxidant properties in therapeutic applications. OLEU has anti-inflammatory properties and performs this property by suppressing ...

    Abstract Oleuropein (OLEU) is the most prevalent phenolic component in olive varieties, and it has been considered for its powerful antioxidant properties in therapeutic applications. OLEU has anti-inflammatory properties and performs this property by suppressing inflammatory cells' function and reducing oxidative stress caused by various factors. This study investigated the ability of OLEU to polarize LPS-stimulated murine macrophage (MQ) cell RAW 264.7 into M1/M2 macrophages. As a first step, the cytotoxicity effects of OLEU were evaluated on LPS-stimulated RAW 264.7 cells using the thiazolyl blue (MTT) colorimetric test. Then, cytokines production, gene expression (Real-Time PCR), and functions (Nitrite oxide assay and phagocytosis assay) of OLEU-treated LPS-stimulated RAW 264.7 cells were evaluated. Our findings demonstrated that OLEU could reduce nitrite oxide (NO) production in LPS-stimulated RAW 264.7 cells by downregulating the inducible nitric oxide synthase gene expression. Furthermore, OLEU therapy decreases the expression of M1-associated pro-inflammatory cytokines production (IL-12, IFN-γ, and TNF-α) and genes expression (iNOS, TNF-α) while increasing the M2-associated anti-inflammatory gene expression and cytokines production (IL-10, and TGF-β). Based on the result, OLEU may be considered a potential therapeutic approach for inflammatory diseases due to its possible effects on oxidative stress-related factors, cytokine expression and production, and phagocytosis.
    Mesh-Begriff(e) Mice ; Animals ; Lipopolysaccharides/adverse effects ; Tumor Necrosis Factor-alpha/metabolism ; Nitrites/metabolism ; Macrophages/metabolism ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/genetics ; Cytokines/metabolism ; Anti-Inflammatory Agents/therapeutic use ; RAW 264.7 Cells ; Nitric Oxide Synthase Type II/metabolism ; Nitric Oxide/metabolism
    Chemische Substanzen Lipopolysaccharides ; oleuropein (2O4553545L) ; Tumor Necrosis Factor-alpha ; Nitrites ; Cytokines ; Anti-Inflammatory Agents ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Nitric Oxide (31C4KY9ESH)
    Sprache Englisch
    Erscheinungsdatum 2023-05-11
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.114857
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Essential considerations during vaccine design against COVID-19 and review of pioneering vaccine candidate platforms.

    Bayat, Maryam / Asemani, Yahya / Najafi, Sajad

    International immunopharmacology

    2021  Band 97, Seite(n) 107679

    Abstract: The calamity of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), COVID-19, is still a global human tragedy. To date, no specific antiviral drug or therapy has been able to break the widespread of SARS-CoV2. It has been generally ... ...

    Abstract The calamity of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), COVID-19, is still a global human tragedy. To date, no specific antiviral drug or therapy has been able to break the widespread of SARS-CoV2. It has been generally believed that stimulating protective immunity via universal vaccination is the individual strategy to manage this pandemic. Achieving an effective COVID-19 vaccine requires attention to the immunological and non-immunological standpoints mentioned in this article. Here, we try to introduce the considerable immunological aspects, potential antigen targets, appropriate adjuvants as well as key points in the various stages of COVID-19 vaccine development. Also, the principal features of the preclinical and clinical studies of pioneering COVID-19 vaccine candidates were pointed out by reviewing the available information. Finally, we discuss the key challenges in the successful design of the COVID-19 vaccine and address the most fundamental strengths and weaknesses of common vaccine platforms.
    Mesh-Begriff(e) Animals ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; Drug Design ; Humans ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; Vaccines
    Chemische Substanzen COVID-19 Vaccines ; Vaccines
    Sprache Englisch
    Erscheinungsdatum 2021-04-15
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2021.107679
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  5. Artikel ; Online: Tumor-educated platelets.

