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  1. Article ; Online: Annotations on Emerging Concerns About Antibiotic-Resistant Urinary Tract Infection.

    Mattoo, Tej K / Asmar, Basim I

    Pediatrics

    2020  Volume 145, Issue 2

    MeSH term(s) Anti-Bacterial Agents ; Antibiotic Prophylaxis ; Cephalosporins ; Humans ; Urinary Tract Infections
    Chemical Substances Anti-Bacterial Agents ; Cephalosporins
    Language English
    Publishing date 2020-01-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2019-3512
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    Um IV Zs.131: Show issues Location:
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  2. Article ; Online: Fever in the Returned Pediatric Traveler.

    Abdel-Haq, Nahed / Asmar, Basim I

    Global pediatric health

    2021  Volume 8, Page(s) 2333794X211026188

    Abstract: Global mobility has been steadily increasing in recent years. The assessment of the febrile child returning from international travel is a diagnostic challenge. The COVID-19 pandemic has profoundly affected international travel and made evaluation and ... ...

    Abstract Global mobility has been steadily increasing in recent years. The assessment of the febrile child returning from international travel is a diagnostic challenge. The COVID-19 pandemic has profoundly affected international travel and made evaluation and management of the sick returned traveler more challenging. Children visiting friends and relatives abroad remain at higher risk of infection compared to tourists. This review presents a guidance on the initial assessment of a traveling febrile child including interpretation of medical history, physical examination, and laboratory findings. Important clues to etiology include exposure to different infectious agents, incubation periods of pathogens, and prophylaxis regimens and vaccines received. Early identification of potentially life-threatening and highly contagious infections is essential. In this article, we discuss the epidemiology, evaluation, and management of specific travel related infections such as malaria, typhoid fever, dengue fever, viral hemorrhagic fever, rickettsiosis, leptospirosis, schistosomiasis, gastrointestinal, and respiratory infections.
    Language English
    Publishing date 2021-08-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2785531-4
    ISSN 2333-794X ; 2333-794X
    ISSN (online) 2333-794X
    ISSN 2333-794X
    DOI 10.1177/2333794X211026188
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  3. Article ; Online: Micafungin injection for the treatment of invasive candidiasis in pediatric patients under 4 months of age.

    Abdel-Haq, Nahed / Smith, Stephanie M / Asmar, Basim I

    Expert review of anti-infective therapy

    2021  Volume 20, Issue 4, Page(s) 493–505

    Abstract: Introduction: Neonates and young infants with invasive candidiasis are particularly at increased risk of dissemination including hematogenous : Areas covered: In this report, we review the micafungin use in infants younger than 4 months of age. ... ...

    Abstract Introduction: Neonates and young infants with invasive candidiasis are particularly at increased risk of dissemination including hematogenous
    Areas covered: In this report, we review the micafungin use in infants younger than 4 months of age. Animal studies as well as clinical data that support its use in neonatal candidiasis are reviewed. In addition, the status of FDA approval and the rationale of micafungin dosing recommendations in infants <4 months are discussed.
    Expert opinion: A dose of 4 mg/kg was approved for treatment of candidemia,
    MeSH term(s) Animals ; Antifungal Agents/therapeutic use ; Candida ; Candidemia/drug therapy ; Candidiasis ; Candidiasis, Invasive/drug therapy ; Child ; Echinocandins/adverse effects ; Humans ; Lipopeptides/adverse effects ; Meningoencephalitis/chemically induced ; Meningoencephalitis/drug therapy ; Micafungin/therapeutic use
    Chemical Substances Antifungal Agents ; Echinocandins ; Lipopeptides ; Micafungin (R10H71BSWG)
    Language English
    Publishing date 2021-12-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2022.2013807
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  4. Article ; Online: Infective Endocarditis at a Referral Children's Hospital During 19-Year Period: Trends and Outcomes.

    Abdel-Haq, Nahed / Shawaqfeh, Ahmed / Gupta, Shipra / Ang, Jocelyn Y / Thomas, Ronald / Asmar, Basim I

    Pediatric cardiology

    2023  

    Abstract: Background: We noted a recent increase in cases of infective endocarditis (IE) at our institution. The purpose of the study is to examine the incidence, risk factors, microbiology and outcome of IE in our pediatric population.: Methods: Retrospective ...

