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Article ; Online: Uncommon Benign Neoplasms and Pseudotumors of the Liver.

Assarzadegan, Naziheh / Montgomery, Elizabeth

Archives of pathology & laboratory medicine

2022 Volume 147, Issue 4, Page(s) 390–402

Abstract: Context.—: The most common benign hepatic mass-forming lesions often display fairly specific imaging characteristics, whereas less familiar, rarer benign neoplasms and pseudotumors may pose a diagnostic challenge in clinical, radiology, and pathology ... ...

Abstract	Context.—: The most common benign hepatic mass-forming lesions often display fairly specific imaging characteristics, whereas less familiar, rarer benign neoplasms and pseudotumors may pose a diagnostic challenge in clinical, radiology, and pathology practice because of either their rarity or their unusual features. Objective.—: To review a selection of pseudotumors and unusual benign hepatic neoplasms encountered in consultation practices with a focus on nonepithelial tumors. Data sources.—: Sources include English-language literature and personal experiences. Conclusions.—: Several benign conditions (namely, segmental atrophy, infections, immunoglobulin G4 [IgG4]-related sclerosing disease, angiomyolipoma, mesenchymal hamartoma, and various vascular lesions) can lead to formation of hepatic masses. Because of their rarity and underrecognition, such lesions are often diagnostically challenging. Awareness of hepatic pseudotumors and various rare hepatic neoplasms and their potential mimics can forestall misdiagnosis and inappropriate management.
MeSH term(s)	Humans ; Liver Neoplasms/diagnosis ; Liver Neoplasms/pathology ; Immunoglobulin G4-Related Disease/pathology ; Brain Neoplasms/diagnosis ; Hamartoma/diagnosis ; Hamartoma/pathology ; Diagnosis, Differential
Language	English
Publishing date	2022-05-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	194119-7
ISSN	1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
ISSN (online)	1543-2165
ISSN	0363-0153 ; 0096-8528 ; 0003-9985
DOI	10.5858/arpa.2021-0539-RA
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Article: Corrigendum: Updates in the Diagnosis of Intraductal Neoplasms of the Pancreas.

Assarzadegan, Naziheh / Babaniamansour, Sepideh / Shi, Jiaqi

Frontiers in physiology

2022 Volume 13, Page(s) 923917

Abstract: This corrects the article DOI: 10.3389/fphys.2022.856803.]. ...

Abstract	[This corrects the article DOI: 10.3389/fphys.2022.856803.].
Language	English
Publishing date	2022-05-13
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.923917
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Article: Updates in the Diagnosis of Intraductal Neoplasms of the Pancreas.

Assarzadegan, Naziheh / Babaniamansour, Sepideh / Shi, Jiaqi

Frontiers in physiology

2022 Volume 13, Page(s) 856803

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer worldwide. There are many reasons for this dismal prognosis, including the advanced stage at the time of diagnosis and the lack of effective therapeutic approaches. ... ...

Abstract	Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer worldwide. There are many reasons for this dismal prognosis, including the advanced stage at the time of diagnosis and the lack of effective therapeutic approaches. Intraductal papillary mucinous neoplasms (IPMNs) represent detectable and treatable precursor lesions of PDAC. Our understanding of the pathology of IPMNs has evolved over the past few decades, and new advances in diagnostic tools have emerged. The new World Health Organization (WHO) classification scheme now recognizes the previously considered variants of IPMNs, such as intraductal oncocytic papillary neoplasms (IOPNs) and intraductal tubulopapillary neoplasms (ITPNs), as distinct neoplasms. New imaging and molecular diagnostic tests are being developed to recognize these PDAC precursor lesions better. Here, we review the advances in diagnostic tools for IPMNs, IOPNs, and ITPNs, emphasizing the new (5th edition, 2019) WHO classification for pathological diagnosis, molecular markers, new laboratory tests, and imaging tools.
Language	English
Publishing date	2022-03-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.856803
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Article ; Online: What is New in the 2019 World Health Organization (WHO) Classification of Tumors of the Digestive System: Review of Selected Updates on Neuroendocrine Neoplasms, Appendiceal Tumors, and Molecular Testing.

Assarzadegan, Naziheh / Montgomery, Elizabeth

Archives of pathology & laboratory medicine

2020 Volume 145, Issue 6, Page(s) 664–677

Abstract: Context.—: The 5th edition of the World Health Organization classification of digestive system tumors discusses several advancements and developments in understanding the etiology, pathogenesis, and diagnosis of several digestive tract tumors.: ... ...

