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  1. Article ; Online: Cutaneous cryptococcosis.

    Requena López, Sheila / Asensi Álvarez, Victor / Santos Juanes, Jorge

    Medicina clinica

    2018  Volume 152, Issue 1, Page(s) e5

    Title translation Criptococosis cutánea.
    MeSH term(s) Aged ; Cryptococcosis/pathology ; Cryptococcus neoformans/isolation & purification ; Facial Dermatoses/microbiology ; Facial Dermatoses/pathology ; HIV Infections/complications ; HIV Infections/diagnosis ; Humans ; Male ; Pneumocystis carinii/isolation & purification ; Pneumonia, Pneumocystis/diagnosis
    Language Spanish
    Publishing date 2018-05-04
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2018.03.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Diagnosis of Tuberculous Infection in Immunosuppressed Patients and/or Candidates for Biologics Using a Combination of 2 IGRA Tests: T-SPOT.TB/QuantiFERON TB Gold In-Tube vs. T-SPOT.TB/QuantiFERON TB Gold Plus.

    Fernández-Blázquez, Ana / Argüelles Menéndez, Pablo / Sabater-Cabrera, Christian / García-García, José-María / Asensi Álvarez, Víctor / Palacios Gutiérrez, Juan José

    Archivos de bronconeumologia

    2020  Volume 58, Issue 4, Page(s) 305–310

    Abstract: Introduction: The diagnosis of latent tuberculous infection (LTI) by IGRA continues to generate debate. Experience in the simultaneous use of 2 IGRA tests is scant. The aim of this study was to compare the results of 2 versions of QuantiFERON-TB Gold ( ... ...

    Title translation Diagnóstico de la infección tuberculosa en pacientes inmunodeprimidos y/o candidatos a terapias biológicas mediante el uso combinado de dos pruebas IGRA: T-SPOT.TB/QuantiFERON TB Gold In-Tube vs. T-SPOT.TB/QuantiFERON TB Gold Plus.
    Abstract Introduction: The diagnosis of latent tuberculous infection (LTI) by IGRA continues to generate debate. Experience in the simultaneous use of 2 IGRA tests is scant. The aim of this study was to compare the results of 2 versions of QuantiFERON-TB Gold (In-Tube/Plus) with those of T-SPOT.TB, and to analyse the effectiveness of a dual strategy (T-SPOT.TB + QTF) for the diagnosis of LTI in an immunosuppressed population.
    Methods: We conducted a prospective study (May 2015-June 2017) that included 2,999 immunosuppressed patients and/or candidates for biologics, in whom 2 simultaneous IGRA tests were performed: Group 1 (1535 patients): T-SPOT.TB + QuantiFERON-TB Gold-In-Tube (QTF-GIT); Group 2 (1464 patients): T-SPOT.TB + QuantiFERON-TB Gold Plus (QTF-Plus).
    Results: The concordance between QTF-GIT and T-SPOT.TB was 83.19% (κ=0.532). The percentage of positive, negative, and indeterminate results were, respectively: 14.33% vs. 17.06%; 82.41% vs. 74.46%; and 3.25% vs. 8.46%. The concordance between QTF-Plus and T-SPOT.TB was 87.56% (κ=0.609). The percentage of positive, negative, and indeterminate results were, respectively: 15.02% vs. 15.36%; 82.92% vs. 79.37%; and 2.04% vs. 5.25%. Discrepancies between T-SPOT.TB and QTF-Plus were 12.43%, suggesting that 103 patients were positive and another 79 were negative due exclusively to 1 of the 2 IGRAs.
    Conclusions: Greater concordance was found between QTF-Plus and T-SPOT.TB than between QTF-GIT and T-SPOT.TB. However, we believe that the proportion of discrepancies between T-SPOT.TB and QTF-Plus is sufficiently important from a clinical point of view to justify the simultaneous use of 2 IGRA in this specific patient group.
    MeSH term(s) Biological Products ; Humans ; Interferon-gamma Release Tests ; Latent Tuberculosis/diagnosis ; Prospective Studies ; Tuberculin Test/methods ; Tuberculosis/diagnosis
    Chemical Substances Biological Products
    Language Spanish
    Publishing date 2020-06-10
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2020.04.011
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  3. Article ; Online: Clinical and Epidemiological Correlates of Low IFN-Gamma Responses in Mitogen Tube of QuantiFERON Assay in Tuberculosis Infection Screening During the COVID-19 Pandemic: A Population-Based Marker of COVID-19 Mortality?

