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Article ; Online: Bespoke nanostars: synthetic strategies, tactics, and uses of tailored branched gold nanoparticles.

Siegel, Asher L / Baker, Gary A

Nanoscale advances

2021 Volume 3, Issue 14, Page(s) 3980–4004

Abstract: Interest in branched colloidal gold nanosystems has gained increased traction due to the structures' outstanding optical and plasmonic properties, resulting in utilization in techniques such as surface-enhanced spectroscopy and bioimaging, as well as ... ...

Abstract	Interest in branched colloidal gold nanosystems has gained increased traction due to the structures' outstanding optical and plasmonic properties, resulting in utilization in techniques such as surface-enhanced spectroscopy and bioimaging, as well as plasmon photocatalysis and photothermal therapy. The unique morphologies of nanostars, multipods, urchins, and other highly branched nanomaterials exhibit selective optical and crystallographic features accessible by alterations in the respective wet-chemical syntheses, opening a vast array of useful applications. Examination of discriminatory reaction conditions, such as seeded growth (
Language	English
Publishing date	2021-04-21
Publishing country	England
Document type	Journal Article ; Review
ISSN	2516-0230
ISSN (online)	2516-0230
DOI	10.1039/d0na01057j
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Article ; Online: Plasmon-controlled shaping of gold nanostar photothermal therapy agents.

Siegel, Asher L / Polo-Parada, Luis / Baker, Gary A

Chemical communications (Cambridge, England)

2022 Volume 58, Issue 94, Page(s) 13119–13122

Abstract: Tunable gold nanostars were synthesized through the reduction of gold salt by an aminosugar, ...

Abstract	Tunable gold nanostars were synthesized through the reduction of gold salt by an aminosugar,
MeSH term(s)	Metal Nanoparticles/therapeutic use ; Photothermal Therapy ; Gold/pharmacology ; Phototherapy
Chemical Substances	Gold (7440-57-5)
Language	English
Publishing date	2022-11-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d2cc04812d
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Article ; Online: Platelet Electron Microscopy: Utilizing LEAN Methodology to Optimize Laboratory Workflow.

Asher, Lucas / Hata, Jessica

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

2020 Volume 23, Issue 5, Page(s) 356–361

Abstract: Background: Platelet electron microscopy (PEM) is the gold standard methodology for diagnosing storage pool disorder, defined as a paucity of delta granules, alpha granules, or both. PEM literature is limited with few published resources and without ... ...

Abstract	Background: Platelet electron microscopy (PEM) is the gold standard methodology for diagnosing storage pool disorder, defined as a paucity of delta granules, alpha granules, or both. PEM literature is limited with few published resources and without well-developed interlaboratory standardization for the preparation and examination of platelet samples. Methods: Whole mount (WM) dense body (DB) counts for 300 pediatric cases were reviewed to determine whether counting fewer platelets could yield the same results. For 6 cases, DB average was determined on the day of WM preparation and on 2 consecutive days. Both WM and thin section (TS) preparations were examined for all cases. Results: Employing LEAN methodology, an algorithm was developed to markedly decrease the number of platelets counted and still ensure accurate results. WMs decay with time; a statistically significant difference in DB counts was noted between day 0 and day 1 ( Conclusion: It is possible to maintain accuracy and decrease 100 platelet DB counts by >75%. WMs must be counted on the day they are prepared to avoid false paucity of DB secondary to sample decay. An accurate evaluation of platelet morphology requires both the WM and TS techniques.
MeSH term(s)	Adolescent ; Algorithms ; Blood Platelets/pathology ; Child ; Child, Preschool ; Clinical Laboratory Services ; Efficiency ; Humans ; Infant ; Microscopy, Electron/methods ; Platelet Count/methods ; Platelet Storage Pool Deficiency/diagnostic imaging ; Platelet Storage Pool Deficiency/pathology ; Specimen Handling/methods ; Workflow ; Young Adult
Language	English
Publishing date	2020-05-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463498-3
ISSN	1615-5742 ; 1093-5266
ISSN (online)	1615-5742
ISSN	1093-5266
DOI	10.1177/1093526620915361
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Article ; Online: Community-based rehabilitation intervention for people with schizophrenia in Ethiopia (RISE): results of a 12-month cluster-randomised controlled trial.

