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  1. Article ; Online: COVID-19-related prothrombotic changes increase with lung injury and remain unaffected by anticoagulation therapy.

    Assinger, Alice

    Research and practice in thrombosis and haemostasis

    2021  Volume 5, Issue 1, Page(s) 11–13

    Language English
    Publishing date 2021-01-04
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1002/rth2.12473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Concept of Thromboinflammation.

    Schrottmaier, Waltraud C / Assinger, Alice

    Hamostaseologie

    2024  Volume 44, Issue 1, Page(s) 21–30

    Abstract: Inflammation and thrombosis are intricate and closely interconnected biological processes that are not yet fully understood and lack effective targeted therapeutic approaches. Thrombosis initiated by inflammatory responses, known as immunothrombosis, can ...

    Abstract Inflammation and thrombosis are intricate and closely interconnected biological processes that are not yet fully understood and lack effective targeted therapeutic approaches. Thrombosis initiated by inflammatory responses, known as immunothrombosis, can confer advantages to the host by constraining the spread of pathogens within the bloodstream. Conversely, platelets and the coagulation cascade can influence inflammatory responses through interactions with immune cells, endothelium, or complement system. These interactions can lead to a state of heightened inflammation resulting from thrombotic processes, termed as thromboinflammation. This review aims to comprehensively summarize the existing knowledge of thromboinflammation and addressing its significance as a challenging clinical issue.
    MeSH term(s) Humans ; Thrombosis ; Inflammation ; Thromboinflammation ; Blood Coagulation ; Blood Platelets
    Language English
    Publishing date 2024-02-28
    Publishing country Germany
    Document type Review ; Journal Article
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/a-2178-6491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1631: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Platelets-Disarmed guardians in the fight against the plague.

    Assinger, Alice

    Journal of thrombosis and haemostasis : JTH

    2021  Volume 18, Issue 12, Page(s) 3169–3171

    MeSH term(s) Blood Platelets ; Humans ; Plague/prevention & control ; Platelet Function Tests ; Thrombosis ; Yersinia pestis
    Language English
    Publishing date 2021-01-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.15063
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    Zs.A 5805: Show issues Location:
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    Zs.MO 295: Show issues

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  4. Article ; Online: Editorial: Molecular drivers of immunothrombosis.

    Assinger, Alice / Chatterjee, Madhumita / McFadyen, James D

    Frontiers in immunology

    2024  Volume 15, Page(s) 1385966

    MeSH term(s) Humans ; Thromboinflammation ; Blood Coagulation ; Hemostasis
    Language English
    Publishing date 2024-02-27
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1385966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Concept of Thromboinflammation

    Schrottmaier, Waltraud C. / Assinger, Alice

    Hämostaseologie

    2024  Volume 44, Issue 01, Page(s) 21–30

    Abstract: Inflammation and thrombosis are intricate and closely interconnected biological processes that are not yet fully understood and lack effective targeted therapeutic approaches. Thrombosis initiated by inflammatory responses, known as immunothrombosis, can ...

    Abstract Inflammation and thrombosis are intricate and closely interconnected biological processes that are not yet fully understood and lack effective targeted therapeutic approaches. Thrombosis initiated by inflammatory responses, known as immunothrombosis, can confer advantages to the host by constraining the spread of pathogens within the bloodstream. Conversely, platelets and the coagulation cascade can influence inflammatory responses through interactions with immune cells, endothelium, or complement system. These interactions can lead to a state of heightened inflammation resulting from thrombotic processes, termed as thromboinflammation. This review aims to comprehensively summarize the existing knowledge of thromboinflammation and addressing its significance as a challenging clinical issue.
    Keywords thromboinflammation ; immunothrombosis ; platelets ; coagulation ; leukocytes ; complement ; Thromboinflammation ; Immunthrombose ; Blutplättchen ; Gerinnung ; Leukozyten ; Komplement
    Language English
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/a-2178-6491
    Database Thieme publisher's database

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    Zs.A 1631: Show issues Location:
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  6. Article ; Online: A not so lonesome kinase secreted by platelets.

    Schmid, Johannes A / Assinger, Alice

    Blood

    2022  Volume 139, Issue 1, Page(s) 8–9

    MeSH term(s) Blood Platelets
    Language English
    Publishing date 2022-01-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021013533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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    Zs.MO 364: Show issues

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  7. Article ; Online: Editorial: Platelet and megakaryocyte dysfunctions in infectious diseases.

    Assinger, Alice / Capron, Claude / Real, Fernando / Bomsel, Morgane

    Frontiers in immunology

    2023  Volume 14, Page(s) 1175200

    MeSH term(s) Humans ; Megakaryocytes ; Blood Platelets ; Platelet Count ; Communicable Diseases
    Language English
    Publishing date 2023-03-28
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1175200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The role of microRNAs in the different phases of liver regeneration.