    Palacios-Gutiérrez, Juan-José / Rodríguez-Guardado, Azucena / Arias-Guillén, Miguel / Alonso-Arias, Rebeca / Palacios-Penedo, Sergio / García-García, José-María / Balbín, Milagros / Pérez-Hernández, Dolores / Sandoval-Torrientes, Marta / Torreblanca-Gil, Aurora / Melón, Santiago / Asensi-Álvarez, Víctor / Clain, Jeremy M / Escalante, Patricio

    Archivos de bronconeumologia

    2022  Volume 58, Issue 9, Page(s) 649–659

    Abstract: Background: The clinical and epidemiological implications of abnormal immune responses in COVID-19 for latent tuberculosis infection (LTBI) screening are unclear.: Methods: We reviewed QuantiFERON TB Gold Plus (QFT-Plus) results (36,709 patients) ... ...

    Abstract Background: The clinical and epidemiological implications of abnormal immune responses in COVID-19 for latent tuberculosis infection (LTBI) screening are unclear.
    Methods: We reviewed QuantiFERON TB Gold Plus (QFT-Plus) results (36,709 patients) from July 2016 until October 2021 in Asturias (Spain). We also studied a cohort of ninety hospitalized patients with suspected/confirmed COVID-19 pneumonia and a group of elderly hospitalized patients with COVID-19 who underwent serial QFT-Plus and immune profiling testing.
    Results: The indeterminate QFT-Plus results rate went from 1.4% (July 2016 to November 2019) to 4.2% during the COVID-19 pandemic. The evolution of the number of cases with low/very low interferon-gamma (IFN-gamma) response in the mitogen tube paralleled the disease activity and number of deaths during the pandemic waves in our region (from March 2020 to October 2021). The percentages of positive QFT-plus patients did not significantly change before and during the pandemic (13.9%
    Conclusion: Low IFN-gamma responses in mitogen tube of QFT-Plus often occur in COVID-19 pneumonia, which is associated with a low number of an effector CD8 + T-cell subset and does not seem to affect LTBI screening; however, this abnormality seems to parallel the dynamics of COVID-19 at the population level and its mortality.
    MeSH term(s) Aged ; Biomarkers ; COVID-19/diagnosis ; COVID-19/epidemiology ; Humans ; Interferon-gamma ; Interferon-gamma Release Tests ; Latent Tuberculosis/diagnosis ; Latent Tuberculosis/epidemiology ; Mitogens ; Mycobacterium tuberculosis ; Pandemics ; Tuberculin Test
    Chemical Substances Biomarkers ; Mitogens ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2022-02-13
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2022.01.011
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  4. Article ; Online: Clinical, epidemiological and treatment failure data among HIV-1 non-B-infected patients in the Spanish AIDS Research Network Cohort.

    Torrecilla García, Esther / Yebra Sanz, Gonzalo / Llácer-Delicado, Teresa / Rubio García, Rafael / González-García, Juan / García García, Federico / López-Aldeguer, José / Asensi Álvarez, Víctor / Holguín Fernández, África

    Enfermedades infecciosas y microbiologia clinica

    2016  Volume 34, Issue 6, Page(s) 353–360

    Abstract: Introduction: The prevalence of HIV-1 non-B variants is increasing in Spain, showing a higher number of transmitted drug resistance mutations (TDR) since 2002. This study presents the features of non-B-infected patients enrolled in the cohort of ... ...

    Abstract Introduction: The prevalence of HIV-1 non-B variants is increasing in Spain, showing a higher number of transmitted drug resistance mutations (TDR) since 2002. This study presents the features of non-B-infected patients enrolled in the cohort of antiretroviral treatment (ART) naïve HIV-infected patients included in the Research Network on HIV/AIDS (CoRIS).
    Methods: The study includes a selected group of HIV-1 non-B-infected subjects from 670 subjects with pol sequences collected from 2004 to 2008 in the CoRIS cohort. Epidemiological-clinical-virological data were analyzed since cohort entry until October 2011, considering the presence or absence of treatment failure (TF).
    Results: Eighty two non-B infected subjects with known HIV-1 variants were selected from 2004 to 2008 in the CoRIS cohort, being mainly female, immigrants, infected by recombinant viruses, and by heterosexual route. They had an intermediate TDR rate (9.4%), a high rate of TF (25.6%), of losses to follow-up (35%), of coinfections (32.9%), and baseline CD4+ counts ≥350cells/mm(3) (61.8%). Non-B subjects with TF showed higher rates of heterosexual infection (85.7% vs. 69.5%, p<0.05), tuberculosis (30.8% vs. 9.1%, p=0.10) and hepatitis C (23.8% vs. 13.9%, p=0.34) coinfections and lower rates of syphilis (0% vs. 21.9%, p<0.05), and had more frequently received first-line ART including protease inhibitors (PIs) than patients without TF (70% vs. 30%, p<0.05). Interestingly, infection with non-B variants reduced the risk of TDR to nucleoside reverse transcriptase inhibitors and increased the risk to PIs.
    Conclusion: HIV-1 non-B-infected patients in Spain had a particular epidemiological and clinical profile that should be considered during their clinical management.
    Language English
    Publishing date 2016-06
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1070941-1
    ISSN 1578-1852 ; 0213-005X
    ISSN (online) 1578-1852
    ISSN 0213-005X
    DOI 10.1016/j.eimc.2015.07.016
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  5. Article: Grado de replicación del virus de la hepatitis C y aparición de hepatotoxicidad por nevirapina en pacientes con infección por el VIH.

