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  1. Article: Innovative Gas-Liquid Membrane Contactor Systems for Carbon Capture and Mineralization in Energy Intensive Industries.

    Asimakopoulou, Akrivi / Koutsonikolas, Dimitrios / Kastrinaki, Georgia / Skevis, George

    Membranes

    2021  Volume 11, Issue 4

    Abstract: ... ...

    Abstract CO
    Language English
    Publishing date 2021-04-08
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes11040271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Fabrication and Optimization of 3D-Printed Silica Scaffolds for Neural Precursor Cell Cultivation.

    Kastrinaki, Georgia / Pechlivani, Eleftheria-Maria / Gkekas, Ioannis / Kladovasilakis, Nikolaos / Gkagkari, Evdokia / Petrakis, Spyros / Asimakopoulou, Akrivi

    Journal of functional biomaterials

    2023  Volume 14, Issue 9

    Abstract: The latest developments in tissue engineering scaffolds have sparked a growing interest in the creation of controlled 3D cellular structures that emulate the intricate biophysical and biochemical elements found within versatile in vivo microenvironments. ...

    Abstract The latest developments in tissue engineering scaffolds have sparked a growing interest in the creation of controlled 3D cellular structures that emulate the intricate biophysical and biochemical elements found within versatile in vivo microenvironments. The objective of this study was to 3D-print a monolithic silica scaffold specifically designed for the cultivation of neural precursor cells. Initially, a preliminary investigation was conducted to identify the critical parameters pertaining to calcination. This investigation aimed to produce sturdy and uniform scaffolds with a minimal wall-thickness of 0.5 mm in order to mitigate the formation of cracks. Four cubic specimens, with different wall-thicknesses of 0.5, 1, 2, and 4 mm, were 3D-printed and subjected to two distinct calcination profiles. Thermogravimetric analysis was employed to examine the freshly printed material, revealing critical temperatures associated with increased mass loss. Isothermal steps were subsequently introduced to facilitate controlled phase transitions and reduce crack formation even at the minimum wall thickness of 0.5 mm. The optimized structure stability was obtained for the slow calcination profile (160 min) then the fast calcination profile (60 min) for temperatures up to 900 °C. In situ X-ray diffraction analysis was also employed to assess the crystal phases of the silicate based material throughout various temperature profiles up to 1200 °C, while scanning electron microscopy was utilized to observe micro-scale crack formation. Then, ceramic scaffolds were 3D-printed, adopting a hexagonal and spherical channel structures with channel opening of 2 mm, and subsequently calcined using the optimized slow profile. Finally, the scaffolds were evaluated in terms of biocompatibility, cell proliferation, and differentiation using neural precursor cells (NPCs). These experiments indicated proliferation of NPCs (for 13 days) and differentiation into neurons which remained viable (up to 50 days in culture). In parallel, functionality was verified by expression of pre- (SYN1) and post-synaptic (GRIP1) markers, suggesting that 3D-printed scaffolds are a promising system for biotechnological applications using NPCs.
    Language English
    Publishing date 2023-09-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb14090465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Biocompatibility of α-Al

    Asimakopoulou, Akrivi / Gkekas, Ioannis / Kastrinaki, Georgia / Prigione, Alessandro / Zaspalis, Vasileios T / Petrakis, Spyros

    Journal of functional biomaterials

    2020  Volume 11, Issue 3

    Abstract: Background: Biocompatible materials-topography could be used for the construction of scaffolds allowing the three-dimensional (3D) organization of human stem cells into functional tissue-like structures with a defined architecture.: Methods: ... ...

    Abstract Background: Biocompatible materials-topography could be used for the construction of scaffolds allowing the three-dimensional (3D) organization of human stem cells into functional tissue-like structures with a defined architecture.
    Methods: Structural characterization of an alumina-based substrate was performed through XRD, Brunauer-Emmett-Teller (BET) analysis, scanning electron microscopy (SEM), and wettability measurements. Biocompatibility of the substrate was assessed by measuring the proliferation and differentiation of human neural precursor stem cells (NPCs).
    Results: α-Al
    Conclusions: Our work indicates the potential use of alumina for the construction of 3D engineered biosystems utilizing human neurons. Such systems may be useful for diagnostic purposes, drug testing, or biotechnological applications.
    Language English
    Publishing date 2020-09-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb11030065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Air-Liquid Interface Cell Exposures to Nanoparticle Aerosols.