Asher, Laura / Birhane, Rahel / Weiss, Helen A / Medhin, Girmay / Selamu, Medhin / Patel, Vikram / De Silva, Mary / Hanlon, Charlotte / Fekadu, Abebaw

The Lancet. Global health

2024 Volume 10, Issue 4, Page(s) e530–e542

Abstract: Background: Community-based rehabilitation (CBR) is recommended to address the social and clinical needs of people with schizophrenia in resource-poor settings. We evaluated the effectiveness of CBR at reducing disability at 12 months in people with ... ...

Abstract	Background: Community-based rehabilitation (CBR) is recommended to address the social and clinical needs of people with schizophrenia in resource-poor settings. We evaluated the effectiveness of CBR at reducing disability at 12 months in people with schizophrenia who had disabling illness after having had the opportunity to access facility-based care for 6 months METHODS: This cluster-randomised controlled trial was conducted in a rural district of Ethiopia. Eligible clusters were subdistricts in Sodo district that had not participated in the pilot study. Available subdistricts were randomised (in a 1:1 ratio) to either the intervention group (CBR plus facility-based care) or to the control group (facility-based care alone). An optimisation procedure (accounting for the subdistrict mean WHO Disability Assessment Schedule (WHODAS) score and the potential number of participants per subdistrict) was applied for each of the eight health facilities in the district. An independent statistician, masked to the intervention or control label, used a computer programme to randomly choose the allocation sequence from the set of optimal ones. We recruited adults with disabling illness as a result of schizophrenia. The subdistricts were eligible for inclusion if they included participants that met the eligibility criteria. Researchers recruiting and assessing participants were masked to allocation status. Facility-based care was a task-shared model of mental health care integrated within primary care. CBR was delivered by lay workers over a 12-month period, comprising of home visits (psychoeducation, adherence support, family intervention, and crisis management) and community mobilisation. The primary outcome was disability, measured with the proxy-rated 36-item WHODAS score at 12 months. The subdistricts that had primary outcome data available were included in the primary analysis. This study is registered with ClinicalTrials.gov, NCT02160249. Findings: Enrolment took place between Sept 16, 2015 and Mar 11, 2016. 54 subdistricts were randomised (27 to the CBR plus facility-based care group and 27 to the facility-based care group). After exclusion of subdistricts without eligible participants, we enrolled 79 participants (66% men and 34% women) from 24 subdistricts assigned to CBR plus facility-based care and 87 participants (59% men and 41% women) from 24 subdistricts assigned to facility-based care only. The primary analysis included 149 (90%) participants in 46 subdistricts (73 participants in 22 subdistricts in the CBR plus facility-based care group and 76 participants in 24 subdistricts in the facility-based care group). At 12 months, the mean WHODAS scores were 46·1 (SD 23·3) in the facility-based care group and 40·6 (22·5) in the CBR plus facility-based care group, indicating a favourable intervention effect (adjusted mean difference -8·13 [95% CI -15·85 to -0·40]; p=0·039; effect size 0·35). Four (5%) CBR plus facility-based care group participants and nine (10%) facility-based care group participants had one or more serious adverse events (death, suicide attempt, and hospitalisation). Interpretation: CBR delivered by lay workers combined with task-shared facility-based care, was effective in reducing disability among people with schizophrenia. The RISE study CBR model is particularly relevant to low-income countries with few mental health specialists. Funding: Wellcome Trust.
MeSH term(s)	Adult ; Disabled Persons ; Ethiopia ; Female ; Humans ; Male ; Mental Health ; Pilot Projects ; Schizophrenia/rehabilitation
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2723488-5
ISSN	2214-109X ; 2214-109X
ISSN (online)	2214-109X
ISSN	2214-109X
DOI	10.1016/S2214-109X(22)00027-4
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Article ; Online: "Medical treatments are also part of God's gift": Holy water attendants' perspectives on a collaboration between spiritual and psychiatric treatment for mental illness in Ethiopia.

Asher, Laura / Birhanu, Ribka / Baheretibeb, Yonas / Fekadu, Abebaw

Transcultural psychiatry

2021 Volume 58, Issue 4, Page(s) 585–599

Abstract: In Ethiopia, traditional and spiritual treatments, such as holy water, are used by people with mental disorders instead of, or alongside, psychiatric services. Collaborations between traditional and psychiatric providers may increase access to evidence- ... ...