    Najafi, Sajad / Asemani, Yahya / Majidpoor, Jamal / Mahmoudi, Reza / Aghaei-Zarch, Seyed Mohsen / Mortezaee, Keywan

    Clinica chimica acta; international journal of clinical chemistry

    2023  Band 552, Seite(n) 117690

    Abstract: Beyond traditional roles in homeostasis and coagulation, growing evidence suggests that platelets also reflect malignant transformation in cancer. Platelets are present in the tumor microenvironment where they interact with cancer cells. This interaction ...

    Abstract Beyond traditional roles in homeostasis and coagulation, growing evidence suggests that platelets also reflect malignant transformation in cancer. Platelets are present in the tumor microenvironment where they interact with cancer cells. This interaction results in direct and indirect "education" as evident by platelet alterations in adhesion molecules, glycoproteins, nucleic acids, proteins and various receptors. Subsequently, these tumor-educated platelets (TEPs) circulate throughout the body and play pivotal roles in promotion of tumor growth and dissemination. Accordingly, platelet status can be considered a unique blood-based biomarker that can potentially predict prognosis and therapeutic success. Recently, liquid biopsies including TEPs have received much attention as safe, minimally invasive and sensitive alternatives for patient management. Herein, we provide an overview of TEPs and explore their benefits and limitations in cancer.
    Mesh-Begriff(e) Humans ; Biomarkers, Tumor ; Liquid Biopsy/methods ; Prognosis ; Blood Platelets/pathology ; Neoplastic Cells, Circulating/pathology ; Tumor Microenvironment
    Chemische Substanzen Biomarkers, Tumor
    Sprache Englisch
    Erscheinungsdatum 2023-12-06
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2023.117690
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  6. Artikel ; Online: Effect of exercise on upper respiratory tract infection in elite runners.

    Bayat, Maryam / Asemani, Yahya / Asemani, Samira

    The Journal of sports medicine and physical fitness

    2020  Band 60, Heft 9, Seite(n) 1269–1274

    Abstract: Background: Since it was assumed that exercise might be a risk factor for upper respiratory tract infection (URTI), the frequency, severity and duration of URTI were assessed in female elite runners compared with matched sedentary group.: Methods: A ... ...

    Abstract Background: Since it was assumed that exercise might be a risk factor for upper respiratory tract infection (URTI), the frequency, severity and duration of URTI were assessed in female elite runners compared with matched sedentary group.
    Methods: A group of elite runners (N.=20) and one of sedentary subjects (N.=20) were selected and matched one by one for their age, nutritional state, their place of living and somewhat genetic factors. These groups were observed for any signs and symptoms of upper respiratory illnesses, during 2.5 cold months of the year.
    Results: Although the mean number of the illnesses in elite athletes (1.0±0.8) was slightly lower than the control people (1.4±0.8); there was not any statistically significant difference between them (P>0.05). Furthermore, the mean days of disease (5.4±3.8 in elite athletes vs. 5.6±3.0 in control group) showed no significant statistical difference (P>0.05). Even though elite athletes showed no severe cases of the disease, no significant difference was observed between the two groups (P>0.05).
    Conclusions: Elite athletes are not at greater risk for URTI and this may be due to the suitable physiological status of athletes or attributed to" repeated bout effect" phenomenon.
    Mesh-Begriff(e) Adolescent ; Adult ; Case-Control Studies ; Exercise/physiology ; Female ; Humans ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/etiology ; Risk Factors ; Running/physiology ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2020-06-11
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 410823-1
    ISSN 1827-1928 ; 0022-4707
    ISSN (online) 1827-1928
    ISSN 0022-4707
    DOI 10.23736/S0022-4707.20.10646-7
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  7. Artikel ; Online: CiRS-7/CDR1as; An oncogenic circular RNA as a potential cancer biomarker.

    Rahmati, Yazdan / Asemani, Yahya / Aghamiri, Shahin / Ezzatifar, Fatemeh / Najafi, Sajad

    Pathology, research and practice

    2021  Band 227, Seite(n) 153639

    Abstract: Circular RNAs (circRNAs) as a new class of non-coding RNAs (ncRNAs) play role in gene regulation in multicellular organisms via various interactions with nucleic acids, proteins and particularly microRNAs. They have been found to be involved in a number ... ...