    Kern, Anna Emilia / Ortmayr, Gregor / Assinger, Alice / Starlinger, Patrick

    Expert review of gastroenterology & hepatology

    2023  Volume 17, Issue 10, Page(s) 959–973

    Abstract: Introduction: Since the first discovery of microRNAs (miRs) extensive evidence reveals their indispensable role in different patho-physiological processes. They are recognized as critical regulators of hepatic regeneration, as they modulate multiple ... ...

    Abstract Introduction: Since the first discovery of microRNAs (miRs) extensive evidence reveals their indispensable role in different patho-physiological processes. They are recognized as critical regulators of hepatic regeneration, as they modulate multiple complex signaling pathways affecting liver regeneration. MiR-related translational suppression and degradation of target mRNAs and proteins are not limited to one specific gene, but act on multiple targets.
    Areas covered: In this review, we are going to explore the role of miRs in the context of liver regeneration and discuss the regulatory effects attributed to specific miRs. Moreover, specific pathways crucial for liver regeneration will be discussed, with a particular emphasis on the involvement of miRs within the respective signaling cascades.
    Expert opinion: The considerable amount of studies exploring miR functions in a variety of diseases paved the way for the development of miR-directed therapeutics. Clinical implementation has already shown promising results, but additional research is warranted to assure safe and efficient delivery. Nevertheless, given the broad functional properties of miRs and their critical involvement during hepatic regeneration, they represent an attractive treatment target to promote liver recovery after hepatic resection.
    MeSH term(s) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Liver Regeneration/genetics ; Signal Transduction ; Focal Nodular Hyperplasia
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-10-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2481021-6
    ISSN 1747-4132 ; 1747-4124
    ISSN (online) 1747-4132
    ISSN 1747-4124
    DOI 10.1080/17474124.2023.2267422
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    Zs.A 6978: Show issues Location:
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  9. Article ; Online: Platelet count, temperature and pH value differentially affect hemostatic and immunomodulatory functions of platelets.

    Schmuckenschlager, Anna / Pirabe, Anita / Assinger, Alice / Schrottmaier, Waltraud C

    Thrombosis research

    2023  Volume 223, Page(s) 111–122

    Abstract: Platelets are primarily recognized for their role in hemostasis, but also regulate immune responses by interacting with leukocytes. Their highly sensitive nature enables platelets to rapidly respond to micro-environmental changes, which is crucial under ... ...

    Abstract Platelets are primarily recognized for their role in hemostasis, but also regulate immune responses by interacting with leukocytes. Their highly sensitive nature enables platelets to rapidly respond to micro-environmental changes, which is crucial under physiological condition but can jeopardize in vitro analyses. Thus, we tested how platelet count and changes in pH and temperatures, which are commonly experienced during inflammation and infection but also affected by ex vivo analyses, influence platelet-leukocyte interaction and immunomodulation. Reducing platelet count by up to 90 % slightly decreased platelet activation and platelet-leukocyte aggregate formation, but did not affect CD11b activation nor CD62L shedding of monocytes or neutrophils. Acidosis (pH 6.9) slightly elevated platelet degranulation and binding to innate leukocytes, though pH changes did not modulate leukocyte activation. While platelet responsiveness was higher at room temperature than at 37 °C, incubation temperature did not affect platelet-leukocyte aggregate formation. In contrast, platelet-mediated CD11b activation and CD62L expression increased with temperature. Our data thus demonstrate the importance of standardized protocols for sample preparation and assay procedure to obtain comparable data. Further, unspecific physiologic responses such as thrombocytopenia, acidosis or temperature changes may contribute to platelet dysfunction and altered platelet-mediated immunomodulation in inflammatory and infectious disease.
    MeSH term(s) Humans ; Temperature ; Platelet Count ; Hemostatics/metabolism ; Blood Platelets/metabolism ; Platelet Activation ; Hemostasis ; Leukocytes/metabolism ; Immunity ; Acidosis/metabolism ; Hydrogen-Ion Concentration
    Chemical Substances Hemostatics
    Language English
    Publishing date 2023-01-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2023.01.026
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    Zs.A 863: Show issues Location:
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  10. Article ; Online: Platelet FcγRIIA signaling: new clues for HIT.

    Assinger, Alice

    Blood

    2015  Volume 126, Issue 26, Page(s) 2777–2778

    MeSH term(s) Animals ; Humans ; MicroRNAs/genetics ; Platelet Activation/genetics ; Protein Tyrosine Phosphatases/biosynthesis ; Receptors, IgG/metabolism ; Thrombosis/genetics
    Chemical Substances MicroRNAs ; Receptors, IgG ; Protein Tyrosine Phosphatases (EC 3.1.3.48)
    Language English
    Publishing date 2015-12-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2015-11-679860
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