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  1. Article: The impact of lamb diets containing either barley or corn on growth performance and carcass quality.

    Ata, M / Obeidat, Belal S

    Veterinary world

    2021  Volume 14, Issue 6, Page(s) 1487–1491

    Abstract: Background and aim: Grains, such as barley (BAR) and corn (CORN), are major energy sources for small ruminants. This study aimed to assess the impact of feeding either BAR or CORN-based diets on growth performance and carcass characteristics.: ... ...

    Abstract Background and aim: Grains, such as barley (BAR) and corn (CORN), are major energy sources for small ruminants. This study aimed to assess the impact of feeding either BAR or CORN-based diets on growth performance and carcass characteristics.
    Materials and methods: Awassi male lambs, average body weight of 20.4±0.49 kg, were chosen randomly. Lambs were acclimated for 10 days and assigned to one of two diets (1) BAR and (2) CORN. Feeding continued for 70 days with 60 days of data collection. Daily intake was recorded. Measurements of body weight were taken starting from day 1 then once per week throughout the study period. On day 40, six lambs were randomly chosen from each group and placed in metabolism cages to assess digestibility and N balance. Lambs were slaughtered on the last day of the study to evaluate carcass characteristics and meat quality.
    Results: Neutral and acid detergent fiber and ether extract intake were greater (p≤0.05) for lambs fed the BAR diets. Nitrogen loss in feces tended to be greater (p=0.09) for the CORN diet. Eye muscle depth (mm) tended to be greater (p=0.07) for the BAR diet. Nutrient digestibility, daily weight gain, carcass characteristics, and meat quality were not different (p≥0.1) between diets.
    Conclusion: The results herein demonstrate that feeding BAR grain improved nutrient intake efficiency and consistency and did not affect weight gain and carcass traits. BAR-based diets might be a useful alternative to CORN for feeding growing lambs.
    Language English
    Publishing date 2021-06-10
    Publishing country India
    Document type Journal Article
    ZDB-ID 2456277-4
    ISSN 2231-0916 ; 0972-8988
    ISSN (online) 2231-0916
    ISSN 0972-8988
    DOI 10.14202/vetworld.2021.1487-1491
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  2. Article ; Online: Case 321: Leigh Syndrome.

    Hai, Bilal / Guntin, Jonathan / Rao, Anil G / Ata, Malik

    Radiology

    2024  Volume 310, Issue 1, Page(s) e222509

    Abstract: History: A 9-month-old preterm male infant born at 33 weeks gestation presented with a 2-month history of developmental decline. The parents reported that over the past several months, they noted regression of milestones, where the infant stopped ... ...

    Abstract History: A 9-month-old preterm male infant born at 33 weeks gestation presented with a 2-month history of developmental decline. The parents reported that over the past several months, they noted regression of milestones, where the infant stopped smiling, crying, expressing himself, or making eye contact. The parents also reported that the infant had multiple seizures during which he would wake up stiff and stare into space for 10-20 seconds while his lips would become blue. The parents were referred to a neurologist, where physical examination was notable for hypotonia. Electroencephalography (EEG) revealed frequent bilateral parietal epileptiform discharges. The patient was subsequently started on lacosamide. The patient's medical history was notable for abnormally low citrulline levels at birth, with negative results of urea cycle disorder testing at the time, along with left inguinal hernia repair performed 3 months ago. More recent laboratory analysis had shown persistently elevated serum lactate and alanine levels. There was no history of travel, recent infection, or vaccine administration. MRI of the brain with spectroscopy was performed for further evaluation.
    MeSH term(s) Infant, Newborn ; Infant ; Humans ; Male ; Leigh Disease/diagnostic imaging ; Brain ; Electroencephalography ; Infant, Premature ; Lacosamide
    Chemical Substances Lacosamide (563KS2PQY5)
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.222509
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  3. Article ; Online: Systematic evaluation of common natural language processing techniques to codify clinical notes.

    Tavabi, Nazgol / Singh, Mallika / Pruneski, James / Kiapour, Ata M

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0298892

    Abstract: Proper codification of medical diagnoses and procedures is essential for optimized health care management, quality improvement, research, and reimbursement tasks within large healthcare systems. Assignment of diagnostic or procedure codes is a tedious ... ...