Abstract	In Ethiopia, traditional and spiritual treatments, such as holy water, are used by people with mental disorders instead of, or alongside, psychiatric services. Collaborations between traditional and psychiatric providers may increase access to evidence-based treatments and address human rights abuses. This study aimed to explore the perspectives of holy water attendants on a novel collaboration between holy water and psychiatric care, at St Mary's Clinic, Entoto, Ethiopia, and to characterize the users of this service. Semi-structured interviews were conducted with 14 holy water attendants, who run group houses for holy water residents and are paid by family members. A thematic analysis was conducted. Socio-demographic and clinical data were extracted from the records of all service users who had attended the clinic. A total of 174 individuals have attended the clinic in the three years since it opened. The majority were diagnosed with schizophrenia. Holy water attendants provide a partial gatekeeping role to psychiatric care, selecting which of their clients they think will benefit and, for these individuals, facilitating attendance to the clinic and antipsychotic medication adherence. Psychiatric care was felt to be compatible with holy water by some, but not all, attendants. However, family members often had the "final say" in individuals attending the clinic, in some cases putting up strong resistance to using psychiatric care. A novel collaboration is acceptable to some holy water attendants and may increase access to psychiatric care amongst people with mental illness living at a holy water site in Ethiopia.
MeSH term(s)	Ethiopia ; Humans ; Mental Disorders/therapy ; Psychotherapy ; Schizophrenia ; Water
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2021-05-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1378978-8
ISSN	1461-7471 ; 1363-4615
ISSN (online)	1461-7471
ISSN	1363-4615
DOI	10.1177/13634615211015082
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Article ; Online: Racial Disparities in Diagnosis and Treatment of Depression Associated with Androgen Deprivation Therapy for Prostate Cancer.

Mandel, Asher L / Simhal, Rishabh K / Shah, Yash B / Wang, Kerith R / Lallas, Costas D / Shah, Mihir S

Urology

2024 Volume 186, Page(s) 75–80

Abstract: Objective: To analyze potential racial disparities in the diagnosis and management of depression associated with androgen deprivation therapy.: Methods: TriNetX health record network was queried for prostate cancer patients treated with androgen ... ...

Abstract	Objective: To analyze potential racial disparities in the diagnosis and management of depression associated with androgen deprivation therapy. Methods: TriNetX health record network was queried for prostate cancer patients treated with androgen deprivation therapy from 2003-2023. Differences in rates of depression diagnosis and treatment were compared between White and Black patients. Means, odds ratios, and t tests were calculated in univariate analysis with 95% confidence intervals (CI). Results: Data were queried from 93 health care organizations to yield 78,313 prostate cancer patients treated with androgen deprivation therapy. Patients on androgen deprivation therapy had 60% greater odds of developing depression vs other patients [9% vs 6%; odds ratio (OR) 1.6; 95% CI (1.5-1.7); P <.0001]. Of those with depression secondary to androgen deprivation therapy, only 35% were treated with antidepressants. After starting androgen deprivation therapy, White patients had 30% greater odds of being diagnosed with depression, compared to Black patients [10% vs 8%; OR 1.3; 95% CI (1.2-1.4); P <.001]. White patients also had higher odds of being treated with a first line antidepressant than Black patients [56% vs 48%; OR 1.4, 95% CI (1.2-1.6), P <.001]. Conclusion: This analysis confirms a significant association between androgen deprivation therapy and the development of clinical depression, and highlights its medical undertreatment. Importantly, our findings also indicate significant racial disparities in the identification and treatment of depression. Routine screening initiatives that account for social determinants of health may alleviate this disparity. Limitations of this study include retrospective design and lack of data describing severity of depression, which might correlate with need for medication.
MeSH term(s)	Male ; Humans ; Prostatic Neoplasms/drug therapy ; Retrospective Studies ; Androgen Antagonists/adverse effects ; Androgens/therapeutic use ; Depression/diagnosis
Chemical Substances	Androgen Antagonists ; Androgens
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2024.01.021
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Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 275: Show issues

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Article ; Online: The effect of piling behavior on the production and mortality of free-range laying hens.