    Abstract Background: We noted a recent increase in cases of infective endocarditis (IE) at our institution. The purpose of the study is to examine the incidence, risk factors, microbiology and outcome of IE in our pediatric population.
    Methods: Retrospective review of IE cases during 2002-2020 at Children's Hospital of Michigan, Detroit.
    Results: 68 patients with IE were identified. There was a 2-fold increase in incidence during the 2012-2020 (late period) compared to the 2002-2011 (early period). The most common predisposing conditions were congenital heart disease (CHD) in 39 (57.4%) and central venous catheter (CVC) in 19 (27.9%). CHD was more frequent in the late period (29/43, 67.4%) compared to early period (10/25, 40.0%) (p = 0.042). In CHD patients, palliative or corrective cardiac surgery was performed prior to IE diagnosis in 4/25 (16%) in early period and 23/43 (53.5%) in the late period (p = 0.004). S. aureus was the most common causative organism (35.3%) followed by streptococci (22.1%). Valve replacement or valvuloplasty was performed in 22.1% of patients. Complications occurred in 20 (29.4%). Mortality occurred in 7 (10.3%): 3 had CHD, 3 had CVC and underlying conditions and 1 had fulminant MRSA infection.
    Conclusion(s): The higher incidence of IE during the late period is likely due to an increase in patients with CHD who had undergone prior cardiac surgery. S. aureus was the predominant pathogen in all patients including those with CHD, followed by streptococci. IE in children continues to be associated with high rates of morbidity and mortality.
    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 800857-7
    ISSN 1432-1971 ; 0172-0643
    ISSN (online) 1432-1971
    ISSN 0172-0643
    DOI 10.1007/s00246-023-03274-y
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Central line-associated blood stream infection (CLABSI) due to

    Abdel-Haq, Nahed / Asmar, Basim I / Ang, Jocelyn Y / Natarajan, Girija / Fairfax, Marilynn / Salimnia, Hossein

    IDCases

    2022  Volume 29, Page(s) e01559

    Abstract: Central line associated blood stream infections (CLABSIs) in infants and children with intestinal failure due to short bowel syndrome may be caused by different organisms due to intestinal translocation and skin contamination. We report what we believe ... ...

    Abstract Central line associated blood stream infections (CLABSIs) in infants and children with intestinal failure due to short bowel syndrome may be caused by different organisms due to intestinal translocation and skin contamination. We report what we believe the first case of candidemia in an infant with short bowel syndrome caused by the environmental yeast
    Language English
    Publishing date 2022-07-02
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2022.e01559
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  6. Article ; Online: Spinal Abscess in a Patient with Undiagnosed Congenital Dermal Sinus Tract.

    Doctor, Pezad / Ang, Jocelyn / Asmar, Basim / McGrath, Eric

    Global pediatric health

    2020  Volume 7, Page(s) 2333794X20953324

    Language English
    Publishing date 2020-09-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2785531-4
    ISSN 2333-794X ; 2333-794X
    ISSN (online) 2333-794X
    ISSN 2333-794X
    DOI 10.1177/2333794X20953324
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  7. Article ; Online: A Teenage Girl With Aseptic Meningitis and Abdominal Pain.

    Abdel-Haq, Nahed / Cortes, Orlando / Asmar, Basim I

    The Pediatric infectious disease journal

    2018  Volume 38, Issue 6, Page(s) 651

    MeSH term(s) Abdominal Pain/virology ; Arenaviridae Infections/diagnostic imaging ; Brain/diagnostic imaging ; Brain/pathology ; Child ; Female ; Humans ; Lymphocytic Choriomeningitis/diagnostic imaging ; Lymphocytic choriomeningitis virus/isolation & purification ; Magnetic Resonance Imaging ; Mastoid/pathology ; Meningitis, Aseptic/diagnostic imaging ; Meningitis, Aseptic/drug therapy ; Meningitis, Aseptic/virology
    Language English
    Publishing date 2018-10-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000002213
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    Zs.A 1852: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Cytomegalovirus viremia and resistance patterns in immunocompromised children: An 11-year experience.

    Kim, Edward / Asmar, Basim I / Thomas, Ronald / Abdel-Haq, Nahed

    Pediatric hematology and oncology

    2019  Volume 37, Issue 2, Page(s) 119–128

    Abstract: We noted a recent increase in number of immunocompromised children with CMV viremia at our institution. The purpose of this study was to determine the frequency of CMV viremia in this population and evaluate factors associated with drug-resistant ... ...

    Abstract We noted a recent increase in number of immunocompromised children with CMV viremia at our institution. The purpose of this study was to determine the frequency of CMV viremia in this population and evaluate factors associated with drug-resistant mutations. A retrospective review of immunocompromised hosts, 0-21 years of age, who had CMV viremia during 2007-2017. CMV viremia was detected using PCR assays. Genetic mutation assays were performed using PCR sequencing of the phosophotransferase UL 97 gene and the polymerase UL54 gene of CMV using Quest Diagnostics (San Juan Capistrano, CA, USA) or ARUP Labs (Salt Lake City, UT, USA). Thirty-one patients were identified, including 10 (32%) during the last 2 years. Of the 31 patients, 18 had hematopoietic stem cell transplantation (HSCT), 5 had primary immunodeficiency, 4 had malignancies, 3 had heart transplantation and 1 had new Human Immunodeficiency virus (HIV) infection. Antiviral resistance testing was performed on isolates from seven patients: five with persistent viremia (>1 mo), and two prior to starting antiviral therapy. Resistance was identified in three patients' isolates: two with common variable immunodeficiency (CVID) and one with recurrent Hodgkin's lymphoma who had undergone autologous HSCT. The two patients with CVID had chronic diarrhea and malabsorption and had received prolonged oral valganciclovir courses prior to emergence of resistance. The patient with Hodgkin's lymphoma had received a prolonged IV ganciclovir course. All three tested positive for UL97 mutation and two had both UL97 and UL54 gene mutations. Majority of our patients (21/31) with CMV viremia were transplant recipients and ganciclovir resistance developed in 10%. Two had intestinal malabsorption. Treatment with oral valganciclovir should be avoided in patients with poor gut absorption as that may increase the risk of resistance.
    MeSH term(s) Adolescent ; Adult ; Child ; Child, Preschool ; Cytomegalovirus/pathogenicity ; Female ; Humans ; Infant ; Male ; Retrospective Studies ; Time Factors ; Viremia/physiopathology ; Young Adult
    Language English
    Publishing date 2019-12-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 632914-7
    ISSN 1521-0669 ; 0888-0018
    ISSN (online) 1521-0669
    ISSN 0888-0018
    DOI 10.1080/08880018.2019.1695031
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    Zs.A 1956: Show issues Location:
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  9. Article ; Online: Are Stethoscopes, Coats, and Pagers Potential Sources of Healthcare Associated Infections?