    Abstract Proper codification of medical diagnoses and procedures is essential for optimized health care management, quality improvement, research, and reimbursement tasks within large healthcare systems. Assignment of diagnostic or procedure codes is a tedious manual process, often prone to human error. Natural Language Processing (NLP) has been suggested to facilitate this manual codification process. Yet, little is known on best practices to utilize NLP for such applications. With Large Language Models (LLMs) becoming more ubiquitous in daily life, it is critical to remember, not every task requires that level of resource and effort. Here we comprehensively assessed the performance of common NLP techniques to predict current procedural terminology (CPT) from operative notes. CPT codes are commonly used to track surgical procedures and interventions and are the primary means for reimbursement. Our analysis of 100 most common musculoskeletal CPT codes suggest that traditional approaches can outperform more resource intensive approaches like BERT significantly (P-value = 4.4e-17) with average AUROC of 0.96 and accuracy of 0.97, in addition to providing interpretability which can be very helpful and even crucial in the clinical domain. We also proposed a complexity measure to quantify the complexity of a classification task and how this measure could influence the effect of dataset size on model's performance. Finally, we provide preliminary evidence that NLP can help minimize the codification error, including mislabeling due to human error.
    MeSH term(s) Humans ; Natural Language Processing ; Electronic Health Records ; Language ; Quality Improvement ; Current Procedural Terminology
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0298892
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  4. Article ; Online: The readability of online patient education materials for slipped capital femoral epiphysis.

    Pruneski, James A / Kiapour, Ata M

    Journal of pediatric orthopedics. Part B

    2021  Volume 31, Issue 2, Page(s) e167–e173

    Abstract: Given the long-term complications of undiagnosed slipped capital femoral epiphysis (SCFE) and the importance of readable health information materials on positive, equitable health outcomes, the objective of this study was to determine if the online ... ...

    Abstract Given the long-term complications of undiagnosed slipped capital femoral epiphysis (SCFE) and the importance of readable health information materials on positive, equitable health outcomes, the objective of this study was to determine if the online patient education materials regarding SCFE are written at or below accepted recommendations. The secondary objective was to determine whether the readability of these materials varied when stratified by the type of website. 'Slipped capital femoral epiphysis', 'SCFE', and 'slipped femoral head' were used as search queries in three common search engines. The readability of each website was evaluated using five established metrics, and the scores were compared by website type and by the complexity of the search query. In this study of 53 unique websites about SCFE, we demonstrated that only one of the web pages was written at the recommended sixth-grade level, and the mean reading level of the online material was above the 10th-grade level. Post hoc testing showed that only websites associated with pediatric academic institutions were written at a significantly lower grade level than general health websites [P < 0.05 for all, range (0.003, 0.04)]. The materials about SCFE that are available to patients and their families continue to be written at an inappropriate level. To increase accessibility and allow for equitable long-term health outcomes, physicians, universities, hospitals and medical societies must ensure that they produce readable education to increase patients' understanding of SCFE, its symptoms and available treatment options. Future studies evaluating progress regarding these metrics are warranted.
    MeSH term(s) Child ; Comprehension ; Humans ; Patient Education as Topic ; Slipped Capital Femoral Epiphyses
    Language English
    Publishing date 2021-12-14
    Publishing country United States
    Document type Journal Article
    ISSN 1473-5865
    ISSN (online) 1473-5865
    DOI 10.1097/BPB.0000000000000943
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  5. Article: Changes in Functional Meniscal Morphology During Skeletal Growth and Maturation.

    Kaushal, Shankar G / Barnett, Samuel C / Hosseinzadeh, Shayan / Perrone, Gabriel S / Kiapour, Ata M

    Orthopaedic journal of sports medicine

    2024  Volume 12, Issue 3, Page(s) 23259671241237810

    Abstract: Background: Little is known on how meniscal morphology develops during skeletal growth and maturation and its subsequent relationship with the corresponding bony anatomy.: Hypotheses: (1) Meniscal dimensions and morphology would change by age during ... ...

    Abstract Background: Little is known on how meniscal morphology develops during skeletal growth and maturation and its subsequent relationship with the corresponding bony anatomy.
    Hypotheses: (1) Meniscal dimensions and morphology would change by age during skeletal growth and maturation in different ways in boys compared with girls. (2) Morphological features of the medial and lateral menisci would correlate to medial and lateral femoral condyle curvatures.
    Study design: Cross-sectional study; Level of evidence, 3.
    Methods: Anatomic features of the medial and lateral menisci were measured on magnetic resonance imaging scans from 269 unique knees (age, 3-18 years; 51% female) with no prior history of injury, congenital or growth-related skeletal disorders, or bony deformities. Morphological shape-based measurements were normalized to tibial plateau width or determined as ratios of meniscal dimensions. The association between age and anatomy was analyzed with linear regression. Two-way analysis of variance with the Holm-Šídák post hoc method was used to compare anatomy between sexes in different age groups. Linear regression was used to evaluate the relationship between femoral condyle curvature radius and meniscal morphology in each compartment after adjusting for age and sex.
    Results: Meniscal length, width, horn distance, mean cross-sectional area (CSA), and mean height increased with age in both sexes (
    Conclusion: Age-related changes in meniscal dimensions and morphology, most notably a nonuniform growth pattern in meniscal geometry, occurred during skeletal growth and maturation, with different trends in boys than in girls.
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2706251-X
    ISSN 2325-9671
    ISSN 2325-9671
    DOI 10.1177/23259671241237810
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  6. Article ; Online: CORR Insights

