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  1. Article ; Online: Skin appendageal tumors: A 1 year data from a tertiary care institute.

    Thakur, Mamta / Vijayamohanan, Lekshmi / Asotra, Sarita

    Journal of cancer research and therapeutics

    2023  Volume 19, Issue Suppl 2, Page(s) S770–S774

    Abstract: Background: Skin appendageal tumors (SAT) are a rare group of tumors that are classified according to their line of appendageal differentiation along eccrine, apocrine, follicular, and sebaceous lines. However, they are relatively uncommon and create ... ...

    Abstract Background: Skin appendageal tumors (SAT) are a rare group of tumors that are classified according to their line of appendageal differentiation along eccrine, apocrine, follicular, and sebaceous lines. However, they are relatively uncommon and create diagnostic difficulties for the pathologist. Recognition of malignant transformation adds to the importance of an accurate diagnosis. A paucity of clinicopathological data from the Himalayan region of India, in particular, prompted the conduct of this study.
    Aim: To study the clinical and histopathological spectrum of SAT during a period of 1 year received at our hospital.
    Materials and methods: A retrospective study was carried out at the Pathology department of our hospital. All relevant clinical characteristics were noted in addition to the histopathological features. Slides stained with both hematoxylin and eosin and special stains where necessary were used to supplement the diagnoses.
    Results: A total of 17 cases were diagnosed in 1 year (January 2021 to December 2021) at our institute. The predominant age group was 40-59 years. Females outnumbered males, with a male: female ratio of 0.8:1. The most common location of tumors was in the head and neck (90.90%). The majority of cases were benign (90.90%). The majority of tumors were of follicular differentiation (54.55%). We found one malignant tumor of sebaceous differentiation.
    Conclusion: The clinical presentation is remarkably similar to most SAT. In our study, we found that majority of tumors were benign and located in the head and neck. The importance of an accurate histopathological diagnosis is essential in these tumors to diagnose the malignant counterparts and differentiate them from more common skin tumors with different prognoses.
    MeSH term(s) Humans ; Male ; Female ; Adult ; Middle Aged ; Retrospective Studies ; Tertiary Healthcare ; Skin Neoplasms/diagnosis ; Skin Neoplasms/epidemiology ; Skin Neoplasms/pathology ; Epithelial Cells/pathology ; Head
    Language English
    Publishing date 2023-09-21
    Publishing country India
    Document type Journal Article
    ZDB-ID 2187633-2
    ISSN 1998-4138 ; 0973-1482
    ISSN (online) 1998-4138
    ISSN 0973-1482
    DOI 10.4103/jcrt.jcrt_174_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cytomorphological analysis of effusion fluids for detection of malignant cells in a tertiary care hospital in northern India.

    Sharma, Shikha / Asotra, Sarita / Asotra, Sehar

    Journal of cancer research and therapeutics

    2023  Volume 19, Issue Suppl 2, Page(s) S628–S632

    Abstract: Introduction: All body cavities are lined by monolayered mesothelial cells and contain a minimal amount of fluid for lubrication and for protecting the underlying viscera. The peritoneal, pleural, cerebrospinal, sputum, urine, and pericardial fluids ... ...