    Lewinski, Nastassja A / Liu, Nathan J / Asimakopoulou, Akrivi / Papaioannou, Eleni / Konstandopoulos, Athanasios / Riediker, Michael

    Methods in molecular biology (Clifton, N.J.)

    2017  Volume 1570, Page(s) 301–313

    Abstract: The field of nanomedicine is steadily growing and several nanomedicines are currently approved for clinical use with even more in the pipeline. Yet, while the use of nanotechnology to improve targeted drug delivery to the lungs has received some ... ...

    Abstract The field of nanomedicine is steadily growing and several nanomedicines are currently approved for clinical use with even more in the pipeline. Yet, while the use of nanotechnology to improve targeted drug delivery to the lungs has received some attention, the use of nanoparticles for inhalation drug delivery has not yet resulted in successful translation to market as compared to intravenous drug delivery. The reasons behind the lack of inhaled nanomedicines approved for clinical use or under preclinical development are unclear, but challenges related to safety are likely to contribute. Although inhalation toxicology studies often begin using animal models, there has been an increase in the development and use of in vitro air-liquid interface (ALI) exposure systems for toxicity testing of engineered nanoparticle aerosols, which will be useful for rapid testing of candidate substances and formulations. This chapter describes an ALI cell exposure assay for measuring toxicological effects, specifically cell viability and oxidative stress, resulting from exposure to aerosols containing nanoparticles.
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-6840-4_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Solvents for Membrane-Based Post-Combustion CO2 Capture for Potential Application in the Marine Environment

    Damartzis, Theodoros / Asimakopoulou, Akrivi / Koutsonikolas, Dimitrios / Skevis, George / Georgopoulou, Chara / George Dimopoulos / Nikolopoulos, Lampros / Bougiouris, Konstantinos / Richter, Hannes / Lubenau, Udo / Economopoulos, Solon / Perinu, Cristina / Hopkinson, David / Panagakos, Grigorios

    2022  

    Abstract: Carbon capture on-board ships represents a powerful technological measure in order for the shipping industry to meet the very stringent GHG emission reduction requirements. Operation within the ship environment introduces a number of constraints ... ...

    Abstract Carbon capture on-board ships represents a powerful technological measure in order for the shipping industry to meet the very stringent GHG emission reduction requirements. Operation within the ship environment introduces a number of constraints associated mainly with space, energy supply, and safety which have to be addressed using compact yet efficient solutions. To this end, solvent-based membrane CO2 capture offers several advantages and has the necessary technological maturity for on-board installation. Solvent choice remains a critical issue both for reasons associated with process efficiency as well as on-board safety. In this paper, we present an up-to-date comprehensive review of the different solvents that can be used for post-combustion CO2 capture. Furthermore, we investigated the solvents’ performance as determined by their inherent characteristics, properties, and behavior for a range of operating conditions against the strict shipping requirements. A preliminary qualitative comparative assessment was carried out based on appropriately selected key performance indicators (KPIs) pertinent to the requirements of the shipping industry. The identified solvent classes were compared using the most critical KPIs for system integration with the ship. It was concluded that at present, no solvent category can efficiently address all the requirements of the ship. However, widely used solvents such as secondary amines showed relatively good compatibility with the majority of the introduced KPIs. On the other hand, more recently developed molecules, such as phase change solvents and ionic liquids, can easily prevail over the vast majority of the identified solvents as long as they are brought to the same level of technological maturity with benchmark solvents. Such a conclusion points toward the need for accelerating research on more tailor-made and performance-targeted solvents.

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    Keywords gas-liquid membrane contactor ; carbon dioxide capture ; solvent ; absorption ; modelling ; maritime transport
    Subject code 660
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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