    Kiapour, Ata M

    Clinical orthopaedics and related research

    2017  Volume 475, Issue 10, Page(s) 2397–2400

    MeSH term(s) Anterior Cruciate Ligament Injuries ; Biomechanical Phenomena ; Cadaver ; Knee ; Knee Joint ; Range of Motion, Articular ; Rotation ; Tibia
    Language English
    Publishing date 2017-06-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1007/s11999-017-5397-3
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    Uk I Zs.188: Show issues Location:
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  7. Article ; Online: Excessive Femoral Anteversion Leading to Symptomatic Posterior Femoroacetabular Impingement, Cam Deformity of the Posterior Femoral Head-Neck Junction, and Anterior Hip Instability in a Dancer: A Case Report.

    Novais, Eduardo N / Movahhedi, Mohammadreza / Kiapour, Ata M / Bixby, Sarah D

    JBJS case connector

    2023  Volume 13, Issue 3

    Abstract: Case: An adolescent female dancer with excessive femoral anteversion presented with posterior and anterior hip pain aggravated by poses that required extension and external rotation. Imaging revealed an atypical cam deformity of the posterior head-neck ... ...

    Abstract Case: An adolescent female dancer with excessive femoral anteversion presented with posterior and anterior hip pain aggravated by poses that required extension and external rotation. Imaging revealed an atypical cam deformity of the posterior head-neck junction. During surgery, the posterior head-neck junction was observed to impinge on the posterior acetabulum with anterior subluxation of the hip. After a derotational femoral osteotomy, the patient experienced resolution of her symptoms.
    Conclusion: Excessive femoral anteversion can lead to reactive cam deformity, posterior intra-articular impingement, and anterior hip instability in patients who require repetitive hip extension and external rotation, such as ballet dancers.
    MeSH term(s) Adolescent ; Humans ; Female ; Femoracetabular Impingement/diagnostic imaging ; Femoracetabular Impingement/surgery ; Femur Head/diagnostic imaging ; Femur Head/surgery ; Tomography, X-Ray Computed ; Range of Motion, Articular ; Hip Joint/diagnostic imaging ; Hip Joint/surgery
    Language English
    Publishing date 2023-07-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2160-3251
    ISSN (online) 2160-3251
    DOI e22.00794
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  8. Article ; Online: Development of Anatomic Risk Factors for ACL Injuries: A Comparison Between ACL-Injured Knees and Matched Controls.

    Pradhan, Pratik / Kaushal, Shankar G / Kocher, Mininder S / Kiapour, Ata M

    The American journal of sports medicine

    2023  Volume 51, Issue 9, Page(s) 2267–2274

    Abstract: Background: Several tibiofemoral anatomic features have been repeatedly associated with increased anterior cruciate ligament (ACL) injury risk. Previous studies have highlighted age and sex differences among these anatomic risk factors, but little is ... ...

    Abstract Background: Several tibiofemoral anatomic features have been repeatedly associated with increased anterior cruciate ligament (ACL) injury risk. Previous studies have highlighted age and sex differences among these anatomic risk factors, but little is known about the normal and pathologic development of these differences during skeletal maturation.
    Purpose: To investigate differences in anatomic risk factors at various stages of skeletal maturation between ACL-injured knees and matched controls.
    Study design: Cross-sectional study; Level of evidence, 3.
    Methods: After institutional review board approval, magnetic resonance imaging scans from 213 unique ACL-injured knees (age, 7-18 years, 48% female) and 239 unique asymptomatic ACL-intact knees (age, 7-18 years, 50% female) were used to measure femoral notch width, posterior slope of the lateral and medial tibial plateau, medial and lateral tibial spinal height (MTSH, LTSH), medial tibial depth, and posterior lateral meniscus-bone angle. Linear regression was performed to assess change in quantified anatomic indices with age for male and female patients in the ACL-injured cohort. Two-way analysis of variance with Holm-Sidak post hoc testing was performed to compare anatomic indices between ACL-injured knees and ACL-intact controls in each age group.
    Results: In the ACL-injured cohort, notch width, notch width index and medial tibial depth increased with age (
    Conclusion: The consistent morphologic differences throughout skeletal growth and maturation suggest a developmental role in high-risk knee morphology. The observed high-risk knee morphology at an earlier age preliminarily suggests the potential of knee anatomy measurements in identifying those with a predisposition toward ACL injury.
    MeSH term(s) Humans ; Male ; Female ; Child ; Adolescent ; Anterior Cruciate Ligament Injuries/etiology ; Anterior Cruciate Ligament Injuries/pathology ; Cross-Sectional Studies ; Case-Control Studies ; Knee Joint/pathology ; Tibia/diagnostic imaging ; Tibia/anatomy & histology ; Risk Factors ; Magnetic Resonance Imaging
    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 197482-8
    ISSN 1552-3365 ; 0363-5465
    ISSN (online) 1552-3365
    ISSN 0363-5465
    DOI 10.1177/03635465231177465
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    Zs.B 1910: Show issues Location:
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  9. Article ; Online: The anticancer effects of thymol on HepG2 cell line.