    Abstract Introduction: All body cavities are lined by monolayered mesothelial cells and contain a minimal amount of fluid for lubrication and for protecting the underlying viscera. The peritoneal, pleural, cerebrospinal, sputum, urine, and pericardial fluids comprise the major chunk of body fluids.
    Material and methods: The study was conducted in the Department of Pathology of a tertiary care hospital in northern India, over a period of 1 year, from January 2021 to December 2021. A total of 241 samples were included in the study.
    Results: Out of the 241 samples studied, 99 were peritoneal fluid, 94 were pleural fluids, 29 were CSF, and 18 were sputum samples. Maximum number of patients affected were in the age group of 41-50 years. Female preponderance was seen with male to female ratio of 1:1.7. A total of 143/241 cases (59.33%) were of transudative nature and 98/241 (27.8%) cases were exudative. Out of 241 cases, 43 (17.84%) were neoplastic, 190 (78.83%) were non-neoplastic, four (1.65%) were suspicious for malignancy, and four (1.65%) were where no opinion was possible. Peritoneal fluid was the most frequently encountered fluid accounting for 99 cases (41.07%). Adenocarcinoma was the most common malignancy accounting for 29 cases (67.44%) out of 43 malignant effusions in the present study.
    Conclusion: Cytological evaluation of body fluids is of significant utility in diagnostic medicine as it allows us to distinguish between benign and malignant etiologies and at the same time offers rapid diagnosis and staging of metastatic disease.
    MeSH term(s) Humans ; Male ; Female ; Adult ; Middle Aged ; Tertiary Care Centers ; Body Fluids ; Pleural Effusion, Malignant/pathology ; Adenocarcinoma/pathology ; Ascitic Fluid/pathology ; Pleural Effusion/pathology
    Language English
    Publishing date 2023-06-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 2187633-2
    ISSN 1998-4138 ; 0973-1482
    ISSN (online) 1998-4138
    ISSN 0973-1482
    DOI 10.4103/jcrt.jcrt_1045_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Primary vaginal malignant melanoma: A rare entity with review of literature.

    Puri, Shailja / Asotra, Sarita

    Journal of cancer research and therapeutics

    2020  Volume 15, Issue 6, Page(s) 1392–1394

    Abstract: Primary vaginal malignant melanoma (PVMM) is an extremely rare tumor of the female genital tract, accounting for only 3% of melanomas of the female genital tract and 0.3%-0.8% of all melanomas in females. Vaginal melanoma is a very aggressive tumor with ... ...

    Abstract Primary vaginal malignant melanoma (PVMM) is an extremely rare tumor of the female genital tract, accounting for only 3% of melanomas of the female genital tract and 0.3%-0.8% of all melanomas in females. Vaginal melanoma is a very aggressive tumor with a 5-year survival rate of 5%-25%. High incidence of recurrence, spread to regional lymph nodes, and distant metastasis are responsible for poor prognosis of PVMM. Grossly, amelanotic melanoma of the vagina may be mistaken for other primary vaginal malignancies. Differentiation of malignant melanoma from other primary vaginal melanomas is essential because of better prognosis of most of other vaginal malignancies as compared to melanoma. Despite having poor prognosis, early detection and early treatment of PVMM may improve the prognosis.
    MeSH term(s) Aged ; Biomarkers ; Biopsy ; Female ; Humans ; Immunohistochemistry ; Melanoma/diagnosis ; Melanoma/mortality ; Melanoma/therapy ; Vaginal Neoplasms/diagnosis ; Vaginal Neoplasms/mortality ; Vaginal Neoplasms/therapy
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-01-02
    Publishing country India
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2187633-2
    ISSN 1998-4138 ; 0973-1482
    ISSN (online) 1998-4138
    ISSN 0973-1482
    DOI 10.4103/jcrt.JCRT_893_15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hemangioma of rib masquerading a malignancy.

    Puri, Shailja / Gupta, Neelam / Asotra, Sarita

    Journal of cancer research and therapeutics

    2018  Volume 14, Issue Supplement, Page(s) S809–S811

    Abstract: Hemangioma of bone is a rare bone tumor accounting for <1% of all osseous tumors. Hemangiomas are common in skull and vertebrae but uncommon in rib. Rib hemangiomas may increase in size over a period and may cause symptoms due to increasing size. ... ...