    Abstract Circular RNAs (circRNAs) as a new class of non-coding RNAs (ncRNAs) play role in gene regulation in multicellular organisms via various interactions with nucleic acids, proteins and particularly microRNAs. They have been found to be involved in a number of biological functions particularly in regulation of cell cycle, and extracellular interactions. Thus, dysregulation of circRNAs is found to be associated with several human diseases and especially numerous types of cancers. ciRS-7 is an example of circRNAs which have been studied in a number of human diseases like neurological diseases, diabetes mellitus, and importantly different malignancies. It has been found to regulate cell proliferation and malignant features in cancer cells. CiRS-7 is upregulated in several cancers and its overexpression promoted malignant phenotype of cancer cells via enhancing cell proliferation, migration, and invasion in vitro and in vivo. As a competing endogenous RNA (ceRNA), ciRS-7 is found to sponge miR-7 as the most common miRNA target in interaction together. Functional analyses show role of ciRS-7 in downregulation of miR-7 and involvement of a series of signaling pathways in turn through them it is believed that ciRS-7 regulates malignant behaviors of cancer cells. Clinical studies demonstrate upregulation of ciRS-7 in cancer tissues compared to their non-cancerous adjacent tissues, correlation with worse clinicopathological features in cancerous patients and an independent prognostic factor. In this review, we have an overview to the role of ciRS-7 in development and progression of cancer and also assess its potentials as a diagnostic and prognostic biomarker in human cancers.
    Mesh-Begriff(e) Animals ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Movement ; Cell Proliferation ; Early Detection of Cancer ; Genetic Therapy ; Humans ; Neoplasm Invasiveness ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/therapy ; Predictive Value of Tests ; Prognosis ; RNA, Circular/genetics ; RNA, Circular/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA, Neoplasm/genetics ; RNA, Neoplasm/metabolism
    Chemische Substanzen Biomarkers, Tumor ; RNA, Circular ; RNA, Long Noncoding ; RNA, Neoplasm ; long non-coding RNA CDR1AS, human
    Sprache Englisch
    Erscheinungsdatum 2021-09-29
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2021.153639
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  8. Artikel: Recent highlights in the immunomodulatory aspects of Treg cell-derived extracellular vesicles: special emphasis on autoimmune diseases and transplantation.

    Asemani, Yahya / Najafi, Sajad / Ezzatifar, Fatemeh / Zolbanin, Naime Majidi / Jafari, Reza

    Cell & bioscience

    2022  Band 12, Heft 1, Seite(n) 67

    Abstract: In order to maintain immunological tolerance to self and non-self antigens, one's T regulatory (Treg) cells play a critical role in the regulation of detrimental inflammation. Treg cells inhibit the immune system in a variety of ways, some of which are ... ...

    Abstract In order to maintain immunological tolerance to self and non-self antigens, one's T regulatory (Treg) cells play a critical role in the regulation of detrimental inflammation. Treg cells inhibit the immune system in a variety of ways, some of which are contact-dependent and the others are soluble factors. Extracellular vesicles (EVs) are mainly secretory membrane structures that play a pivotal role in intercellular communication in both the local and systemic environments, enabling the transport of proteins, lipids, and nucleic acids between immune and non-immune cells. A number of studies have shown that Treg-derived EVs are specially formulated intercellular exchanging devices capable of regulating immunological responses by producing a cell-free tolerogenic milieu. Some of the processes suggested include miRNA-induced gene shutdown and upmodulation, surface protein activity, and enzyme transfer. Instead of being influenced by external circumstances like Tregs, exosomes' cohesive structure allows them to transmit their charge intact across the blood-brain barrier and deliver it to the target cell with particular receptors. These properties have resulted in the use of Treg-derived EVs' immunomodulatory effects moving beyond laboratory research and into preclinical applications in animal models of a variety of inflammatory, autoimmune, and transplant rejection disorders. However, insufficient evidence has been produced to permit enrollment in human clinical studies. As such, we begin our research by introducing the most potent immunosuppressive elements discovered in Treg-derived EVs elucidating likely mechanisms of action in inhibiting immunological responses. Following that, we address recent research on the potential of suppressive EVs to regulate autoimmune inflammatory responses and improve tissue transplant survival.
    Sprache Englisch
    Erscheinungsdatum 2022-05-23
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-022-00808-4
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  9. Artikel: Extracellular vesicles (EVs): What we know of the mesmerizing roles of these tiny vesicles in hematological malignancies?