    Arora, Harbir S / Kamat, Deepak / Choudhry, Swati / Asmar, Basim I / Abdel-Haq, Nahed

    Global pediatric health

    2020  Volume 7, Page(s) 2333794X20969285

    Abstract: We conducted a study to determine the rate of bacterial colonization of stethoscopes, coats, and pagers of residents at a pediatric residency training program as compared to that of badges, sleeves, and pagers of non-patient care staff (control group). ... ...

    Abstract We conducted a study to determine the rate of bacterial colonization of stethoscopes, coats, and pagers of residents at a pediatric residency training program as compared to that of badges, sleeves, and pagers of non-patient care staff (control group). Among 213 cultures obtained from 71 residents, 27 potential pathogens were isolated from 22 residents (27/213, 12.7%) as compared to 10 potential pathogens out of 162 samples obtained from 54 control participants (10/162, 6.2%) (
    Language English
    Publishing date 2020-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2785531-4
    ISSN 2333-794X ; 2333-794X
    ISSN (online) 2333-794X
    ISSN 2333-794X
    DOI 10.1177/2333794X20969285
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  10. Article ; Online: Intraperitoneal vancomycin treatment of multifocal methicillin-resistant Staphylococcus aureus osteomyelitis in a patient on peritoneal dialysis.

    Abid, Qassim / Asmar, Basim / Kim, Edward / Molloy, Leah / Gregory, Melissa / Valentini, Rudolph P

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2020  Volume 77, Issue 21, Page(s) 1746–1750

    Abstract: Purpose: We report the case of a 2-year-old girl with end-stage renal disease managed by peritoneal dialysis (PD) who developed methicillin-resistant staphylococcal osteomyelitis of the left shoulder and was successfully treated with intraperitoneal (IP) ...

    Abstract Purpose: We report the case of a 2-year-old girl with end-stage renal disease managed by peritoneal dialysis (PD) who developed methicillin-resistant staphylococcal osteomyelitis of the left shoulder and was successfully treated with intraperitoneal (IP) administration of vancomycin for 2 weeks followed by oral clindamycin therapy.
    Summary: The patient was hospitalized with tactile fever and a 3-day history of worsening fussiness. Radiography of the left shoulder showed findings indicative of osteomyelitis. Vancomycin was administered via central venous line for 3 days, during which time the patient underwent PD 24 hours a day. After magnetic resonance imaging revealed proximal humeral osteomyelitis, septic arthritis of the shoulder joint, and osteomyelitis of the scapula, the patient underwent incision and drainage of the left shoulder joint. Both blood and joint drainage cultures grew methicillin-resistant Staphylococcus aureus that was sensitive to vancomycin. The patient's central venous catheter was removed on hospital day 4; due to difficulties with peripheral i.v. access and a desire to avoid placing a peripherally inserted central venous catheter, vancomycin administration was changed to the IP route, with vancomycin added to the PD fluid. During IP treatment, serum vancomycin levels were maintained at 13.5 to 18.5 mg/L, and the calculated ratio of vancomycin area under the curve to minimum inhibitory concentration was maintained above 400. After completing a 14-day course of IP vancomycin therapy, the patient was switched to oral clindamycin, with subsequent complete resolution of osteomyelitis.
    Conclusion: IP vancomycin was effective for treatment of invasive S. aureus infection in this case. This approach should be considered in patients undergoing PD for whom peripheral i.v. access options are limited and/or not preferred.
    MeSH term(s) Anti-Bacterial Agents/administration & dosage ; Child, Preschool ; Female ; Hemodialysis Solutions/administration & dosage ; Hemodialysis Solutions/chemistry ; Humans ; Kidney Failure, Chronic/therapy ; Magnetic Resonance Imaging ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Methicillin-Resistant Staphylococcus aureus/isolation & purification ; Osteomyelitis/diagnosis ; Osteomyelitis/drug therapy ; Osteomyelitis/microbiology ; Peritoneal Dialysis/methods ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology ; Treatment Outcome ; Vancomycin/administration & dosage
    Chemical Substances Anti-Bacterial Agents ; Hemodialysis Solutions ; Vancomycin (6Q205EH1VU)
    Language English
    Publishing date 2020-09-10
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.1093/ajhp/zxaa244
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