    Rodríguez Guardado, Azucena / Maradona Hidalgo, José Antonio / Asensi Alvarez, Víctor / Cartón Sánchez, José Antonio

    Medicina clinica

    2004  Volume 122, Issue 8, Page(s) 317

    Title translation Assessment of nevirapine liver toxicity in patients with HIV and HVC coinfection.
    MeSH term(s) Adult ; Anti-HIV Agents/adverse effects ; Chemical and Drug Induced Liver Injury/epidemiology ; Chemical and Drug Induced Liver Injury/etiology ; Female ; HIV Infections/blood ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV-1 ; Hepatitis C, Chronic/blood ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/epidemiology ; Humans ; Liver/drug effects ; Liver Function Tests ; Male ; Nevirapine/adverse effects ; Viral Load
    Chemical Substances Anti-HIV Agents ; Nevirapine (99DK7FVK1H)
    Language Spanish
    Publishing date 2004-03-08
    Publishing country Spain
    Document type Comparative Study ; Letter
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/s0025-7753(04)74218-9
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  6. Article: Interrupción del tratamiento antirretroviral en la práctica clínica.

    Rodríguez Guardado, Azucena / Maradona Hidalgo, José Antonio / Cartón Sánchez, José Antonio / Asensi Alvarez, Víctor

    Medicina clinica

    2002  Volume 118, Issue 15, Page(s) 597

    Title translation Interruption of antirretroviral treatment in the clinical practice.
    MeSH term(s) Adult ; Antiretroviral Therapy, Highly Active ; Female ; HIV Infections/blood ; HIV Infections/drug therapy ; Humans ; Male ; Treatment Refusal ; Viral Load
    Language Spanish
    Publishing date 2002-08-16
    Publishing country Spain
    Document type Letter
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/s0025-7753(02)72462-7
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  7. Article: Estudio comparativo de la meningitis posquirúrgica por Staphylococcus aureus sensible y resistente a meticilina.

    Rodríguez Guardado, Azucena / Maradona Hidalgo, José Antonio / Pérez González, Francisco / Cartón Sánchez, José Antonio / Blanco, Armando / Rial, Juan Carlos / Asensi Alvarez, Víctor

    Medicina clinica

    2005  Volume 124, Issue 3, Page(s) 102–103

    Abstract: Background and objective: In recent years, meningitis caused by methicillin-resistant S. aureus has increased. This study was undertaken to compare the clinical characteristics and prognosis of methicillin-resistant S. aureus (MRSA) postneurosurgical ... ...

    Title translation Postsurgery meningitis by Staphylococcus aureus: comparison between methicillin-sensitive and resistant strains.
    Abstract Background and objective: In recent years, meningitis caused by methicillin-resistant S. aureus has increased. This study was undertaken to compare the clinical characteristics and prognosis of methicillin-resistant S. aureus (MRSA) postneurosurgical meningitis and methicillin-sensible S. aureus (MSSA) postneurosurgical meningitis.
    Patients and methods: Twenty-five episodes of postneurosurgical meningitis due to S. aureus (13 methicillin-resistant strains) seen during a ten-year period were retrospectively reviewed.
    Results: Most common underlying diseases were: intracerebral hemorrhage (50% of MRSA patients and 46% of MSSA patients) and neoplasm (53% of MRSA patients and 33% of MSSA patients). Eleven patients (6 of them with MRSA infection) had received antibiotic treatment previously. Thirteen patients were carriers of intraventricular catheters (8 with MRSA infection), 5 wore a ventriculoperitoneal shunt (4 with infections by MSSA), 5 cases had a CSF leakage (4 with infections by MRSA), and one patient with infection by MSSA wore an epidural catheter. Fifteen patients were cured (7 with MRSA infection), and 8 died due to the infection (27% with MSSA infection and 38% with MRSA infection).
    Conclusions: The prognosis of postneurosurgical meningitis by S. aureus does not depend on the presence of resistance to methicillin. Nowadays, the intravenous administration of vancomycin is the treatment of choice in MRSA meningitis.
    MeSH term(s) Cross Infection/drug therapy ; Cross Infection/epidemiology ; Female ; Humans ; Male ; Meningitis, Bacterial/drug therapy ; Meningitis, Bacterial/epidemiology ; Methicillin Resistance ; Middle Aged ; Neurosurgical Procedures ; Prognosis ; Retrospective Studies ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/epidemiology ; Staphylococcus aureus/drug effects ; Surgical Wound Infection/drug therapy ; Surgical Wound Infection/epidemiology
    Language Spanish
    Publishing date 2005-01-28
    Publishing country Spain
    Document type English Abstract ; Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1157/13070850
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  8. Article ; Online: Role of age and comorbidities in mortality of patients with infective endocarditis.