Abstract	Context.—: The 5th edition of the World Health Organization classification of digestive system tumors discusses several advancements and developments in understanding the etiology, pathogenesis, and diagnosis of several digestive tract tumors. Objective.—: To provide a summary of the updates with a focus on neuroendocrine neoplasms, appendiceal tumors, and the molecular advances in tumors of the digestive system. Data sources.—: English literature and personal experiences. Conclusions.—: Some of the particularly important updates in the 5th edition are the alterations made in the classification of neuroendocrine neoplasms, understanding of pathogenesis of appendiceal tumors and their precursor lesions, and the expanded role of molecular pathology in establishing an accurate diagnosis or predicting prognosis and response to treatment.
MeSH term(s)	Appendiceal Neoplasms/genetics ; Appendiceal Neoplasms/pathology ; Appendix/metabolism ; Appendix/pathology ; Digestive System/metabolism ; Digestive System/pathology ; Digestive System Neoplasms/classification ; Digestive System Neoplasms/genetics ; Digestive System Neoplasms/pathology ; Gastrointestinal Neoplasms/genetics ; Gastrointestinal Neoplasms/pathology ; Genomics/methods ; Humans ; Molecular Diagnostic Techniques/methods ; Neuroendocrine Tumors/genetics ; Neuroendocrine Tumors/pathology ; World Health Organization
Language	English
Publishing date	2020-03-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	194119-7
ISSN	1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
ISSN (online)	1543-2165
ISSN	0363-0153 ; 0096-8528 ; 0003-9985
DOI	10.5858/arpa.2019-0665-RA
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Article ; Online: HPV-driven anal neoplasia: review and recent developments.

Assarzadegan, Naziheh / Brooks, Eugene / Voltaggio, Lysandra

Pathology

2021 Volume 54, Issue 2, Page(s) 184–194

Abstract: A host of human papillomavirus (HPV)-associated squamous and glandular lesions may be identified in the anal canal in men and women. Given their relative rarity, familiarity with the morphological spectrum associated with HPV-driven anal neoplasia is ... ...

Abstract	A host of human papillomavirus (HPV)-associated squamous and glandular lesions may be identified in the anal canal in men and women. Given their relative rarity, familiarity with the morphological spectrum associated with HPV-driven anal neoplasia is important for proper identification and diagnosis. In this article, we review the classification and basic histopathological features of HPV-related squamous intraepithelial and invasive lesions as well as associated pitfalls. In addition, we provide an update on recently described HPV-driven, non-squamous tumours. As our experience with these lesions evolves, we expect the histological spectrum to further expand, particularly as it relates to non-squamous HPV-driven neoplasia.
MeSH term(s)	Alphapapillomavirus ; Anal Canal/anatomy & histology ; Anal Canal/pathology ; Anus Neoplasms/diagnosis ; Anus Neoplasms/pathology ; Anus Neoplasms/virology ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/virology ; Diagnosis, Differential ; Humans ; Papillomavirus Infections/complications ; Papillomavirus Infections/pathology
Language	English
Publishing date	2021-10-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	7085-3
ISSN	1465-3931 ; 0031-3025
ISSN (online)	1465-3931
ISSN	0031-3025
DOI	10.1016/j.pathol.2021.07.003
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Article ; Online: Intolerable Unilateral Hip Pain: Clues from the History.

Cheah, Jenice X / Assarzadegan, Naziheh / Ghosh, Jyotsna / Connolly, Caoilfhionn M / Gelber, Allan C

The American journal of medicine

2022 Volume 135, Issue 9, Page(s) e364–e365

MeSH term(s)	Arthralgia/etiology ; Arthroplasty, Replacement, Hip ; Hip Joint/diagnostic imaging ; Humans ; Pain/etiology
Language	English
Publishing date	2022-05-14
Publishing country	United States
Document type	Case Reports
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2022.04.020
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Article ; Online: Immunohistochemical Expression of CDX2 and SATB2 in Primary Breast Carcinomas.