    Abstract Hemangioma of bone is a rare bone tumor accounting for <1% of all osseous tumors. Hemangiomas are common in skull and vertebrae but uncommon in rib. Rib hemangiomas may increase in size over a period and may cause symptoms due to increasing size. Preoperative diagnosis is not always possible due to overlapping radiological features between benign and malignant lesions. Use of preoperative aspiration and biopsy has their own risks and benefit. Excision of rib in case of monostotic rib lesions is the treatment of choice due to low risk of recurrence and no reported postoperative complications. We report a case of rib hemangioma which mimicked a malignancy preoperatively.
    MeSH term(s) Biopsy ; Bone Neoplasms/diagnosis ; Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/pathology ; Diagnosis, Differential ; Hemangioma/diagnosis ; Hemangioma/diagnostic imaging ; Hemangioma/pathology ; Hemangioma/surgery ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/surgery ; Neoplasms/diagnosis ; Neoplasms/diagnostic imaging ; Neoplasms/pathology ; Neoplasms/surgery ; Radiography ; Ribs/diagnostic imaging ; Ribs/pathology ; Ribs/surgery ; Tomography, X-Ray Computed
    Language English
    Publishing date 2018-09-24
    Publishing country India
    Document type Case Reports ; Letter
    ZDB-ID 2187633-2
    ISSN 1998-4138 ; 0973-1482
    ISSN (online) 1998-4138
    ISSN 0973-1482
    DOI 10.4103/0973-1482.204847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Giant cell tumor of soft tissue

    Asotra Sarita / Sharma Sudershan

    Journal of Cytology, Vol 26, Iss 1, Pp 33-

    Cytological diagnosis of a case

    2009  Volume 35

    Abstract: Giant cell tumors of soft tissue (GCT-STs) are rare neoplasms and are mainly seen in adults and in the elderly population, usually in the extremities. When evaluated along with clinical features, the cytological features are sufficient to distinguish GCT- ...

    Abstract Giant cell tumors of soft tissue (GCT-STs) are rare neoplasms and are mainly seen in adults and in the elderly population, usually in the extremities. When evaluated along with clinical features, the cytological features are sufficient to distinguish GCT-STs from other more common tumors with giant cell morphology. We report here a case of a giant cell tumor of soft tissue diagnosed on the basis of fine needle aspiration cytology and confirmed after histopathology.
    Keywords Giant cell tumor; multinucleated giant cell; fine needle aspiration cytology. ; Cytology ; QH573-671 ; Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Cytology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Language English
    Publishing date 2009-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Giant cell tumor of soft tissue: Cytological diagnosis of a case.

    Asotra, Sarita / Sharma, Sudershan

    Journal of cytology

    2011  Volume 26, Issue 1, Page(s) 33–35

    Abstract: Giant cell tumors of soft tissue (GCT-STs) are rare neoplasms and are mainly seen in adults and in the elderly population, usually in the extremities. When evaluated along with clinical features, the cytological features are sufficient to distinguish GCT- ...

    Abstract Giant cell tumors of soft tissue (GCT-STs) are rare neoplasms and are mainly seen in adults and in the elderly population, usually in the extremities. When evaluated along with clinical features, the cytological features are sufficient to distinguish GCT-STs from other more common tumors with giant cell morphology. We report here a case of a giant cell tumor of soft tissue diagnosed on the basis of fine needle aspiration cytology and confirmed after histopathology.
    Language English
    Publishing date 2011-09-22
    Publishing country India
    Document type Case Reports
    ZDB-ID 645018-0
    ISSN 0970-9371
    ISSN 0970-9371
    DOI 10.4103/0970-9371.54866
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Role of AgNORs in thyroid lesions on fine needle aspiration cytology smears

    Asotra Sarita / Sharma Jaishree

    Journal of Cytology, Vol 25, Iss 1, Pp 18-

    2008  Volume 22

    Abstract: Background: Fine needle aspiration has an important role in diagnosis of thyroid neoplasm. However, it is difficult to differentiate between follicular adenoma and follicular carcinoma by cytology alone. Recently, silver staining has been performed for ... ...