    Armiñanzas, Carlos / Fariñas-Alvarez, Concepción / Zarauza, Jesús / Muñoz, Patricia / González Ramallo, Víctor / Martínez Sellés, Manuel / Miró Meda, José Mª / Pericás, Juan Manuel / Goenaga, Miguel Ángel / Ojeda Burgos, Guillermo / Rodríguez Álvarez, Regino / Castelo Corral, Laura / Gálvez-Acebal, Juan / Martínez Marcos, Francisco Javier / Fariñas, Maria Carmen / Fernández Sánchez, Fernando / Noureddine, Mariam / Rosas, Gabriel / de la Torre Lima, Javier /
    Aramendi, José / Bereciartua, Elena / Blanco, María José / Blanco, Roberto / Boado, María Victoria / Campaña Lázaro, Marta / Crespo, Alejandro / Goikoetxea, Josune / Iruretagoyena, José Ramón / Irurzun Zuazabal, Josu / López-Soria, Leire / Montejo, Miguel / Nieto, Javier / Rodrigo, David / Rodríguez, David / Rodríguez, Regino / Vitoria, Yolanda / Voces, Roberto / García López, Mª Victoria / Georgieva, Radka Ivanova / Ojeda, Guillermo / Rodríguez Bailón, Isabel / Ruiz Morales, Josefa / Cuende, Ana María / Echeverría, Tomás / Fuerte, Ana / Gaminde, Eduardo / Idígoras, Pedro / Iribarren, José Antonio / Izaguirre Yarza, Alberto / Kortajarena Urkola, Xabier / Reviejo, Carlos / Carrasco, Rafael / Climent, Vicente / Llamas, Patricio / Merino, Esperanza / Plazas, Joaquín / Reus, Sergio / Álvarez, Nemesio / Bravo-Ferrer, José María / Castelo, Laura / Cuenca, José / Llinares, Pedro / Miguez Rey, Enrique / Rodríguez Mayo, María / Sánchez, Efrén / Sousa Regueiro, Dolores / Martínez, Francisco Javier / Alonso, Mª Del Mar / Castro, Beatriz / García Rosado, Dácil / Durán, Mª Del Carmen / Miguel Gómez, Mª Antonia / Lacalzada, Juan / Nassar, Ibrahim / Plata Ciezar, Antonio / Reguera Iglesias, José Mª / Asensi Álvarez, Víctor / Costas, Carlos / de la Hera, Jesús / Fernández Suárez, Jonnathan / Iglesias Fraile, Lisardo / León Arguero, Víctor / López Menéndez, José / Mencia Bajo, Pilar / Morales, Carlos / Moreno Torrico, Alfonso / Palomo, Carmen / Paya Martínez, Begoña / Rodríguez Esteban, Ángeles / Rodríguez García, Raquel / Telenti Asensio, Mauricio / Almela, Manuel / Ambrosioni, Juan / Azqueta, Manuel / Brunet, Mercè / Bodro, Marta / Cartañá, Ramón / Falces, Carlos / Fita, Guillermina / Fuster, David / García de la Mària, Cristina / Hernández-Meneses, Marta / Llopis Pérez, Jaume / Marco, Francesc / Miró, José M / Moreno, Asunción / Nicolás, David / Ninot, Salvador / Quintana, Eduardo / Paré, Carlos / Pereda, Daniel / Pericás, Juan M / Pomar, José L / Ramírez, José / Rovira, Irene / Sandoval, Elena / Sitges, Marta / Soy, Dolors / Téllez, Adrián / Tolosana, José M / Vidal, Bárbara / Vila, Jordi / Adán, Iván / Bermejo, Javier / Bouza, Emilio / Celemín, Daniel / Cuerpo Caballero, Gregorio / Delgado Montero, Antonia / Fernández Cruz, Ana / García Mansilla, Ana / García Leoni, Mª Eugenia / Kestler Hernández, Martha / Hualde, Amaia Mari / Marín, Mercedes / Martínez-Sellés, Manuel / Menárguez, Mª Cruz / Rincón, Cristina / Rodríguez-Abella, Hugo / Rodríguez-Créixems, Marta / Pinilla, Blanca / Pinto, Ángel / Valerio, Maricela / Vázquez, Pilar / Verde Moreno, Eduardo / Antorrena, Isabel / Loeches, Belén / Martín Quirós, Alejandro / Moreno, Mar / Ramírez, Ulises / Rial Bastón, Verónica / Romero, María / Saldaña, Araceli / Agüero Balbín, Jesús / Amado, Cristina / Armiñanzas Castillo, Carlos / Arnaiz García, Ana / Cobo Belaustegui, Manuel / Fariñas, María Carmen / Fariñas-Álvarez, Concepción / Gómez Izquierdo, Rubén / García, Iván / González-Rico, Claudia / Gutiérrez-Cuadra, Manuel / Gutiérrez Díez, José / Pajarón, Marcos / Parra, José Antonio / Sarralde, Aurelio / Teira, Ramón / Domínguez, Fernando / García Pavía, Pablo / González, Jesús / Orden, Beatriz / Ramos, Antonio / Centella, Tomasa / Hermida, José Manuel / Moya, José Luis / Martín-Dávila, Pilar / Navas, Enrique / Oliva, Enrique / Del Río, Alejandro / Ruiz, Soledad / Hidalgo Tenorio, Carmen / Almendro Delia, Manuel / Araji, Omar / Barquero, José Miguel / Calvo Jambrina, Román / de Cueto, Marina / Gálvez Acebal, Juan / Méndez, Irene / Morales, Isabel / López-Cortés, Luis Eduardo / de Alarcón, Arístides / García, Emilio / Haro, Juan Luis / Lepe, José Antonio / López, Francisco / Luque, Rafael / Alonso, Luis Javier / Azcárate, Pedro / Azcona Gutiérrez, José Manuel / Blanco, José Ramón / García-Álvarez, Lara / Oteo, José Antonio / Sanz, Mercedes / de Benito, Natividad / Gurguí, Mercé / Pacho, Cristina / Pericas, Roser / Pons, Guillem / Álvarez, M / Fernández, A L / Martínez, Amparo / Prieto, A / Regueiro, Benito / Tijeira, E / Vega, Marino / Canut Blasco, Andrés / Cordo Mollar, José / Gainzarain Arana, Juan Carlos / García Uriarte, Oscar / Martín López, Alejandro / Ortiz de Zárate, Zuriñe / Urturi Matos, José Antonio / García Domínguez, Gloria / Sánchez-Porto, Antonio / Arribas Leal, José Mª / García Vázquez, Elisa / Hernández Torres, Alicia / Blázquez, Ana / de la Morena Valenzuela, Gonzalo / Alonso, Ángel / Aramburu, Javier / Calvo, Felicitas Elena / Moreno Rodríguez, Anai / Tarabini-Castellani, Paola / Heredero Gálvez, Eva / Maicas Bellido, Carolina / Largo Pau, José / Sepúlveda, Mª Antonia / Toledano Sierra, Pilar / Iqbal-Mirza, Sadaf Zafar / Cascales Alcolea, Eva / Egea Serrano, Pilar / Hernández Roca, José Joaquín / Keituqwa Yañez, Ivan / Peláez Ballesta, Ana / Soriano, Víctor / Moreno Escobar, Eduardo / Peña Monje, Alejandro / Sánchez Cabrera, Valme / Vinuesa García, David / Arrizabalaga Asenjo, María / Cifuentes Luna, Carmen / Núñez Morcillo, Juana / Pérez Seco, Mª Cruz / Villoslada Gelabert, Aroa / Aured Guallar, Carmen / Fernández Abad, Nuria / García Mangas, Pilar / Matamala Adell, Marta / Palacián Ruiz, Mª Pilar / Porres, Juan Carlos / Alcaraz Vidal, Begoña / Cobos Trigueros, Nazaret / Del Amor Espín, María Jesús / Giner Caro, José Antonio / Jiménez Sánchez, Roberto / Jimeno Almazán, Amaya / Ortín Freire, Alejandro / Viqueira González, Monserrat / Pericás Ramis, Pere / Ribas Blanco, Mª Ángels / Ruiz de Gopegui Bordes, Enrique / Vidal Bonet, Laura / Bellón Munera, Mª Carmen / Escribano Garaizabal, Elena / Tercero Martínez, Antonia / Segura Luque, Juan Carlos