    Abbaszade Dibavar, Mahnoosh / Pourbagheri-Sigaroodi, Atieh / Asemani, Yahya / Salari, Sina / Bashash, Davood

    Life sciences. 2021 Apr. 15, v. 271

    2021  

    Abstract: Cancer is a complex disease in which a bidirectional collaboration between malignant cells and surrounding microenvironment creates an appropriate platform which ultimately facilitates the progression of the disease. The discovery of extracellular ... ...

    Abstract Cancer is a complex disease in which a bidirectional collaboration between malignant cells and surrounding microenvironment creates an appropriate platform which ultimately facilitates the progression of the disease. The discovery of extracellular vesicles (EVs) was a turning point in the modern era of cancer biology, as their importance in human malignancies has set the stage to widen research interest in the field of cell-to-cell communication. The implication in short- and long-distance interaction via horizontally transfer of cellular components, ranging from non-coding RNAs to functional proteins, as well as stimulating target cells receptors by the means of ligands anchored on their membrane endows these “tiny vesicles with giant impacts” with incredible potential to re-educate normal tissues, and thus, to re-shape the surrounding niche. In this review, we highlight the pathogenic roles of EVs in human cancers, with an extensive focus on the recent advances in hematological malignancies.
    Schlagwörter cell communication ; disease progression ; humans ; ligands
    Sprache Englisch
    Erscheinungsverlauf 2021-0415
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    Anmerkung NAL-light
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2021.119177
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  10. Artikel: Allium vegetables for possible future of cancer treatment

    Asemani, Yahya / Zamani, Nasrindokht / Bayat, Maryam / Amirghofran, Zahra

    Phytotherapy research. 2019 Dec., v. 33, no. 12

    2019  

    Abstract: Natural resources such as plants are an upright curing option in treating cancers and reducing the side effects of current therapeutic modalities. Allium genus vegetables are of the most interesting herbs in restricting cancers that includes garlic, ... ...

    Abstract Natural resources such as plants are an upright curing option in treating cancers and reducing the side effects of current therapeutic modalities. Allium genus vegetables are of the most interesting herbs in restricting cancers that includes garlic, onions, leeks, chives, and shallots. These plants have been exploited in folk medicine because of their beneficial health effects in improving numerous diseases. The phytochemical analysis of various Allium genus members showed that, to date, 16 species have proved potential anticancer properties due to the accumulation of various sulfur and organic compounds like S‐allyl mercaptocysteine, quercetin, flavonoids, and ajoene. These compounds with various mechanisms such as hindering cell cycle, inhibiting signaling pathways, inducing apoptosis, and antioxidant activity interfere with diverse stages of formation, growth, differentiation, and metastasis of cancer cells. Similar to garlic and onion, other species have exhibited anticancer activities, so that active natural molecules extracted from them might serve as possible anticancer agents. Therefore, evaluating the main ingredients and studying their anticancer mechanisms are of great importance. In this review, we aim to summarize the available data on anticancer mechanisms of 16 species of Allium genus and their major compounds to assist further researches on the treatment and prevention of cancers.
    Schlagwörter Allium ; adverse effects ; ajoene ; antineoplastic activity ; antineoplastic agents ; antioxidant activity ; apoptosis ; cell cycle ; chives ; garlic ; health effects assessments ; ingredients ; leeks ; medicinal plants ; metastasis ; neoplasm cells ; neoplasms ; quercetin ; shallots ; signal transduction ; sulfur ; therapeutics ; traditional medicine
    Sprache Englisch
    Erscheinungsverlauf 2019-12
    Umfang p. 3019-3039.
    Erscheinungsort John Wiley & Sons, Ltd
    Dokumenttyp Artikel
    Anmerkung REVIEW
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.6490
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