Assarzadegan, Naziheh / Gonzalo, David H / Leon, Marino E / Asirvatham, Jaya R

Applied immunohistochemistry & molecular morphology : AIMM

2019 Volume 28, Issue 6, Page(s) e53

MeSH term(s)	Biomarkers, Tumor/metabolism ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; CDX2 Transcription Factor/metabolism ; Female ; Gastrointestinal Tract/metabolism ; Humans ; Immunohistochemistry ; Matrix Attachment Region Binding Proteins/metabolism ; Neoplasm Metastasis ; Transcription Factors/metabolism
Chemical Substances	Biomarkers, Tumor ; CDX2 Transcription Factor ; CDX2 protein, human ; Matrix Attachment Region Binding Proteins ; SATB2 protein, human ; Transcription Factors
Language	English
Publishing date	2019-02-07
Publishing country	United States
Document type	Letter
ZDB-ID	1473273-7
ISSN	1533-4058 ; 1062-3345 ; 1541-2016
ISSN (online)	1533-4058
ISSN	1062-3345 ; 1541-2016
DOI	10.1097/PAI.0000000000000748
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Zs.A 3783: Show issues

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Article ; Online: Clinicopathological study of blue nevi of the gastrointestinal (GI) tract: first case series.

Assarzadegan, Naziheh / Salimian, Kevan / Hutchings, Danielle / Windon, Annika Lisbeth / Voltaggio, Lysandra / Montgomery, Elizabeth A

Journal of clinical pathology

2020 Volume 74, Issue 3, Page(s) 167–170

Abstract: Aim: Blue nevus (BN) is a benign melanocytic proliferation that is typically cutaneous. Extracutaneous BN is infrequent and is reported in the mucosa of various organs. Gastrointestinal (GI) tract BN is rare. Here, we describe the clinicopathological ... ...

Abstract	Aim: Blue nevus (BN) is a benign melanocytic proliferation that is typically cutaneous. Extracutaneous BN is infrequent and is reported in the mucosa of various organs. Gastrointestinal (GI) tract BN is rare. Here, we describe the clinicopathological findings of the largest series of GI tract BNs. Methods: A search of our Pathology Data System (1984-2019) identified six GI tract blue nevi. Clinical information, pathology reports and available H&E-stained section slides were reviewed. Results: Lesions predominated in the middle-aged adults (mean 54, range 27-80) with a slight female predominance (66%). Most cases arose in the rectum and colon (83%), with one gastric lesion (17%). Four cases were identified during endoscopic examination performed either for screening or for unrelated symptoms (66%). Two patients presented with rectal bleeding (33%) unassociated with the BN. Endoscopically, most lesions appeared as superficial hyperpigmented areas (83%). One case was described as abnormal mucosa (17%). Microscopically, the mucosa was involved in all of the cases (100%). One case showed submucosal extension in addition to the mucosal component (17%). Lesions showed a proliferation of bland spindle cells with abundant granular pigment. No nuclear atypia or mitoses were identified. Immunostains showed immunoreactivity for melanocytic markers. Follow-up information available for five patients showed no recurrences to date (mean follow-up 1 year). Conclusions: BN is a benign melanocytic proliferation. It is important to be aware of the occurrence of such lesions outside of the skin and consider the possibility of BN when pigmented lesions are encountered in the GI tract.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Cell Proliferation ; Female ; Gastrointestinal Diseases/diagnosis ; Gastrointestinal Diseases/pathology ; Gastrointestinal Neoplasms/diagnosis ; Gastrointestinal Neoplasms/pathology ; Gastrointestinal Tract/pathology ; Humans ; Male ; Melanocytes/pathology ; Middle Aged ; Mucous Membrane/pathology ; Nevus, Blue/diagnosis ; Nevus, Blue/pathology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/pathology
Language	English
Publishing date	2020-07-06
Publishing country	England
Document type	Journal Article
ZDB-ID	80261-x
ISSN	1472-4146 ; 0021-9746
ISSN (online)	1472-4146
ISSN	0021-9746
DOI	10.1136/jclinpath-2020-206757
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Article ; Online: Perianal Paget's disease as spread from non-invasive colorectal adenomas.

Hutchings, Danielle / Windon, Annika / Assarzadegan, Naziheh / Salimian, Kevan J / Voltaggio, Lysandra / Montgomery, Elizabeth A

Histopathology

2020 Volume 78, Issue 2, Page(s) 276–280

Abstract: Aims: Paget's disease of the perianal skin is a rare form of extramammary Paget's disease, and may be a primary intraepithelial adnexal neoplasm or secondary due to spread from an underlying colorectal lesion, nearly always colorectal adenocarcinoma. ... ...

