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  1. Article ; Online: Detecting Plant-Wide Oscillation Propagation Effects of Disturbances and Faults in a Chemical Process Plant Using Network Topology of Variance Decompositions

    Dhan Lord B. Fortela / Ashley P. Mikolajczyk

    Processes, Vol 11, Iss 1747, p

    2023  Volume 1747

    Abstract: This work demonstrates for the first time the application of network topology of variance decompositions in analyzing the connectedness of chemical plant process variable oscillations arising from disturbances and faults. Specifically, the time-based ... ...

    Abstract This work demonstrates for the first time the application of network topology of variance decompositions in analyzing the connectedness of chemical plant process variable oscillations arising from disturbances and faults. Specifically, the time-based connectedness and frequency-based connectedness of variables can be used to compute the net pairwise dynamic connectedness (NPDC), which originated as a volatility spillover index for financial markets studies in the field of econometrics. This work used the anomaly-detection benchmark Tennessee-Eastman chemical process (TEP) dataset, which consists of 41 measured variables and 11 manipulated variables subjected to various faulty operating conditions. The data analytics was performed using key functions from the R-package ‘ConnectednessApproach’ that implements connectedness computations based on time and frequency. The NPDC coefficient matrices were then transformed into network adjacency matrices for the rendering of the network topology of connectedness for TEP. The resulting network topologies allow a comprehensive analysis of oscillation effects across all plant-measured and manipulated variables. Analyzing the directed connectedness of the system dynamics at short-range, mid-range, and long-range frequencies showed how the oscillation effects of disturbances and faults propagate and dissipate in the short-term, mid-term, and long-term periods.
    Keywords chemical process control ; network analysis ; oscillation propagation analysis ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
    Subject code 000
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Impacts of Diet on Reproductive Performance of Captive American Alligators ( Alligator mississippiensis )

    Ted Joanen / Ashley P. Mikolajczyk / Mark Staton / Josh Kaplan / William E. Holmes / Mark E. Zappi

    Animals, Vol 13, Iss 24, p

    2023  Volume 3797

    Abstract: Historically, there has been little success with the captive breeding of American alligators ( Alligator mississippiensis ) for both commercial and conservative purposes. This study, conducted at Golden Ranch in Gheens, LA, between 2016 and 2022, ... ...

    Abstract Historically, there has been little success with the captive breeding of American alligators ( Alligator mississippiensis ) for both commercial and conservative purposes. This study, conducted at Golden Ranch in Gheens, LA, between 2016 and 2022, utilized a newly formulated commercial feed and practical dietary supplementation (crawfish waste products) to enhance egg production, fertility, and hatch rates. The primary focus of this study was to compare the outcome of this captive breeding program at Golden Ranch with a program conducted at Rockefeller Refuge (RR) between 1979 and 1984. Notable success was achieved in terms of reproductive performance in comparison to the captive breeding program conducted at Rockefeller Refuge. In this study, 16.1 hatchlings were produced per nest on Golden Ranch from captive breeders. Additionally, when wild nests from Golden Ranch were incubated in the same controlled environmental chambers, they produced an average of 16.3 hatchlings per nest. This comparison emphasizes the similarity in egg production between captive-bred A. mississippiensis and their wild counterparts. The findings of this study suggest that a closed farming system for A. mississippiensis can be established by employing captive breeders derived from artificially incubated wild eggs. Furthermore, American alligators raised in controlled environmental chambers during their initial three years of life demonstrated adaptability to captive conditions and tolerated stocking rates associated with farming conditions and served as breeding stock.
    Keywords Alligator mississippiensis ; alligator ; captive breeding ; nutrition ; fertility ; hatch rates ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
    Subject code 590 ; 333
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Predicting molecular docking of per- and polyfluoroalkyl substances to blood protein using generative artificial intelligence algorithm DiffDock

    Dhan Lord B Fortela / Ashley P Mikolajczyk / Miranda R Carnes / Wayne Sharp / Emmanuel Revellame / Rafael Hernandez / William E Holmes / Mark E Zappi

    BioTechniques, Vol 76, Iss 1, Pp 14-

    2024  Volume 26

    Abstract: This study computationally evaluates the molecular docking affinity of various perfluoroalkyl and polyfluoroalkyl substances (PFAs) towards blood proteins using a generative machine-learning algorithm, DiffDock, specialized in protein–ligand blind- ... ...

    Abstract This study computationally evaluates the molecular docking affinity of various perfluoroalkyl and polyfluoroalkyl substances (PFAs) towards blood proteins using a generative machine-learning algorithm, DiffDock, specialized in protein–ligand blind-docking learning and prediction. Concerns about the chemical pathways and accumulation of PFAs in the environment and eventually in the human body has been rising due to empirical findings that levels of PFAs in human blood has been rising. DiffDock may offer a fast approach in determining the fate and potential molecular pathways of PFAs in human body.
    Keywords blood proteins ; generative artificial intelligence ; human health ; molecular docking ; per- and polyfluoroalkyl substances ; target-based screening ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Future Science Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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