    Abstract Background: Fine needle aspiration has an important role in diagnosis of thyroid neoplasm. However, it is difficult to differentiate between follicular adenoma and follicular carcinoma by cytology alone. Recently, silver staining has been performed for nucleolar organizer regions (AgNORs) to differentiate various tumors. Aims: The present study was undertaken to see if the AgNOR technique could distinguish between benign and malignant lesions, particularly, follicular neoplasm. Materials and Methods: One hundred forty cases of thyroid lesions were examined, which included colloid goiter ( n = 36), multinodular goiter ( n = 38), subacute thyroiditis ( n = 6), Hashimoto′s thyroiditis ( n = 17), lymphocytic thyroiditis ( n = 3), follicular neoplasm ( n = 18), Hurthle cell neoplasm ( n = 3), papillary carcinoma ( n = 16), and medullary carcinoma ( n = 3). Diagnosis was confirmed by histopathology in 80 cases. The usual one-step silver colloidal reaction was performed at room temperature for 35 minutes and intranuclear dots of silver deposits were counted in 100 cells. Results: AgNOR counts of benign and malignant lesions were compared and were found to be statistically significant ( P < 0.001). The mean AgNOR counts were higher in neoplastic lesions. Conclusions: AgNOR counting in fine needle aspiration smears is a simple, sensitive, and cost-effective method for differentiating benign from malignant thyroid follicular neoplasms.
    Keywords AgNORs; fine needle aspiration cytology; thyroid. ; Cytology ; QH573-671 ; Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Cytology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Subject code 610
    Language English
    Publishing date 2008-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Primary psammocarcinoma of peritoneum

    Asotra Sarita / Gupta Saurabh / Gupta Neelam

    Indian Journal of Pathology and Microbiology, Vol 52, Iss 2, Pp 280-

    2009  Volume 281

    Keywords Pathology ; RB1-214 ; Medicine ; R ; DOAJ:Pathology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Microbiology ; QR1-502 ; Science ; Q ; DOAJ:Microbiology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Language English
    Publishing date 2009-04-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Metastatic ovarian tumor

    Asotra Sarita / Sharma Jaishree / Sharma Neelam

    Journal of Cytology, Vol 26, Iss 4, Pp 144-

    2009  Volume 145

    Abstract: 58-year-old woman with a history of breast carcinoma presented with a bilateral ovarian tumor. On fine needle aspiration cytology, diagnosis of metastatic adenocarcinoma was made. At subsequent hysterectomy and bilateral salpingo-oophrectomy, specimen ... ...

    Abstract 58-year-old woman with a history of breast carcinoma presented with a bilateral ovarian tumor. On fine needle aspiration cytology, diagnosis of metastatic adenocarcinoma was made. At subsequent hysterectomy and bilateral salpingo-oophrectomy, specimen showed extensive metastatic carcinoma involving both ovaries.
    Keywords Breast; metastatic carcinoma; ovary ; Cytology ; QH573-671 ; Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Cytology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Language English
    Publishing date 2009-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Metastatic ovarian tumor.

    Asotra, Sarita / Sharma, Jaishree / Sharma, Neelam

    Journal of cytology

    2011  Volume 26, Issue 4, Page(s) 144–145

    Abstract: 58-year-old woman with a history of breast carcinoma presented with a bilateral ovarian tumor. On fine needle aspiration cytology, diagnosis of metastatic adenocarcinoma was made. At subsequent hysterectomy and bilateral salpingo-oophrectomy, specimen ... ...

    Abstract 58-year-old woman with a history of breast carcinoma presented with a bilateral ovarian tumor. On fine needle aspiration cytology, diagnosis of metastatic adenocarcinoma was made. At subsequent hysterectomy and bilateral salpingo-oophrectomy, specimen showed extensive metastatic carcinoma involving both ovaries.
    Language English
    Publishing date 2011-09-22
    Publishing country India
    Document type Case Reports
    ZDB-ID 645018-0
    ISSN 0974-5165 ; 0970-9371
    ISSN (online) 0974-5165
    ISSN 0970-9371
    DOI 10.4103/0970-9371.62183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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