    European journal of internal medicine

    2019  Volume 64, Page(s) 63–71

    Abstract: Purpose: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality.: Methods: Prospective cohort study of all ... ...

    Abstract Purpose: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality.
    Methods: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk.
    Results: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32-3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39-1.88),and non-performed surgery (HR:1.64;95% CI:11.16-1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality.
    Conclusion: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group.
    MeSH term(s) Adult ; Age Factors ; Aged ; Aged, 80 and over ; Area Under Curve ; Comorbidity ; Databases, Factual ; Endocarditis/etiology ; Endocarditis/mortality ; Female ; Heart Failure/mortality ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Proportional Hazards Models ; Prospective Studies ; ROC Curve ; Risk Factors ; Spain/epidemiology ; Staphylococcal Infections/mortality
    Language English
    Publishing date 2019-03-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2019.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain

    Berenguer, Juan / Ryan, Pablo / Rodríguez-Baño, Jesús / Jarrín, Inmaculada / Carratalà, Jordi / Pachón, Jerónimo / Yllescas, María / Arriba, José Ramón / Aznar Muñoz, Esther / Gil Divasson, Pedro / González Muñiz, Patricia / Muñoz Aguirre, Clara / López, Juan Carlos / Ramírez-Schacke, Margarita / Gutiérrez, Isabel / Tejerina, Francisco / Aldámiz-Echevarría, Teresa / Díez, Cristina / Fanciulli, Chiara /
    Pérez-Latorre, Leire / Parras, Francisco / Catalán, Pilar / García-Leoni, María E. / Pérez-Tamayo, Isabel / Puente, Luis / Cedeño, Jamil / Díaz Menéndez, Marta / de la Calle Prieto, Fernando / Arsuaga Vicente, Marta / Trigo Esteban, Elena / Lago Núñez, Mª del Mar / de Miguel Buckley, Rosa / Cadiñaños Loidi, Julen / Busca Arenzana, Carmen / Mican, Alfredo / Mora Rillo, Marta / Ramos Ramos, Juan Carlos / Loeches Yagüe, Belén / Bernardino de la Serna, José Ignacio / García Rodríguez, Julio / Arribas López, José Ramón / Such Diaz, Ana / Álvaro Alonso, Elena / Izquierdo García, Elsa / Torres Macho, Juan / Cuevas Tascon, Guillermo / Troya García, Jesús / Mestre Gómez, Beatriz / Jiménez González de Buitrago, Eva / Fernández Jiménez, Inés / Tebar Martínez, Ana Josefa / Brañas Baztán, Fátima / Valencia de la Rosa, Jorge / Pérez Butragueño, Mario / Alvarado Blasco, Marta / Sepúlveda Berrocal, Mª Antonia / Yera Bergua, Carmen / Toledano Sierra, Pilar / Cano Llorente, Verónica / Zafar Iqubal-Mirza, Sadaf / Muñiz, Gema / Martín Pérez, Inmaculada / Mozas Moriñigo, Helena / Alguacil, Ana / García Butenegro, María Paz / Peláez Ballesta, Ana Isabel / Morcillo Rodríguez, Elena / Goikoetxea Agirre, Josune / Blanco Vidal, María José / Nieto Arana, Javier / del Álamo Martínez de Lagos, Mikel / Pérez Hernández, Isabel A. / Pérez Zapata, Inés / Silvariño Fernández, Rafael / Ugalde Espiñeira, Jon / Asensi Álvarez, Víctor / Suárez Pérez, Lucia / Suárez Diaz, Silvia / Yllera Gutiérrez, Carmen / Boix, Vicente / Díez Martínez, Marcos / Carreres Candela, Melissa / Gómez-Ayerbe, Cristina / Sánchez-Lora, Javier / Velasco Garrido, José Luis / López-Jódar, María / Santos González, Jesús / Ruiz Aragón, Jesús / Virto Peña, Ianire / Alende Castro, Vanessa / Brea Aparicio, Ruth / Vega Molpeceres, Sonia / Pons Viñas, Estel / del Río Pérez, Oscar / Valero Rovira, Silvia / Villar-García, Judit / Gómez-Junyent, Joan / Knobel, Hernando / Cánepa, María Cecilia / Castañeda Espinosa, Silvia / Sorli Redò, Luisa / Güerri-Fernández, Roberto / Milagro Montero, María / Horcajada, Juan Pablo / García Vázquez, Elisa / Moral Escudero, Encarnación / Hernández Torres, Alicia / García Almodóvar, Esther / Sáez Barberá, Carmen / Karroud, Zineb / Hernández Quero, José / Vinuesa García, David / García Fogeda, José Luis / Peregrina, José Antonio / Novella Mena, María / Hernández Gutiérrez, Cristina / Sanz Moreno, José / Pérez Tanoira, Ramón / Sierra Rodríguez, Rodrigo / Alonso Menchén, David / Gutiérrez García, Aida / Arranz Caso, Alberto / Cuadros González, Juan / Álvarez de Mon Soto, Melchor / Díaz de Brito Fernández, Vicente Ferrer / Sanmarti Vilamala, Montserrat / Gabarrell Pascuet, Aina / Molina Morant, Daniel / España Cueto, Sergio / Cámara Fernández, Jonathan / Sabater Gil, Albert / Muñoz López, Laura / Sáez Escolano, Paula / Bejarano Tello, Esperanza / Sempere Alcocer, Marco Antonio / Álvarez Martin, Salvador / De los Santos Gil, Ignacio / García-Fraile, Lucio / Sampedro Núñez, Miguel / Barrios Blandino, Ana / Rodríguez Franco, Carlos / Useros Brañas, Daniel / Villa Martí, Almudena / Oliver Ortega, Javier / Costanza Espiño Álvarez, Alexia / Sanz Sanz, Jesús / Rexach Fumaña, María / Abascal Cambras, Ivette / Pérez Jaén, Ana del Cielo / Sala Jofre, Clara / Casas Rodríguez, Susana / Tortajada Alamilla, Cecilia / Oltra, Carmina / Masiá Canuto, Mar / Gutiérrez Rodero, Félix / Ferrer Ribera, Ana / Bea Serrano, Carlos / Pedromingo Kus, Miguel / Garcinuño, María Ángeles / Fiorante, Silvana / Pérez Pinto, Sergio / Hernández Machín, Pilar / Alastrué Violeta, Alba / Fariñas Álvarez, María Carmen / González Rico, Claudia / Arnaiz de las Revillas, Francisco / Calvo, Jorge / Gozalo, Mónica / Mora Gómez, Francisco / Milagro Beamonte, Ana / Latorre-Millán, Miriam / Rezusta López, Antonio / Martínez Sapiña, Ana / Meije, Yolanda / Duarte Borges, Alejandra / Pareja Coca, Julia / Clemente Presas, Mercedes / Losa García, Juan Emilio / Vegas Serrano, Ana / Pérez-Rodríguez, M. Teresa / Pérez González, Alexandre / Belhassen-García, Moncef / Rodríguez-Alonso, Beatriz / López-Bernus, Amparo / Carbonell, Cristina / Torres Perea, Rafael / Cantón de Seoane, Juan / Alonso, Blanca / Kamal, Sara Lidia / Cajuela, Lucia / Roa, David / Cervero, Miguel / Oreja, Alberto / Avilés, Juan Pablo / Martín, Lidia / Pelegrín Senent, Iván / Rouco Esteves Marques, Rosana / Parra Ruiz, Jorge / Ramos Sesma, Violeta / Abadia Otero, Jessica / Salillas Hernando, Juan / Torres Sánchez del Arco, Robert / Torralba González de Suso, Miguel / Serrano Martínez, Alberto / Gilaberte Reyzábal, Sergio / Pacheco Martínez-Atienza, Marina / Liébana Gómez, Mónica / Fernández Rodríguez, Sara / Varela Plaza, Álvaro / Calvo Sánchez, Henar / Martínez Martín, Patricia / González- Ruano, Patricia / Malmierca Corral, Eduardo / Rábago Lorite, Isabel / Pérez-Monte Mínguez, Beatriz / García Flores, Ángeles / Comas Casanova, Pere / Sirisi, Merce / Rojas, Richard / Díaz de Tuesta del Arco, José Luis / Figueroa Cerón, Ruth / González Sarria, Ander / Alemán Valls, Remedios / Alonso Socas, María del Mar / Sanz Peláez, Oscar / Mohamed Ramírez, Karim / Riera Jaume, Melchor / Vilchez, Helem Haydee / Albertí, Francesc / Cañabate, Ana Isabel / Moreno Cuerda, Víctor J. / Álvarez Kaelis, Silvia / Álvarez Zapatero, Beatriz / García García, Alejandro / Isaba Ares, Elena / Morcate Fernández, Covadonga / Pérez Rodríguez, Andrea / Ramos Merino, Lucía / Castelo Corral, Laura / Rodríguez Mahía, María / González Bardanca, Mónica / Sánchez Vidal, Efrén / Míguez Rey, Enrique / De la Torre Lima, Javier / García de Lomas Guerrero, José Mª / Morte, Elena / Loscos, Silvia / Camón, Ana / Gómez García, Lucía / Boix Palop, Lucia / Dietl Gómez-Luengo, Beatriz / Pedrola Gorrea, Iris / Blasco Claramunt, Amparo / López Mestanza, Cristina / Fraile Villarejo, Esther / Tosco Núñez, Tomás / Aroca Ferri, María / Algado Rabasa, José Tomas / Garijo Saiz, Ana María / Amador Prous, Concepción / Baño, Jesús Rodriguez / Retamar, Pilar / Valiente, Adoración / López-Cortés, Luis E. / Sojo, Jesús / Gutiérrez-Gutiérrez, Belén / Bravo-Ferrer, José / Salamanca, Elena / Palacios, Zaira R. / Pérez-Palacios, Patricia / Peral, Enrique / Pérez de León, José Antonio / Sánchez-Gómez, Jesús / Marín-Barrera, Lucía / García-Jiménez, Domingo / Abelenda-Alonso, Gabriela / Ardanuy, Carmen / Bergas, Alba / Cuervo, Guillermo / Domínguez, María Ángeles / Fernández-Huerta, Miguel / Gudiol, Carlota / Lorenzo-Esteller, Laia / Niubó, Jordi / Pérez-Recio, Sandra / Podzamczer, Daniel / Pujol, Miquel / Rombauts, Alexander / Trullen, Núria / Salavert Lletí, Miguel / Castro Hernández, Iván / Hernández Belmonte, Adriana / Martínez Goñi, Raquel / Navarro Vilasaró, Marta / Calzado Isbert, Sonia / Cervantes García, Manuel / Gomila Grange, Aina / Gasch Blasi, Oriol / Machado Sicilia, María Luisa / Van den Eynde Otero, Eva / Falgueras López, Luis / Navarro Sáez, María del Carmen / Martínez, Esteban / Marcos, Mª Ángeles / Mosquera, Mar / Blanco, José Luis / Laguno, Montserrat / Rojas, Jhon / González-Cordón, Ana / Inciarte, Alexy / Torres, Berta / De la Mora, Lorena / Soriano, Alex / Martínez Macias, Olalla / Pérez Doñate, Virginia / Cabello Úbeda, Alfonso / Carrasco Antón, Nerea / Álvarez Álvarez, Beatriz / Petkova Saiz, Elizabet / Górgolas Hernández-Mora, Miguel / Prieto Pérez, Laura / Carrillo Acosta, Irene / Heili Frades, Sara / Villar Álvarez, Felipe / Fernández Roblas, Ricardo / Milicua Muñoz, José María / Fernández Espinilla, Virginia / Dueñas Gutiérrez, Carlos Jesús / Hernán García, Cristina / González-Romo, Fernando / Merino Amador, Paloma / Rueda López, Alba / Martínez Jordán, Jorge / Medrano Pardo, Sara / Díaz de la Torre, Irene / Posada Franco, Yolanda / Delgado-Iribarren, Alberto / López-Contreras González, Joaquín / Pascual Alonso, Pablo / Pomar Solchaga, Virginia / Rabella García, Nuria / Benito Hernández, Natividad / Domingo Pedrol, Pere / Bonfill Cosp, Xavier / Padrós Selma, Rafael / Puig Campmany, Mireia / Mancebo Cortés, Jordi / Gurguí Ferrer, Mercè / Íñigo Pestaña, Melania / Pérez García, Alejandra / Sorní Moreno, Patricia / Izko Gartzia, Nora / Membrillo de Novales, Francisco Javier / Simón Sacristán, María / Zamora Cintas, Maribel / Martínez Martínez, Yolanda / Fernández-González, Pablo / Alcántara Nicolás, Francisco / Aguirre Vila-Cora, Alejandro / López Tizón, Elena / Ramírez-Olivencia, Germán / Estébanez Muñoz, Miriam / Sáez de Adana Arróniz, Ester / Portu Zapirain, Joseba / Gainzarain Arana, Juan Carlos / Ortiz de Zárate Ibarra, Zuriñe / Moran Rodríguez, Miguel Ángel / Canut Blasco, Andrés / Hernáez Crespo, Silvia / Balerdi Sarasola, Leire / Morales García, Cristina / Corral Saracho, Miguel / Valcarce González, Zeltia / Arenal Andrés, Noelia / Rodríguez Tarazona, Raquel Elisa / Iglesias Llorente, Laura / Loureiro Rodríguez, Beatriz / Sánchez Montalvá, Adrián / Espinosa Pereiro, Juan / Almirante, Benito / Miarons, Marta / Sellarés, Júlia / Larrosa, María / García, Sonia / Marzo, 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    Clinical Microbiology and Infection

    2020  Volume 26, Issue 11, Page(s) 1525–1536

    Keywords Microbiology (medical) ; Infectious Diseases ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2020.07.024
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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