Armstrong, David / Asher, Lucy / Rayner, Ann / Ngidda, Halima / Sharma, Bryony / Gray, Helen

Poultry science

2023 Volume 102, Issue 10, Page(s) 102989

Abstract: Piling, a dense cluster of hens, is a behavior of major concern to the cage-free egg industry. It can cause large numbers of mortalities at which point it is considered smothering. The aim of this study was to quantify whether piling can also have ... ...

Abstract	Piling, a dense cluster of hens, is a behavior of major concern to the cage-free egg industry. It can cause large numbers of mortalities at which point it is considered smothering. The aim of this study was to quantify whether piling can also have consequences on production and non-smothering mortalities, which have not previously been described. Additionally, we aimed to describe characteristics of piling behavior relevant to for management. Video footage from 12 flocks of laying hens was analyzed for piling behavior across 3 wks. Production and mortality data were accessed using an integrated online management system. Bayesian linear mixed-effect models were used for formal statistical testing of the relationships between piling and production. Accounting for some missing data, a total of 252 d amounting to approximately 15,624 h were analyzed for the presence or absence of piling behavior, which we believe constitutes the largest analysis of piling behavior in the scientific literature to date. All flocks observed exhibited piling behavior even if they had no history of smothering. On average, flocks piled more than 4 times per day for around 44 min per event and the peak piling time occurred between 1300 and 1359. We found that the number of piling events was associated with a reduction in the number of eggs produced the next day; based on the average of 4 piles per day this amounted to 7.35 fewer eggs per 1,000 birds per day. Contrary to our hypothesis, we found total piling duration per day was positively associated with fewer Grade B eggs, with a decrease of 0.74 Grade B eggs for every hour of piling per day. No relationship was observed between piling and mortality not attributed to smothering. We discuss possible causes and explanations for these results including birds' response to stress, crowd dynamics, and daily rhythms. Here we show the potential for piling behavior to have sublethal consequences on production even in the absence of smothering-related deaths.
MeSH term(s)	Animals ; Female ; Chickens/physiology ; Bayes Theorem ; Housing, Animal ; Ovum ; Crowding ; Animal Husbandry/methods
Language	English
Publishing date	2023-08-05
Publishing country	England
Document type	Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.102989
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Article: A little could go a long way: financing for mental healthcare in low- and middle-income countries.

Asher, L / De Silva, M J

Epidemiology and psychiatric sciences

2017 Volume 26, Issue 3, Page(s) 248–251

MeSH term(s)	Developing Countries ; Health Policy ; Health Services Accessibility/economics ; Health Services Research ; Humans ; Insurance Coverage/organization & administration ; Insurance, Health ; Mental Health ; Mental Health Services/economics
Language	English
Publishing date	2017-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2607964-1
ISSN	2045-7979 ; 2045-7960
ISSN (online)	2045-7979
ISSN	2045-7960
DOI	10.1017/S2045796016001116
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Article ; Online: A step in the right direction: an open-design pedometer algorithm for dogs.

Ladha, C / Belshaw, Z / O'Sullivan, J / Asher, L

BMC veterinary research

2018 Volume 14, Issue 1, Page(s) 107

Abstract: Background: Accelerometer-based technologies could be useful in providing objective measures of canine ambulation, but most are either not tailored to the idiosyncrasies of canine gait, or, use un-validated or closed source approaches. The aim of this ... ...