Abstract	Aims: Paget's disease of the perianal skin is a rare form of extramammary Paget's disease, and may be a primary intraepithelial adnexal neoplasm or secondary due to spread from an underlying colorectal lesion, nearly always colorectal adenocarcinoma. Secondary perianal Paget's disease associated with non-invasive colorectal adenomas is exceedingly uncommon, with only a few reported cases. Methods and results: Herein, we present the clinical and pathological features of the largest series of secondary perianal Paget's disease arising in association with colorectal adenomas. There was gender parity and the median age was 72 years (range = 68-76 years). In all cases, perianal Paget's disease was associated with colorectal adenomas, including three (75%) conventional tubular adenomas and one (25%) tubulovillous adenoma with serrated foci. All adenomas had high-grade dysplasia and one had intramucosal adenocarcinoma (lamina propria invasion; Tis), but all lacked submucosal invasion. The intraepithelial Paget's cells showed a colorectal phenotype by immunohistochemistry in all cases. At follow-up, two patients had no evidence of disease at 6 and 87 months, one had residual perianal Paget's disease at 8 months and one developed invasive adenocarcinoma of the perianal tissue at 36 months. Conclusions: Similar to its mammary analogue, secondary perianal Paget's disease may arise in association with invasive and/or in-situ colorectal lesions. Although the latter is an uncommon presentation of a recognised rare disease, knowledge of this phenomenon is important to forestall overdiagnosis of invasion and potential overtreatment. The clinical course is variable, such that close follow-up is required.
MeSH term(s)	Adenocarcinoma/complications ; Adenocarcinoma/pathology ; Adenoma/complications ; Adenoma/pathology ; Aged ; Anal Canal/pathology ; Anus Neoplasms/diagnosis ; Anus Neoplasms/etiology ; Anus Neoplasms/pathology ; Anus Neoplasms/secondary ; Colorectal Neoplasms/complications ; Colorectal Neoplasms/pathology ; Female ; Humans ; Immunohistochemistry ; Male ; Paget Disease, Extramammary/diagnosis ; Paget Disease, Extramammary/etiology ; Paget Disease, Extramammary/pathology ; Paget Disease, Extramammary/secondary
Language	English
Publishing date	2020-09-23
Publishing country	England
Document type	Journal Article
ZDB-ID	131914-0
ISSN	1365-2559 ; 0309-0167
ISSN (online)	1365-2559
ISSN	0309-0167
DOI	10.1111/his.14218
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Zs.A 1328: Show issues

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Article ; Online: Aberrant p53 Expression in Gastric Biopsies and Resection Specimens Following Neoadjuvant Chemoradiation: A Diagnostic Pitfall.

Hutchings, Danielle A / Salimian, Kevan J / Waters, Kevin M / Birkness-Gartman, Jacqueline E / Voltaggio, Lysandra / Assarzadegan, Naziheh / Huang, Jialing / Lin, Ming-Tseh / Singhi, Aatur D / Montgomery, Elizabeth A

International journal of surgical pathology

2023 Volume 31, Issue 8, Page(s) 1458–1465

Abstract: Gastric mucosal biopsies and resections from patients treated with neoadjuvant radiation and/or chemotherapy are frequently encountered. These samples may show histologic features related to therapy including inflammation, ulceration, and epithelial ... ...

Abstract	Gastric mucosal biopsies and resections from patients treated with neoadjuvant radiation and/or chemotherapy are frequently encountered. These samples may show histologic features related to therapy including inflammation, ulceration, and epithelial atypia. In some cases, epithelial atypia may be marked, prompting the use of adjunct p53 immunohistochemistry. We examined p53 expression by immunohistochemistry in gastric mucosa following therapy. We evaluated the histology and p53 immunohistochemical expression in gastric mucosa from 5 We identified histomorphologic features of therapy-related epithelial changes in 50 of 60 cases (83%). Abnormal p53 expression was present at least focally in nearly half the cases (27 of 60 cases; 45%), all of which showed morphologic evidence of therapy-related epithelial changes Our results demonstrate that abnormal p53 expression is relatively common in gastric mucosal samples following radiation and/or chemotherapy and suggest that p53 expression should be avoided when distinguishing therapy
MeSH term(s)	Humans ; Tumor Suppressor Protein p53/metabolism ; Neoadjuvant Therapy ; Biopsy ; Esophageal Neoplasms/diagnosis ; Esophageal Neoplasms/therapy ; Carcinoma
Chemical Substances	Tumor Suppressor Protein p53
Language	English
Publishing date	2023-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1336393-1
ISSN	1940-2465 ; 1066-8969
ISSN (online)	1940-2465
ISSN	1066-8969
DOI	10.1177/10668969231157304
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