Article ; Online: Intra-pancreatic fat deposition and its relation to obesity: a magnetic resonance imaging study.
Scandinavian journal of gastroenterology
2024 , Page(s) 1–7
Abstract: Objectives: Intra-pancreatic fat deposition (IPFD) is suspected to be associated with various medical conditions. This study aimed to assess pancreatic fat content in lean and obese individuals, characterize obese individuals with and without IPFD, and ... ...
Abstract | Objectives: Intra-pancreatic fat deposition (IPFD) is suspected to be associated with various medical conditions. This study aimed to assess pancreatic fat content in lean and obese individuals, characterize obese individuals with and without IPFD, and explore the underlying mechanisms. Materials and methods: Sixty-two obese individuals without diabetes and 35 lean controls underwent magnetic resonance imaging (MRI) using proton density fat fraction (PDFF) maps to evaluate pancreatic and hepatic fat content, and visceral adipose tissue (VAT) content. Pancreatic fibrosis was explored by T1 relaxation time and MR elastography (MRE) measurements. Associations between pancreatic fat, measures of obesity and metabolic syndrome were examined using uni- and multivariate regression analyses. Results: Pancreatic PDFF was higher in obese than in lean controls (median 8.0%, interquartile range (6.1;13.3) % vs 2.6(1.7;3.9)%, Conclusions: Pancreatic fat content was increased in obese individuals compared with lean controls and predominantly correlated with the amount of visceral adipose tissue. Pancreatic fat content was not clearly linked to measures of pancreatic fibrosis. |
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Language | English |
Publishing date | 2024-04-01 |
Publishing country | England |
Document type | Journal Article ; Review |
ZDB-ID | 82042-8 |
ISSN | 1502-7708 ; 0036-5521 |
ISSN (online) | 1502-7708 |
ISSN | 0036-5521 |
DOI | 10.1080/00365521.2024.2333365 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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