Abstract	Background: Accelerometer-based technologies could be useful in providing objective measures of canine ambulation, but most are either not tailored to the idiosyncrasies of canine gait, or, use un-validated or closed source approaches. The aim of this paper was to validate algorithms which could be applied to accelerometer data for i) counting the number of steps and ii) distance travelled by a dog. To count steps, an approach based on partitioning acceleration was used. This was applied to accelerometer data from 13 dogs which were walked a set distance and filmed. Each footfall captured on video was annotated. In a second experiment, an approach based on signal features was used to estimate distance travelled. This was applied to accelerometer data from 10 dogs with osteoarthritis during normal walks with their owners where GPS (Global Positioning System) was also captured. Pearson's correlations and Bland Altman statistics were used to compare i) the number of steps measured on video footage and predicted by the algorithm and ii) the distance travelled estimated by GPS and predicted by the algorithm. Results: Both step count and distance travelled could be estimated accurately by the algorithms presented in this paper: 4695 steps were annotated from the video and the pedometer was able to detect 91%. GPS logged a total of 20,184 m meters across all dogs; the mean difference between the predicted and GPS estimated walk length was 211 m and the mean similarity was 79%. Conclusions: The algorithms described show promise in detecting number of steps and distance travelled from an accelerometer. The approach for detecting steps might be advantageous to methods which estimate gross activity because these include energy output from stationary activities. The approach for estimating distance might be suited to replacing GPS in indoor environments or others with limited satellite signal. The algorithms also allow for temporal and spatial components of ambulation to be calculated. Temporal and spatial aspects of dog ambulation are clinical indicators which could be used for diagnosis or monitoring of certain diseases, or used to provide information in support of canine weight-loss programmes.
MeSH term(s)	Accelerometry/instrumentation ; Accelerometry/methods ; Accelerometry/veterinary ; Algorithms ; Animals ; Dogs/physiology ; Female ; Male ; Walking/physiology ; Walking/statistics & numerical data
Language	English
Publishing date	2018-03-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2191675-5
ISSN	1746-6148 ; 1746-6148
ISSN (online)	1746-6148
ISSN	1746-6148
DOI	10.1186/s12917-018-1422-3
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Article ; Online: Could it be osteoarthritis? How dog owners and veterinary surgeons describe identifying canine osteoarthritis in a general practice setting.

Belshaw, Zoe / Dean, Rachel / Asher, Lucy

Preventive veterinary medicine

2020 Volume 185, Page(s) 105198

Abstract: Canine osteoarthritis is a common, painful condition that is typically managed in a general practice setting. Osteoarthritis may have significant negative impacts on the welfare of both dogs and their owners. Anticipated early clinical signs of canine ... ...

Abstract	Canine osteoarthritis is a common, painful condition that is typically managed in a general practice setting. Osteoarthritis may have significant negative impacts on the welfare of both dogs and their owners. Anticipated early clinical signs of canine osteoarthritis and the preferred route to its diagnosis are well described by veterinary subject experts in published literature. However, little is known about changes owners first recognise in a dog ultimately diagnosed with osteoarthritis, how they make decisions about when to present that dog to a general practitioner, or whether the described diagnostic pathways are followed by general practitioners. The aim of this research was to investigate how dog owners and veterinary surgeons describe identifying and diagnosing canine osteoarthritis. Owners of osteoarthritic dogs were recruited for semi-structured interview, and veterinary surgeons working in general practice were invited to take part in practice-based focus groups. Transcripts from both datasets were thematically analysed using a contextualist epistemology with an ontology based on critical realism to construct convergent themes from latent and semantic codes. Thirty-two interviews were completed with 40 owners from 32 households who discussed 35 dogs with osteoarthritis, and 26 veterinary surgeons engaged in four practice-based focus groups. Owners described identifying a wide range of acute and chronic, typically subtle and intermittent, behavioural and demeanour changes prior to their dogs' osteoarthritis diagnosis. Few attributed these changes to canine osteoarthritis, and some waited many months before presenting their dog to a veterinary practice. Veterinary surgeons described a consistent 'typical osteoarthritis' presentation that they recognised through history taking and clinical examination. Their diagnostic work-up rarely followed that advocated by subject experts for reasons including lack of time and perceptions that it would not change the outcome. Many veterinary surgeons described frustration that some owners did not accept their recommendations to provide analgesia for affected dogs. Short consultation lengths, poor awareness of owner knowledge levels, and lack of recognition of the importance of owners' prior knowledge, beliefs and assumptions may contribute to these consultations being perceived as challenging by some veterinary surgeons and owners. This research demonstrates that veterinary surgeons and owners want dogs with clinical signs of osteoarthritis to be happy and comfortable, but that ineffective communication and lack of trust in the consulting room may be a barrier. Our data identifies many new avenues for future research and improved communication strategies that could facilitate earlier identification and treatment of canine osteoarthritis in general practice.
MeSH term(s)	Animals ; Communication ; Dog Diseases/diagnosis ; Dogs ; Osteoarthritis/diagnosis ; Osteoarthritis/veterinary ; Ownership ; Veterinarians
Language	English
Publishing date	2020-11-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	43399-8
ISSN	1873-1716 ; 0167-5877
ISSN (online)	1873-1716
ISSN	0167-5877
DOI	10.1016/j.prevetmed.2020.105198
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