    Altintas, Fatih / Tunc-Ata, Melek / Secme, Mucahit / Kucukatay, Vural

    Medical oncology (Northwood, London, England)

    2023  Volume 40, Issue 9, Page(s) 260

    Abstract: There is an increasing incidence of liver cancer, which is a hazard for global health. The present study was designed to evaluate possible cytotoxic, genotoxic, apoptotic, oxidant and antioxidant effects of thymol on hepatocellular carcinoma (HepG2) cell ...

    Abstract There is an increasing incidence of liver cancer, which is a hazard for global health. The present study was designed to evaluate possible cytotoxic, genotoxic, apoptotic, oxidant and antioxidant effects of thymol on hepatocellular carcinoma (HepG2) cell line. The cytotoxic effect of thymol on HepG2 cell line was determined by XTT test. We also used the HUVEC cell line to show whether thymol damages healthy cells. Oxidative stress level was determined with Total Oxidant Status (TOS) and Total Antioxidant Status (TAS) measurement kits. Apoptosis of cells was detected in flow cytometry with Annexin V apoptosis kit. Apoptotic gene expressions were analyzed by real-time PCR. Genotoxicity was determined by comet assay, which measures DNA damage. The thymol IC
    MeSH term(s) Humans ; Hep G2 Cells ; Thymol/pharmacology ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Apoptosis ; Antioxidants/pharmacology ; Oxidants/pharmacology
    Chemical Substances Thymol (3J50XA376E) ; Antioxidants ; Oxidants
    Language English
    Publishing date 2023-08-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1201189-7
    ISSN 1559-131X ; 0736-0118 ; 1357-0560
    ISSN (online) 1559-131X
    ISSN 0736-0118 ; 1357-0560
    DOI 10.1007/s12032-023-02134-2
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  10. Article ; Online: Effect of insulin on IR and GLP1-R expressions in HT22 cells.

    Tunc-Ata, Melek / Altunay, Zeynep Mine / Alphan, Aysel / Kucukatay, Vural

    Medical oncology (Northwood, London, England)

    2023  Volume 40, Issue 10, Page(s) 301

    Abstract: Insulin is a significant growth factor that specifically binds to the insulin receptor (IR) in the brain and then activates the PI3K-AKT pathway. Glucagon-like peptide 1 (GLP-1) has a variety of functions including neuroprotection, support for ... ...

    Abstract Insulin is a significant growth factor that specifically binds to the insulin receptor (IR) in the brain and then activates the PI3K-AKT pathway. Glucagon-like peptide 1 (GLP-1) has a variety of functions including neuroprotection, support for neurogenesis, and increasing insulin signal. This study aims to investigate the effect of insulin administered to immortalized clonal mouse hippocampal cell line (HT22) at different doses and intervals on IR, insulin receptor A (IRA), insulin receptor B (IRB), and Glucagon-like peptide 1 receptor (GLP1-R) mRNA expression and protein levels. The cells were planted in 6 well plates at a density of 3 × 10
    MeSH term(s) Animals ; Mice ; Insulin/pharmacology ; Receptor, Insulin/genetics ; Phosphatidylinositol 3-Kinases ; Glucagon-Like Peptide 1 ; RNA, Messenger/genetics
    Chemical Substances Insulin ; Receptor, Insulin (EC 2.7.10.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Glucagon-Like Peptide 1 (89750-14-1) ; RNA, Messenger
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1201189-7
    ISSN 1559-131X ; 0736-0118 ; 1357-0560
    ISSN (online) 1559-131X
    ISSN 0736-0118 ; 1357-0560
    DOI 10.1007/s12032-023-02172-w
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